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Berlin Brandenburg

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  • 1
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Format: 1 Online-Ressource (XVII, 501 p. 70 illus., 58 illus. in color)
    ISBN: 9783319601748 , 978-3-319-60172-4
    Series Statement: The Receptors 33
    Additional Edition: Erscheint auch als
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 2
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Format: 1 Online-Ressource (X, 282 p. 28 illus., 26 illus. in color)
    ISBN: 9783319561707 , 978-3-319-56168-4
    Series Statement: The Receptors 31
    Additional Edition: Erscheint auch als
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 3
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    Format: 1 Online-Ressource (XII, 446 p. 69 illus., 23 illus. in color)
    ISBN: 9783319704746 , 978-3-319-70472-2
    Series Statement: The Receptors 32
    Additional Edition: Erscheint auch als
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 4
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Format: 1 Online-Ressource (204 Seiten) , Illustrationen, Diagramme
    ISBN: 9782889451234
    Note: Published in: Frontiers in neuroscience and frontiers in pharmacology
    Language: English
    Keywords: Nervenkrankheit ; Arzneimitteldesign ; Aufsatzsammlung
    URL: Volltext  (kostenfrei)
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  • 5
    Format: XV, 665 S., [3] Bl. , Ill., graph. Darst.
    Edition: 1. ed.
    ISBN: 9780444532350
    Series Statement: Progress in brain research 172
    Note: Literaturangaben
    Language: English
    Keywords: Serotonin ; Dopamin ; Neurochemie ; Aufsatzsammlung
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  • 6
    Format: 60 S. , zahlr. Ill.
    Language: Italian
    Keywords: Villa Romana del Casale ; Mosaik
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  • 7
    Format: 71 S.
    Language: Italian
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  • 8
    Book
    Book
    Wien [u.a.] : Springer-Verlag
    Format: XI, 369 Seiten , Ill., graph. Darst.
    ISBN: 9783211926598
    Series Statement: Journal of neutral transmission: Supplement 73
    Note: Text engl.
    Language: English
    Keywords: Parkinson-Krankheit ; Dopaminrezeptor
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  • 9
    Online Resource
    Online Resource
    Totowa, NJ : Springer Science+Business Media, LLC
    Format: Online-Ressource , v.: digital
    Edition: 1
    Edition: Online-Ausg.] 2011 Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9781607619413 , 9781607619406
    Series Statement: The Receptors 22
    Content: Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor research has grown so fruitful, given that it is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of numerous behaviors. It has further been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of central nervous system disorders. The time, therefore, is more than appropriate to offer the first ever overview of the research of 5-HT2c receptors. Part of the popular and important series, 'The Receptors,' The 5-HT2c Receptor provides a thorough update of the functional status of the 5-HT2c receptor. It covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor so as to highlight its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. In addition, the book investigates the receptors' therapeutic potential in a range of different diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy. While not exhaustive, this text is a vital tool in understanding the past and inspiring the future of interdisciplinary research on the 5-HT2c receptor.
    Note: Description based upon print version of record , 5-HT2C Receptors in the Pathophysiologyof CNS Disease; Preface; Contents; Chapter 1: The Making of the 5-HT2C Receptor; Chapter 2: Serotonin 5-HT2C Receptors: Chemical Neuronatomy in the Mammalian Brain; Chapter 3: The Medicinal Chemistry of 5-HT2CReceptor Ligands; Chapter 4: Insights into 5-HT2C Receptor Function Gained from Transgenic Mouse Models; Chapter 5: Serotonin 5-HT2C Receptor Signal Transduction; Chapter 6: Homology Modeling of 5-HT2C Receptors; Chapter 7: 5-HT2C Receptor Dimerization; Chapter 8: RNA Editing of 5-HT2C Receptor and Neuropsychiatric Diseases , Chapter 9: Serotonergic Control of Adult Neurogenesis: Focus on 5-HT2C ReceptorsChapter 10: The Constitutive Activity of 5-HT2C Receptors as an Additional Modality of Interactionof the Serotonergic System; Chapter 11: The 5-HT2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neuroch; Chapter 12: The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression; Chapter 13: 5-HT2C Receptors and Suicidal Behavior; Chapter 14: The 5-HT2C Receptor as a Target for Schizophrenia , Chapter 15: Serotonin and Reward-Related Behavior: Focus on 5-HT2C ReceptorsChapter 16: Tat-3L4F: A Novel Peptide for Treating Drug Addiction by Disrupting Interaction Between PTEN and 5-HT2C Receptor; Chapter 17: The Role of Serotonin in Eating Behavior: Focus on 5-HT2C Receptors; Chapter 18: Physiological and Pathophysiological Aspects of 5-HT2c Receptors in Basal Ganglia; Chapter 19: Modeling Tardive Dyskinesia: Predictive 5-HT2C Receptor Antagonist Treatment; Chapter 20: The Role of 5-HT2A/2C Receptors in Sleep and Waking , Chapter 21: Role of Alternative Splicing of the 5-HT2C Receptor in the Prader-Willi SyndromeChapter 22: The Role of 5-HT2C Receptor in Epilepsy; Chapter 23: The Role of Serotonin on Attentional Processes and Executive Functioning: Focus on 5-HT2C Receptors; Chapter 24: 5-HT2C Receptors in Learning; Chapter 25: The Role of 5-HT2C Polymorphisms in Behavioral and Psychological Symptoms of Alzheimer Disease; Chapter 26: Ocular Hypotension: Involvement of Serotonergic 5-HT2 Receptors; Index;
    Additional Edition: Print version 5-HT2C Receptors in the Pathophysiology of CNS Disease
    Language: English
    URL: Volltext  (Lizenzpflichtig)
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  • 10
    Online Resource
    Online Resource
    New York, NY : Springer New York
    Format: Online-Ressource (IX, 295 p. 34 illus., 18 illus. in color) , online resource
    Edition: Online-Ausg.] Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9781493914265 , 9781493914258
    Series Statement: The Receptors 27
    Content: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the ge
    Content: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes
    Note: Includes index , A brief introduction to extrasynaptic GABAA receptors and ‘tonic’ GABAA receptor mediated inhibition in physiology and diseaseExtrasynaptic GABAA receptors: subunit composition, distribution, and regulation -- Biophysical properties of recombinant 2- AND δ- subunit containing GABAA receptors -- The pharmacology of extrasynaptic GABAA receptors -- Neurosteroids and extrasynaptic GABAA receptors -- Sources of GABA that activate extrasynaptic GABAA receptors -- Modulation of Extrasynaptic GABAA Receptors by G-protein-coupled Receptors -- Extrasynaptic GABAA receptors and tonic inhibition in spinal cord -- The role of peri-synaptic GABA receptors after stroke -- The role of extrasynaptic GABAA receptors in focal epilepsy -- Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures -- GABAergic control of the hypothalamic-pituitary-adrenal (HPA) axis: role of extrasynaptic GABAA receptors -- Tonic GABAA receptor mediated inhibition in Fragile-X Syndrome: A cause of dysfunction or a pathway for a cure?.
    Additional Edition: Print version Extrasynaptic GABAA Receptors
    Language: English
    URL: Volltext  (Lizenzpflichtig)
    URL: Cover
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