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  • 1
    Language: English
    In: Tetrahedron Letters, 26 October 2016, Vol.57(43), pp.4842-4844
    Description: Total synthesis of optically pure (+)-Fuligocandin A from -proline has been achieved in 29% overall yield. The key step, one-pot reductive cyclodehydration of the chiral 2-nitrophenyl-1,3-dicarbonyl compound, proceeds with 〉98% retention of configuration. This method represents a convenient approach to the synthesis of 2-methylenebenzo[ ][1,4]diazepin-5-ones containing one chiral center. A series of benzo[ ][1,4]diazepin-5-one derivatives have been successfully synthesized with retention of chirality by the one-pot reaction developed in this work. A possible reductive cyclodehydration mechanism was also proposed.
    Keywords: (+)-Fuligocandin ; 2-Methylenebenzo[E][1,4]Diazepin-5-One ; Vinylogous Amide ; One-Pot Reductive Cyclodehydration ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 2
    Language: English
    In: Journal of Applied Physics, 01 September 2011, Vol.110(5)
    Description: We investigated multilevel resistance switching characteristics of the thin FeO x transition layer in a TiN/SiO 2 /FeO x /Fe structure by controlling the current compliance and stopped voltage during the set and reset processes, respectively. It is observed that the resistive state could be easily tunable by controlling external electric conditions. The multilevel memristive mechanism was characterized by distinguishing the electrical behaviors statistically, inferring that the reset process is associated with the mobile-ion-assisted electrochemical redox. Moreover, the set process is also modeled by power dissipation behaviors. The presented mathematical and physical model provides a possibility to elucidate a universal mechanism for bipolar multilevel memristor.
    Keywords: Articles
    ISSN: 0021-8979
    E-ISSN: 1089-7550
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  • 3
    Language: English
    In: PLoS ONE, 01 January 2013, Vol.8(7), p.e68986
    Description: Automatic identification of various perfusion compartments from dynamic susceptibility contrast magnetic resonance brain images can assist in clinical diagnosis and treatment of cerebrovascular diseases. The principle of segmentation methods was based on the clustering of bolus transit-time...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 4
    In: PLoS ONE, 2018, Vol.13(3)
    Description: Introduction Paraquat poisoning can result in dysfunction of multiple organs, and pulmonary fibrosis with respiratory failure is the major cause of mortality. For terminally ill patients, some life-prolonging treatments can be non-beneficial treatments (NBT). The objective of this study was to determine if intubation is a NBT for patients with respiratory failure due to paraquat poisoning. Methods The study included 68 patients with respiratory failure due to paraquat poisoning. Patients were hospitalized at MacKay Memorial Hospital, Taitung Branch, Taiwan, between 2005 to April 2016. Composite outcomes of intra-hospital mortality, the rate of do-not-resuscitate (DNR) orders, prescribed medications, length of stay, and medical costs were recorded and compared between the do-not-intubate (DNI) group and endotracheal intubation (EI) group. Results Intra-hospital mortality rate for the entire population was 100%. There were significantly more patients with DNR orders in the DNI group (P = 0.007). There were no differences in the length of hospital stay. However, patients in DNI group had significantly less vasopressor use and more morphine use, shorter time in the intensive care unit, and fewer medical costs. Conclusion The procedure of intubation in patients with respiratory failure due to paraquat poisoning can be considered inappropriate life-prolonging treatment.
    Keywords: Research Article ; Medicine And Health Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; Medicine And Health Sciences ; People And Places
    E-ISSN: 1932-6203
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  • 5
    In: PLoS ONE, 2015, Vol.10(8)
    Description: Objective To investigate whether there is an increased risk of cardiac events in diabetic patients with a combined therapy of clopidogrel (CLO) and proton pump inhibitors (PPIs) after drug-eluting stent (DES) deployment. Methods By using National Health Insurance Research Database, all patients who received CLO with or without PPI therapy within 90 days after undergoing DES (limus-eluting or paclitaxel-eluting stents) deployment were enrolled. Endpoints were acute coronary syndrome (ACS) and readmission for revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery) after 3, 6, and 12 months. Results A total of 6,603 diabetic patients received LESs (5,933 in the CLO subgroup and 670 in the CLO plus PPIs subgroup), and 3,202 patients received PESs (2,923 in the CLO subgroup and 279 in the CLO plus PPIs subgroup). The patients who received CLO plus PPIs were at higher risk of ACS than those receiving CLO within 1 year after DES deployment (LESs: 6-month hazard ratio [HR] = 1.63, and 1-year HR = 1.37; PESs: 3-month HR = 1.72). Patients with a history of ACS who received CLO plus PPIs were at higher risk of ACS after LES implantation (HR = 1.55) than those in the CLO group. Conclusion In “real-world” diabetic patients with LES deployment, the combination of PPIs and CLO is associated with higher rates of ACS after 6 months and 1 year. Even after correction for confounding factors, concomitant PPI use remained an independent predictor of cardiac events, emphasizing the clinical importance of this drug—drug interaction.
    Keywords: Research Article
    E-ISSN: 1932-6203
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  • 6
    In: Chemical Communications, 2008, Issue.1, pp.50-52
    Description: Reported in this paper is the first example of a biomimetic iron complex, ([Fe II (TPA)(NCMe) 2 ] 2+ (TPA = tris(2-pyridylmethyl)amine), that catalyses the cis -dihydroxylation of an aromatic double bond, mimicking the action of the non-haem iron enzyme naphthalene dioxygenase and shedding light on its possible mechanism of action.
    Keywords: Chemistry;
    ISSN: 1359-7345
    E-ISSN: 1364-548X
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  • 7
    Language: Chinese
    In: Journal of Biomedical & Laboratory Sciences / 生物醫學暨檢驗科學雜誌, 2018-12-31, 30卷4期 (Vol.30, Issue 4), pp.105-114
    Description: 結核病是致命的傳染病,故治療監控需快速檢驗協助。實驗研究被感染個體受結核桿菌刺激,反應Th細胞激發不同細胞激素含量分析,以輔助臨床診斷。病人收集群包含確診TB及治療2及6個月,潛伏性TB陽性和健康對照,分類五群以螢光微球抗原技術分析細胞激素IL-1β, IL-6, IL-4, IL-12, IL-17A, IFN-γ, TNF-α, TGFβ-1分泌量關係。結果發現IL-17在確診TB或潛伏群比健康群皆有顯著差異,且IL-6上升為對照痰中有菌指標,故這2項測值上升可做為感染或是開放性TB病人指標,做為加強治療或是持續隔離之依據。
    Description: Tuberculosis is a fatal contagious disease, by providing Immediate and quick test result for TB patients to make appropriate treatment and monitoring is important. The aim of the study is to analyze the T helper cell-associated cytokine expressed by TB patients, to see whether it can be used to aid the diagnosis of TB. Samples collected from confirmed TB patients were grouped into five categories 1) TB confirmed cases 2) TB patients after 2 months of treatment 3) TB patients after 6 months of treatment 4) latent TB patients 5) healthy donors. Cytokines levels of IL-1β, IL-6, IL-4, IL-12, IL-17A, IFN-γ, TNF-α, TGFβ-1 were analyzed respectively. Compared to healthy donors, the level of IL-17 is higher in TB confirmed patients and latent TB patients; on the other hand, increasing of IL-6 level indicates MTB in the sputum. In conclusion, the increasing of both cytokine levels mentioned above maybe used as the indicators to aid the clinician determine whether patients are in the period of MTB infection, in contagious status, need to receive intensive treatment or need to be isolated continuously.
    Keywords: 結核病(Tuberculosis,Tb) ; 結核分枝桿菌(Mtb) ; 潛伏性tb病人 ; 細胞激素(Cytokine) ; Il-6、Il17 ; Tuberculosis(Tb) ; Mycobacterium Tuberculosis (Mtb) ; Latent Tb Patients ; Cytokine ; Il-6 ; Il-17
    ISSN: 1013-7653
    Source: 中文電子期刊服務 - Chinese Electronic Periodical Services (CEPS) (Airiti Library)〈img src="http://exlibris-pub.s3.amazonaws.com/airiti_logo.gif" style="vertical-align:middle;margin-left:7px"〉
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  • 8
    Language: English
    In: Phytochemistry, May, 2013, Vol.89, p.78(11)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.phytochem.2013.01.011 Byline: Wen-Chun Lan (a), Cheng-Wei Tzeng (b), Chun-Ching Lin (b)(c), Feng-Lin Yen (a), Horng-Huey Ko (a) Keywords: Breadfruit tree; Artocarpus altilis; Moraceae; Antioxidant; Tyrosinase; Melanin Abstract: Compounds 1-5, together with 12 known compounds, were isolated from the heartwood and cortex of Artocarpus altilis. Several of these showed free radical scavenging activity, and some reduced melanin production without affecting cell viability. These compounds could be considered as cosmetic agents in the future. Display Omitted Author Affiliation: (a) Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC (b) Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC (c) School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC Article History: Received 5 October 2012; Revised 25 December 2012; Accepted 29 January 2013
    Keywords: Isoflavones ; Drugstores ; Antioxidants (Nutrients)
    ISSN: 0031-9422
    Source: Cengage Learning, Inc.
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  • 9
    In: Journal of the American Geriatrics Society, August 2014, Vol.62(8), pp.1600-1602
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/jgs.12964/abstract Byline: Yen-Chun Lee, Jin-Shang Wu, Yi-Ching Yang, Chin-Sung Chang, Feng-Hwa Lu, Chih-Jen Chang ***** No abstract is available for this article. *****
    Keywords: Hepatitis C – Risk Factors ; Gallstones – Risk Factors ; Hepatitis B – Risk Factors;
    ISSN: 0002-8614
    E-ISSN: 1532-5415
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  • 10
    Language: English
    In: Journal of Applied Physics, 01 December 2011, Vol.110(11)
    Keywords: Errata
    ISSN: 0021-8979
    E-ISSN: 1089-7550
    Source: © 2011 American Institute of Physics (AIP)〈img src=http://exlibris-pub.s3.amazonaws.com/AIP_edited.gif style="vertical-align:middle;margin-left:7px"〉
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