Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (795 p.)

ISBN: 1-281-03295-6 , 9786611032951 , 0-08-053855-X

Content: Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and bas

Note: Description based upon print version of record. , Front Cover; Pediatric Bone: Biology and Diseases; Copyright Page; Table of Contents; Contributors; Foreword; Preface; Chapter 1. Structure of Growth Plate and Bone Matrix; Introduction; Type I Collagen; Type V Collagen; Type II Collagen; Type IX Collagen; Type XI Collagen; Type X Collagen; Aggrecan; Cartilage Link Protein 1; Small, Leucine-Rich, Interstitial Proteoglycans; Perlecan; Matrilins; Thrombospondins; Osteonectin; Osteocalcin; Matrix Gla Protein; Bone Sialoprotein; Bone Acidic Glycoprotein-75; Dentin Matrix Acidic Phosphoprotein-1; Osteopontin; References , Chapter 2. Bone Cell Biology: Osteoblasts, Osteocytes, and OsteoclastsIntroduction; Ontogeny of Osteoblasts and Control of Osteoblast Development; Osteoprogenitor Cells and Regulation of Osteoblast Differentiation and Activity; Regulation of Osteoblast Differentiation and Activity; Osteocytes; Morphological Features of Osteoclasts; Mechanisms of Osteoclastic Bone Resorption; Origin of Osteoclasts; Regulation of Ostoclast Activity and Differentiation; Osteoclast Size: Multinucleation and Function; Stem Cell, Osteoblast, and Osteoclast Changes in Disease , Tissue Engineering and Stem Cell Therapy for Skeletal DiseasesReferences; Chapter 3. Prenatal Bone Development: Ontogeny and Regulation; Introduction; Skeletogenesis; Skeletal Organization and Embryonic Origin of Bones; Molecular Regulation of Bone Formation; References; Chapter 4. Postnatal Bone Growth: Growth Plate Biology, Modeling, and Remodeling; Endochondral and Intramembranous Bone Formation; Growth Hormone and Insulin-Like Growth Factor- 1; Fibroblast Growth Factors; Thyroid Hormone; Estrogen and Androgen; Osteoblasts and Bone Growth; Endocrine Regulation of Bone Formation; References , Chapter 5. Parathyroid Hormone and Calcium HomeostasisCellular and Extracellular Calcium Homeostasis; Parathyroids and Secretion and Metabolism of Parathyroid Hormone; Assay of PTH; Parathyroid Hormone Action; References; Chapter 6. Phosphate Homeostasis Regulatory Mechanisms; Introduction; Physiological Aspects; Cellular and Molecular Aspects; Pathophysiological Aspects; References; Chapter 7. Vitamin D Biology; Metabolic Activation of Vitamin D; Mechanism of Action; Role of Vitamin D in Calcium Homeostasis; Summary and Perspectives; References , Chapter 8. Other Factors Controlling Bone Growth and Development: Calcitonin, CGRP, Osteostatin, Amylin, and AdrenomedullinIntroduction; Calcitonin; Calcitonin Gene-Related Peptide; Parathyroid Hormone-Related Protein; Amylin; Adrenomedullin; References; Chapter 9. Peak Bone Mass and Its Regulation; Definition and Importance of Peak Bone Mass; Characteristics of Peak Bone Mass Acquisition; Calcium-Phosphate Metabolism During Growth; Determinants of Bone Mass Gain; Conclusions; References; Chapter 10. Pregnancy and Lactation; Introduction; Mineral Fluxes from Mother to Offspring; Pregnancy , Lactation , English

Additional Edition: ISBN 0-12-286551-0

Language: English

UID:

Format: 1 online resource (1970 p.)

Edition: 2nd ed.

ISBN: 1-282-28503-3 , 9786612285035 , 0-08-054364-2

Content: Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.*Most comprehensive, up-to-date two-

Note: Description based upon print version of record. , 9780122526879v1; Front Cover; Vitamin D; Copyright Page; Contents; List of Contributors; Preface to the 2nd Edition; Preface to the 1st Edition; Abbreviations; Introduction; Chapter 1. Historical Perspective; Section I: CHEMISTRY, METABOLISM, AND CIRCULATION; Chapter 2. Vitamin D Metabolism; Chapter 3. Photobiology of Vitamin D; Chapter 4. The Vitamin D 25-Hydroxylase; Chapter 5. The 25-Hydroxyvitamin D 1- -Hydroxylase; Chapter 6. The 25-Hydroxyvitamin D 24-Hydroxylase; Chapter 7. Mutant Mouse Models of Vitamin D Metabolic Enzymes; Chapter 8. Vitamin D Binding Protein , Chapter 9. New Aspects of DBPChapter 10. Endocytic Pathways for 25-(OH) Vitamin D3; Section II: MECHANISM OF ACTION; Chapter 11. The Vitamin D Receptor; Chapter 12. Vitamin D Receptor Promoter and Regulation of Receptor Expression; Chapter 13. Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions; Chapter 14. Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity; Chapter 15. VDR LBD Crystal Structures; Chapter 16. Comodulators of VDR-Mediated Gene Expression , Chapter 17. Promoter Targeting of VDR Through A Chromatin Remodeling ComplexChapter 18. Molecular Basis of the Diversity of Vitamin D Target Genes; Chapter 19. Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene Expression; Chapter 20. Mouse Models of Vitamin D Receptor Ablation; Chapter 21. Intranuclear Vitamin D Response Element Binding Proteins; Chapter 22. VDR and RXR Subcellular Trafficking , Chapter 23. 1 ,25(OH)2-Vitamin D3 Mediated Rapid and Genomic Responses are Dependent upon Critical Structure-Function Relationships for Both the Ligand and Receptor(s)Section III: MINERAL HOMEOSTASIS; Chapter 24. Vitamin D and the Intestinal Absorption of Calcium: A View and Overview; Chapter 25. Intestinal Calcium Absorption: Lessons from Knockout Mice and Men; Chapter 26. Phosphate Homeostasis; Chapter 27. Mineralization; Chapter 28. Modeling and Remodeling: How Bone Cells Work Together; Chapter 29. Vitamin D and the Kidney; Chapter 30. Vitamin D and the Parathyroids , Chapter 31. Calcium-Sensing ReceptorSection IV: TARGET ORGANS AND TISSUES; Chapter 32. Bone; Chapter 33. Cartilage and Vitamin D: Genomic and Nongenomic Regulation by 1,25(OH)2D3 and 24,25(OH)2D3; Chapter 34. Dento-alveolar Bone Complex and Vitamin D; Chapter 35. Vitamin D: Role in Skin and Hair; Chapter 36. Regulation of Immune Responses by Vitamin D Receptor Ligands; Chapter 37. Vitamin D and Osteoblasts; Chapter 38. Vitamin D and Osteoclastogenesis; Chapter 39. Vitamin D Control of the Calcitonin Gene in Thyroid C Cells , Chapter 40. Vitamin D Regulation of Type I Collagen Expression in Bone , English

Additional Edition: ISBN 0-12-252687-2

Language: English

UID:

Format: 1 online resource (885 p.)

Edition: 2nd ed.

ISBN: 1-283-73500-8 , 0-12-382041-3

Content: Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and bas

Note: Two columns to the page. , 1. Bone cell biology: osteoclasts, osteoblasts, osteocytes / Katharine Jahn and Lynda F. Bonewald -- 2. Bone matrix and mineralization / Marc D. McKee and William G. Cole -- 3. Prenatal bone development / Fanxin Long -- 4. Postnatal bone growth: growth plate biology, bone formation, and remodeling / Christa Maes and Henry M. Kronenberg -- 5. Dental development and maturation, from the dental crypt to the final occlusion / Jean-Marc Retrouvey, Michel Goldberg and Stephane Schwartz -- 6. Parathyroid hormone and calcium homeostasis / John T. Potts and Thomas J. gardella -- 7. Phosphate homeostasis regulatory mechanisms / Clemens Bergwitz and Harald Juppner -- 8. Vitamin D biology / Rene St-Arnaud and Marie B. Demay -- 9. Peak bone mass and its regulation / Jean-Philippe Bonjour ... [et al.] -- 10. Pregnancy and lactation / Ann Prentice -- 11. Fetal mineral homeostasis / Christopher S. Kovacs -- 12. Radiology / Judith E. Adams ... [et al.] -- 13. Non-invasive techniques for bone mass measurement / Mary B. Leonard and Laura K. Bachrach -- 14. Assessment of maturation: bone age and pubertal assessment / Noel Cameron and David D. Martin -- , 15. Biochemical markers of bone metabolism / Nick Shaw and Wolfgang Hogler -- 16. Pediatric bone histomorphometry / frank Rauch -- 17. A diagnostic approach to skeletal dysplasias / Sheila Unger, Andrea Superti-Furga and David L. Rimoin -- 18. The spectrum of pediatric osteoporosis / Maria Luisa Bianchi and Francis H. Glorieux -- 19. Osteogenesis imperfecta / Francis H. Glorieux and David Rowe -- 20. Sclerosing bone dysplasias / Bram Perdu ... [et al.] -- 21. Parathyroid disorders / Murat Bastepe, Harald Juppner and Rajesh V. Thakker -- 22. Fibrous dysplasia / Paolo Bianco and Shlomo Wientroub -- 23. Nutritional rickets / John M. Pettifor -- 24. Metabolic bone disease in the neonatal period and its later sequelae / Nick Bishop, Mary Pewtrell and Nick Harvey -- 25. Rickets due to hereditary abnormalities of vitamin D synthesis or action / Anthony A. Portale, Farzana Perwad and Walter L. Miller -- 26. Familial hypophosphatemia and related disorders / Ingrid A. Holm, Michael J. Econs and Thomas O. Carpenter -- , 27. Hereditary tubular disorders of mineral handling / Daniella Magen and Israel Zelikovic -- 28. Hypophosphatasia / michael P. Whyte -- 29. Chronic kidney disease mineral and bone disorder / Katherine Wesseling Perry and Isidro B. Salusky -- 30. Extraskeletal bone formation / Eileen M. Shore and Frederick S. Kaplan. , English

Additional Edition: ISBN 0-12-382040-5

Language: English

UID:

Format: XXII, 1285 S , Ill., graph. Darst , 29 cm

ISBN: 0122526856

Note: Literaturangaben

Language: English

Keywords: Vitamin D3 ; Aufsatzsammlung

URL: Inhaltsverzeichnis

URL: http://www.loc.gov/catdir/toc/els032/97023438.html

UID:

Format: 1 online resource (xxii, 555 pages) : , illustrations (some color)

ISBN: 0-12-397789-4

Series Statement: Gale eBooks

Content: Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the

Note: Description based upon print version of record. , Front Cover; Osteogenesis Imperfecta; Copyright Page; Dedication; Contents; Foreword; Acknowledgments; List of Contributors; I: INTRODUCTION; Introduction to Osteogenesis Imperfecta; 1. Evolution of the Present Understanding of the Clinical and Genetic Heterogeneity and Molecular and Biochemical Bas...; Advances in Collagen Protein Biochemistry Led to Identification of the First OI Mutations; Molecular Biology of Collagen Genes and its Relevance to OI Research; A Return to Research in Matrix Biology; Collagen and Molecular Chaperones; Defects in Mineralization; Whole Gene Deletions , Patient and Parent Support Organizations and the Facilitation of Research in OIReviews and Doctoral Theses; Pamidronate Modified OI (Less Severe); Future Research; References; 2. Clinical and Genetic Classification of Osteogenesis Imperfecta and Epidemiology; Introduction; Clinical and Genetic Classifications of OI; Epidemiology of OI; References; 3. The Osteogenesis Imperfecta Community and Scientific Research: A Valuable Partnership; OI Foundation History; OI Research is Complicated; The Role of the OI Foundation in Research; A Model that Works; But Wait, There's More; In Conclusion , II: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY4. Mineralized Tissue: Histology, Biology and Biochemistry; Introduction; Methodology; Tissue Sources; Analyses and How they Inform About Normal Vs. OI Bone as a Function of Age; Matrix and Whole Tissue Analysis; Histology; Electron Microscopy; Ftir and Raman Microspectroscopy and Imaging; Mineral Analyses; X-Ray Diffraction; Small-Angle Scattering; Quantitative Backscattered Electron Imaging; Chemical Analyses; Micro-Computed Tomography; Recent Biochemical and Genetic Analysis Related to Mineralization Processes , Normal and OI Mineralization ProcessesConclusions; Acknowledgments; References; 5. Osteoblast/Osteoclast Development and Function in Osteogenesis Imperfecta; Introduction; Bone Components; Osteoblasts; Osteoclasts; Collagen; Collagen Feedback; Matrix Elaboration; Mutations in OI; Autosomal Dominant Mutations; Autosomal Recessive Mutations; Consequences; Skin and Fibroblasts in OI; In Vitro Effects on Collagen; In Vitro Effects in Other Molecular and Cellular Domains; Bone and Cells in the Osteoblastic Lineage in OI; In Vitro Effects on Osteoblasts , In Vitro Effects in Other Molecular and Cellular DomainsOsteoblast Differentiation; Osteoclasts in OI; Pathways Leading to Altered Osteoblast Differentiation; References; 6. The Collagen Folding Machinery: Biosynthesis and Post-Translational Modifications of Collagens; Introduction; Procollagen Biosynthesis; A New Paradigm in OI; Discovery of the P3H1/CRTAP/CypB Complex; Role of the Prolyl 3-Hydroxylase 1 Complex in OI; Covering the Gap between Genotype and Phenotype; What Happens to Type I Collagen when the P3H1 Complex is not Working Properly? , The Amount of 3-Hydroxyproline in Type I Collagen is Generally Greatly Reduced when Components of the Complex are Missing o... , English

Additional Edition: ISBN 0-12-397165-9

Additional Edition: ISBN 1-299-84717-X

Language: English

UID:

Format: 1 online resource (xxii, 555 pages) : , illustrations (some color)

ISBN: 0-12-397789-4

Series Statement: Gale eBooks

Content: Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the

Note: Description based upon print version of record. , Front Cover; Osteogenesis Imperfecta; Copyright Page; Dedication; Contents; Foreword; Acknowledgments; List of Contributors; I: INTRODUCTION; Introduction to Osteogenesis Imperfecta; 1. Evolution of the Present Understanding of the Clinical and Genetic Heterogeneity and Molecular and Biochemical Bas...; Advances in Collagen Protein Biochemistry Led to Identification of the First OI Mutations; Molecular Biology of Collagen Genes and its Relevance to OI Research; A Return to Research in Matrix Biology; Collagen and Molecular Chaperones; Defects in Mineralization; Whole Gene Deletions , Patient and Parent Support Organizations and the Facilitation of Research in OIReviews and Doctoral Theses; Pamidronate Modified OI (Less Severe); Future Research; References; 2. Clinical and Genetic Classification of Osteogenesis Imperfecta and Epidemiology; Introduction; Clinical and Genetic Classifications of OI; Epidemiology of OI; References; 3. The Osteogenesis Imperfecta Community and Scientific Research: A Valuable Partnership; OI Foundation History; OI Research is Complicated; The Role of the OI Foundation in Research; A Model that Works; But Wait, There's More; In Conclusion , II: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY4. Mineralized Tissue: Histology, Biology and Biochemistry; Introduction; Methodology; Tissue Sources; Analyses and How they Inform About Normal Vs. OI Bone as a Function of Age; Matrix and Whole Tissue Analysis; Histology; Electron Microscopy; Ftir and Raman Microspectroscopy and Imaging; Mineral Analyses; X-Ray Diffraction; Small-Angle Scattering; Quantitative Backscattered Electron Imaging; Chemical Analyses; Micro-Computed Tomography; Recent Biochemical and Genetic Analysis Related to Mineralization Processes , Normal and OI Mineralization ProcessesConclusions; Acknowledgments; References; 5. Osteoblast/Osteoclast Development and Function in Osteogenesis Imperfecta; Introduction; Bone Components; Osteoblasts; Osteoclasts; Collagen; Collagen Feedback; Matrix Elaboration; Mutations in OI; Autosomal Dominant Mutations; Autosomal Recessive Mutations; Consequences; Skin and Fibroblasts in OI; In Vitro Effects on Collagen; In Vitro Effects in Other Molecular and Cellular Domains; Bone and Cells in the Osteoblastic Lineage in OI; In Vitro Effects on Osteoblasts , In Vitro Effects in Other Molecular and Cellular DomainsOsteoblast Differentiation; Osteoclasts in OI; Pathways Leading to Altered Osteoblast Differentiation; References; 6. The Collagen Folding Machinery: Biosynthesis and Post-Translational Modifications of Collagens; Introduction; Procollagen Biosynthesis; A New Paradigm in OI; Discovery of the P3H1/CRTAP/CypB Complex; Role of the Prolyl 3-Hydroxylase 1 Complex in OI; Covering the Gap between Genotype and Phenotype; What Happens to Type I Collagen when the P3H1 Complex is not Working Properly? , The Amount of 3-Hydroxyproline in Type I Collagen is Generally Greatly Reduced when Components of the Complex are Missing o... , English

Additional Edition: ISBN 0-12-397165-9

Additional Edition: ISBN 1-299-84717-X

Language: English

UID:

Format: 1 online resource (xxii, 555 pages) : , illustrations (some color)

ISBN: 0-12-397789-4

Series Statement: Gale eBooks

Content: Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the

Note: Description based upon print version of record. , Front Cover; Osteogenesis Imperfecta; Copyright Page; Dedication; Contents; Foreword; Acknowledgments; List of Contributors; I: INTRODUCTION; Introduction to Osteogenesis Imperfecta; 1. Evolution of the Present Understanding of the Clinical and Genetic Heterogeneity and Molecular and Biochemical Bas...; Advances in Collagen Protein Biochemistry Led to Identification of the First OI Mutations; Molecular Biology of Collagen Genes and its Relevance to OI Research; A Return to Research in Matrix Biology; Collagen and Molecular Chaperones; Defects in Mineralization; Whole Gene Deletions , Patient and Parent Support Organizations and the Facilitation of Research in OIReviews and Doctoral Theses; Pamidronate Modified OI (Less Severe); Future Research; References; 2. Clinical and Genetic Classification of Osteogenesis Imperfecta and Epidemiology; Introduction; Clinical and Genetic Classifications of OI; Epidemiology of OI; References; 3. The Osteogenesis Imperfecta Community and Scientific Research: A Valuable Partnership; OI Foundation History; OI Research is Complicated; The Role of the OI Foundation in Research; A Model that Works; But Wait, There's More; In Conclusion , II: BONE BIOLOGY, STRUCTURE AND BIOCHEMISTRY4. Mineralized Tissue: Histology, Biology and Biochemistry; Introduction; Methodology; Tissue Sources; Analyses and How they Inform About Normal Vs. OI Bone as a Function of Age; Matrix and Whole Tissue Analysis; Histology; Electron Microscopy; Ftir and Raman Microspectroscopy and Imaging; Mineral Analyses; X-Ray Diffraction; Small-Angle Scattering; Quantitative Backscattered Electron Imaging; Chemical Analyses; Micro-Computed Tomography; Recent Biochemical and Genetic Analysis Related to Mineralization Processes , Normal and OI Mineralization ProcessesConclusions; Acknowledgments; References; 5. Osteoblast/Osteoclast Development and Function in Osteogenesis Imperfecta; Introduction; Bone Components; Osteoblasts; Osteoclasts; Collagen; Collagen Feedback; Matrix Elaboration; Mutations in OI; Autosomal Dominant Mutations; Autosomal Recessive Mutations; Consequences; Skin and Fibroblasts in OI; In Vitro Effects on Collagen; In Vitro Effects in Other Molecular and Cellular Domains; Bone and Cells in the Osteoblastic Lineage in OI; In Vitro Effects on Osteoblasts , In Vitro Effects in Other Molecular and Cellular DomainsOsteoblast Differentiation; Osteoclasts in OI; Pathways Leading to Altered Osteoblast Differentiation; References; 6. The Collagen Folding Machinery: Biosynthesis and Post-Translational Modifications of Collagens; Introduction; Procollagen Biosynthesis; A New Paradigm in OI; Discovery of the P3H1/CRTAP/CypB Complex; Role of the Prolyl 3-Hydroxylase 1 Complex in OI; Covering the Gap between Genotype and Phenotype; What Happens to Type I Collagen when the P3H1 Complex is not Working Properly? , The Amount of 3-Hydroxyproline in Type I Collagen is Generally Greatly Reduced when Components of the Complex are Missing o... , English

Additional Edition: ISBN 0-12-397165-9

Additional Edition: ISBN 1-299-84717-X

Language: English

UID:

Format: xvii, 758 p., [16] p. of col. plates : , ill.

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 Online-Ressource (xxix, 1892 S.).

Edition: 2. ed.

ISBN: 978-0-12-252687-9 , 0-12-252687-2 , 978-0-08-054364-2 , 0-08-054364-2 , 0-12-252689-9 , 978-0-12-252689-3 , 0-12-252690-2 , 978-0-12-252690-9 , 0-12-252688-0 , 978-0-12-252688-6

Note: Printausg. in zwei Bd. ersch.

Language: English

Keywords: Vitamin-D-Gruppe

DOI: 10.1016/B978-0-12-252687-9.X5000-1

URL: Volltext

UID:

Format: 1 Online-Ressource (xxix, 1892 S.).

Edition: 2. ed.

ISBN: 978-0-12-252687-9 , 0-12-252687-2 , 978-0-08-054364-2 , 0-08-054364-2 , 0-12-252689-9 , 978-0-12-252689-3 , 0-12-252690-2 , 978-0-12-252690-9 , 0-12-252688-0 , 978-0-12-252688-6

Note: Printausg. in zwei Bd. ersch.

Language: English

Keywords: Vitamin-D-Gruppe

DOI: 10.1016/B978-0-12-252687-9.X5000-1

URL: Volltext