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  • 1
    Language: English
    In: Cancer Research, 04/15/2011, Vol.71(8 Supplement), pp.4081-4081
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 2
    Language: English
    In: Gastroenterology, 2000, Vol.118(4), pp.A326-A326
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    In: Infection and Immunity, 2001, Vol. 69(4), p.2277
    Description: Resident bacteria are incriminated in the pathogenesis of experimental colitis and inflammatory bowel diseases. We investigated the relative roles of various enteric bacteria populations in the induction and perpetuation of experimental colitis. HLA-B27 transgenic rats received antibiotics (ciprofloxacin, metronidazole, or vancomycin-imipenem) in drinking water or water alone in either prevention or treatment protocols. Mice were treated similarly with metronidazole or vancomycin-imipenem before or after receiving 5% dextran sodium sulfate (DSS). Germfree transgenic rats were colonized with specific-pathogen-free enteric bacteria grown overnight either in anaerobic or aerobic atmospheres. Nontransgenic rats colonized with anaerobic bacteria served as negative controls. Although preventive metronidazole significantly attenuated colitis in transgenic rats and DSS-treated mice, it had no therapeutic benefit once colitis was established. Ciprofloxacin also partially prevented but did not treat colitis in B27 transgenic rats. In both animal models vancomycin-imipenem most effectively prevented and treated colitis. Germfree transgenic rats reconstituted with enteric bacteria grown under anaerobic conditions had more aggressive colitis than those associated with aerobic bacteria. These results suggest that a subset of resident luminal bacteria induces colitis, but that a complex interaction of commensal aerobic and anaerobic bacteria provides the constant antigenic drive for chronic immune-mediated colonic inflammation.
    Keywords: Colitis -- Microbiology ; Enterobacteriaceae -- Physiology;
    ISSN: 0019-9567
    ISSN: 00199567
    E-ISSN: 10985522
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  • 4
    Language: English
    In: Int. J. of Web and Grid Services, 2012, Vol 8 Issue 3, pp 225 - 247
    Description: Self-adaptation enables distributed software to modify its behaviour based on changes in the operating environment. In large-scale information systems for cloud computing that use hierarchical data aggregation, self-adaption may be used to respond to an approximate query, thereby reducing use of network bandwidth and retrieval time. We present a novel algorithm that uses an Analytic Hierarchical Process (AHP) in order to apply self-adaption to approximate queries based on network-awareness. The AHP-based algorithm provides a trade-off among network usage, retrieval time and the accuracy of the retrieved results. Simulations show that the number of needed messages reduces with AHP to a constant upper bound. The retrieval time reduces to a constant factor under an increasing number of nodes. Our results demonstrate that the algorithm is able to provide responses with the required accuracy, primarily by adapting the depth of the query based on the number of messages and the network conditions.
    Keywords: cloud computing; information retrieval; information aggregation; approximate queries; large-scale networks; self-adaptive queries; distributed software; distributed computing; self-adaptation; network bandwidth; retrieval time; simulation; analytical hierarchical process; AHP.
    ISSN: 1741-1106
    ISSN: 17411106
    ISSN: 1741-1114
    ISSN: 17411114
    E-ISSN: 1741-1114
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  • 5
    Language: English
    In: WIRTSCHAFTSINFORMATIK, 2008, Vol.50(1), pp.25-30
    Description: Service Oriented Computing has a deep impact on how IT infrastructures are conceived both in academia (e-science) and in industry (Service Oriented Architecture and commercial Web Services). Increasingly, economic models are being considered as suitable coordination mechanism for the management of service allocations to clients. However, few complete infrastructures have demonstrated the enabling of economics-based Service Oriented Grids (SOGs). The authors propose a complete infrastructure for economics-based SOGs and demonstrate its application in a prototype. They conduct experiments showing that practical agent-based automatic and fair trading of services at stable prices can be achieved using the proposed infrastructure. Die Technologie agentenbasierter elektronischer Märkte stellt einen Vorschlag für einen passenden Koordinationsmechanismus für Grid- und SOA-Umgebungen dar. Dieser Artikel beschreibt eine vollständige Infrastruktur für marktbasierte serviceorientierte Grids und demonstriert deren Anwendung anhand eines Data-Mining-Prototyps. Die dargestellten Entwicklungen und Experimente zeigen drei Ergebnisse. Erstens integriert die vorgeschlagene Infrastruktur verschiedene Middleware-Werkzeuge und ermöglicht damit die technische Implementierung des Handelns von Grid-Services. Zweitens kann agentenbasiert automatisches und faires Handeln von Services erreicht werden. Schließlich kann gezeigt werden, dass der Einsatz eines ökonomischen Marktmechanismus keine Einschränkung der Systemgröße oder der technischen Anforderung nach sich zieht, sodass prinzipiell eine hohe Skalierbarkeit möglich ist. Stichworte: Ressourcenallokation, Kontraktnetze, dezentrale ökonomische Modelle, serviceorientiertes Grid-Computing
    Keywords: automatic resource allocation ; contract-net ; decentralized economic models ; service oriented grids
    ISSN: 0937-6429
    E-ISSN: 1861-8936
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  • 6
    In: Stroke, 2016, Vol.47(8), pp.e207-e209
    Description: An 89-year-old woman with hypertension, hyperlipidemia, stroke, deep venous thrombosis, and atrial fibrillation presented with 4 days of right eye (OD) redness and swelling and intermittent diplopia. An ophthalmologic evaluation revealed visual acuity 20/50 OD. There was limited abduction OD, right upper and lower lid erythema and edema, and conjunctival injection. Funduscopic examination was unremarkable. Erythrocyte sedimentation rate and C-reactive protein were normal. Follow-up ophthalmologic examination 2 weeks later showed visual acuity decreased to 20/70 OD with increased right orbital congestion, exophthalmos (25 mm OD and 21 mm OS [left eye]), and worsening limitation of ductions OD. A magnetic resonance imaging/magnetic resonance angiography of her head demonstrated fusiform dilatation of the cavernous segment of the right internal carotid artery (ICA) with asymmetrical enhancement of the right cavernous sinus and an enlarged right superior ophthalmic vein (SOV) consistent with arterialized flow from a carotid-cavernous fistula (CCF). The patient was urgently referred to neuro-interventional radiology for diagnostic angiography and embolization of the CCF. The cerebral angiogram showed a right direct (Barrow type A) CCF, with rapid enhancement of the right cavernous sinus and right SOV. A 7-mm fusiform aneurysm of the right cavernous ICA was found to be the likely cause of the CCF (Figure 1A). Transarterial access of the fistula for coil embolization was unsuccessful. Figure 1. A , Pretreatment digital subtraction angiography, lateral magnified view, right common carotid artery injection, showing early, rapid opacification of the right cavernous sinus (black arrow) and right superior ophthalmic vein (white arrows) consistent with a direct carotid-cavernous fistula. There is also fusiform dilatation of the cavernous right internal carotid artery representing dysplasia with an aneurysm. B , Photograph showing the direct access provided to the right superior ophthalmic vein for coil embolization. C , …
    Keywords: Medicine;
    ISSN: 0039-2499
    E-ISSN: 15244628
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  • 7
    Language: English
    In: PLoS ONE, 01 January 2017, Vol.12(4), p.e0175279
    Description: To investigate the association of Epstein-Barr virus (EBV) nuclear antigen-1 (EBNA-1) and viral capsid antigen (VCA) immunoglobulin (Ig)G antibodies in serum as well as EBV DNA load in saliva with radiological and clinical disease activity in...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 8
    Language: English
    In: PLoS ONE, 01 January 2016, Vol.11(1), p.e0147968
    Description: BACKGROUND:In response to DNA double-strand breaks, the histone protein H2AX becomes phosphorylated at its C-terminal serine 139 residue, referred to as γ-H2AX. Formation of γ-H2AX foci is associated with recruitment of p53-binding protein 1 (53BP1), a regulator of the cellular response to...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: PLoS ONE, Jan 28, 2016, Vol.11(1)
    Description: Background In response to DNA double-strand breaks, the histone protein H2AX becomes phosphorylated at its C-terminal serine 139 residue, referred to as [gamma]-H2AX. Formation of [gamma]-H2AX foci is associated with recruitment of p53-binding protein 1 (53BP1), a regulator of the cellular response to DNA double-strand breaks. [gamma]-H2AX expression in peripheral blood mononuclear cells (PBMCs) was recently proposed as a diagnostic and disease activity marker for multiple sclerosis (MS). Objective To evaluate the significance of [gamma]-H2AX and 53BP1 foci in PBMCs as diagnostic and disease activity markers in patients with clinically isolated syndrome (CIS) and early relapsing-remitting MS (RRMS) using automated [gamma]-H2AX and 53BP1 foci detection. Methods Immunocytochemistry was performed on freshly isolated PBMCs of patients with CIS/early RRMS (n = 25) and healthy controls (n = 27) with [gamma]-H2AX and 53BP1 specific antibodies. Nuclear [gamma]-H2AX and 53BP1 foci were determined using a fully automated reading system, assessing the numbers of [gamma]-H2AX and 53BP1 foci per total number of cells and the percentage of cells with foci. Patients underwent contrast enhanced 3 Tesla magnetic resonance imaging (MRI) and clinical examination including expanded disability status scale (EDSS) score. [gamma]-H2AX and 53BP1 were also compared in previously frozen PBMCs of each 10 CIS/early RRMS patients with and without contrast enhancing lesions (CEL) and 10 healthy controls. Results The median (range) number of [gamma]-H2AX (0.04 [0-0.5]) and 53BP1 (0.005 [0-0.2]) foci per cell in freshly isolated PBMCs across all study participants was low and similar to previously reported values of healthy individuals. For both, [gamma]-H2AX and 53BP1, the cellular focus number as well as the percentage of positive cells did not differ between patients with CIS/RRMS and healthy controls. [gamma]-H2AX and 53BP1 levels neither correlated with number nor volume of T2-weighted lesions on MRI, nor with the EDSS. Although [gamma]-H2AX, but not 53BP1, levels were higher in previously frozen PBMCs of patients with than without CEL, [gamma]-H2AX values of both groups overlapped and [gamma]-H2AX did not correlate with the number or volume of CEL. Conclusion [gamma]-H2AX and 53BP1 foci do not seem to be promising diagnostic or disease activity biomarkers in patients with early MS. Lymphocytic DNA double-strand breaks are unlikely to play a major role in the pathophysiology of MS.
    Keywords: Dna Damage -- Physiological Aspects ; Dna Damage -- Research ; Multiple Sclerosis -- Development And Progression ; Multiple Sclerosis -- Genetic Aspects ; Multiple Sclerosis -- Research
    ISSN: 1932-6203
    Source: Cengage Learning, Inc.
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  • 10
    In: European Journal of Neurology, January 2016, Vol.23(1), pp.62-67
    Description: Background and purpose Low 25-hydroxyvitamin D [25(OH)D] levels correlate with higher disease activity in patients with multiple sclerosis (MS). However, it is not clear whether low 25(OH)D levels directly contribute to increased disease activity or merely represent a consequence of reduced endogenous vitamin D synthesis in more disabled MS patients. Furthermore, recent data suggest that bioavailable vitamin D, which also integrates the levels of vitamin D binding proteins and albumin, could be a biologically more relevant parameter than 25(OH)D. Methods Measured de-seasonalized 25(OH)D3 and vitamin D binding protein and calculated bioavailable and free vitamin D were compared in the baseline serum samples of 76 patients with clinically isolated syndrome enrolled in a longitudinal observational study and in 76 age- and sex-matched healthy controls (HC). Results 25(OH)D3 levels were lower in patients with clinically isolated syndrome (P = 0.002) than in HC, and more patients (8/76, 10.5%) than HC (1/76, 1.3%) had 25(OH)D3 levels 〈25 nmol/l (P = 0.03). In contrast, levels of 25(OH)D2, vitamin D binding protein and calculated levels of free and bioavailable vitamin D did not differ between the two groups. Conclusions Lower 25(OH)D3 levels already in the earliest phase of disease and in clinically hardly affected patients suggest that low 25(OH)D3 levels are rather a risk factor for than a consequence of MS. Nevertheless, because bioavailable vitamin D levels did not differ between the two groups, the mechanism underlying the association of 25(OH)D3 and MS does not appear to be related to reduced bioavailability of vitamin D.
    Keywords: Bioavailable Vitamin D ; Clinically Isolated Syndrome ; 25‐Hydroxyvitamin D ; Multiple Sclerosis ; Risk Factor ; Vitamin D Binding Protein
    ISSN: 1351-5101
    E-ISSN: 1468-1331
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