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  • 1
    Language: English
    In: Langenbeck's archives of surgery, January 2012, Vol.397(1), pp.69-74
    Description: The efficacy of Heller myotomy in patients 〉40 years-a significant predictor suggesting a favorable response to pneumatic dilation-has been questioned. The aim of our study was to evaluate the results obtained in patients aged 40 years undergoing minimally invasive surgery (MIS) for achalasia. In January 2008, we established the MIS technique for achalasia in our clinic. In the following period from January 2008 to March 2011, 74 patients underwent primary laparoscopic myotomy for achalasia. The procedure was accomplished with an anterior 180° semifundoplication according to Dor in all patients. The Eckardt score and the Gastrointestinal Quality of Life Index (GQLI) served as outcome measures. The median age of patients was 45.5 years (range, 18-85 years) with a median duration of preoperative achalasia symptoms of 57 months (range, 2-468 months). There were no conversions to open surgery and-except for one patient with a sterile pleural effusion-no postoperative complications. At a median follow-up of 12 months, the preoperative Eckardt score of 7.0 (range, 3-12) was found to be significantly decreased to a median of 2 (range, 0-6; P 40 years, the postoperative Eckardt score obtained in the older patient population was not significantly lower (P = 0.074). There was no statistically significant difference between the two groups with respect to the postoperative GQLI (P = 0.860). Neither gender nor preoperative Botox injection or pneumatic dilation inserted a significant influence on the postoperative clinical outcome (P 〉 0.05). Laparoscopic Heller myotomy for achalasia is associated with a high success rate as the primary therapeutic option and after failure of endoscopic therapy. It can be performed safely and with favorable outcomes also in patients 〉40 years. However, the long-term durability of the procedure remains to be established.
    Keywords: Esophageal Achalasia -- Surgery ; Esophagus -- Surgery ; Laparoscopy -- Methods
    ISSN: 14352443
    E-ISSN: 1435-2451
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  • 2
    Language: English
    In: Cancer Research, 07/01/2017, Vol.77(13 Supplement), pp.4261-4261
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 3
    Language: English
    In: Langenbeck's Archives of Surgery, 2012, Vol.397(1), pp.69-74
    Keywords: Achalasia ; Minimally invasive Heller myotomy ; Dor semifundoplication ; Eckardt score ; Gastrointestinal quality of life index (GQLI)
    ISSN: 1435-2443
    E-ISSN: 1435-2451
    Source: Springer Science & Business Media B.V.
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  • 4
    Language: English
    In: Anticancer research, November 2014, Vol.34(11), pp.6459-66
    Description: The treatment of osteosarcoma, especially wide resection, is challenging. An additional local drug therapy after resection using anti-neoplastic bone cement (Polymethylmethacrylate (PMMA)) could help improve the outcome of therapy. In this study, we evaluated the effects of PMMA loaded with valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) on the cell activity of a SaOs-2 cell culture, as well as the elution rate of the drugs out of the bone cement. In our experiments, we used the SaOs-2 osteosarcoma and the SW1353 chondrosarcoma cell line. Bone cement clots (5 g) were prepared and loaded with different drug concentrations of VPA (25 mg and 50 mg) and SAHA (1 mg, 2.5 mg and 5 mg). Two control groups were established, one with a native cement clot, the other with human mesenchymal stem cells, in order to evaluate toxicity on non tumor-cells. Cell activity was measured using an Alamar Blue assay on days 1, 2, 3, 4 and 7. The cement clots were additionally examined in a material testing unit for biomechanical and structural changes. Tumor cells showed a significant and complete reduction of activity under therapy with VPA and SAHA. Drug release of VPA was extensive between days 0 and 3 and decreased progressively to day 7. Cumulative drug concentration in the medium continuously increased. Biomechanical testing of the cement clots showed no differences in stability and architecture compared to the control group. SaOs-2 and SW1353 cells with medium from native cement clots without drug therapy presented a cell activity of 100% in all groups and during all measurements. Human mesenchymal stem cells were not significantly affected during therapy with VPA and low concentrations of SAHA. In contrast, cell activity of human mesenchymal stem cells was significantly reduced under therapy with higher concentrations of SAHA, with an approximately linear decrease between days 0-3 and a rapidly decreasing activity between days 4-7. A local cytotoxic therapy in the treatment of osteosarcoma and chondrosarcoma might improve the rate of metastasis and survival of patients. Our results present an encouraging approach to loading PMMA with anti-neoplastic drugs.
    Keywords: Bone Cement ; Hdac Inhibitor ; Pmma ; Saha ; Local Therapy ; Valproic Acid ; Bone Cements -- Pharmacology ; Bone Neoplasms -- Drug Therapy ; Chondrosarcoma -- Drug Therapy ; Histone Deacetylase Inhibitors -- Pharmacology ; Osteosarcoma -- Drug Therapy ; Polymethyl Methacrylate -- Chemistry
    ISSN: 02507005
    E-ISSN: 1791-7530
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 5
    Language: English
    In: Knee Surgery, Sports Traumatology, Arthroscopy, 2019, Vol.27(7), pp.2167-2172
    Description: Byline: Lukas Eckhard (1,2), Todd Jones (2), Jamie E. Collins (3), Swastina Shrestha (3), Wolfgang Fitz (2) Keywords: TKA; Pain; Opioids; Glucocorticoids; Gabapentin Abstract: Purpose Dexamethasone and gabapentin are used in multimodal pain management protocols to reduce postoperative pain after total knee arthroplasty. For both analgesic adjuvants, the optimal dose regimen to reduce opioid usage is still unclear. Methods The opioid consumption of patients undergoing primary TKA before and after a change of the analgesic adjuvant medication in our protocol (old protocol: 4 mg of dexamethasone daily for 2 days, 600 mg gabapentin daily for 1 week new protocol: 10 mg dexamethasone daily for 2 days, 300 mg gabapentin every 8 h for 1 week) were retrospectively compared. All surgeries were performed under spinal anesthesia. Peri- and postoperative pain medication remained unchanged. Results A total of 186 patients who received TKA between 11/29/2016 and 06/09/2017 were screened. Six patients who received general anesthesia, 4 patients who underwent simultaneous bilateral TKA, and 16 patients with ongoing opioid consumption at the time of surgery were excluded, leaving 80 patients in each group. Opioid consumption within 24 h [morphine equivalents in mg: mean 50.5, standard deviation (SD) 30.0 (old) vs. 39.8, SD 24.2 (new) P=0.0470], cumulative consumption over 48 h (97.3, SD 64.4 vs. 70.4, SD 51.2 P=0.0040) and cumulative consumption over 72 h (108.1, SD 79.5 vs. 82.5, SD 72.6 P=0.0080), were all significantly lower in the new protocol. Conclusion Increased postoperative administration of dexamethasone and gabapentin after TKA is associated with lower opioid consumption. Within the first 48 h, up to about 25% of opioids can be spared, comparing high-dose to low-dose protocols. Level of evidence Therapeutic Level III. Author Affiliation: (1) grid.410607.4, Department of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany (2) 0000 0004 0378 8294, grid.62560.37, Department of Orthopedic Surgery, Brigham and Women's Hospital, 850 Boylston Street, Chestnut Hill, MA, 02467, USA (3) 0000 0004 0378 8294, grid.62560.37, Orthopedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital, 75 Francis Street, BTM 5016, Boston, MA, 02115, USA Article History: Registration Date: 25/02/2019 Received Date: 13/11/2018 Accepted Date: 25/02/2019 Online Date: 02/03/2019
    Keywords: TKA ; Pain ; Opioids ; Glucocorticoids ; Gabapentin
    ISSN: 0942-2056
    E-ISSN: 1433-7347
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  • 6
    Language: English
    In: Biochemical and Biophysical Research Communications, 2010, Vol.398(3), pp.601-605
    Description: ► Adipose tissue-derived stem cells (ASC) migrated toward the tumor-conditioned medium. ► Migration of ASCs increased in response to increased concentrations of PDGF-BB. ► Neutralizing antibodies to PDGFR-β decreased migration of ASCs. The origin of vascular cells in tumors is unknown, but it is believed that tumors use cells from the host to build new vessels. To determine whether adipose tissue stem cells (ASCs) could be attracted by cancer cells, we performed migration assays in which ASCs were seeded on a transwell migration system top chamber and tumor-conditioned medium was placed in the bottom chamber. Our data showed that a significant number of ASCs migrated toward the tumor-conditioned medium ( 〈 0.0001), and migration of human ASCs significantly ( 〈 0.0001) increased in response to increased concentrations of recombinant PDGF-BB. In addition, neutralizing antibodies to PDGF receptor (PDGFR)-β decreased migration of ASCs toward a breast cancer-conditioned medium to the level of serum-free control. These data suggest that tumor cell-derived PDGF-BB is an important factor in governing the microenvironment interaction between tumor cells and local tissue-resident stem cells.
    Keywords: Pdgf-Bb ; Stem Cells ; Migration ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
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  • 7
    Language: English
    In: International Journal of Psychiatry in Clinical Practice, 01 January 2001, Vol.5(1), pp.33-40
    Description: INTRODUCTION: The goal of this open clinical study was to perform a detailed investigation of the cardiovascular effects of the novel atypical neuroleptic sertindole. METHOD: Thirty initially untreated schizophrenic inpatients (diagnosed according to DSM-III-R) underwent a total of 103 serial...
    Keywords: Schizophrenia Heart Rate Variability Torsades De Pointes Neuroleptic Electrocardiography ; Public Health
    ISSN: 1365-1501
    E-ISSN: 1471-1788
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  • 8
    Language: English
    In: The Journal of biological chemistry, 25 September 2015, Vol.290(39), pp.23692-710
    Description: Cav1.2 and Cav1.3 are the major L-type voltage-gated Ca(2+) channels in the CNS. Yet, their individual in vivo functions are largely unknown. Both channel subunits are expressed in the auditory brainstem, where Cav1.3 is essential for proper maturation. Here, we investigated the role of Cav1.2 by targeted deletion in the mouse embryonic auditory brainstem. Similar to Cav1.3, loss of Cav1.2 resulted in a significant decrease in the volume and cell number of auditory nuclei. Contrary to the deletion of Cav1.3, the action potentials of lateral superior olive (LSO) neurons were narrower compared with controls, whereas the firing behavior and neurotransmission appeared unchanged. Furthermore, auditory brainstem responses were nearly normal in mice lacking Cav1.2. Perineuronal nets were also unaffected. The medial nucleus of the trapezoid body underwent a rapid cell loss between postnatal days P0 and P4, shortly after circuit formation. Phosphorylated cAMP response element-binding protein (CREB), nuclear NFATc4, and the expression levels of p75NTR, Fas, and FasL did not correlate with cell death. These data demonstrate for the first time that both Cav1.2 and Cav1.3 are necessary for neuronal survival but are differentially required for the biophysical properties of neurons. Thus, they perform common as well as distinct functions in the same tissue.
    Keywords: Apoptosis ; Calcium Channel ; Mouse ; Neuron ; Signal Transduction ; Auditory Pathways -- Cytology ; Brain Stem -- Cytology ; Calcium Channels, L-Type -- Physiology
    E-ISSN: 1083-351X
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  • 9
    In: Journal of the American Ceramic Society, June 2013, Vol.96(6), pp.1673-1681
    Description: Highly sensitive magnetic field sensors are presented using magnetoelectric composites consisting of magnetostrictive and piezoelectric phases. They are offering passive nature, high sensitivity, large effect enhancement at mechanical resonance, and large linear dynamic range. Thin‐film magnetoelectric 2‐2 composites benefit from perfect coupling between the piezoelectric and magnetostrictive phases and from the reduction in size which is essential for high spatial resolution. Their design uses and a plate capacitor or with interdigital electrodes and magnetostrictive amorphous single layers or exchanged biased multilayers. At mechanical resonance and depending on the geometry, extremely high coefficients of up to 9.7 kV/cm Oe in air and up to 19 kV/cm Oe under vacuum were obtained. To avoid external magnetic bias fields, composites consisting of exchanged biased multilayers serving as the magnetostrictive component with a maximum magnetoelectric coefficient at zero magnetic bias field are employed. Furthermore, the anisotropic response of these exchanged biased composites can be utilized for three‐dimensional vector field sensing. Sensitivity and noise of the sensors revealed limits of detection as good as to 2.3 pT/Hz at mechanical resonance. Sensitivity between 0.1 and 1000 Hz outside resonance can be enhanced through frequency conversion using magnetic bias fields.
    Keywords: Magnetic Fields ; Sensors ; Air Conditioning ; Magnetic Resonance ; Multilayers ; Exchanging ; Bias ; Thin Films ; Magnetostriction ; General (Wc) ; Solid State Milieux (General) (So) ; General and Nonclassified (EC) ; Aluminium Nitride ; Amorphous ; Amorphous Material ; Anisotropic ; Biomedical Application ; Capacitor ; Ceramic Matrix Composite ; Characterisation ; Cmc ; Composite ; Coupling ; Electroceramic ; Electrode ; Fabrication ; Film ; Frequency ; Interdigitated Electrode ; Iron Cobalt Alloy ; Layer ; LEAD Zirconate Titanate ; Magnetic Field ; Magnetic Field Sensor ; Magnetoelectric Effect ; Magnetostriction ; Magnetostrictive Material ; Modelling ; Particle-Reinforced Composite ; Phase ; Piezoelectric Phase ; Pzt ; Resonance ; Sensitivity ; Sensor ; Spatial Resolution ; Structure ; Technical ; Theory ; Thickness ; Thin Film ; Voltage;
    ISSN: 0002-7820
    E-ISSN: 1551-2916
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  • 10
    Language: English
    In: Angewandte Chemie International Edition, 22 May 2018, Vol.57(21), pp.6065-6068
    Description: Coadsorbed anions are well‐known to influence surface reactivity and dynamics at solid–liquid interfaces. Here we demonstrate that the chemical nature of these spectator species can entirely determine the microscopic dynamic behavior. Quantitative in situ video‐STM data on the surface diffusion of adsorbed sulfur atoms on Cu(100) electrodes in aqueous solution covered by bromide and chloride spectators, respectively, reveal in both cases a strong exponential potential dependence, but with opposite sign. This reversal is highly surprising in view of the isostructural adsorbate arrangement in the two systems. Detailed DFT studies suggest an anion‐induced difference in the sulfur diffusion mechanism, specifically an exchange diffusion on the Br‐covered surface. Experimental evidence for the latter is provided by the observation of Cu vacancy formation in the Br system, which can be rationalized by a side reaction of the sulfur exchange diffusion. of specifically adsorbed chloride and bromide ions on a Cu(100) surface on the diffusion of additionally adsorbed sulfur atoms has been studied experimentally and theoretically. Although the adsorbed halides show similar properties, sulfur diffusion on a bromide‐ or chloride‐covered Cu(100) surface shows an opposite dependence on the electrode potential.
    Keywords: Density Functional Calculations ; Electrochemistry ; Scanning Tunneling Microscopy ; Surface Dynamics
    ISSN: 1433-7851
    E-ISSN: 1521-3773
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