Kooperativer Bibliotheksverbund

Berlin Brandenburg


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  • 1
    BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
    Language: English
    In: Archives of Disease in Childhood, 23 November 2011, Vol.96(11), p.1072
    Description: Persistent cloaco is the most severe type of anorectal malformation encountered in children. Patients with cloacal anomalies have a high incidence of associated anomalies most commonly: urinary tract and spinal. Persistent cloaca remains a difficult reconstructive challenge but it is now possible to anatomically correct the defect with surgery in the majority of patients. This review discusses embryology, prenatal diagnosis, neonatal physical and radiological findings. A summary of early management and investigation is provided and the commonest surgical reconstruction techniques are discussed.
    Keywords: Medicine;
    ISSN: 0003-9888
    ISSN: 00039888
    E-ISSN: 1468-2044
    E-ISSN: 14682044
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  • 2
    Language: English
    In: Journal of Applied Physics, March 15, 2011, Vol.109(6), p.063104 -1-063104 -7
    Description: Various studies are carried out for examining the optical properties exhibited by the [Yb.sup.3+] and [Tm.sup.3+] co-doped [Y.sub.2]BaZn[O.sub.5]. The compounds are found to exhibit the maximum efficiencies of around 1.53% in the 730-870 nm near-infrared emission range.
    Keywords: Oxides -- Chemical Properties ; Tellurium -- Chemical Properties ; Tellurium -- Optical Properties ; Cobalt -- Chemical Properties ; Cobalt -- Optical Properties
    ISSN: 0021-8979
    E-ISSN: 10897550
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  • 3
    In: Anaesthesia, February 2010, Vol.65(2), pp.217-217
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1365-2044.2009.06224.x Byline: A. Jeffrey, P. Curry
    Keywords: Aged–Prevention & Control ; Arthroplasty, Replacement, Hip–Standards ; Female–Methods ; Humans–Methods ; Medical Errors–Methods ; Nerve Block–Methods ; Operating Rooms–Methods ; Patient Identification Systems–Methods ; Patient Participation–Methods ; Safety Management–Methods ; Scotland–Methods ; Abridged;
    ISSN: 0003-2409
    E-ISSN: 1365-2044
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  • 4
    In: Transplantation, 2017, Vol.101(5), pp.933-937
    Description: ABSTRACT: All patients with chronic hepatitis C virus (HCV) infections can and should be treated. Though highly effective direct-acting antiviral therapies are costly, the price of a cure is a 1-time investment that is outweighed by future benefits. For clinicians caring for patients requiring liver transplant, the key question relates to the timing of treatment: before or after liver transplantation? On 1 hand, treating HCV often improves our patientsʼ model for end-stage liver disease (MELD) score, decreasing costs, and potentially improving longevity by reducing our patientsʼ risk of death and transplantation. On the other hand, there is a concern that the cured patient with decompensated cirrhosis will find themselves in “MELD purgatory” with nonprogressive liver disease but a poor quality of life. At the same time, some patients, such as those with hepatocellular carcinoma, will require liver transplant irrespective of their MELD meaning that pretransplant therapy cannot reduce costs in such settings. These important tradeoffs are often difficult reconcile for clinicians who care for patients awaiting liver transplant. Fortunately, guidance for navigating these competing concerns can be obtained from cost-effectiveness analyses. Herein, we review the available data on this approach to HCV therapy before or after liver transplant.
    Keywords: Cost-Benefit Analysis ; Liver Transplantation ; Antiviral Agents -- Economics ; End Stage Liver Disease -- Surgery ; Hepatitis C, Chronic -- Drug Therapy ; Postoperative Care -- Methods ; Preoperative Care -- Methods;
    ISSN: 0041-1337
    E-ISSN: 15346080
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  • 5
    In: Chemical Communications, 2011, Vol.47(22), pp.6263-6265
    Description: We report efficient white upconversion luminescence in Yb 3+ -, Er 3+ - and Tm 3+ -doped monophasic and biphasic Y 2 BaZnO 5 phosphors under 977 nm near-infrared excitation and at low excitation power densities (down to ∼25 mW mm −2 ).
    Keywords: Density ; Emission ; Excitation ; Luminescence ; Phosphors ; Upconversion ; White Light ; Miscellaneous Sciences (So) ; Components and Materials (General) (Ea);
    ISSN: 1359-7345
    E-ISSN: 1364-548X
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  • 6
    Language: English
    In: Journal of Infectious Diseases, March 15, 2013, Vol.207(6), p.S40(5)
    Keywords: Hiv Infections -- Care And Treatment ; Hepatitis C -- Care And Treatment ; Comorbidity -- Care And Treatment ; Comorbidity -- Analysis
    ISSN: 0022-1899
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  • 7
    Language: English
    In: Transplantation Proceedings, 2011, Vol.43(2), pp.623-628
    Description: Heart transplantation is optimal treatment for many patients with end-stage heart failure. Current data report 1-year graft survival rates of 85% after transplantation. The success of transplantation in large part is attributable to immunosuppression, including steroids, one of the mainstay agents. Despite its efficacy to treat acute graft rejection, steroids show numerous adverse effects. With newer immunosuppressive agents, steroid withdrawal is possible. We compared cardiac transplant patients who died versus survived between 2001 and 2006. We obtained Personal, transplant, occurrence of and cause of death data as well as postoperative intervals. Steroid therapy details were gathered, particularly whether the patient had been weaned off these agents. We calculated steroid doses and steroid-free years, as well as the steroid therapy status of posttransplant patients who remained alive in 2006. Fifty cardiac transplant patients died between 2001 and 2006 excluding 6 who had graft failure and 2 who died of multiorgan failure before initial discharge. Of the 42 patient who died, 29 (69%) were on and 13 (31%) had been withdrawn from steroid therapy at time of death. There were 132 posttransplant patients currently alive in April 2006, including 43 (33%) on and 89 (67%) withdrawn from steroids. The percentages of patients who were on versus off steroids were compared for main causes of death. Thirty-eight percent of patients on steroids at the time of death died of graft vasculopathy compared with 46% of patients who had been weaned off steroids. Fifteen percent of deceased patients taking steroids at the time of death died of chronic rejection. The current literature focuses on early withdrawal or reduction of steroids or steroid avoidance after organ transplantation. Although steroid avoidance remains controversial, steroid withdrawal has been generally incorporated into immunosuppressive protocols. Early steroid withdrawal has a positive influence on the emergence of de novo osteoporosis and cataracts. The benefits of steroid avoidance versus withdrawal are controversial topics being currently debated.
    Keywords: Biology ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0041-1345
    E-ISSN: 1873-2623
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  • 8
    Language: English
    In: Biology of reproduction, July 2010, Vol.83(1), pp.147-54
    Description: The process of ovulation involves weakening of the follicular wall by proteolytic enzymes. The function of FURIN (also known as PCSK3) is to activate various proteolytic enzymes. In the present study, the expression, localization, and function of FURIN were investigated in the periovulatory rat ovary. Immature female rats were injected with equine chorionic gonadotropin followed by human chorionic gonadotropin (hCG) 48 h later to stimulate ovulation. Ovaries were collected at 0, 4, 8, 12, and 24 h after hCG injection. Administration of hCG increased Furin mRNA expression in both intact ovaries and cultured ovarian follicles to maximal levels at 8 and 12 h before decreasing at 24 h. In cultured granulosa cells, Furin mRNA levels were significantly induced at 12 h after hCG. In situ hybridization of Furin mRNA demonstrated expression in the granulosa cells, with predominant expression in the theca layer. Regulation studies demonstrated that Furin mRNA was induced in residual tissue by forskolin or amphiregulin. To examine the role of FURIN in protease activation and ovulation, rats were treated with a FURIN inhibitor and oocyte release was determined. There was a 38% decrease in the number of oocytes released in ovaries treated with the FURIN inhibitor. Likewise, the FURIN inhibitor decreased the activation of MMP2. The induction of Furin mRNA after treatment with hCG, along with the decrease in MMP2 activation and oocyte release after FURIN inhibition, supports the hypothesis that FURIN is upregulated during the preovulatory period, which results in activation of proteinases associated with the breakdown of the follicular wall during ovulation.
    Keywords: Ovulation ; Furin -- Metabolism ; Matrix Metalloproteinases -- Metabolism ; Ovary -- Enzymology
    ISSN: 00063363
    E-ISSN: 1529-7268
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  • 9
    Language: English
    In: The Journal of infectious diseases, March 2013, Vol.207 Suppl 1, pp.S40-4
    Description: Since the advent of highly active antiretroviral therapy, liver disease has been a major cause of morbidity and mortality in patients with human immunodeficiency virus (HIV) infection. Chronic viral hepatitis accounts for 〉80% of liver-related mortality. Liver-related morbidity is due to acceleration of hepatitis C virus (HCV) disease, drug-induced hepatotoxicity, and, possibly, direct damage from HIV infection itself. As a consequence of this complex interaction, end-stage liver disease and hepatocellular carcinoma are frequent complications in patients with HIV infection. Infectious diseases physicians who care for HIV-infected patients with advanced HCV-related liver disease need to know how to assess for advanced fibrosis, to know when to refer a patient for endoscopic screening for varices, and to enroll patients in a screening program for hepatocellular carcinoma.
    Keywords: Coinfection -- Complications ; HIV Infections -- Complications ; Hepatitis C -- Complications ; Liver Cirrhosis -- Epidemiology
    ISSN: 00221899
    E-ISSN: 1537-6613
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  • 10
    In: The New England Journal of Medicine, 2010, Vol.362(25), pp.2421-2422
    Description: Gastroesophageal varices are present in 50% of patients with cirrhosis, and variceal hemorrhage develops in up to one third of these patients. The risk of variceal hemorrhage is increased in patients who have large varices and advanced stages of liver disease, as assessed on the basis of the Child–Pugh class. 1 Several studies published between 1942 and 1981 showed poor outcomes after variceal hemorrhage, with mortality rates of 40% at 6 weeks and 70% at 1 year. 2 – 5 Over the past five decades, a number of randomized trials have shown an improvement in the efficacy of endoscopic, pharmacologic, surgical, and radiologic . . .
    Keywords: Polytetrafluoroethylene -- Patient Outcomes ; Liver Cirrhosis -- Care And Treatment ; Liver Cirrhosis -- Patient Outcomes;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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