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  • 1
    Language: English
    In: BMC Cardiovascular Disorders, 01 June 2011, Vol.11(1), p.32
    Description: Abstract Background This systematic review summarized recent evidence pertaining to the clinical effectiveness of 64-slice or higher computed tomography angiography (CTA) in patients with suspected coronary artery disease (CAD). If CTA proves...
    Keywords: Medicine
    ISSN: 1471-2261
    E-ISSN: 1471-2261
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  • 2
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(11), p.e110727
    Description: PURPOSE: To analyze if tumor vessels can be visualized, segmented and quantified in glioblastoma patients with time of flight (ToF) angiography at 7 Tesla and multiscale vessel enhancement filtering. MATERIALS AND METHODS: Twelve patients with newly diagnosed glioblastoma were examined with...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 3
    Language: English
    In: PLoS ONE, 01 January 2015, Vol.10(3), p.e0121220
    Description: To explore the correlation between Nuclear Overhauser Enhancement (NOE)-mediated signals and tumor cellularity in glioblastoma utilizing the apparent diffusion coefficient (ADC) and cell density from histologic specimens. NOE is one type of chemical exchange saturation transfer (CEST) that...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: PLoS ONE, 01 January 2017, Vol.12(4), p.e0176077
    Description: To evaluate a fractional order calculus (FROC) model in diffusion weighted imaging to differentiate between malignant and benign breast lesions in breast cancer screening work-up using recently introduced parameters (βFROC, DFROC and μFROC).This...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 5
    Language: English
    In: BMC Cardiovascular Disorders, June 16, 2011, Vol.11, p.32
    Description: Background This systematic review summarized recent evidence pertaining to the clinical effectiveness of 64-slice or higher computed tomography angiography (CTA) in patients with suspected coronary artery disease (CAD). If CTA proves to be a successful diagnostic performance measure, it could prevent the use of invasive diagnostic procedures in some patients. This would provide multiple health and cost benefits, particularly for under resourced areas where invasive coronary angiography is not always available. Methods A systematic method of literature searching and selection was employed with searches limited to December 2006 to March 2009. Included studies were quality assessed using National Health and Medical Research Council (NHMRC) diagnostic levels of evidence and a modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Individual and pooled diagnostic performance measures were calculated using standard meta-analytic techniques at the patient, vessel and segment level. A positive result was defined as greater than or equal to 50% stenosis. Results Twenty-eight studies were included in the systematic review examining 3,674 patients. The primary meta-analysis at the patient-level indicated a sensitivity of 98.2% and specificity of 81.6%. The median (range) positive predictive value (PPV) was 90.5% (76%-100%) and negative predictive value (NPV) 99.0% (83%-100%). In all vessels, the pooled sensitivity was 94.9%, specificity 89.5%, and median (range) PPV 75.0% (53%-95%) and NPV 99.0% (93%-100%). At the individual artery level, overall diagnostic accuracy appeared to be slightly higher in the left main coronary artery and slightly lower in the left anterior descending and circumflex artery. In all segments, the sensitivity was 91.3%, specificity 94.0% and median (range) PPV 69.0% (44%-86%) and NPV 99.0% (98%-100%). Conclusions The high sensitivity indicates that CTA can effectively identify the majority of patients with significant coronary artery stenosis. The high NPV at the patient, vessel and segment level establishes CTA as an effective non-invasive alternative to invasive coronary angiography (ICA) for the exclusion of stenosis.
    Keywords: Coronary Angiography -- Usage ; Coronary Heart Disease -- Diagnosis ; Coronary Heart Disease -- Care And Treatment ; Coronary Heart Disease -- Research ; Cardiac Patients -- Health Aspects ; Cardiac Patients -- Research
    ISSN: 1471-2261
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: BMC Cardiovascular Disorders, June 16, 2011, Vol.11, p.32
    Description: Background This systematic review summarized recent evidence pertaining to the clinical effectiveness of 64-slice or higher computed tomography angiography (CTA) in patients with suspected coronary artery disease (CAD). If CTA proves to be a successful diagnostic performance measure, it could prevent the use of invasive diagnostic procedures in some patients. This would provide multiple health and cost benefits, particularly for under resourced areas where invasive coronary angiography is not always available. Methods A systematic method of literature searching and selection was employed with searches limited to December 2006 to March 2009. Included studies were quality assessed using National Health and Medical Research Council (NHMRC) diagnostic levels of evidence and a modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Individual and pooled diagnostic performance measures were calculated using standard meta-analytic techniques at the patient, vessel and segment level. A positive result was defined as greater than or equal to 50% stenosis. Results Twenty-eight studies were included in the systematic review examining 3,674 patients. The primary meta-analysis at the patient-level indicated a sensitivity of 98.2% and specificity of 81.6%. The median (range) positive predictive value (PPV) was 90.5% (76%-100%) and negative predictive value (NPV) 99.0% (83%-100%). In all vessels, the pooled sensitivity was 94.9%, specificity 89.5%, and median (range) PPV 75.0% (53%-95%) and NPV 99.0% (93%-100%). At the individual artery level, overall diagnostic accuracy appeared to be slightly higher in the left main coronary artery and slightly lower in the left anterior descending and circumflex artery. In all segments, the sensitivity was 91.3%, specificity 94.0% and median (range) PPV 69.0% (44%-86%) and NPV 99.0% (98%-100%). Conclusions The high sensitivity indicates that CTA can effectively identify the majority of patients with significant coronary artery stenosis. The high NPV at the patient, vessel and segment level establishes CTA as an effective non-invasive alternative to invasive coronary angiography (ICA) for the exclusion of stenosis.
    Keywords: Coronary Angiography -- Usage ; Coronary Heart Disease -- Diagnosis ; Coronary Heart Disease -- Care And Treatment ; Coronary Heart Disease -- Research ; Cardiac Patients -- Health Aspects ; Cardiac Patients -- Research
    ISSN: 1471-2261
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: European Radiology, 2017, Vol.27(5), pp.2153-2160
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-016-4554-5 Byline: Daniel Paech (1,2), Frederik L. Giesel (3), Roland Unterhinninghofen (4), Heinz-Peter Schlemmer (1), Thomas Kuner (2), Sara Doll (2) Keywords: Radiology; Gross anatomy; CT scans; Cadaver CT scans; Medical education Abstract: Objectives The purpose of this study was to quantify the benefit of the incorporation of radiologic anatomy (RA), in terms of student training in RA seminars, cadaver CT scans and life-size virtual dissection tables on the learning success in general anatomy. Methods Three groups of a total of 238 students were compared in a multiple choice general anatomy exam during first-year gross anatomy: (1) a group (year 2015, n .sub.1=50) that received training in radiologic image interpretation (RA seminar) and additional access to cadaver CT scans (CT + seminar group) (2) a group (2011, n .sub.2=90) that was trained in the RA seminar only (RA seminar group) (3) a group (2011, n .sub.3=98) without any radiologic image interpretation training (conventional anatomy group). Furthermore, the students' perception of the new curriculum was assessed qualitatively through a survey. Results The average test score of the CT + seminar group (21.8[+ or -]5.0) was significantly higher when compared to both the RA seminar group (18.3[+ or -]5.0) and the conventional anatomy group (17.1[+ or -]4.7) (p〈0.001). Conclusions The incorporation of cadaver CT scans and life-size virtual dissection tables significantly improved the performance of medical students in general gross anatomy. Medical imaging and virtual dissection should therefore be considered to be part of the standard curriculum of gross anatomy. Key Points acents Students provided with cadaver CT scans achieved 27 % higher scores in anatomy. acents Radiological education integrated into gross anatomy is highly appreciated by medical students. acents Simultaneous physical and virtual dissection provide unique conditions to study anatomy. Author Affiliation: (1) Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany (2) Institute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany (3) Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany (4) Institute of Anthropomatics, Karlsruhe Institute of Technology, Karlsruhe, Germany Article History: Registration Date: 09/08/2016 Received Date: 01/03/2016 Accepted Date: 09/08/2016 Online Date: 27/08/2016
    Keywords: Radiology ; Gross anatomy ; CT scans ; Cadaver CT scans ; Medical education
    ISSN: 0938-7994
    E-ISSN: 1432-1084
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  • 8
    Language: English
    In: PLoS ONE, Nov 21, 2014, Vol.9(11)
    Description: Purpose To analyze if tumor vessels can be visualized, segmented and quantified in glioblastoma patients with time of flight (ToF) angiography at 7 Tesla and multiscale vessel enhancement filtering. Materials and Methods Twelve patients with newly diagnosed glioblastoma were examined with ToF angiography (TR = 15 ms, TE = 4.8 ms, flip angle = 15#176;, FOV = 160x210 mm.sup.2, voxel size: 0.31x0.31x0.40 mm.sup.3) on a whole-body 7 T MR system. A volume of interest (VOI) was placed within the border of the contrast enhancing part on T1-weighted images of the glioblastoma and a reference VOI was placed in the non-affected contralateral white matter. Automated segmentation and quantification of vessels within the two VOIs was achieved using multiscale vessel enhancement filtering in ImageJ. Results Tumor vessels were clearly visible in all patients. When comparing tumor and the reference VOI, total vessel surface (45.3#177;13.9 mm.sup.2 vs. 29.0#177;21.0 mm.sup.2 (p0.035)) and number of branches (3.5#177;1.8 vs. 1.0#177;0.6 (p0.001) per cubic centimeter were significantly higher, while mean vessel branch length was significantly lower (3.8#177;1.5 mm vs 7.2#177;2.8 mm (p0.001)) in the tumor. Discussion ToF angiography at 7-Tesla MRI enables characterization and quantification of the internal vascular morphology of glioblastoma and may be used for the evaluation of therapy response within future studies.
    Keywords: Medical Research ; Glioblastomas ; Angiography
    ISSN: 1932-6203
    Source: Cengage Learning, Inc.
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  • 9
    In: Nachrichten aus der Chemie, May 2018, Vol.66(5), pp.496-498
    Description: Um zu ermitteln, wie groß Tumore sind und wie sie sich im umliegenden Gewebe ausgebreitet haben, nutzen Mediziner bisher Diagnostikverfahren, bei denen dem Patienten Kontrastmittel verabreicht wird oder er Strahlung ausgesetzt wird. Das könnte sich nun ändern.
    Keywords: Traubenzucker ; Zucker ; Tumor ; Magnetresonanz ; Wasserstoffatom ; Magnetresonanztomographie ; Positronenemissionstomographie ; Kontrastmittel ; Strahlung ; Bildgebungsverfahren ; Oh-Gruppe ; Gadoliniumkomplex ; Diagnoseverfahren ; Chemistry;
    ISSN: 1439-9598
    E-ISSN: 1868-0054
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  • 10
    Language: English
    In: Radiology, June 2017, Vol.283(3), pp.828-836
    Description: Purpose To determine the effect of at least five serial injections of the macrocyclic gadolinium-based contrast agent (GBCA) gadoterate meglumine on the signal intensity (SI) of the dentate nucleus (DN) of the pediatric brain on nonenhanced T1-weighted magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 41 pediatric patients (age range, 3-17 years) who were imaged in at least five consecutive 1.5-T MR examinations with the exclusive use of gadoterate meglumine (plus a final additional nonenhanced MR imaging examination) were evaluated. SI ratio differences between the first and last MR examination were calculated for DN-to-pons and DN-to-middle cerebellar peduncle (MCP) ratios in a region-of-interest-based analysis, and one-sample t tests were used to examine if the SI ratio differences differed from 0. Bayes factors were calculated to quantify the strength of evidence for each test. Results Patients underwent a mean of 8.6 ± 3.9 GBCA administrations (mean accumulated dose, 32.07 mmol ± 17.62, with an average of 16.7 weeks ± 7.9 between every administration). Both ratio differences did not differ significantly from 0 (DN-to-pons ratio: -0.0012 ± 0.0101, P = .436; DN-to-MCP ratio: 0.0007 ± 0.0088, P = .604), and one-sided Bayes factors provided substantial evidence against an SI ratio increase (0.10 for DN-to-pons ratio; 0.27 for DN-to-MCP ratio). Conclusion No increase of the SI in the DN was found after a mean of 8.6 serial injections of the macrocyclic GBCA gadoterate meglumine in pediatric patients, confirming previous studies that did not find this effect after serial injections of macrocyclic GBCAs in adults. RSNA, 2017.
    Keywords: Neuroimaging ; Brain Diseases -- Diagnostic Imaging ; Cerebellar Nuclei -- Diagnostic Imaging ; Contrast Media -- Administration & Dosage ; Magnetic Resonance Imaging -- Methods ; Meglumine -- Administration & Dosage ; Organometallic Compounds -- Administration & Dosage
    ISSN: 00338419
    E-ISSN: 1527-1315
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