Format:
1 Band (verschiedene Seitenzählungen)
,
Illustrationen, Diagramme
Content:
The metabolic state of an organism reflects the entire phenotype that is jointly affected by genetic and environmental changes. Due to the complexity of metabolism, system-level modelling approaches have become indispensable tools to obtain new insights into biological functions. In particular, simulation and analysis of metabolic networks using constraint-based modelling approaches have helped the analysis of metabolic fluxes. However, despite ongoing improvements in prediction of reaction flux through a system, approaches to directly predict metabolite concentrations from large-scale metabolic networks remain elusive. In this thesis, we present a computational approach for inferring concentration ranges from genome-scale metabolic models endowed with mass action kinetics. The findings specify a molecular mechanism underling facile control of concentration ranges for components in large-scale metabolic networks. Most importantly, an extended version of the approach can be used to predict concentration ranges without knowledge of ...
Note:
Dissertation Universität Potsdam 2020
Language:
English
Keywords:
Pflanzenphysiologie
;
Metabolit
;
Hochschulschrift
Author information:
Willmitzer, Lothar 1952-
Author information:
Küken, Anika
Author information:
Ebenhöh, Oliver 1970-
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