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  • 1
    Language: English
    In: Archives of neurology, April 2012, Vol.69(4), pp.523-6
    Description: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. Immunohistochemical analysis. University hospital. Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease.
    Keywords: Brain Neoplasms -- Genetics ; Glioma -- Genetics ; Isocitrate Dehydrogenase -- Genetics ; Mutation -- Genetics
    ISSN: 00039942
    E-ISSN: 1538-3687
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  • 2
    Language: English
    In: International journal of cancer, 01 October 2013, Vol.133(7), pp.1624-30
    Description: The differentiation between hereditary and sporadic microsatellite-unstable (MSI-H) colorectal cancer is a crucial step in Lynch syndrome diagnostics. Within MSI-H colorectal cancers, the BRAF V600E mutation is strongly associated with sporadic origin. Here, we asked whether BRAF V600E-specific immunohistochemistry (clone VE1) is helpful in separating sporadic from Lynch syndrome-associated MSI-H colorectal cancers. To that end, we performed VE1 immunohistochemistry and BRAF sequencing in a series of 91 MSI-H colorectal cancer specimens from patients tested for Lynch syndrome. Concordance of VE1 immunohistochemistry and molecular BRAF mutation status was observed in 90 of 91 (98.9%) MSI-H samples. All 11 tumors classified as BRAF V600E mutation-positive by Sanger sequencing were immunopositive, and 79 (98.8%) of 80 tumors classified as BRAF wild type showed negative staining. All VE1-positive tumors were MLH1- and PMS2-negative by immunohistochemistry. None of the tumors from mismatch repair (MMR) gene germline mutation carriers (n = 28) displayed positive VE1 staining, indicating that BRAF V600E mutation-specific immunostaining has a low risk of excluding Lynch syndrome patients from germline mutation analysis. In conclusion, implementation of VE1 immunohistochemistry was able to detect BRAF-mutated MSI-H colorectal cancers with a sensitivity of 100% and a specificity of 98.8%. Among MLH1-negative colorectal cancers, the rate of VE1-positive lesions was 21%, offering the exclusion of these patients from MMR germline testing. Therefore, we suggest the integration of VE1 immunohistochemistry into the diagnostic panel of Lynch syndrome.
    Keywords: Braf V600e ; Lynch Syndrome ; Colorectal Cancer ; Hereditary Nonpolyposis Colorectal Cancer ; Microsatellite Instability ; Microsatellite Instability ; Adaptor Proteins, Signal Transducing -- Genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis -- Diagnosis ; Nuclear Proteins -- Genetics ; Proto-Oncogene Proteins B-Raf -- Genetics
    ISSN: 00207136
    E-ISSN: 1097-0215
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  • 3
    Language: English
    In: Journal of Professional Negligence, March, 2013, Vol.29(1), p.7-24
    Description: Discusses the professional liability of advocates and "friendly" expert witnesses in both civil and criminal trials. Focuses on whether, and to what extent, such persons should owe a contractual or a tortious duty of care to their clients. Considers the role of advocates, looking at criminal and child welfare cases. Explains the issue of witness immunity, highlighting the significance of the Supreme Court decision in Jones v Kaney.
    Keywords: Legal Malpractice -- Laws, Regulations And Rules ; Witnesses -- Privileges And Immunities ; Duty Of Care (Law) -- Laws, Regulations And Rules
    ISSN: 1746-6709
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  • 4
    Language: English
    In: Journal of the American Academy of Dermatology, September 2012, Vol.67(3), pp.488-491
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jaad.2012.03.022 Byline: Alexander Skorokhod (a), David Capper (b)(c), Andreas von Deimling (b)(c), Alexander Enk (a), Peter Helmbold (a) Author Affiliation: (a) Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany (b) Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany (c) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany Article Note: (footnote) Supported by Deutsche Krebshilfe DKH108856., Disclosure: Drs Capper and von Deimling declare shared inventorship of BRAF V600E specific antibody clone VE1; a patent for diagnostic application of VE1 is pending. Drs Skorokhod, Enk, and Helmbold have no conflicts of interest to declare.
    Keywords: Medicine
    ISSN: 0190-9622
    E-ISSN: 1097-6787
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  • 5
    Language: English
    In: Dublin University Law Journal, 2018, Vol.41(1), pp.197-207
    Keywords: Prepaid Legal Services – Laws, Regulations and Rules ; Prepaid Legal Services – Usage
    ISSN: 0332-3250
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  • 6
    In: Nature, 2018
    Description: Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
    Keywords: DNA Methylation ; Tumors ; Standardization ; Data Processing ; Classification ; Methylation ; Brain Cancer ; Bioinformatics ; Cancer ; Generalized Linear Models ; DNA Methylation ; Diagnosis ; Tumors ; Genomes ; Classification ; Central Nervous System ; Central Nervous System ; Diagnosis ; Cancer ; Learning Algorithms ; Diagnostic Software ; Data Processing ; Tumors ; Central Nervous System ; Gene Expression ; Standardization ; Classification ; Cancer ; Classifiers ; Classification ; Clinical Trials ; Deoxyribonucleic Acid–DNA ; Probability ; Diagnostic Systems ; Nervous System ; Methylation ; Data Processing ; Tumors ; Data Processing ; Deoxyribonucleic Acid–DNA ; Deoxyribonucleic Acid–DNA ; World Health Organization;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
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  • 7
    Language: English
    In: Law Quarterly Review, July, 2010, Vol.126, p.403-419
    Keywords: Unconscionable Contracts -- Evaluation
    ISSN: 0023-933X
    Source: Cengage Learning, Inc.
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  • 8
    Language: English
    In: Civil Justice Quarterly, April, 2010, Vol.29(2), p.150-154
    Description: Examines the Court of Appeal judgment in Nationwide Building Society v Wright on when, for the purposes of the Insolvency Act 1986 s.346, a bankruptcy commenced - whether at the date of the act of bankruptcy, of presentation of a bankruptcy petition, or of the bankruptcy order - and on the...
    Keywords: Orders (Law) -- Laws, Regulations And Rules ; Priorities Of Claims And Liens -- Laws, Regulations And Rules ; Bankruptcy Law -- Practice
    ISSN: 0261-9261
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  • 9
    Language: English
    In: Law Quarterly Review, July, 2010, Vol.126, p.403-419
    Keywords: Unconscionable Contracts -- Evaluation
    ISSN: 0023-933X
    Source: Cengage Learning, Inc.
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  • 10
    Language: English
    In: Journal of Professional Negligence, 2017, Vol.33(3), pp.207-210
    Description: Reports on the High Court of Australia decision in Kendirjian v Lepore on whether an advocates' immunity from suit covered negligent advice in respect of an out-of-court settlement offer in a personal injury claim.
    Keywords: Immunity (Law) – Laws, Regulations and Rules ; Negligence – Laws, Regulations and Rules ; Settlements (Law) – Laws, Regulations and Rules
    ISSN: 1746-6709
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