Tetrahedron, 07 January 2012, Vol.68(1), pp.244-249
Seven new diterpenoids, namely, flexibilisolides C–G ( – ), flexibilisin C ( ), and a novel 11,12-secoflexibillin ( ), along with seven known compounds, – , were isolated from the Dongsha Atoll soft coral . The structures of the new metabolites were elucidated by extensive spectroscopic analysis and comparison of the NMR data with those of known analogues. Compounds , , and were shown to exhibit moderate cytotoxic activity against HeLa and B16 cancer cell lines, and compound was found to exhibit more potent cytotoxic activity against SK-Hep1 and B16 cancer cell lines. Moreover, compounds , , , , and – could significantly inhibit the accumulation of the pro-inflammatory iNOS protein and , , , and could reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells. Seven new diterpenoids, flexibilisolides C–G ( – ), flexibilisin C ( ), and a novel 11,12-secoflexibillin ( ), along with seven known compounds, – , were isolated from the Dongsha Atoll soft coral . Several compounds have been shown to exhibit anti-inflammatory activity.
Cytotoxic ; Anti-Inflammatory ; Soft Coral ; Sinularia Flexibilis ; Chemistry
View record in ScienceDirect (Access to full text may be restricted)