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  • 1
    Article
    Article
    Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action (2010)
    Details
    Language: English
    In: The American journal of psychiatry, April 2010, Vol.167(4), pp.388-96
    Description: Dopamine D(2) receptor antagonism is a unifying property of all antipsychotic drugs in clinical use. Remarkably, the effector molecules through which these medications exert their actions remain poorly characterized. Increasing attention is being focused on Akt/glycogen synthase kinase-3 (GSK-3) and wingless (Wnt) signaling pathways, which have been associated with schizophrenia in a number of genetic and postmortem studies. Antipsychotic medications may treat symptoms of psychosis, at least in part, through modulation of levels and activity of Akt, GSK-3, and Wnt-related intracellular signaling. The authors review evidence that Akt/GSK-3 and Wnt-related pathways are involved in the pathogenesis of schizophrenia as well as details of intracellular events related to these molecules mediated by both typical and atypical antipsychotic medications. Further study of Akt/GSK-3 and Wnt signaling may ultimately lead to alternative therapeutics of schizophrenia-related disorders.
    Keywords: Adaptor Proteins, Signal Transducing -- Physiology ; Antipsychotic Agents -- Pharmacology ; Apoptosis Regulatory Proteins -- Physiology ; Glycogen Synthase Kinase 3 -- Physiology ; Schizophrenia -- Drug Therapy ; Signal Transduction -- Drug Effects ; Wnt Proteins -- Genetics
    ISSN: 0002953X
    E-ISSN: 1535-7228
    DOI: 10.1176/appi.ajp.2009.08121873
    URL: View this record in MEDLINE/PubMed
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  • 2
    Article
    Article
    Estimation of groundwater recharge and drought severity with varying model complexity (2015)
    Details
    Language: English
    In: Journal of Hydrology, 2015, Vol.527, p.844(14)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jhydrol.2015.05.025 Byline: Jana von Freyberg, Christian Moeck, Mario Schirmer Abstract: * Six frequently used methods for groundwater recharge estimation were compared. * Methods represent different spatio-temporal scales and degrees of complexity. * Considerable differences among the methods even after calibration to lysimeter data. * Increasing model complexity not necessarily leads to better model performance. * Strengths and limitations of the methods are compiled and recommendations are made. Article History: Received 20 November 2014; Revised 20 April 2015; Accepted 13 May 2015 Article Note: (miscellaneous) This manuscript was handled by Corrado Corradini, Editor-in-Chief, with the assistance of Xunhong Chen, Associate Editor
    Keywords: Droughts – Analysis ; Droughts – Models ; Groundwater – Analysis ; Groundwater – Models
    ISSN: 0022-1694
    Source: Cengage Learning, Inc.
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  • 3
    Article
    Article
    Blue peace or blue problems? a report on water scarcity in the Middle East suggests setting up a collective water council in the region to help bring peace between countries. Changing water's role to an olive branch will be tough.(Perspective) (2011)
    Details
    Language: English
    In: Water and Wastewater International, Feb-March, 2011, Vol.26(1), p.5(1)
    Keywords: Shortages -- Reports
    ISSN: 0891-5385
    Source: Cengage Learning, Inc.
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  • 4
    Article
    Article
    Land of the black [& blue] prosperous gold: political uncertainty has spread across the Middle East over the last couple of months but future demand for freshwater supplies will continue to grow. Tom Freyberg visited Saudi Arabia and Bahrain before civil unrest swept across the Arab world to find out what opportunities exist when it comes water supply and wastewater treatment.(Regional Spotlight: Middle East & Africa) (2011)
    Details
    Language: English
    In: Water and Wastewater International, Feb-March, 2011, Vol.26(1), p.18(6)
    Keywords: Sewage Treatment ; Arab Countries
    ISSN: 0891-5385
    Source: Cengage Learning, Inc.
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  • 5
    Article
    Article
    Reuse steps up in water-poor Jordan: prior to the recent protests in Amman, USAID awarded a US$28 million, task order for a water reuse and environmental conservation project in Jordan. Tom Freyberg speaks to senior engineer George Harris about the project and challenges of changing wastewater perceptions across the Middle East.(Regional Spotlight: Middle East & North Africa)(Interview) (2011)
    Details
    Language: English
    In: Water and Wastewater International, Feb-March, 2011, Vol.26(1), p.27(3)
    Keywords: Natural Resource Conservation ; Water ; Environmental Engineering
    ISSN: 0891-5385
    Source: Cengage Learning, Inc.
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  • 6
    Article
    Article
    MDGs: the next stage: as part of a live webcast that discussed the future challenges of meeting the Millennium Development Goals (MDGs), WWi brought together some of the industry's leading experts. Tom Freyberg summarises what the Stockholm International Water Institute, International Water Association and WaterHealth International had to say.(Making Ripples: Water Leader Focus) (2011)
    Details
    Language: English
    In: Water and Wastewater International, Feb-March, 2011, Vol.26(1), p.12(2)
    Keywords: Sustainable Development ; Drinking Water
    ISSN: 0891-5385
    Source: Cengage Learning, Inc.
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  • 7
    Article
    Article
    Potential evapotranspiration from forest and pasture in the tropics: A case study in Kona, Hawai'i (2012)
    Details
    Language: English
    In: Journal of Hydrology, May 29, 2012, Vol.440-441, p.52(10)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jhydrol.2012.03.014 Byline: Kate A Brauman (a), David L Freyberg (b), Gretchen C Daily (c) Keywords: Penman-Monteith; Land use change; Stomatal resistance; Aerodynamic resistance; Wet canopy evaporation; Ecohydrology Abstract: a* Potential evapotranspiration (PET) is low on leeward Hawai'i Island. a* In this tropical region without water stress, PET is higher in pasture than in forest. a* Aerodynamic and stomatal control of PET differ for the two vegetation types. a* Land use changes such as increased cattle grazing may impact rates of PET. a* Forest conversion in tropical montane landscapes could affect downstream water users. Author Affiliation: (a) Emmett Interdisciplinary Program in Environment and Resources, 473 Via Ortega, Suite 226, Stanford University, Stanford, CA 94305, United States (b) Department of Civil and Environmental Engineering, Yang and Yamazaki Environment and Energy Building, MC 4020, 473 Via Ortega, Room 257, Stanford University, Stanford, CA 94305, United States (c) Department of Biology and Woods Institute for the Environment, 371 Serra Mall, MC 5020, Stanford University, Stanford, CA 94305, United States Article History: Received 22 April 2011; Revised 7 March 2012; Accepted 10 March 2012 Article Note: (miscellaneous) This manuscript was handled by Konstantine P. Georgakakos, Editor-in-Chief, with the assistance of Christa D. Peters-Lidard, Associate Editor
    Keywords: Water Resources -- Case Studies
    ISSN: 0022-1694
    Source: Cengage Learning, Inc.
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  • 8
    Article
    Article
    An analysis of trends in baseflow recession and low-flows in rain-dominated coastal streams of the pacific coast (2014)
    Details
    Language: English
    In: Journal of Hydrology, 27 November 2014, Vol.519, pp.599-610
    Description: The work presented here centers on the identification and calculation of indices representative of annual low-flow conditions and baseflow recession form, and the evaluation of trends in these indices with time for rain-dominated streams of the Pacific coastal mountain ranges. Two different baseflow recession analysis techniques are employed, which when combined are capable of modeling the varied dry-season flow conditions that exist over the broad range of catchments included in the study area. Results indicate that over the past 40–80 years widespread trends of increasing rates of baseflow recession and decreasing annual low-flow conditions exist throughout the region. Of streamgages analyzed, 44% were identified as having a statistically significant trend in either low-flow conditions or recession form with time. While spring flow conditions show little change over the study period, trends of decreasing late-summer flow conditions and increasing rates of recession are particularly common. Northern California and Oregon are especially impacted locations, with upwards of 60% of study gages exhibiting decreasing trends in late summer flow conditions. Detailed conceptual explanations for the connections between trends in recession form and indices of low-flow are also presented.
    Keywords: Low-Flow ; Baseflow ; Trend Analysis ; Rain-Dominated ; Pacific Coast ; Geography
    ISSN: 0022-1694
    E-ISSN: 1879-2707
    DOI: 10.1016/j.jhydrol.2014.07.046
    URL: View record in ScienceDirect (Access to full text may be restricted)
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  • 9
    Article
    Article
    Quantitative and qualitative measures of behavior in adolescent girls (2009)
    Details
    Language: English
    In: Adolescence, 2009, Vol.44(173), pp.33-54
    Description: Social experiences are central to the adolescent experience (Hartup & Stevens, 1997). The current study examined how this emphasis on social behavior would be reflected in both quantitative and qualitative measures. To do this, 57 adolescent girls (aged 11-19 years) completed questionnaires about their achievements and social and relaxation activities. They also composed a sample of a personal experience. Results demonstrated that social activities were among the most time-consuming and enjoyable activities of their day and were engaged in voluntarily. Analysis of their writing samples demonstrated that adolescents incorporated more affiliation themes than achievement or power themes. However, quantitative measures did not predict qualitative measures. Such findings demonstrate the importance of incorporating multiple methods of measurement in adolescent research.
    Keywords: Achievement ; Leisure Activities ; Psychology, Adolescent ; Social Behavior
    ISSN: 0001-8449
    URL: View this record in MEDLINE/PubMed
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  • 10
    Article
    Article
    An analysis of trends in baseflow recession and low-flows in rain-dominated coastal streams of the pacific coast (2014)
    Details
    Language: English
    In: Journal of Hydrology, Nov 27, 2014, Vol.519, p.599(12)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jhydrol.2014.07.046 Byline: Spencer R. Sawaske, David L. Freyberg Abstract: acents We evaluate trends in dry-season flow conditions of rain-dominated watersheds. acents Trends in time of baseflow recession form and annual low-flows are assessed. acents 46% of gages analyzed have significant trends in either low-flows or recession form. acents Trends are primarily negative, indicating declining low-flows and faster recessions. acents Northern California and Oregon are particularly affected by decreasing summer flows. Article History: Received 27 January 2014; Revised 2 June 2014; Accepted 21 July 2014 Article Note: (miscellaneous) This manuscript was handled by Andras Bardossy, Editor-in-Chief, with the assistance of Attilio Castellarin, Associate Editor
    ISSN: 0022-1694
    Source: Cengage Learning, Inc.
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