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  • 1
    Article
    Article
    Language: English
    In: Nursing standard (Royal College of Nursing (Great Britain) : 1987), 12 October 2016, Vol.31(7), pp.30
    Description: Well done to 83-year-old nurse Monica Bulman (news, 14 September, page 7 ). At 71 and working on an orthopaedic rehabilitation ward at a hospital in Birmingham, I thought I was getting near to being the oldest nurse practising on a ward.
    ISSN: 00296570
    E-ISSN: 2047-9018
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  • 2
    Language: English
    In: Neuron, 2012, Vol.73(1), pp.149-158
    Description: Here we provide evidence that revises the inhibitory circuit diagram of the cerebellar cortex. It was previously thought that Golgi cells, interneurons that are the sole source of inhibition onto granule cells, were exclusively coupled via gap junctions. Moreover, Golgi cells were believed to receive GABAergic inhibition from molecular layer interneurons (MLIs). Here we challenge these views by optogenetically activating the cerebellar circuitry to determine the timing and pharmacology of inhibition onto Golgi cells and by performing paired recordings to directly assess synaptic connectivity. In contrast to current thought, we find that Golgi cells, not MLIs, make inhibitory GABAergic synapses onto other Golgi cells. As a result, MLI feedback does not regulate the Golgi cell network, and Golgi cells are inhibited approximately 2 ms before Purkinje cells, following a mossy fiber input. Hence, Golgi cells and Purkinje cells receive unique sources of inhibition and can differentially process shared granule cell inputs. ► We identify an inhibitory cerebellar circuit: GABAergic synapses between Golgi cells ► Molecular layer interneurons do not inhibit Golgi cells, as was previously thought ► Inhibition arrives earlier onto Golgi cells than onto Purkinje cells ► Inhibition onto Golgi cells arrives simultaneously with parallel fiber excitation Golgi cells are a crucial source of inhibition in the cerebellum. It was previously thought that Golgi cell activity was regulated by inhibition from molecular layer interneurons (MLIs). Hull and Regehr overturn this view by revealing instead that Golgi cells inhibit each other.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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  • 3
    Article
    Article
    In: Journal of Paediatrics and Child Health, November 2013, Vol.49(11), pp.883-886
    Description: Byline: John M Court ***** No abstract is available for this article. ***** Article Note: Conflict of interest: None declared.
    Keywords: Adolescence;
    ISSN: 1034-4810
    E-ISSN: 1440-1754
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  • 4
    Language: English
    In: Trends in Neurosciences, June 2012, Vol.35(6), pp.364-372
    Description: Axonal degeneration is a major contributor to neuronal dysfunction in many neurological conditions and has additional roles in development. It can be triggered by divergent stimuli including mechanical, metabolic, infectious, toxic, hereditary and inflammatory stresses. Axonal mitochondria are an important convergence point as regulators of bioenergetic metabolism, reactive oxygen species (ROS), Ca homeostasis and protease activation. The challenges likely to render axonal mitochondria more vulnerable than their cellular counterparts are reviewed, including axonal transport, replenishing nuclear-encoded proteins and maintenance of quality control, fusion and fission in locations remote from the cell body. The potential for mitochondria to act as a decision node in axon loss is considered, highlighting the need to understand the biology of axonal mitochondria and their contributions to degenerative mechanisms for novel therapeutic strategies.
    Keywords: Axonal Degeneration ; Mitochondria ; Axonal Transport ; Mitochondrial Permeability Transition Pore ; Reactive Oxygen Species ; Medicine ; Anatomy & Physiology
    ISSN: 0166-2236
    E-ISSN: 1878-108X
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  • 5
    Article
    Article
    BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
    Language: English
    In: Archives of Disease in Childhood, 23 August 2014, Vol.99(8), p.708
    Description: Much has been written about the differences between the working practices of paediatricians and psychiatrists (table 1). Enzer et al11 showed that they seem to have different character traits with different perceptions of how childhood is experienced, differences that predate their training.
    Keywords: Mental Disorders ; Collaboration ; Problems ; Child & Adolescent Psychiatry ; Teenagers ; Children & Youth ; Advocacy ; Patients ; Mental Health Care ; Funding ; Comorbidity;
    ISSN: 0003-9888
    ISSN: 00039888
    E-ISSN: 1468-2044
    E-ISSN: 14682044
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  • 6
    In: Plastic and Reconstructive Surgery, 2012, Vol.129(2), pp.499-501
    Keywords: Cleft Lip -- Surgery ; Reconstructive Surgical Procedures -- Methods;
    ISSN: 0032-1052
    E-ISSN: 15294242
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  • 7
    Language: English
    In: Journal of Marketing Research, 1 June 2012, Vol.49(3), pp.320-335
    Description: The diversification effect, a tendency toward greater variety as multiple choices are made simultaneously, in advance of consumption, is a robust and important phenomenon. Researchers have typically explained the diversification effect in terms of differences in the process by which people select items from among those available. This precludes the possibility that the locus of the effect lies in people's choice sets themselves—that is, how people decide which options to consider when making choices. The authors examine the effects of set formation using an experimental choice sequence task and conjoined stochastic model of set formation and conditional choice. The findings demonstrate that set formation plays a critical role in diversification: Previously chosen options are indeed discounted, but only for simultaneous choices and only in the set formation portion of the model. Furthermore, the expected number of choice set items is substantially greater in multiple-versus single-item choice. Specifically, when consumers choose simultaneously, choice set sizes appear relatively larger overall, but the previously chosen item is less likely to be in a person's (latent) choice set. These findings cannot be attributed to alternative patterns of covariation, including latent error correlations; to temporal stochastic inflation; or to unobserved heterogeneity.
    Keywords: Behavioral sciences -- Human behavior -- Habitual behavior ; Applied sciences -- Research methods -- Modeling ; Business -- Business administration -- Corporate communications ; Philosophy -- Logic -- Logical topics ; Philosophy -- Axiology -- Ethics ; Mathematics -- Applied mathematics -- Statistics ; Business -- Business information -- Consumer research ; Applied sciences -- Research methods -- Observational research ; Business -- Business administration -- Corporate communications ; Economics -- Economic disciplines -- Financial economics
    ISSN: 00222437
    E-ISSN: 15477193
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  • 8
    Language: English
    In: Accident Analysis and Prevention, Nov, 2012, Vol.49, p.96(9)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.aap.2011.09.011 Byline: Isabelle Ragot-Court (a), Christophe Munduteguy (b), Jean-Yves Fournier (a) Keywords: Interaction between powered two-wheeler riders and car drivers; Risk perception; Threat; Prior representations; Conspicuity Abstract: a* We questioned PTW riders and car drivers about what they consider as the riskiest. a* Car drivers mention PTW riders less than PTW riders mention car drivers. a* Exclusive car drivers mention PTW riders less than dual car drivers do. a* Risk factors that users attribute to others are related to their various practices. a* Results show the mutual misunderstanding of determinants in driving situations. Author Affiliation: (a) French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR) - "Accident Mechanisms" Research Unit, Chemin de la croix blanche, 13300 Salon de Provence, France (b) University Paris Est - French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR) - Production Systems, Logistics, Transport Organisation and Work Research Unit, Descartes 2-2, rue de la butte verte, 93166 Noisy-le-Grand Cedex, France Article History: Received 21 December 2010; Revised 24 August 2011; Accepted 9 September 2011
    Keywords: Motor Vehicle Drivers ; Motor Vehicle Driving ; Automobiles
    ISSN: 0001-4575
    Source: Cengage Learning, Inc.
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  • 9
    Article
    Article
    Language: English
    In: School Librarian, Summer, 2015, Vol.63(2), p.88(1)
    ISSN: 0036-6595
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  • 10
    Article
    Article
    Language: English
    In: School Librarian, Summer, 2015, Vol.63(2), p.121(1)
    ISSN: 0036-6595
    Source: Cengage Learning, Inc.
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