Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 1
    Language: English
    In: Skeletal Radiology, 2014, Vol.43(4), pp.493-498
    Description: Our goal was to assess the technical results in patients who underwent long-axis sacroplasty for the treatment of sacral insufficiency fractures (SIF) by radiofrequency-induced high-viscosity bone cement augmentation. Twelve patients with bilateral sacral fractures were treated by augmentation with radiofrequency-activated, high-viscosity polymethylmethacrylate (PMMA) bone cement under local anesthesia. CT-guided sacroplasty was performed by using a long-axis approach through a single entry point. Thirty-six vertebrae were treated in 12 sessions under a combination of CT and fluoroscopic guidance using a bilateral access and a cavity-creating osteotome prior to remote-controlled, hydraulically driven cement injection. The visual analogue scale (VAS) score before sacroplasty and at 1 and 3 months after the treatment was obtained. PMMA leaks were evaluated retrospectively using the post-interventional CT. The mean amount of high-viscosity PMMA injected per patient was 7.8 ml. No major adverse events were observed. In the first 4 days after the procedure, the mean VAS score decreased from 8.1 ± 1.9 to mean 3.1 ± 1.2 and was followed by a gradual but continuous decrease throughout the rest of the follow-up period at 24 weeks (mean 2.2 ± 1.1) and 48 weeks (mean 2.1 ± 1.4). CT fluoroscopy-guided sacral augmentation was safe and effective in all 12 patients with osteoporotic SIF.
    Keywords: Sacroplasty ; Radiofrequency ; Osteoporosis
    ISSN: 0364-2348
    E-ISSN: 1432-2161
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: European Journal of Radiology, December 2013, Vol.82(12), pp.e816-e822
    Description: Evaluation of the efficacy and tolerability of transarterial chemoembolization with gemcitabine in patients with inoperable liver metastases of breast cancer. Open-label, prospective non-randomized single-center study design; patients had previous chemotherapy including anthracyclines and/or taxanes in the metastatic setting, adequate bone marrow reserve, sufficient liver/renal function, no centralnervous system metastases, Karnovsky-performance-status 〉70%, and life expectancy 〉12 weeks. Forty-three patients were enrolled (median 58 years, range 48–71). A suspension of gemcitabine 1.200 mg/m , 2–10 ml/m of Lipiodol, and 5 ml of a degradable starch microsphere (Embocept) suspension, were administered intra-arterially up to 3 times with a 4-weaks-interval. Dose-limiting toxicit is defined as grade 4 thrombocytopenia, neutropenia, or nonhematologic toxicity 〉 grade 3. Tumor response was evaluated by magnetic resonance (MRI) and computed tomography (CT) imaging. All patients tolerated the treatment well; with no dose limiting toxicities. Imaging follow-up according to the RECIST-criteria (Response Evaluation Criteria in Solid Tumors) revealed a partial response in 3 patients, stable disease in 16 patients and progression in 22 patients. The progression free survival was 3.3 months. A significant correlation exists only with the factor vascularization: strongly vascularized tumors show a significantly lowered response. Patients with complete or partial response and the main fraction of the stable disease group showed in the MRI and angiography only a moderate vascularization. The resulting estimate of the total survival rate amounts to a median of 10.2 months. Transarterial chemoembolization with gemcitabine is well tolerated and provides an alternative treatment method for patients with liver metastases of breast cancer.
    Keywords: Transarterial Chemoembolization ; Liver Metastases ; Breast Cancer ; Medicine
    ISSN: 0720-048X
    E-ISSN: 1872-7727
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: International Journal of Cancer, 01 March 2014, Vol.134(5), pp.1225-1231
    Description: The aims of the study were to evaluate therapeutic efficacy and to determine the prognostic factors for treatment success in patients with liver metastases from colorectal cancer (CRC) treated with transarterial chemoembolization (TACE). A total of 564 patients (mean age, 60.3 years) with liver metastases of CRC were repeatedly treated with TACE. In total, 3,384 TACE procedures were performed (mean, six sessions per patient). The local chemotherapy protocol consisted of mitomycin C alone (43.1%), mitomycin C with gemcitabine (27.1%), mitomycin C with irinotecan (15.6%) or mitomycin C with irinotecan and cisplatin (15.6%). Embolization was performed with lipiodol and starch microspheres. Tumor response was evaluated using magnetic resonance imaging or computed tomography. The change in tumor size was calculated and the response was evaluated according to the RECIST‐Criteria. Survival rates were calculated according to the Kaplan–Meier method. Prognostic factors for patient's survival were evaluated using log‐rank test. Evaluation of local tumor control showed partial response in 16.7%, stable disease in 48.2% and progressive disease in 16.7%. The 1‐year survival rate after chemoembolization was 62%, the 2‐year survival rate was 28% and the 3‐year survival rate was 7%. Median survival from the start of chemoembolization treatment was 14.3 months. The indication ( = 0.001) and initial tumor response ( = 0.015) were statistically significant factors for patient's survival. TACE is a minimally invasive therapy option for controlling local metastases and improving survival time in patients with hepatic metastases from CRC. TN stage, extrahepatic metastases, number of lesions, tumor location within the liver and choice of chemotherapy protocol of TACE are none significant factors for patient's survival. What's new? About two‐thirds of colorectal cancer patients develop life‐threatening liver metastases, for which the only potentially curative therapy is resection. But only a small proportion of patients are candidates for resection, and those who undergo resection may suffer from intrahepatic recurrence. Here, transarterial chemoembolization (TACE), a minimally invasive procedure, was explored for colorectal cancer liver metastases. TACE was performed repeatedly for each of more than 560 patients. Following treatment, 48.2 percent of patients had stable disease, and the 1‐year survival rate was 62 percent. Initial tumor response was a significant prognostic factor for patient survival after TACE.
    Keywords: Chemoembolization ; Liver Metastases ; Colorectal Cancer
    ISSN: 0020-7136
    E-ISSN: 1097-0215
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Clinical Imaging, January 2015, Vol.39(1), pp.110-115
    Description: The purpose of this retrospective monocenter study was to evaluate a monophasic multidetector computed tomography (MDCT) protocol with a fixed delay for patients with polytrauma. A total of 2086 patients were evaluated retrospectively. For the intravenous contrast media, we used a fixed protocol with an injection for an adult patient of 120 mL at a rate of 2 mL/s. In the venous phase, we detected injuries of parenchyma and localized ongoing bleedings in regard to the clinical follow-up, with regard to the easy feasibility and the quickness with only one scan. Monophasic venous injection protocol can detect all injuries in the whole-body MDCT for patients with polytrauma.
    Keywords: Mdct ; Polytrauma ; Fixed Venous Protocol ; Image Quality ; Medicine
    ISSN: 0899-7071
    E-ISSN: 1873-4499
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Visceral Medicine, October 2012, Vol.28(5), pp.317-323
    Description: Hintergrund: Lange Wartezeiten vor einer Lebertransplantation führen bei Patienten mit hepatozellulärem Karzinom (HCC) aufgrund eines Tumorprogresses zunehmend zu einem Ausschluss von der Transplantationsliste und damit auch zu einem reduzierten Langzeitüberleben. Methode und Ergebnisse: Aus diesem Grund werden heute verschiedene lokale Therapien wie die transarterielle Chemoembolisation (TACE) und verschiedene lokal ablative Verfahren einschließlich der perkutanen Alkoholinjektion (PEI), der Radiofrequenzablation (RFA), der MR-gesteuerten Laserablation (LITT) und der Mikrowellenablation (MWA) zum Bridging vor einer Lebertransplantation eingesetzt. Die Auswahl der geeigneten Verfahren ist hierbei abhängig von der Anwendbarkeit, den Limitationen und den spezifischen Risiken der verschiedenen Techniken. Insbesondere das Management von HCC-Patienten mit Leberzirrhose ist komplex, sodass die Auswahl der therapeutischen Maßnahmen interdisziplinär abgestimmt werden sollte. Schlussfolgerung: Auch wenn für die Bridging-Therapien derzeit keine evidenzbasierten Daten vorliegen, zeigen sich die verschiedenen interventionellen Therapien als vielversprechende therapeutische Optionen zum Bridging vor einer Lebertransplantation.
    Keywords: Hauptthema · Main Topic
    ISBN: 9783318021004
    ISBN: 3318021008
    ISSN: 2297-4725
    ISSN: 16626664
    E-ISSN: 2297-475X
    E-ISSN: 16626672
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Radiology, June 2011, Vol.259(3), pp.903-10
    Description: To examine the feasibility and safety of magnetic resonance (MR)-guided biopsy by using a transgluteal approach in patients with suspicious prostate lesions by using an MR-compatible robotic system and a 1.5-T MR system. The study was approved by the institutional review board of University Frankfurt, and informed consent was obtained from each patient. A total of 20 patients (age range, 57.8-71.9 years; mean age, 65.1 years) underwent biopsy in a closed-bore high-field-strength MR system. Biopsy was performed with an MR-compatible pneumatically driven robotic system. T1-weighted gradient-echo fast low-angle shot and T2-weighted true fast imaging with steady-state precession sequences were used to plan and guide the intervention with a transgluteal access on the external planning computer of the assistance system. The system calculated the trajectory and then moved the guiding arm to the insertion point. The cannula was advanced manually, and biopsies were performed with the coaxial technique by using a 15-gauge pencil tip needle. Intervention time, complications, and biopsy findings were documented. The MR-compatible robotic system did not interfere with image quality, nor did MR imaging cause dysfunction of the robot. In one patient, the interventionist caused a fail-safe system shutdown. This was due to inadvertent displacement of the guiding arm during cannula insertion. This problem was solved by increasing the displacement threshold. Accurate coaxial cannula biopsy could be performed in all subsequent patients. Sufficient histopathologic assessment was performed in 19 patients. Insufficient material was retrieved in the patient who experienced fail-safe system shutdown. The median intervention time was 39 minutes (23-65 minutes). No procedure-related complications were observed. Preliminary results indicate that MR-guided robot-assisted biopsy is feasible and can be performed safely with highly accurate cannula placement.
    Keywords: Biopsy, Needle -- Instrumentation ; Magnetic Resonance Imaging, Interventional -- Instrumentation ; Prostatic Neoplasms -- Diagnosis ; Robotics -- Instrumentation
    ISSN: 00338419
    E-ISSN: 1527-1315
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Radiology, 04 December 2018, pp.181286
    Description: Purpose To assess the diagnostic performance of dual-energy CT with reconstruction of virtual noncalcium (VNCa) images for the detection of lumbar disk herniation compared with standard CT image reconstruction. Materials and Methods For this retrospective study, 41 patients (243 intervertebral disks; overall mean age, 68 years; 24 women [mean age, 68 years] and 17 men [mean age, 68 years]) underwent clinically indicated third-generation, dual-source, dual-energy CT and 3.0-T MRI within 2 weeks between March 2017 and January 2018. Six radiologists, blinded to clinical and MRI information, independently evaluated conventional grayscale dual-energy CT series for the presence and degree of lumbar disk herniation and spinal nerve root impingement. After 8 weeks, readers reevaluated examinations by using color-coded VNCa reconstructions. MRI evaluated by two separate experienced readers, blinded to clinical and dual-energy CT information, served as the standard of reference. Sensitivity and specificity were the primary metrics of diagnostic performance. Results A total of 112 herniated lumbar disks were depicted at MRI. VNCa showed higher overall sensitivity (612 of 672 [91%] vs 534 of 672 [80%]) and specificity (723 of 786 [92%] vs 665 of 786 [85%]) for detecting lumbar disk herniation compared with standard CT (all comparisons, P 〈 .001). Interreader agreement was excellent for VNCa and substantial for standard CT (κ = 0.82 vs 0.67; P 〈 .001). VNCa achieved superior diagnostic confidence, image quality, and noise scores compared with standard CT (all comparisons, P 〈 .001). Conclusion Color-coded dual-energy CT virtual noncalcium reconstructions show substantially higher diagnostic performance and confidence for depicting lumbar disk herniation compared with standard CT. © RSNA, 2018.
    Keywords: Adult–Diagnostic Imaging ; Aged–Diagnostic Imaging ; Aged, 80 and Over–Diagnostic Imaging ; Female–Diagnostic Imaging ; Humans–Methods ; Intervertebral Disc–Methods ; Intervertebral Disc Degeneration–Methods ; Intervertebral Disc Displacement–Methods ; Lumbar Vertebrae–Methods ; Male–Methods ; Middle Aged–Methods ; Retrospective Studies–Methods ; Sensitivity and Specificity–Methods ; Tomography, X-Ray Computed–Methods ; Abridged;
    ISSN: 00338419
    E-ISSN: 1527-1315
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: European Radiology, Jan, 2013, Vol.23(1), p.198(7)
    Description: Byline: Boris Schulz (1,3), Katrin Eichler (1), Petra Siebenhandl (1), Tatjana Gruber-Rouh (1), Christoph Czerny (2), Thomas Josef Vogl (1), Stephan Zangos (1) Keywords: Flat-panel computed tomography; Interventional CT; Percutaneus biopsy; Robot; Robotic device Abstract: Objective To analyse the feasibility and accuracy of robotic aided interventions on a phantom when using a modern C-arm-mounted cone beam computed tomography (CBCT) device in combination with needle guidance software. Methods A small robotic device capable of holding and guiding needles was attached to the intervention table. After acquiring a 3D data set the access path was planned on the CBCT workstation and shown on the intervention monitor. Then the robot was aligned to the live fluorosopic image. A total of 40 punctures were randomly conducted on a phantom armed with several targets (diameter 2 mm) in single and double oblique trajectory (n=20 each). Target distance, needle deviation and time for the procedures were analysed. Results All phantom interventions (n=40) could be performed successfully. Mean target access path within the phantom was 8.5 cm (min 4.2 cm, max 13.5 cm). Average needle tip deviation was 1.1 mm (min 0 mm, max 4.5 mm), time duration was 3:59 min (min 2:07 min, max 10:37 min). Conclusion When using the proposed robot device in a CBCT intervention suite, highly accurate needle-based interventional punctures are possible in a reasonable timely manner in single as well as in double oblique trajectories. Key Points aC/ Percutaneous image-guided biopsy is an important contribution of modern radiology. aC/ A compact robotic device has been developed which may facilitate such procedures. aC/ Accurate needle-based interventions are possible in a timely manner. aC/ Complex trajectories and even deep access paths are possible. Author Affiliation: (1) Institute for Diagnostic and Interventional Radiology, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany (2) Department of Trauma Surgery, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany (3) Department of Diagnostic and Interventional Radiology, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany Article History: Registration Date: 30/06/2012 Received Date: 10/05/2012 Accepted Date: 22/06/2012 Online Date: 21/07/2012
    Keywords: Robots ; Cat Scans
    ISSN: 0938-7994
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Zeitschrift fur Gastroenterologie, June 2017, Vol.55(6), pp.564-568
    Description:  Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Infection with the hepatitis C virus (HCV) is one of the most frequent underlying diseases leading to HCC development. Sorafenib is the standard of care for HCC patients not amenable to local treatment, resection, or liver transplantation. Although overall survival can be increased, objective response rates in patients treated with sorafenib are low. In HCC patients who underwent resection or ablation, HCV eradication with interferon-based regimens reduces the risk of recurrence. However, it is not known and under strong debate if patients with HCC should be treated with interferon-free regimens. Furthermore, it is not known if patients with advanced HCC at the time of diagnosis should be treated with antiviral therapy.  A patient with histologically confirmed advanced-stage HCC due to HCV-related cirrhosis was treated with sorafenib according to current guideline recommendations. Furthermore, he received subsequent treatment with direct antiviral agents (DAAs).  The patient achieved a complete response after sorafenib treatment was initiated. Sorafenib treatment was terminated 1 year after complete response. As no recurrence of HCC was evident after treatment cessation, antiviral treatment was initiated with paritaprevir/ritonavir, ombitasvir, dasabuvir, and dose-reduced ribavirin because of chronic kidney disease. The patient achieved a sustained viral response.  Complete response to sorafenib treatment is scarce. Antiviral treatment should be considered in such patients as well as in patients with HCC who underwent resection or ablation.
    Keywords: Antiviral Agents -- Administration & Dosage ; Carcinoma, Hepatocellular -- Drug Therapy ; Hepatitis C -- Drug Therapy ; Liver Neoplasms -- Drug Therapy ; Niacinamide -- Analogs & Derivatives ; Phenylurea Compounds -- Administration & Dosage ; Precancerous Conditions -- Drug Therapy
    ISSN: 00442771
    E-ISSN: 1439-7803
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: German
    In: Deutsche Zeitschrift fur Onkologie, 2011, Vol.43(01), pp.19-23
    Description: Zusammenfassung Interventionelle onkologische Therapiemaßnahmen zur palliativen, symptomatischen, neoadjuvanten sowie auch kurativen Therapie von Lebermetastasen werden vorgestellt, wobei eine Übersicht über die Therapieprinzipien, die Indikationen und die Ergebnisse gegeben wird. Die jeweilige Entscheidung zur Durchführung einer interventionellen onkologischen Therapiemaßnahme muss abgestimmt werden mit der primär onkologischen Gesamtsituation. Minimal-invasive Therapien zur Behandlung von Tumoren in soliden Organen wie der Leber oder der Lunge basieren auf verschiedenen intravaskulären Techniken wie z. B. der transarteriellen Chemoperfusion (TACP), der transarteriellen Chemoembolisation (TACE) oder auf thermischen Techniken wie der Laser-induzierten Thermotherapie (LITT), der Radiofrequenzablation (RFA), der Mikrowellenablation (MWA) oder der Kryoablation. Hinzu kommen radioaktive Techniken wie die SIRT.
    Description: SummaryInterventional oncological therapy strategies for palliative, symptomatic, neoadjuvant as well as curative therapies of liver metastases are introduced by presenting an overview of therapy principles, indications and results. The decision for performing the respective interventional oncological treatment should be based on the general oncological condition of the patient.Minimal invasive therapies for treating tumors of solid organs such as liver or lung are based on different intravascular techniques such as transarterial chemoperfusion (TACP), transarterial chemoembolization (TACE) or on thermal techniques such as laser-induced thermotherapy (LITT), radiofrequency ablation (RFA), microwave ablation (MWA), or cryoablation. In addition, there are radioactive techniques such as selective internal radiation therapy (SIRT).
    Keywords: Lebermetastasen ; Minimal-Invasive Therapie ; Lokale Ablation ; Transarterielle Chemoembolisation ; Liver Metastases ; Minimal-Invasive Therapy ; Local Ablation ; Transarterial Chemoembolization
    ISSN: 1617-5891
    E-ISSN: 1439-0930
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages