UID:
edoccha_9961427336802883
Format:
1 online resource (1 streaming video file (38 min.)) :
,
color, sound
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003730
Note:
Retrieved April 15, 2024, from https://hstalks.com/bs/2499/.
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Introduction -- Drug resistant (DR) tuberculosis: current scenario -- Multi drug resistant tuberculosis -- Extensively drug resistant tuberculosis -- Importance of understanding DR mechanisms -- Diagnosis of drug resistance -- Technical challenges of conventional DST -- WHO policies -- LPA performance in isolates and clinical samples -- Main anti-TB drugs and mechanisms of action -- Mechanisms of drug resistance acquisition -- Development of drug resistant tuberculosis -- Drug resistant TB is a man-made disease -- Clinical relevance of drugs resistance -- Mechanisms of drug resistance in tuberculosis -- Isoniazid: targeting mycolic acid biosynthesis -- Ethionamide -- ethA mutations and ethionamide resistance -- Other genes correlated to ethionamide resistance -- Rifampicin -- Low concordance of "rare mutations": MGIT DST -- Pyrazinamide - Mechanism of action -- Pyrazinamide - Mechanisms of resistance -- Ethambutol -- Role of point mutations in outcome prediction -- Fluoroquinolones -- Second line injectable drugs -- Fluoroquinolones & injectables: commercial tests -- PAS -- Linezolid -- Point mutations and drug resistance -- Conclusions -- Acknowledgements.
Language:
English
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