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  • 1
    In: Journal of Democracy, 2017, Vol.28(4), pp.147-161
    Description: Abstract: Much has been written about the retreat of liberal democracy. In Asia, a region where the notion of illiberal democracy has long been advocated, illiberalism and populism have spawned numerous constitutional crises. Drawing on experience from countries across Asia, this article stresses seven principles as a roadmap to establishing and maintaining a liberal constitutional democracy. These cover all stages of the process, from early mobilization and constitution-making to full implementation and consolidation, and they address issues of institutional autonomy, popular engagement, and ethnic and regional inclusion. Efforts at democratization in Asia have too often given insufficient attention to constitutional fundamentals and popular inclusion as critical ingredients on the path to establishing and maintaining stable democracies.
    ISSN: 1045-5736
    E-ISSN: 1086-3214
    Source: Project MUSE
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  • 2
    Article
    Article
    Language: English
    In: Journal of Democracy, 2015, Vol.26(2), pp.101-110
    Keywords: Political Movements – Analysis
    ISSN: 1045-5736
    Source: Cengage Learning, Inc.
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  • 3
    Article
    Article
    In: Journal of Democracy, 2015, Vol.26(2), pp.101-110
    Description: China’s “one country, two systems” model elaborated in the 1984 Sino-British Joint Declaration and the 1990 Hong Kong Basic Law promise Hong Kong a high degree of autonomy, universal suffrage, human rights and the rule of law. The June 2014 Chinese White Paper on the “one country, two systems” model and the August 2014 NPC Standing Committee decision on democratic development undermined both the rule of law and Hong Kong’s democratic development. This essay argues Hong Kong’s “one country, two systems” model is broken. A high degree of autonomy and the rule of law can no longer be maintained without democracy.
    Keywords: Suffrage -- China -- Hong Kong ; Democracy -- China -- Hong Kong ; China -- Relations -- China -- Hong Kong ; Hong Kong (China) -- Relations -- China
    ISSN: 1045-5736
    E-ISSN: 1086-3214
    Source: Project MUSE
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  • 4
    Language: English
    In: Geochimica et Cosmochimica Acta, 2011, Vol.75(2), pp.401-415
    Description: The dissolution–precipitation of quartz controls porosity and permeability in many lithologies and may be the best studied mineral-water reaction. However, the rate of quartz-water reaction is relatively well characterized far from equilibrium but relatively unexplored near equilibrium. We present kinetic data for quartz as equilibrium is approached from undersaturation and more limited data on the approach from supersaturated conditions in 0.1 molal NaCl + NaOH + NaSiO(OH) solutions with pH 8.2–9.7 at 398, 423, 448, and 473 K. We employed a potentiometric technique that allows precise determination of solution speciation within 2 kJ mol of equilibrium without the need for to perturb the system through physical sampling and chemical analysis. Slightly higher equilibrium solubilities between 423 and 473 K were found than reported in recent compilations. Apparent activation energies of 29 and 37 kJ mol are inferred for rates of dissolution at two surface sites with different values of connectedness: dissolution at or silicon sites, respectively. The dissolution mechanism varies with Δ such that reactions at both sites control dissolution up until a critical free energy value above which only reactions at sites are important. When our near-equilibrium dissolution rates are extrapolated far from equilibrium, they agree within propagated uncertainty at 398 K with a recently published model by . However, our extrapolated rates become progressively slower than model predictions with increasing temperature. Furthermore, we see no dependence of the postulated reaction rate on pH, and a poorly-constrained pH dependence of the postulated rate. Our slow extrapolated rates are presumably related to the increasing contribution of dissolution at sites far from equilibrium. The use of the potentiometric technique for rate measurement will yield both rate data and insights into the mechanisms of dissolution over a range of chemical affinity. Such measurements are needed to model the evolution of many natural systems quantitatively.
    Keywords: Geology
    ISSN: 0016-7037
    E-ISSN: 1872-9533
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  • 5
    Language: English
    In: Biological Psychiatry, 15 October 2016, Vol.80(8), pp.e71-e72
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.biopsych.2016.02.028 Byline: Suzanne R. Monsivais, Nick Wisdom, Jennifer L. Kruse, Michael C. Davis Author Affiliation: (a) Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas (b) Mental Health Care Line, Michael E. DeBakey VA Medical Center, Houston, Texas (c) Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California
    Keywords: Medicine ; Biology ; Chemistry
    ISSN: 0006-3223
    E-ISSN: 1873-2402
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  • 6
    Language: English
    In: Schizophrenia Research, July 2013, Vol.147(2-3), pp.393-397
    Description: Deficits in social cognition are common in schizophrenia and predict poor community functioning. Given the current limitations of psychosocial treatments and the lack of pharmacological treatments for social cognitive deficits, the development of novel therapeutic agents could greatly enhance functional recovery in schizophrenia. This study evaluated whether a single dose of intranasal oxytocin acutely improves social cognitive functioning in schizophrenia. Twenty-three male veterans with schizophrenia completed baseline assessments of social cognition that were divided into lower-level (facial affect perception, social perception, detection of lies) and higher-level (detection of sarcasm and deception, empathy) processes. One week later, patients received the same battery after being randomized to a single dose of 40 IU intranasal oxytocin or placebo. Though the groups did not differ significantly on the social cognition composite score, oxytocin improved performance for the higher-level social cognitive tasks (Cohen's = 1.0, p = 0.045). Subjects were unable to accurately guess which treatment they had received. The improvements found in higher-level social cognition encourage further studies into the therapeutic potential of oxytocin in schizophrenia.
    Keywords: Schizophrenia ; Social Cognition ; Oxytocin ; Clinical Trial
    ISSN: 0920-9964
    E-ISSN: 1573-2509
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  • 7
    Language: English
    In: American journal of physical anthropology, April 2011, Vol.144(4), pp.516-25
    Description: The Basques have a well-documented history of migration and settlement in the Americas, and they often retain cultural identity across generations. Numerous genetic studies have been carried out on European Basques; thus, immigrant Basques are an ideal population for investigating the genetic consequences of a recent human migration event. We have sampled 53 unrelated individuals with Basque ancestry in Boise, Idaho and determined the mitochondrial DNA (mtDNA) sequence variation of the first and second hypervariable regions. Thirty-six mtDNA haplotypes were detected in our sample. We found evidence of genetic changes consistent with founder effects, which is compatible with the known history of migration. Compared with the European Basque population, the immigrant Basques are significantly different in terms of haplogroup frequency distribution and diversity. They have a lower measure of weighted intralineage mean pairwise diversity (WIMP) and greater genetic distance from other European populations. These data indicate that this immigrant Basque population has experienced a reduction in genetic diversity compared with the putative source population. However, this loss of diversity is not detectable using indices of demographic history such as Tajima's D and Fu's F. This study represents the first description of mtDNA diversity in an immigrant Basque population, and our findings indicate that founder effects accompanying this relatively recent migration event have shaped the genetic diversity of this population.
    Keywords: Emigration and Immigration ; Founder Effect ; Genetic Variation ; DNA, Mitochondrial -- Analysis
    ISSN: 00029483
    E-ISSN: 1096-8644
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  • 8
    Language: English
    In: New England Journal of Medicine, 05/10/2017
    ISSN: 0028-4793
    E-ISSN: 1533-4406
    Source: CrossRef
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  • 9
    In: The New England Journal of Medicine, 2017, Vol.376(26), pp.2503-2506
    Description: In the case of valbenazine, which was recently approved for tardive dyskinesia, a small company pursued thoughtful, efficient trial design and an unusual application of remote assessment in clinical trials, and the FDA took an engaged and flexible approach to review. A well-executed development program that addresses both regulatory and clinical requirements is critical for making novel therapeutics available as quickly as possible to patients with unmet medical needs. In the case of valbenazine, which was recently approved by the U.S. Food and Drug Administration (FDA) for tardive dyskinesia — a debilitating, iatrogenic movement disorder that primarily affects patients with psychiatric illnesses — a small company pursued thoughtful, efficient trial design and an unusual application of remote assessment in clinical trials. The FDA took an engaged and flexible approach to review, which led to its first approval of a drug for . . .
    Keywords: Valbenazine -- Licensing, Certification And Accreditation ; Valbenazine -- Dosage And Administration ; Movement Disorders -- Drug Therapy ; Clinical Trials -- Methods ; Clinical Trials -- Usage;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 10
    Language: English
    In: Journal of child and adolescent psychopharmacology, April 2014, Vol.24(3), pp.166-7
    Keywords: Antipsychotic Agents -- Adverse Effects ; Carbamazepine -- Analogs & Derivatives ; Drug Therapy, Combination -- Adverse Effects ; Movement Disorders -- Complications ; Risperidone -- Adverse Effects
    ISSN: 10445463
    E-ISSN: 1557-8992
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