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  • 1
    Language: English
    In: Journal of the American College of Cardiology, 12 March 2013, Vol.61(10), pp.E828-E828
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0735-1097(13)60828-1 Byline: Dominik Buckert, Patricia Dewes, Thomas Walcher, Wolfgang Rottbauer, Peter Bernhardt Author Affiliation: Internal Medicine II, Ulm, Germany Article Note: (footnote) Moderated Poster Contributions Poster Sessions, Expo North Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m. Session Title: Imaging: MRI II Clinical Outcomes and CMR Abstract Category: 19. Imaging: MRI Presentation Number: 1138M-314
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 12 March 2013, Vol.61(10), pp.E808-E808
    Description: Adenosine perfusion cardiac magnetic resonance imaging (CMR) has been proven to be useful for short-term prognosis in patients with stable coronary artery disease. Most of the available studies so far only included specific subsets of patients and defined rather soft clinical endpoints. Thus, it remains still uncertain, whether CMR can be used as prognostic tool concerning long-term follow up and the occurrence of major clinical endpoints such as cardiac death or myocardial infarction. Aim of our prospective study was to evaluate the incremental prognostic value of adenosine CMR over other conventional risk factors in a large, consecutive and thus unselected population of patients with stable angina pectoris.
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 3
    Language: English
    In: Journal of the American College of Cardiology, March 12, 2013, Vol.61(10), p.E808
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0735-1097(13)60808-6 Byline: Dominik Buckert, Patricia Dewes, Thomas Walcher, Wolfgang Rottbauer, Peter Bernhardt Author Affiliation: Internal Medicine II, Ulm, Germany Article Note: (footnote) Oral Contributions South, Room 104 Saturday, March 09, 2013, 8:45 a.m.-9:00 a.m. Session Title: Cardiac MRI in CAD: Acute and Chronic Applications, Prognosis and Safety Abstract Category: 19. Imaging: MRI Presentation Number: 907-6
    Keywords: Cardiac Patients -- Care And Treatment ; Coronary Heart Disease -- Care And Treatment ; Medical Research ; Magnetic Resonance Imaging
    ISSN: 0735-1097
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: European Journal of Radiology, June 2016, Vol.85(6), pp.1058-1062
    Description: To evaluate a novel tin filter-based abdominal CT protocol for urolithiasis in terms of image quality and CT dose parameters. 130 consecutive patients with suspected urolithiasis underwent CT with three different protocols: 48 patients (group 1) were examined at tin-filtered 150 kV (150 kV Sn) on a third-generation dual-source-CT, 33 patients were examined with automated kV-selection (110–140 kV) based on the scout view on the same CT-device (group 2), and 49 patients were examined on a second-generation dual-source-CT (group 3) with automated kV-selection (100–140 kV). Automated exposure control was active in all groups. Image quality was subjectively evaluated on a 5-point-likert-scale by two radiologists and interobserver agreement as well as signal-to-noise-ratio (SNR) was calculated. Dose-length-product (DLP) and volume CT dose index (CTDIvol) were compared. Image quality was rated in favour for the tin filter protocol with excellent interobserver agreement (ICC = 0.86–0.91) and the difference reached statistical significance (p 〈 0.001). SNR was significantly higher in group 1 and 2 compared to second-generation DSCT ( ). On third-generation dual-source CT, there was no significant difference in SNR between the 150 kV Sn and the automated kV selection protocol (p = 0.5). The DLP of group 1 was 23% and 21% (p 〈 0.002) lower in comparison to group 2 and 3, respectively. So was the CTDIvol of group 1 compared to group 2 (−36%) and 3 (−32%) (p 〈 0.001). Additional shaping of a 150 kV source spectrum by a tin filter substantially lowers patient exposure while improving image quality on un-enhanced abdominal computed tomography for urinary stone disease.
    Keywords: Low-Dose Abdominal CT ; Urinary Stone Disease ; Spectral Shaping ; Tin Filter ; Medicine
    ISSN: 0720-048X
    E-ISSN: 1872-7727
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  • 5
    Language: English
    In: Journal of Cardiovascular Magnetic Resonance, 01 January 2013, Vol.15(Suppl 1), p.P262
    Description: Doc number: P262
    Keywords: Medicine
    ISSN: 1097-6647
    E-ISSN: 1532-429X
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  • 6
    Language: English
    In: JACC: Cardiovascular Imaging, January 2013, Vol.6(1), pp.56-63
    Description: The aim of this study was to assess the hypothesis that cardiac magnetic resonance (CMR) myocardial perfusion imaging can provide incremental prognostic value over other risk factors regarding the prediction of major cardiovascular events in a large, consecutive, and thereby unselected population of patients presenting with stable angina pectoris. Recently, it has been shown that CMR provides good short-term prognosis in patients with stable coronary heart disease. Reversible myocardial ischemia can be assessed using a combination of perfusion and late gadolinium enhancement imaging. Data concerning intermediate-term prognostic information, especially on major clinical endpoints such as cardiac death or myocardial infarction, are limited. From 2003 to 2007, consecutive patients with stable angina pectoris who underwent adenosine perfusion CMR were enrolled unless they met the predefined exclusion criteria. Myocardial perfusion imaging by adenosine stress and late gadolinium enhancement was assessed using a 1.5-T whole-body CMR scanner. Follow-up information concerning the combined endpoint of cardiac death, nonfatal myocardial infarction, and stroke was obtained from patients, general practitioners, or treating hospitals, respectively. In our study, 1,229 consecutive patients were enrolled. The mean follow-up period was 4.2 ± 2.1 years. During this time, 88 primary endpoints occurred. In patients with reversible perfusion deficits, significantly more cardiac deaths (p 〈 0.0001) and nonfatal myocardial infarctions (p = 0.001) were observed than in the control group. On multivariate analysis, reversible perfusion deficit was the strongest independent predictor for an event, with a 3-fold increased risk. Moreover, the absence of a perfusion deficit was shown to exhibit high negative predictive value. Adenosine perfusion CMR provides excellent risk stratification and intermediate-term prognostic value in patients with stable coronary artery disease. The presence of a myocardial perfusion deficit is an incremental prognostic risk factor over other risk factors.
    Keywords: Cardiac Magnetic Resonance ; Long-Term ; Outcome ; Reversible Perfusion Deficit ; Medicine
    ISSN: 1936-878X
    E-ISSN: 1876-7591
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  • 7
    Language: English
    In: European Journal of Radiology, January 2016, Vol.85(1), pp.193-198
    Description: To evaluate the diagnostic accuracy, subjective image quality, and interobserver agreement of non-contrast Controlled Aliasing In Parallel Imaging Results In Higher Acceleration (CAIPIRINHA) volumetric interpolated breath-hold examination (VIBE) 3T magnetic resonance imaging (MRI) for the detection of pulmonary nodules with intra-individual comparison to computed tomography (CT). We evaluated 54 patients (27 male, 27 female; mean age, 60.8 ± 11.5 years) who prospectively underwent thoracic 3T-MRI using CAIPIRINHA-VIBE sequences and chest CT. Diagnostic accuracy for the detection of lung nodules on CAIPIRINHA-VIBE MRI by three independent observers were compared to the reference standard CT. Subjective image quality was rated using a 5-point grading scale. Diagnostic accuracy was calculated and interobserver agreement was assessed using intraclass correlation coefficient (ICC). Sensitivity of 3T-MRI for the detection of pulmonary lesions compared to CT was 88.1% (95% confidence interval [CI]: 0.81–0.93) and specifity was 79.1% (95% CI: 0.50–0.95). Sensitivity for lesions 〈5 mm was 77.2% (95% CI: 0.59–0.90) and for lesions from 5 to 10 mm was 87.2% (95% CI: 0.76–0.94). Sensitivity for lesions 〉10 mm was 100%. Observer ratings regarding subjective image quality were good to excellent for 3T-MRI (1.54) and CT (1.14) with almost perfect interobserver agreement for 3T-MRI and CT (ICC = 0.83, 95% CI: 0.78–0.89; ICC = 0.89, 95% CI: 0.85–0.94). Non-contrast CAIPIRINHA-VIBE 3T-MRI allows for the reliable detection of pulmonary lesions with a diameter 〉5 mm in comparison with chest CT with high diagnostic accuracy, subjective image quality, and interobserver agreement.
    Keywords: Solitary Pulmonary Nodule ; Lung ; Magnetic Resonance Imaging ; Computed Tomography ; Medicine
    ISSN: 0720-048X
    E-ISSN: 1872-7727
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  • 8
    Language: English
    In: European Radiology, 2015, Vol.25(8), pp.2493-2501
    Keywords: Monoenergetic Plus ; Dual-Energy CT ; Monochromatic imaging ; Computed Tomography ; Head and Neck Cancer
    ISSN: 0938-7994
    E-ISSN: 1432-1084
    Source: Springer Science & Business Media B.V.
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  • 9
    Language: English
    In: European Radiology, 2018, Vol.28(5), pp.2143-2150
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00330-017-5177-1 Byline: Michael Messerli (1), Patricia Dewes (2), Jan-Erik Scholtz (3), Christophe Arendt (2), Simon Wildermuth (4), Thomas J. Vogl (2), Ralf W. Bauer (5) Keywords: Multi-detector CT; Adaptive detector collimation; Dual-source CT; Coronary CT angiography; Over-ranging Abstract: Objectives To investigate the impact of an adaptive detector collimation on the dose parameters and accurateness of scan length adaption at prospectively ECG-triggered sequential cardiac CT with a wide-detector third-generation dual-source CT. Methods Ideal scan lengths for human hearts were retrospectively derived from 103 triple-rule-out examinations. These measures were entered into the new scanner operated in prospectively ECG-triggered sequential cardiac scan mode with three different detector settings: (1) adaptive collimation, (2) fixed 64 x 0.6-mm collimation, and (3) fixed 96 x 0.6-mm collimation. Differences in effective scan length and deviation from the ideal scan length and dose parameters (CTDIvol, DLP) were documented. Results The ideal cardiac scan length could be matched by the adaptive collimation in every case while the mean scanned length was longer by 15.4% with the 64 x 0.6 mm and by 27.2% with the fixed 96 x 0.6-mm collimation. While the DLP was almost identical between the adaptive and the 64 x 0.6-mm collimation (83 vs. 89 mGycm at 120 kV), it was 62.7% higher with the 96 x 0.6-mm collimation (135 mGycm), p 〈 0.001. Conclusion The adaptive detector collimation for prospectively ECG-triggered sequential acquisition allows for adjusting the scan length as accurate as this can only be achieved with a spiral acquisition. This technique allows keeping patient exposure low where patient dose would significantly increase with the traditional step-and-shoot mode. Key points acents Adaptive detector collimation allows keeping patient exposure low in cardiac CT. acents With novel detectors the desired scan length can be accurately matched. acents Differences in detector settings may cause 62.7% of excessive dose. Author Affiliation: (1) 0000 0004 0478 9977, grid.412004.3, Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland (2) 0000 0004 1936 9721, grid.7839.5, Department of Diagnostic and Interventional Radiology, Clinic of the Goethe University, Frankfurt am Main, Germany (3) 000000041936754X, grid.38142.3c, Massachusetts General Hospital, Cardiac CT PET MRI Program, Harvard Medical School, Boston, MA, USA (4) 0000 0001 2294 4705, grid.413349.8, Clinic of Radiology and Nuclear Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland (5) RNS Gemeinschaftspraxis GbR, Atle Schmelze 20, 65201, Wiesbaden, Germany Article History: Registration Date: 06/11/2017 Received Date: 25/04/2017 Accepted Date: 06/11/2017 Online Date: 07/12/2017
    Keywords: Multi-detector CT ; Adaptive detector collimation ; Dual-source CT ; Coronary CT angiography ; Over-ranging
    ISSN: 0938-7994
    E-ISSN: 1432-1084
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  • 10
    Language: English
    In: European radiology, August 2015, Vol.25(8), pp.2493-501
    Description: To define optimal keV settings for advanced monoenergetic (Mono+) dual-energy computed tomography (DECT) in patients with head and neck squamous cell carcinoma (SCC). DECT data of 44 patients (34 men, mean age 55.5 ± 16.0 years) with histopathologically confirmed SCC were reconstructed as 40, 55, 70 keV Mono + and M_0.3 (30 % 80 kV) linearly blended series. Attenuation of tumour, sternocleidomastoid muscle, internal jugular vein, submandibular gland, and noise were measured. Three radiologists with 〉3 years of experience subjectively assessed image quality, lesion delineation, image sharpness, and noise. The highest lesion attenuation was shown for 40 keV series (248.1 ± 94.1 HU), followed by 55 keV (150.2 ± 55.5 HU; P = 0.001). Contrast-to-noise ratio (CNR) at 40 keV (19.09 ± 13.84) was significantly superior to all other reconstructions (55 keV, 10.25 ± 9.11; 70 keV, 7.68 ± 6.31; M_0.3, 5.49 ± 3.28; all P 〈 0.005). Subjective image quality was highest for 55 keV images (4.53; κ = 0.38, P = 0.003), followed by 40 keV (4.14; κ = 0.43, P 〈 0.001) and 70 keV reconstructions (4.06; κ = 0.32, P = 0.005), all superior (P 〈 0.004) to linear blending M_0.3 (3.81; κ = 0.280, P = 0.056). Mono + DECT at low keV levels significantly improves CNR and subjective image quality in patients with head and neck SCC, as tumour CNR peaks at 40 keV, and 55 keV images are preferred by observers. • Mono + DECT combines increased contrast with reduced image noise, unlike linearly blended images. • Mono + DECT imaging allows for superior CNR and subjective image quality. • Head and neck tumour contrast-to-noise ratio peaks at 40 keV. • 55 keV images are preferred over all other series by observers.
    Keywords: Head and Neck Neoplasms -- Diagnostic Imaging ; Tomography, X-Ray Computed -- Methods
    ISSN: 09387994
    E-ISSN: 1432-1084
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