Format:
1 Online-Ressource (IX, 130 Seiten, KB)
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Illustrationen, Diagramme
Content:
Aptamers are single-stranded DNA (ssDNA) or RNA molecules that can bind specifically and with high affinity to target molecules due to their unique three-dimensional structure. For this reason, they are often compared to antibodies and sometimes even referred to as “chemical antibodies”. They are simple and inexpensive to synthesize, easy to modify, and smaller than conventional antibodies. Enzymes, especially hydrolases, are interesting targets in this context. This class of enzymes is capable of hydrolytically cleaving various macromolecules such as proteins, as well as smaller molecules such as antibiotics. Hence, they play an important role in many biological processes including diseases and their treatment. Hydrolase detection as well as the understanding of their function is therefore of great importance for diagnostics and therapy. Due to their various desirable features compared to antibodies, aptamers are being discussed as alternative agents for analytical and diagnostic use in various applications. The use of aptamers in therapy is also frequently investigated, as the binding of aptamers can have effects on the catalytic activity, protein-protein interactions, or proteolytic cascades. [...]
Note:
Kumulative Dissertation
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Dissertation Universität Potsdam 2023
Additional Edition:
Erscheint auch als Druck-Ausgabe Dreymann, Nico Identification and functional characterization of aptamers targeting human urokinase and NDM-1 for therapeutic and diagnostic applications Potsdam, 2023
Language:
English
Keywords:
Hochschulschrift
DOI:
10.25932/publishup-61291
URN:
urn:nbn:de:kobv:517-opus4-612919
Author information:
Arndt, Katja
Author information:
Füssel, Susanne 1971-
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