Journal of Theoretical Biology, August 7, 2014, Vol.354, p.105(8)
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtbi.2014.03.028 Byline: Joanna Kawka, Dominik Sturm, Sabrina Pleier, Stefan Pfister, Anna Marciniak-Czochra Abstract: Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/[beta]-catenin signaling pathway, and GSK3[beta] (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Author Affiliation: (a) Institute of Applied Mathematics, Interdisciplinary Center for Scientific Computing (IWR) and BIOQUANT, University of Heidelberg, Germany (b) Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany Article History: Received 2 September 2013; Revised 6 February 2014; Accepted 16 March 2014
Medulloblastoma -- Analysis ; Glucose Metabolism -- Analysis ; Deregulation -- Analysis ; Glucocorticoids -- Analysis ; Glycogen Synthesis -- Analysis ; Glycogen -- Analysis ; Gene Expression -- Analysis
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