Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Year
  • 1
    Language: Portuguese
    In: Remate de Males, 01 December 2012, Vol.32(2), pp.167-189
    Keywords: Henrique Alvim Corrêa. Utopia. Ficção Científica ; Languages & Literatures
    ISSN: 0103-183X
    E-ISSN: 2316-5758
    Source: Directory of Open Access Journals (DOAJ)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Nature, 2012, Vol.492(7429), p.376
    Description: In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of the minimal renewal of cardiomyocytes during adult life, repair of cardiac damage through myocardial regeneration is very limited. Here we show that the exogenous administration of selected microRNAs (miRNAs) markedly stimulates cardiomyocyte proliferation and promotes cardiac repair. We performed a high-content microscopy, high-throughput functional screening for human miRNAs that promoted neonatal cardiomyocyte proliferation using a whole-genome miRNA library. Forty miRNAs strongly increased both DNA synthesis and cytokinesis in neonatal mouse and rat cardiomyocytes. Two of these miRNAs (hsa-miR-590 and hsa-miR-199a) were further selected for testing and were shownto promote cell cycle re-entry of adult cardiomyocytes ex vivo and to promote cardiomyocyte proliferation in both neonatal and adult animals. After myocardial infarction in mice, these miRNAs stimulated marked cardiac regeneration and almost complete recovery of cardiac functional parameters. The miRNAs identified hold great promise for the treatment of cardiac pathologies consequent to cardiomyocyte loss. [PUBLICATION ]
    Keywords: Animals–Biosynthesis ; Cell Proliferation–Growth & Development ; Cytokinesis–Analysis ; DNA–Genetics ; Down-Regulation–Therapeutic Use ; Gene Library–Genetics ; Genetic Therapy–Pathology ; Heart–Prevention & Control ; Humans–Therapy ; Mice–Cytology ; Micrornas–Metabolism ; Micrornas–Cytology ; Micrornas–Metabolism ; Myocardial Infarction–Genetics ; Myocardial Infarction–Genetics ; Myocardial Infarction–Genetics ; Myocardial Infarction–Genetics ; Myocardium–Genetics ; Myocardium–Genetics ; Myocytes, Cardiac–Genetics ; Myocytes, Cardiac–Genetics ; Rats–Genetics ; Rats, Wistar–Genetics ; Regeneration–Genetics ; Heart Attacks ; Kinases ; Rodents ; Cell Division ; Cell Cycle ; Gene Expression ; Mirn590 Microrna, Human ; Micrornas ; Mirn199 Microrna, Human ; DNA;
    ISSN: 0028-0836
    E-ISSN: 14764687
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: PLoS ONE, 2011, Vol.6(3), p.e17296
    Description: P-bodies are dynamic aggregates of RNA and proteins involved in several post-transcriptional regulation processes. P-bodies have been shown to play important roles in regulating viral infection, whereas their interplay with bacterial pathogens, specifically intracellular bacteria that extensively manipulate host cell pathways, remains unknown. Here, we report that Salmonella infection induces P-body disassembly in a cell type-specific manner, and independently of previously characterized pathways such as inhibition of host cell RNA synthesis or microRNA-mediated gene silencing. We show that the Salmonella -induced P-body disassembly depends on the activation of the SPI-2 encoded type 3 secretion system, and that the secreted effector protein SpvB plays a major role in this process. P-body disruption is also induced by the related pathogen, Shigella flexneri , arguing that this might be a new mechanism by which intracellular bacterial pathogens subvert host cell function.
    Keywords: Research Article ; Biology ; Medicine ; Infectious Diseases ; Microbiology ; Molecular Biology ; Cell Biology
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Computers in Human Behavior, May 2017, Vol.70, pp.523-534
    Description: Resource Distribution is a topic from the field of distributive judgement, generally studied by cognitive psychology researchers, which make use of economic experiments to investigate aspects of the evolution of cooperation, altruism and selfishness in humanity. Researchers commonly set experiments to observe human behavior, seeking to increase the degree of engagement of the participants, in order to improve the quality and the amount of results. Digital entertainment artifacts, such as video games, are then used as a viable way of bringing such a high level of engagement. However, psychology researchers usually do not have the knowledge needed to develop digital applications. In addition, as far as we know, no scientific work have tried to describe the impact of using digital entertainment tools in experiments on decision making for resource division. This work aims to report a compilation of discoveries and knowledge learned when designing digital entertainment tools, tailored for scientific experiments on Resources Distribution. The task included interviews with specialists, a questionnaire sent to researchers, the conduction of ideation techniques to generate new concepts and, finally, a set of tools were prototyped and a subset was ultimately developed. Results were collected and six main lessons we learned are reported. We hope these lessons learned to be helpful to guide others researchers to conceive and develop their own digital entertainment tools for scientific experimentation.
    Keywords: Resources Distribution ; Video Games ; Research Instruments ; Cognitive Psychology ; Computer Science ; Psychology
    ISSN: 0747-5632
    E-ISSN: 1873-7692
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Nucleic acids research, 20 June 2017, Vol.45(11), pp.e96
    Description: RNA-binding proteins (RBPs) have been established as core components of several post-transcriptional gene regulation mechanisms. Experimental techniques such as cross-linking and co-immunoprecipitation have enabled the identification of RBPs, RNA-binding domains (RBDs) and their regulatory roles in the eukaryotic species such as human and yeast in large-scale. In contrast, our knowledge of the number and potential diversity of RBPs in bacteria is poorer due to the technical challenges associated with the existing global screening approaches. We introduce APRICOT, a computational pipeline for the sequence-based identification and characterization of proteins using RBDs known from experimental studies. The pipeline identifies functional motifs in protein sequences using position-specific scoring matrices and Hidden Markov Models of the functional domains and statistically scores them based on a series of sequence-based features. Subsequently, APRICOT identifies putative RBPs and characterizes them by several biological properties. Here we demonstrate the application and adaptability of the pipeline on large-scale protein sets, including the bacterial proteome of Escherichia coli. APRICOT showed better performance on various datasets compared to other existing tools for the sequence-based prediction of RBPs by achieving an average sensitivity and specificity of 0.90 and 0.91 respectively. The command-line tool and its documentation are available at https://pypi.python.org/pypi/bio-apricot.
    Keywords: Sequence Analysis, Protein ; Software ; RNA-Binding Proteins -- Chemistry
    ISSN: 03051048
    E-ISSN: 1362-4962
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: Canadian Geotechnical Journal, June 2012, Vol.49(6), pp.743-745
    Description: This discussion is an application of theoretical equations of compressibility given by the principle of natural proportionality to the interpretation of experimental oedometer test data of cement-treated organic soil.
    Keywords: One - Dimensional Consolidation Test ; Organic Soil ; Essai De Consolidation Unidimensionnel ; Sol Organique ; One - Dimensional Consolidation Test ; Organic Soil ; Essai De Consolidation Unidimensionnel ; Sol Organique
    ISSN: 0008-3674
    Source: IngentaConnect
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    In: MOJ Orthopedics & Rheumatology, 1/19/2018, Vol.10(2)
    ISSN: MOJ Orthopedics & Rheumatology
    E-ISSN: 23746939
    Source: CrossRef
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Canadian Geotechnical Journal, 2012, Vol.49(12), p.1444(3)
    Description: This is an application of theoretical equations of compressibility given by the principle of natural proportionality to the interpretation of experimental oedometer test data on the Bearpaw Shale. Key words: one-dimensional consolidation test. Ceci est une application des equations theoriques de compressibilite obtenues par le principe de proportionnalite naturelle servant a l'interpretation des resultats experimentaux d'essais a l'odometre sur le Shale de Bearpaw. Mots-cles : essai de consolidation unidimensionnel.
    Keywords: Shales – Mechanical Properties ; Soil Mechanics – Research
    ISSN: 0008-3674
    E-ISSN: 12086010
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Canadian Geotechnical Journal, 06/2012, Vol.49(6), pp.743-745
    Description: This discussion is an application of theoretical equations of compressibility given by the principle of natural proportionality to the interpretation of experimental oedometer test data of cement-treated organic soil.
    Keywords: Engineering;
    ISSN: 0008-3674
    E-ISSN: 1208-6010
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: Spanish
    In: Alfinge: Revista de filología, 2013, Issue 25, pp.25-34
    Description: Esta contribución presenta los presupuestos epistemológicos de la metodología usada en la Universidad de Córdoba (España) para enseñar inglés como lengua extranjera a los estudiantes senior (más de 50 años) durante los últimos cuatro años. El método se basa en la evidencia científica proporcionada por los más recientes avances alcanzados en el ámbito de la psicolingüística y la teoría cognitiva del aprendizaje. Los resultados de esta experiencia revelan que este método favorece especialmente los procesos de aprendizaje del inglés como lengua extranjera mediante la reducción de la distancia social de los aprendices adultos hacia la L2 a través del acceso directo al conocimiento explícito y declarativo de la lengua destino.
    ISSN: 0213-1854
    Source: Fundación Dialnet
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages