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  • 1
    Language: English
    In: The World Allergy Organization journal, 2017, Vol.10(1), pp.47
    Keywords: Medicine;
    ISSN: 1939-4551
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  • 2
    Language: English
    In: The Journal of Allergy and Clinical Immunology, October 2017, Vol.140(4), pp.982-984
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jaci.2017.04.034 Byline: Erika Jensen-Jarolim (a)(b), Michelle C. Turner (c)(d)(e)(f), Sophia N. Karagiannis (g)(h) Author Affiliation: (a) Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria (b) The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria (c) Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain (d) Universitat Pompeu Fabra (UPF), Barcelona, Spain (e) CIBER Epidemiolog?a y Salud P?blica (CIBERESP), Madrid, Spain (f) McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Ontario, Canada (g) St John's Institute of Dermatology, Division of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom (h) NIHR Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London, Guy's Hospital, King's College London, London, United Kingdom Article History: Received 31 January 2017; Revised 8 March 2017; Accepted 5 April 2017 Article Note: (footnote) Supported by the European Academy for Allergy and Clinical Immunology, as an initiative of its AllergoOncology Task Force. E.J.-J. was supported by the Austrian Science Fund FWF (grant SFB F4606-B28). S.N.K. was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) based at Guy's and St Thomas' NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. S.N.K. was also supported by the Medical Research Council (MR/L023091/1), Cancer Research UK (C30122/A11527; C30122/A15774), the Academy of Medical Sciences, Breakthrough Breast Cancer (147), and the CR UK/NIHR in England/DoH for Scotland, Wales, and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya., Disclosure of potential conflict of interest: E. Jensen-Jarolim has received grants from the Austrian Science Fund (SFB F4606-B28), has received travel support from the European Academy of Allergy and Clinical Immunology, has consultant arrangements with Allergy Therapeutics, and has received payment for lectures from Allergy Therapeutics and Thermo Fisher. M. C. Turner has consultant arrangements with ICF Incorporated. S. N. Karagiannis has received grants from the NIHR Biomedical Research Centre at Guy's and St Thomas's Hospitals NHS Trust and King's College London, the Medical Research Council, Cancer Research UK, the Academy of Medical Sciences, Breast Cancer Now, and CR UK/NIHR in England/DOH for Scotland, Wales, and Northern Ireland Experimental Cancer Medicine Centre and has received travel support from the European Academy of Allergy and Clinical Immunology.
    Keywords: Allergy ; Cancer ; Tumor ; Tolerance ; Ige ; Effector Cells ; Antibody-Dependent Cell-Mediated Cytotoxicity ; Allergooncology ; Clinical Oncology ; Oncoimmunology ; Medicine
    ISSN: 0091-6749
    E-ISSN: 1097-6825
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  • 3
    Language: English
    In: Expert Review of Vaccines, 01 September 2011, Vol.10(9), pp.1281-1289
    Description: To date, passive immunotherapy with monoclonal antibodies is a well-established option in clinical oncology. By contrast, anticancer vaccines are less advanced, with the exception of successfully applied prophylactic vaccines against oncogenic virus infections. The creation of therapeutic vaccines is still a great challenge mostly due to the self-nature of tumor antigens. Therapeutic vaccines may be based on patient-specific material including pulsed effector cells, or tumor-associated antigens and derivatives thereof, such as peptides, mimotopes and nucleic acids. The latter represents a more universal approach, which would set an ideal economic framework resulting in broad patient access. In this article we focus on cancer vaccines for antibody production, in particular mimotope vaccines. The collected evidence suggests that they will open up new treatment options in minimal residual disease and early stage disease.
    Keywords: Active/Passive Immunotherapy ; Antibody Therapy ; Cancer ; DNA ; Ige ; Mimotope ; Passive ; Treg ; Tumor Vaccine ; Biology
    ISSN: 1476-0584
    E-ISSN: 1744-8395
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  • 4
    Language: English
    In: World Allergy Organization Journal, 01 January 2015, Vol.8
    Description: Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact that it is a typical Th2 adjuvant, aluminium redirects the immune response in systemic allergen immunotherapy (SIT) upon prolonged immunization. SIT in the US, and SLIT in general, are at present non-adjuvanted therapies, but in Europe aluminium is used as adjuvant in most SIT preparations. It enhances the safety of SIT by local deposition of the allergen. Undesired properties of aluminium adjuvants comprise acute and chronic inflammation at the injection site, its Th2 immune stimulatory capacity, its accumulation besides biodistribution in the body. The adjuvant and safety profile of aluminium adjuvants in allergy vaccines are discussed, as well as the need for putting modern delivery systems and adjuvants on the fast track. Keywords: Allergen, Aluminium, Adjuvant, Allergen immunotherapy, Th2
    Keywords: Medicine
    ISSN: 1939-4551
    E-ISSN: 1939-4551
    Source: Directory of Open Access Journals (DOAJ)
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  • 5
    Language: English
    In: PloS one, 2014, Vol.9(6), pp.e99008
    Description: Remarkably limited information is available about biological mechanisms that determine the disease entity of metastatic colorectal cancer in the liver (CRCLM) with no good clinical parameters to estimate prognosis. For the last few years, understanding the relationship between tumor characteristics and local immune response has gained increasing attention. Given the multifaceted roles of B-cell-driven responses, we aimed to elucidate the immunological imprint of B lymphocytes at the metastatic site, the interrelation with macrophages, and their prognostic relevance. Here we present novel algorithm allowing to assess a link between the local patient-specific immunological capacity and clinical outcome. The microscopy-based imaging platform was used for automated scanning of large-scale tissue sections and subsequent qualitative and quantitative analyses of immune cell subtypes using lineage markers and single-cell recognition strategy. Results indicate massive infiltration of CD45-positive leukocytes confined to the metastatic border. We report for the first time the accumulation of CD20-positive B lymphocytes at the tumor-liver interface comprising the major population within the large CD45-positive aggregates. Strikingly, functionally active, activation-induced cytidine deaminase (AID)-positive ectopic lymphoid structures were found to be assembled within the metastatic margin. Furthermore, the CD20-based data set revealed a strong prognostic power: patients with high CD20 content and/or ectopic follicles had significantly lower risk for disease recurrence as revealed by univariate analysis (p〈0.001 for both) and in models adjusted for clinicopathological variables (p〈0.001 and p = 0.01, respectively), and showed prolonged overall survival. In contrast, CD68 staining-derived data set did not show an association with clinical outcome. Taken together, we nominate the magnitude of B lymphocytes, including those organized in ectopic follicles, as novel prognostic marker which is superior to clinicopathological parameters. Findings emphasize anti-tumoral role of B cell-driven mechanism(s) and thus indicate a new way of thinking about potential treatment strategies for CRCLM patients.
    Keywords: B-Lymphocytes -- Cytology ; Colorectal Neoplasms -- Pathology ; Liver Neoplasms -- Diagnosis
    E-ISSN: 1932-6203
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  • 6
    Language: English
    In: 2015, Vol.10(1), p.e0117904
    Description: Dendritic cells play a fundamental role in shaping the immune response to allergens. The events that lead to allergic sensitization or tolerance induction during the interaction of the major birch pollen allergen Bet v 1 and dendritic cells are not very well studied. Here, we analyzed the uptake of Bet v 1 and the cross-reactive celery allergen Api g 1 by immature monocyte-derived dendritic cells (iMoDCs) of allergic and normal donors. In addition, we characterized the allergen-triggered intracellular signaling and transcriptional events. Uptake kinetics, competitive binding, and internalization pathways of labeled allergens by iMoDCs were visualized by live-cell imaging. Surface-bound IgE was detected by immunofluorescence microscopy and flow cytometry. Allergen- and IgE-induced gene expression of early growth response genes and Th1 and Th2 related cytokines and chemokines were analyzed by real-time PCR. Phosporylation of signaling kinases was analyzed by Western blot. Internalization of Bet v 1 by iMoDCs of both donor groups, likely by receptor-mediated caveolar endocytosis, followed similar kinetics. Bet v 1 outcompeted Api g 1 in cell surface binding and uptake. MoDCs of allergic and healthy donors displayed surface-bound IgE and showed a pronounced upregulation of Th2 cytokine- and NFκB-dependent genes upon non-specific Fcε receptor cross-linking. In contrast to these IgE-mediated responses, Bet v 1-stimulation increased transcript levels of the Th2 cytokines IL-4 and IL-13 but not of NFκB-related genes in MoDCs of BP allergic donors. Cells of healthy donors were either unresponsive or showed elevated mRNA levels of Th1-promoting chemokines. Moreover, Bet v 1 was able to induce Erk1/2 and p38 MAPK activation in BP allergics but only a slight p38 activation in normal donors. In conclusion, our data indicate that Bet v 1 favors the activation of a Th2 program only in DCs of BP allergic individuals.
    Keywords: Research Article
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: PLOS ONE, 2011
    Description: Activation-induced cytidine deaminase (AID) is expressed in B cells within germinal centers and is critically involved in class switch recombination and somatic hypermutation of immunoglobulin loci. Functionally active AID can additionally be detected within ectopic follicular structures developed at sites of chronic inflammation. Furthermore, AID may target non-Ig genes in B-and non-B-cell background. Therefore, AID-associated effects are of increasing interest in disease areas such as allergy, inflammation, autoimmunity, and cancer. Pathway-or disease-relevant multigene signatures have attracted substantial attention for therapeutic target proposal, diagnostic tools, and monitoring of therapy response. To delineate the impact of AID in etiology of multifactorial diseases, we designed the AID-associated 25-gene signature. Chronic rhinosinusitis with nasal polyps was used as an inflammation-driven airway disease model; high levels of IgE have been previously shown to be present within polyp tissue. Expression levels of 16 genes were found to be modulated in polyps including AID, IgG and IgE mature transcripts which reflect AID activity; clustering algorithm revealed an AID-specific gene signature for the disease state with nasal polyp. Complementary, AID-positive ectopic lymphoid structures were detected within polyp tissues by in situ immunostaining. Our data demonstrate the class switch recombination and somatic hypermutation events likely taking place locally in the airways and in addition to the previously highlighted markers and/or targets as IL5 and IgE suggest novel candidate genes to be considered for treatment of nasal polyposis including among others IL13 and CD23. Thus, the algorithm presented herein including the multigene signature approach, analysis of co-regularities and creation of AID-associated functional network gives an integrated view of biological processes and might be further applied to assess role of altered AID expression in etiology of other diseases, in particular, aberrant immunity and cancer.
    Keywords: Biology And Life Sciences ; Nasal Polyp Tissue ; Class Switch Recombination ; Center B-Cells ; Gene-Expression ; Chronic Rhinosinusitis ; Somatic Hypermutation ; T-Cells ; Monoclonal-Antibody ; Dna Recombination ; Ige Antibodies
    ISSN: 1932-6203
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  • 8
  • 9
    In: PLoS ONE, 2016, Vol.11(3)
    Description: In highly sensitized patients, the encounter with a specific allergen from food, insect stings or medications may rapidly induce systemic anaphylaxis with potentially lethal symptoms. Countless animal models of anaphylaxis, most often in BALB/c mice, were established to understand the pathophysiology and to prove the safety of different treatments. The most common symptoms during anaphylactic shock are drop of body temperature and reduced physical activity. To refine, improve and objectify the currently applied manual monitoring methods, we developed an imaging method for the automated, non-invasive measurement of the whole-body surface temperature and, at the same time, of the horizontal and vertical movement activity of small animals. We tested the anaphylaxis imaging in three in vivo allergy mouse models for i) milk allergy, ii) peanut allergy and iii) egg allergy. These proof-of-principle experiments suggest that the imaging technology represents a reliable non-invasive method for the objective monitoring of small animals during anaphylaxis over time. We propose that the method will be useful for monitoring diseases associated with both, changes in body temperature and in physical behaviour.
    Keywords: Research Article ; Research And Analysis Methods ; Medicine And Health Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Engineering And Technology
    E-ISSN: 1932-6203
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  • 10
    Language: English
    In: World Allergy Organization Journal, 01 January 2016, Vol.9
    Description: Contributing reviewers: The editors of World Allergy Organization Journal would like to thank all of our reviewers who have contributed to the journal in Volume 8 (2015).
    Keywords: Medicine
    ISSN: 1939-4551
    E-ISSN: 1939-4551
    Source: Directory of Open Access Journals (DOAJ)
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