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  • 1
    Language: English
    In: Journal of the American College of Cardiology, 13 October 2015, Vol.66(15), pp.B331-B331
    Description: Furthermore administration of new oral anticoagulants plus low-dose aspirin would prevent further IVC obstruction and VTE. Peripheral Vascular Disease and Intervention Keywords Inferior Vena Cava Filter, Inferior Vena Cava Filter Thrombosis, Venous intervention
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 2
    Language: English
    In: Social Studies and the Young Learner, 2010, Vol.23(2), p.21
    Description: Mental flexibility emerges as an essential skill for preparing young learners for global competency and denotes the ability to learn from and about different perspectives. Students who are regularly exposed to "alternative approaches to a wide range of scientific, social and everyday problems"...
    Keywords: Empathy ; Thinking Skills ; Teaching Methods ; Social Studies ; Prediction ; Creative Thinking ; Cognitive Ability ; Critical Thinking ; Skill Development ; Childrens Literature ; Education
    ISSN: 1056-0300
    Source: ERIC (U.S. Dept. of Education)
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  • 3
    Language: English
    In: Innovate: Journal of Online Education, 2007, Vol.3(5)
    Description: In this article Kathleen Roney and MaryAnn Davies report on the use of TaskStream, a Web-based tool to supervise interns and develop reflective practices in a university teacher training program. Providing examples from the internship/student teaching semester, they discuss the use of the tool...
    Keywords: Student Teaching ; Exhibits ; Internet ; Mentors ; Supervision ; Internship Programs ; Professional Development ; Reflection ; Teacher Education ; Teacher Education Programs ; Competence ; Educational Technology ; Higher Education ; North Carolina ; Education
    ISSN: 1552-3233
    E-ISSN: 1552-3233
    Source: ERIC (U.S. Dept. of Education)
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  • 4
    Language: English
    In: Childhood Education, 01 March 2011, Vol.87(3), pp.154-160
    Keywords: Education ; Social Welfare & Social Work
    ISSN: 0009-4056
    E-ISSN: 2162-0725
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  • 5
    Language: English
    In: Food Research International, February 2018, Vol.104, pp.134-142
    Description: Red meat enriched versions of bread, spaghetti, yoghurt, ice cream and chocolate were prototyped and assessed for some of their physical, chemical and microbiological properties, as well as sensory appeal. The protein content of the products were significantly increased and their colour went darker with meat enrichment ( 〈 0.05). Bread volume and spaghetti tensile strength increased and ice cream meltability and yoghurt apparent viscosity decreased with meat enrichment ( 〈 0.05). The overall acceptability/liking of bread, flavoured ice cream and spaghetti were not affected ( 〉 0.05) but that of non-flavoured ice cream and yoghurt went down ( 〈 0.05) with meat enrichment. 75% of the 940 panellist who ate the meat-enriched chocolates either loved or slightly-liked them. The outcome of the present study would assist in making the nutrition of meat available in a wider range of product categories, helping the meat industry stretch its established business models, and encouraging further development of novel food choices for elderly and other groups of consumers.
    Keywords: Elderly ; Bread ; Spaghetti ; Yoghurt ; Ice Cream ; Chocolate ; Meat ; Engineering ; Economics
    ISSN: 0963-9969
    E-ISSN: 1873-7145
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  • 6
    Language: English
    In: The Annals of Thoracic Surgery, 2006, Vol.82(4), pp.1400-1405
    Description: We examined the genetic nature and phenotypic features of thoracic aortic aneurysms (TAAs) and dissections in a large cohort of patients. Interviews were conducted with 520 patients with TAAs and their pedigrees were compiled to identify family members with aneurysms. Study patients were divided into three groups: 101 non-Marfan patients, in 88 pedigrees, had a family pattern for TAA (familial group), 369 had no family pattern (sporadic group), and 50 had Marfan syndrome (MFS). We determined incidence of familial clustering, age at presentation, rate of aneurysm growth, incidence of hypertension, correlation of aneurysm sites among kindred, and pedigree inheritance patterns. An inherited pattern for TAA was present in 21.5% of non-MFS patients. The predominant inheritance pattern was autosomal dominant (76.9%), with varying degrees of penetrance and expressivity. The familial TAA group was significantly younger than the sporadic group ( 〈 0.0001), but not as young as the MFS group ( 〈 0.0001) (mean ages, 58.2 versus 65.7 versus 27.4 years). Among all 197 probands and kindred with aneurysm, 131 (66.5%) had TAA, 49 (24.9%) had abdominal aortic aneurysm (AAA), and 17 (8.6%) had cerebral or other aneurysms. Ascending aneurysm paired most commonly with ascending, and descending with abdominal. Abdominal aortic aneurysms (AAAs) and hypertension were more often associated with descending than with ascending TAAs ( 〈 0.001). Aortic growth rate was highest for the familial group (0.21cm/y), intermediate for the sporadic group (0.16 cm/y), and lowest for the Marfan group (0.1 cm/y; 〈 0.01). TAAs are frequently familial diseases. The predominant mode of inheritance is autosomal dominant. Familial TAAs have a relatively early age of onset. Aneurysms in relatives may be seen in the thoracic aorta, the abdominal aorta, or the cerebral circulation. Screening of first-order relatives of probands with TAA is essential. Familial TAAs tend to grow at a higher rate, exemplifying a more aggressive clinical entity.
    Keywords: 26;
    ISSN: 0003-4975
    E-ISSN: 1552-6259
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  • 7
    In: Proceedings of the National Academy of Sciences of the United States of America, 2018, Vol.115(8), p.1697-1706
    Description: Significance Alzheimer’s disease (AD) is an age-related neurodegenerative disease. Genome-wide association studies predominately focusing on Caucasian populations have identified risk loci and genes associated with AD; the majority of these variants reside in noncoding regions with unclear functions. Here, we report a whole-genome sequencing study for AD in the Chinese population. Other than the APOE locus, we identified common variants in GCH1 and KCNJ15 that show suggestive associations with AD. For these two risk variants, an association with AD or advanced onset of disease can be observed in non-Asian AD cohorts. An association study of risk variants with expression data revealed their modulatory effects on immune signatures, linking the potential roles of these genes with immune-related pathways during AD pathogenesis. Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed a whole-genome sequencing study of AD in the Chinese population. In addition to the variants identified in or around the APOE locus (sentinel variant rs73052335, P = 1.44 × 10 −14 ), two common variants, GCH1 (rs72713460, P = 4.36 × 10 −5 ) and KCNJ15 (rs928771, P = 3.60 × 10 −6 ), were identified and further verified for their possible risk effects for AD in three small non-Asian AD cohorts. Genotype–phenotype analysis showed that KCNJ15 variant rs928771 affects the onset age of AD, with earlier disease onset in minor allele carriers. In addition, altered expression level of the KCNJ15 transcript can be observed in the blood of AD subjects. Moreover, the risk variants of GCH1 and KCNJ15 are associated with changes in their transcript levels in specific tissues, as well as changes of plasma biomarkers levels in AD subjects. Importantly, network analysis of hippocampus and blood transcriptome datasets suggests that the risk variants in the APOE , GCH1 , and KCNJ15 loci might exert their functions through their regulatory effects on immune-related pathways. Taking these data together, we identified common variants of GCH1 and KCNJ15 in the Chinese population that contribute to AD risk. These variants may exert their functional effects through the immune system.
    Keywords: 1 ; Biological Sciences ; Alzheimer’s Disease ; Whole-Genome Sequencing ; Gwas ; Risk Variant ; Immune
    ISSN: 0027-8424
    E-ISSN: 1091-6490
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  • 8
    In: Anesthesiology, 2018, Vol.128(4), pp.728-744
    Description: BACKGROUND:: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS:: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9). The association of 6-week amyloid deposition with cognitive dysfunction was assessed by multivariable regression, accounting for age, years of education, and baseline cognition. Differences between the surgical cohort with cognitive deficit and the Alzheimer’s Disease Neuroimaging Initiative cohorts (normal and early/late mild cognitive impairment) was assessed, adjusting for age, education, and apolipoprotein E4 genotype. RESULTS:: The authors found that 6-week abnormal global cortical amyloid deposition was not associated with cognitive dysfunction (13 of 37, 35%) at 6 weeks postoperatively (median standard uptake value ratio [interquartile range]: cognitive dysfunction 0.92 [0.89 to 1.07] vs. 0.98 [0.93 to 1.05]; P = 0.455). In post hoc analyses, global cortical amyloid was also not associated with cognitive dysfunction at 1 or 3 yr postoperatively. Amyloid deposition at 6 weeks in the surgical cohort was not different from that in normal Alzheimer’s Disease Neuroimaging Initiative subjects, but increased over 1 yr in many areas at a rate greater than in controls. CONCLUSIONS:: In this study, postoperative cognitive dysfunction was not associated with 6-week cortical amyloid deposition. The relationship between cognitive dysfunction and regional amyloid burden and the rate of postoperative amyloid deposition merit further investigation.
    Keywords: Amyloidosis -- Research ; Positron Emission Tomography -- Usage ; Postoperative Complications -- Diagnosis ; Postoperative Complications -- Research;
    ISSN: 0003-3022
    E-ISSN: 15281175
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  • 9
    In: Pathology, 1985, Vol.17(1), pp.5-6
    Keywords: Medicine ; Biology;
    ISSN: 1465-3931
    ISSN: 00313025
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  • 10
    In: Pathology, 1985, Vol.17(1), pp.135-136
    Keywords: Polyagglutination of Red Cells ; Tn Polyagglutination ; Lectin Studies ; Medicine ; Biology;
    ISSN: 1465-3931
    ISSN: 00313025
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