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  • 1
    Online Resource
    Online Resource
    GFP Whole Cell Microbial Biosensors : Scale-up and scale-down effects on biopharmaceutical processes (2013)
    New York : Momentum Press
    Details
    UID:
    (DE-627)1746269693
    Format: 1 online resource (54 pages)
    ISBN: 9781606504178
    Content: Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters. Recent developments in bioreactor technologies follow the scaling-out principle, i.e. carrying out several cultures in parallel with controlled conditions for screening purposes. Several mini-bioreactor concepts, i.e. bioreactor with working volume of 1 to 100 mL with controlling devices, have been developed following this principle. In general, chemical engineering similarities between conventional stirred bioreactors and their miniature equivalent are well characterized. However, the actual scaling-up rules are not able to cope with the complexity of the microbial stress response. Indeed, microbial stress response still remains not completely understood considering the process perturbations and the environmental fluctuations accompanying the scaling-up to industrial bioreactors. At this time, this kind of response can only be experimentally predicted by using scale-down bioreactors, i.e. lab-scale bioreactors designed in order to reproduce mixing imperfections that have to be expected at large-scale. However, the use of such an approach is time consuming and requires an experimented staff to elaborate the scaling-down protocols. Indeed, bioprocess development involves several steps which cannot be necessarily linked with each other considering the different cultivation equipment used.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9781606504277
    Additional Edition: Erscheint auch als Druck-Ausgabe 9781606504277
    Language: English
    URL: lizenzpflichtig
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    Online Resource
    BSZ
  • 2
    Online Resource
    Online Resource
    GFP whole cell microbial biosensors : scale-up and scale-down effects on biopharmaceutical processes (2013)
    New York, N.Y. : ASME
    Details
    UID:
    (DE-604)BV043152491
    Format: 1 electronic text (43 p.)
    ISBN: 1606504177 , 1606504274 , 9781606504178 , 9781606504277
    Series Statement: Biomedical & nanomedical technologies
    Note: Title from PDF t.p. (viewed on January 26, 2013) , Includes bibliographical references (p. 36-43) , 1. Interaction between fluid flow and microbial cells: importance of the operating scale -- 1.1 Different scales involved in the development of microbial bioprocesses -- 1.2 Hydrodynamic modeling of the substrate heterogeneites perceived by cells -- , 2. Stochastic simulation of the displacement of microbial cells along concentration field -- 2.1 Microbial stress response: different timescales involved -- , 3. Experimental results gained from the physiological response of GFP biosensors in scale-down conditions -- 3.1 General stress response in scale-down bioreactors: rpoS::GFP -- 3.2 Use of destabilized GFP variants -- , 4. Another source of information: protein leakage and the study of the secretome -- References , Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters
    Additional Edition: Erscheint auch als Druckausgabe ISBN 978-1-60650-427-7
    Language: English
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    BVB
  • 3
    Book
    Book
    GFP whole cell microbial biosensors : scale-up and scale-down effects on biopharmaceutical processes (2013)
    New York, NY : American Society of Mechanical Engineers
    Details
    UID:
    (DE-627)778687163
    Format: 43 S. , graph. Darst.
    ISBN: 9780791860090
    Series Statement: Biomedical & nanomedical technologies - concise monograph series
    Content: Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters. Recent developments in bioreactor technologies follow the scaling-out principle, i.e. carrying out several cultures in parallel with controlled conditions for screening purposes. Several mini-bioreactor concepts, i.e. bioreactor with working volume of 1 to 100 mL with controlling devices, have been developed following this principle. In general, chemical engineering similarities between conventional stirred bioreactors and their miniature equivalent are well characterized. However, the actual scaling-up rules are not able to cope with the complexity of the microbial stress response. Indeed, microbial stress response still remains not completely understood considering the process perturbations and the environmental fluctuations accompanying the scaling-up to industrial bioreactors. At this time, this kind of response can only be experimentally predicted by using scale-down bioreactors, i.e. lab-scale bioreactors designed in order to reproduce mixing imperfections that have to be expected at large-scale. However, the use of such an approach is time consuming and requires an experimented staff to elaborate the scaling-down protocols. Indeed, bioprocess development involves several steps which cannot be necessarily linked with each other considering the different cultivation equipment used--
    Note: Literaturverz. S. [36] - 43 , Interaction between fluid flow and microbial cells : importance of the operating scaleStochastic simulation of the displacement of microbial cells along concentration field -- Experimental results gained from the physiological response of GFP biosensors in scale-down conditions -- Another source of information : protein leakage and the study of the secretome.
    Additional Edition: 9781606504178
    Language: English
    URL: Inhaltsverzeichnis
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    Book
    GBV
  • 4
    Online Resource
    Online Resource
    GFP whole cell microbial biosensors : scale-up and scale-down effects on biopharmaceutical processes (2013)
    New York, N.Y : ASME
    Details
    UID:
    (DE-627)1652353925
    Format: Online-Ressource (1 electronic text (43 p.)) , Mode of access: World Wide Web , System requirements: Adobe Acrobat reader , ill., digital file.
    Edition: Online-Ausg.
    ISBN: 9781606504178
    Series Statement: Biomedical & nanomedical technologies
    Content: 2. Stochastic simulation of the displacement of microbial cells along concentration field -- 2.1 Microbial stress response: different timescales involved --
    Content: 3. Experimental results gained from the physiological response of GFP biosensors in scale-down conditions -- 3.1 General stress response in scale-down bioreactors: rpoS::GFP -- 3.2 Use of destabilized GFP variants --
    Content: 4. Another source of information: protein leakage and the study of the secretome -- References
    Content: Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters
    Note: Includes bibliographical references (p. 36-43). - Title from PDF t.p. (viewed on January 27, 2013) , 1. Interaction between fluid flow and microbial cells: importance of the operating scale -- 1.1 Different scales involved in the development of microbial bioprocesses -- 1.2 Hydrodynamic modeling of the substrate heterogeneites perceived by cells --
    Additional Edition: 9781606504277
    Additional Edition: Druckausg. 978-1-606-50427-7
    Language: English
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    BSZ
  • 5
    Online Resource
    Online Resource
    GFP whole cell microbial biosensors : scale-up and scale-down effects on biopharmaceutical processes (2013)
    New York, N.Y : ASME
    Details
    UID:
    (DE-627)1653802111
    Format: Online Ressource (1 electronic text (43 p.) , ill., digital file.
    Edition: Online-Ausg.
    ISBN: 9781606504178 , 1606504177 , 1606504274 , 9781606504277
    Series Statement: Biomedical & nanomedical technologies
    Content: Two strategies are usually considered for the optimization of microbial bioprocesses. The first one involves genetic or metabolic engineering of the target microbial strains in order to improve its production efficiency or its tolerance to adverse conditions. The second one is based on the chemical engineering improvement of the bioreactors and scaling-up rules. This work is more particularly dedicated to this second class of parameters
    Note: Title from PDF t.p. (viewed on January 26, 2013). - Includes bibliographical references (p. 36-43)
    Additional Edition: 1606504274
    Additional Edition: 9781606504277
    Additional Edition: 1283948346
    Additional Edition: 9781283948340
    Additional Edition: 9781606504277
    Additional Edition: 9781606504277
    Additional Edition: Erscheint auch als Druck-Ausgabe 9781606504277
    Language: English
    Keywords: Electronic books ; Electronic books
    URL: lizenzpflichtig
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    BSZ
  • 6
    Online Resource
    Online Resource
    Microbial heterogeneity affects bioprocess robustness: Dynamic single‐cell analysis contributes to understanding of microbial populations (2013)
    Show associated volumes
    Details
    UID:
    (DE-101)1277491526
    Format: Online-Ressource
    ISSN: 1860-7314
    Content: Abstract: Heterogeneity or segregation of microbial populations has been the subject of much research, but the real impact of this phenomenon on bioprocesses remains poorly understood. The main reason for this lack of knowledge is the difficulty in monitoring microbial population heterogeneity under dynamic process conditions. The main concepts resulting in microbial population heterogeneity in the context of bioprocesses have been summarized by two distinct hypotheses. The first involves the individual history of microbial cells or the “path“ followed during their residence time inside the process equipment. The second hypothesis involves a coordinated response by the microbial population as a bet‐hedging strategy, in order to cope with process‐related stresses. The respective contribution of each hypothesis to microbial heterogeneity in bioprocesses is still unclear. This illustrates the fact that, although microbial phenotypic heterogeneity has been thoroughly investigated at a fundamental level, the implications of this phenomenon in the context of microbial bioprocesses are still subject to debate. At this time, automated flow cytometry is the best technique for investigating microbial heterogeneity under process conditions. However, dedicated software and relevant biomarkers are needed for the proper integration of flow cytometry as a bioprocess control tool.
    In: volume:9
    In: number:1
    In: year:2014
    In: pages:61-72
    In: extent:12
    In: Biotechnology journal, Weinheim : Wiley-VCH, [2006]-, 9, Heft 1 (2014), 61-72 (gesamt 12), 1860-7314
    Language: English
    DOI: 10.1002/biot.201300119
    URN: urn:nbn:de:101:1-2023010805052726194328
    URL: https://doi.org/10.1002/biot.201300119
    URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023010805052726194328
    URL: https://d-nb.info/1277491526/34
    URL: https://doi.org/10.1002/biot.201300119
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    Online Resource
    Open Access Request
    DNB
  • 7
    Online Resource
    Online Resource
    2e Journée de réflexion de l'EDT GEPROC : Génie des procédés appliqué aux bio-industries, 16 décembre 2009, Faculté universitaire des Sciences agronomiques, Gembloux (Belgique) (2010)
    Gembloux : Uliège Library
    Details
    UID:
    (DE-627)1832381021
    Format: 1 Online-Ressource (96 p.)
    ISBN: 9782870161074
    Content: The aim of the Thematic Doctoral School in Process Engineering (EDT GEPROC) is to promote multidisciplinary doctoral research in the various fields of application of process engineering. It is therefore quite logical that the 2nd thematic day of reflection organized by the EDT-GEPROC was devoted to the theme of Process Engineering applied to the bio-industries (agri-food, agrofuels and energy, environment, pharmaceutical industry). This event was held on December 16, 2009 on the site of Gembloux Agro-Bio Tech. It brought together 80 participants from the 4 university institutions that are part of the EDT GEPROC (ULg, UMONS, ULB and UCL). It is important at this level to note also the participation of several representatives of the industrial world. Indeed, the contact between PhD students and the industrial world is one of the objectives of the EDT GEPROC. The following program was spread over half a day Translated with www.DeepL.com/Translator (free version)
    Note: French
    Language: Undetermined
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Stabi Berlin
    UB Potsdam
    BSZ
    GBV
  • 8
    Online Resource
    Online Resource
    2e Journée de réflexion de l'EDT GEPROC. Génie des procédés appliqué aux bio-industries, 16 décembre 2009, Faculté universitaire des Sciences agronomiques, Gembloux (Belgique) (2010)
    [Erscheinungsort nicht ermittelbar] : Presses agronomiques de Gembloux (Liege University) | The Hague : OAPEN FOUNDATION
    Details
    UID:
    (DE-603)402505786
    Format: 1 Online-Ressource (96 p.)
    ISBN: 9782870161074
    Language: Undetermined
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    HeBIS
  • 9
    Online Resource
    Online Resource
    2e Journée de réflexion de l'EDT GEPROC : Génie des procédés appliqué aux bio-industries, 16 décembre 2009, Faculté universitaire des Sciences agronomiques, Gembloux (Belgique) (2010)
    Gembloux : Uliège Library
    Details
    UID:
    (DE-605)HT021608567
    Format: 1 electronic resource (96 pages)
    ISBN: 9782870161074
    Note: French
    Language: Undetermined
    URL: DOAB: download the publication
    URL: DOAB: description of the publication
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    HBZ
  • 10
    Online Resource
    Online Resource
    2e Journée de réflexion de l'EDT GEPROC : Génie des procédés appliqué aux bio-industries, 16 décembre 2009, Faculté universitaire des Sciences agronomiques, Gembloux (Belgique) (2010)
    Gembloux : Uliège Library | The Hague : OAPEN FOUNDATION
    Details
    UID:
    (DE-603)497454424
    Format: 1 Online-Ressource (96 p.)
    ISBN: 9782870161074
    Content: The aim of the Thematic Doctoral School in Process Engineering (EDT GEPROC) is to promote multidisciplinary doctoral research in the various fields of application of process engineering. It is therefore quite logical that the 2nd thematic day of reflection organized by the EDT-GEPROC was devoted to the theme of Process Engineering applied to the bio-industries (agri-food, agrofuels and energy, environment, pharmaceutical industry). This event was held on December 16, 2009 on the site of Gembloux Agro-Bio Tech. It brought together 80 participants from the 4 university institutions that are part of the EDT GEPROC (ULg, UMONS, ULB and UCL). It is important at this level to note also the participation of several representatives of the industrial world. Indeed, the contact between PhD students and the industrial world is one of the objectives of the EDT GEPROC. The following program was spread over half a day Translated with www.DeepL.com/Translator (free version)...
    Language: French
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    HeBIS
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