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  • 1
    In: NMR in Biomedicine, September 2013, Vol.26(9), pp.1079-1088
    Description: Obesity is associated with insulin resistance (IR) and hepatosteatosis. Understanding the link between IR and hepatosteatosis could be relevant to chronic clinical outcomes. The objective of this study was to quantitatively assess lipid deposition (fractional lipid mass, fLM) and composition (fraction of polyunsaturated lipids, fPUL and mean chain length, MCL) in livers of ob/ob mice, a genetic model of obesity and mild diabetes, and ob/+ heterozygous control animals in a noninvasive manner using H‐MRS at 9.4T. For accurate quantification, intensity values were corrected for differences in T values while T effects were considered minimal due to the long T values used. Values of fLM, fPUL and MCL were derived from T‐corrected signal intensities of lipids and water resonance. Hepatic lipid signals were compared with fasted plasma insulin, glucose and lipid levels. Statistically significant correlations between fPUL and fasting plasma insulin/glucose levels were found in adolescent ob/ob mice. A similar correlation was found between fLM and fasting plasma insulin levels; however, the correlation between fLM and fasting plasma glucose levels was less obvious in adolescent ob/ob mice. These correlations were lost in adult ob/ob mice. The study showed that in adolescent ob/ob mice, there was an obvious link between lipid deposition/composition in the liver and plasma insulin/glucose levels. This correlation was lost in adult animals, probably due to the limited lipid storage capacity of the liver. Copyright © 2013 John Wiley & Sons, Ltd. Statistically significant correlations between hepatic lipid deposition/ composition and fasting plasma insulin/glucose levels were found in adolescent ob/ob mice. These correlations were lost in adult ob/ob mice probably due to the limited lipid storage capacity of the liver.
    Keywords: Hepatic Lipids Ihcl ; Insulin ; Mouse ; Obesity ; Magnetic Resonance Spectroscopy Mrs
    ISSN: 0952-3480
    E-ISSN: 1099-1492
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  • 2
  • 3
    Language: English
    In: Proceedings of the VLDB Endowment, 08/01/2017, Vol.10(12), pp.1893-1896
    Keywords: Computer Science;
    ISSN: 21508097
    Source: CrossRef
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  • 4
    Language: English
    In: Journal of Neuro-Oncology, 2016, Vol.129(1), pp.189-191
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11060-016-2159-0 Byline: Andre O. Bueren (1,2), Clemens Seidel (3), Carsten Friedrich (3) Author Affiliation: (1) University Medical Center Geneva, Geneva, Switzerland (2) University Medical Center Goettingen, Goettingen, Germany (3) University Medical Center Leipzig, Leipzig, Germany Article History: Registration Date: 02/06/2016 Received Date: 27/03/2016 Accepted Date: 01/06/2016 Online Date: 09/06/2016
    Keywords: Gliomas ; Adjuvant Chemotherapy;
    ISSN: 0167-594X
    E-ISSN: 1573-7373
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  • 5
    Language: English
    In: European Journal of Cancer, November 2015, Vol.51(16), pp.2434-2443
    Description: Due to the rarity of metastatic medulloblastoma in adults, knowledge about the efficacy and toxicity of intensified chemotherapy and radiotherapy is limited. Adults with disseminated medulloblastoma registered in the HIT2000 trial as observational patients and treated according to one of two different treatment regimens were analysed. The sandwich strategy MET-HIT2000AB4 consists of postoperative chemotherapy, hyperfractionated craniospinal radiotherapy, and maintenance chemotherapy; while the HIT′91 maintenance strategy consists of postoperative craniospinal radiotherapy, and maintenance chemotherapy. Twenty-three patients (median age: 30.7 years), diagnosed from November 2001 to July 2009, and treated in 18 institutions in Germany and Austria, were eligible. The median follow-up of surviving patients was 3.99 years. The 4-year event-free survival (EFS) and overall survival (OS) ± standard error (SE) were 52% ± 12% and 91% ± 6%, respectively. The survival was similar in both treatment groups (HIT′91 maintenance strategy, = 9; MET-HIT2000AB4 sandwich strategy, = 14). Patients with large cell/anaplastic medulloblastoma relapsed and died ( = 2; 4-year EFS/OS: 0%) and OS differed compared to patients with classic ( = 11; 4-year EFS/OS: 71%/91%) and desmoplastic medulloblastoma ( = 10; 4-year EFS/OS: 48%/100%), respectively ( = 0.161 for EFS and = 0.033 for OS). Treatment-induced toxicities consisted mainly of neurotoxicity (50% of patients, ⩾ °II), followed by haematotoxicity and nephrotoxicity/ototoxicity. The professional outcome appeared to be negatively affected in the majority of evaluable patients (9/10). Treatment of adults with metastatic medulloblastoma according to the intensified paediatric HIT2000 protocol was feasible with acceptable toxicities. EFS rates achieved by both chemotherapeutic protocols were favourable and appear to be inferior to those obtained in older children/adolescents with metastatic disease.
    Keywords: Brain Tumour ; Medulloblastoma ; Adults ; Toxicity ; Treatment ; Radiotherapy ; Chemotherapy ; Prognosis ; Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 6
    Language: English
    In: European Journal of Cancer, November 2015, Vol.51(17), pp.2634-2642
    Description: To assess feasibility, acute toxicity, and efficacy of intraventricular methotrexate administered as part of the primary therapy in medulloblastoma. From 2001 to 2007, 240 patients 〈22 years from 61 treatment centres were registered. Patients received 2–3 cycles of intraventricular methotrexate with systemic chemotherapy in three different treatment arms of the prospective multicentre trial HIT2000 (150 children 〉4 years with metastatic, 59 〈4 years with non-metastatic, 31 〈4 years with metastatic medulloblastoma). 211 patients received an intraventricular access device with a subcutaneous reservoir for the application of chemotherapy. Reservoir-associated complications were documented in 57 (27%) patients, mostly due to infection ( = 32) and reservoir malfunction ( = 19), requiring removal in 39 (18%) patients. Acute neurotoxicity likely associated with intraventricular MTX was observed in 9/202 documented patients. Toxicity was usually mild, apart from one therapy-associated death due to toxic oedema followed by seizures. Of 519 treatment cycles including intraventricular methotrexate, 226 (43%) were reduced or omitted, most frequently due to the absence of an intraventricular device. Survival rates were higher in patients receiving ⩾75% of the scheduled intraventricular methotrexate dose compared to those receiving 〈75% in both univariate and multivariate models (event-free survival (EFS), 61.5 versus 46.2%, = 0.004; OS, 75.5% versus 60.4%, = 0.015; hazard ratio: EFS 1.723, = 0.016; OS 1.648, = 0.051). Intraventricular methotrexate therapy was feasible and mostly well tolerated. Infections were the most frequent complication. A higher cumulative dose of intraventricular methotrexate was associated with better survival. Further evaluation of efficacy and late effects is warranted.
    Keywords: Methotrexate ; Intraventricular ; Medulloblastoma ; Brain Tumours ; Chemotherapy ; Treatment ; Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 7
    Language: English
    In: European Journal of Cancer, March 2013, Vol.49(4), pp.893-903
    Description: Medulloblastoma in adulthood is rare. Knowledge is limited, and the efficacy and toxicity of chemotherapy – especially in nonmetastatic disease – is still elusive. Seventy adults aged ⩾21 years (median age: 28.5 years) with nonmetastatic medulloblastoma were followed as observational patients within the prospective paediatric multicentre trial HIT 2000. Treatment consisted of radiotherapy (35.2 Gy to the craniospinal axis and a boost to 55.2 Gy to the posterior fossa) followed in most patients by maintenance chemotherapy (lomustine (CCNU), vincristine and cisplatin, = 49). The implementation of maintenance chemotherapy was feasible. Peripheral neuropathy (74%) and haematotoxicity (55%) during maintenance chemotherapy appear to be more common in adults than in children. At a median follow-up of 3.7 years, the 4-year event-free survival (EFS) and overall survival (OS) rates ± standard error (SE) were 68% ± 7% and 89% ± 5%. Patients with desmoplastic medulloblastoma and lateral tumour location ( = 19) had a lower EFS compared to patients with centrally located desmoplastic tumours ( = 10) ( = 0.011). Absence of residual postoperative tumour ( = 40) was associated to a lower rate of progression/relapse compared to present ( = 11) or unknown ( = 12) residual tumour status ( = 0.006). Lateral tumour location and unknown residual tumour status were independent negative prognostic factors. Maintenance chemotherapy is applicable in adults with nonmetastatic medulloblastoma. Histological subtype and tumour location were newly identified risk factors in this age-group, and should be further analysed in prospective trials.
    Keywords: Brain Tumour ; Medulloblastoma ; Adults ; Treatment ; Radiotherapy ; Chemotherapy ; Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 8
    In: Journal of the American Chemical Society, July 26, 2000, Vol.122(29), p.6955(4)
    Description: The synthesis and structure of a neutral SiA114 cluster is described.
    Keywords: Biosynthesis -- Methods ; Halides -- Research
    ISSN: 0002-7863
    E-ISSN: 15205126
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  • 9
    Language: English
    In: Magnetic Resonance Materials in Physics, Biology and Medicine, 2012, Vol.25(5), pp.381-389
    Description: Object: Hepatic lipid accumulation is associated with nonalcoholic fatty liver disease, and the metabolic syndrome constitutes an increasing medical problem. In vivo proton magnetic resonance spectroscopy ( super(1)H MRS) allows the assessment of hepatic lipid levels noninvasively and also yields information on the fat composition due to its high spectral resolution. Materials and methods: We applied super(1)H MRS at 9.4T to study lipid content and composition in eight leptin-deficient ob/ob mice as a model of obesity and in four lean ob/+ control mice at 24 weeks of age. PRESS sequence was used. For accurate estimation of signal intensity, differences in relaxation behavior of individual signals were accounted for each mouse individually. Also, in order to minimize spectral degrading due to motion artifacts, respiration gating was applied. Results: Significant differences between ob/ob and ob/+ control mice were found in both lipid content and composition. The mean chain length was found to be significantly longer in ob/ob mice with a higher fraction of monounsaturated lipids. Conclusion: super(1)H MRS enables accurate assessment in hepatic lipids in mice, which is attractive for mechanistic studies of altered metabolism given the large number of genetically engineered mouse models available.
    Keywords: Hepatic steatosis ; Mouse ; Obesity ; Magnetic resonance spectroscopy (MRS)
    ISSN: 0968-5243
    E-ISSN: 1352-8661
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  • 10
    Language: English
    In: Journal of Neuro-Oncology, Feb, 2014, Vol.116(3), p.567(9)
    Description: Byline: Carsten Friedrich (1), Klaus Muller (2), Katja Hoff (1), Robert Kwiecien (3), Torsten Pietsch (4), Monika Warmuth-Metz (5), Nicolas U. Gerber (6), Peter Hau (7), Joachim Kuehl (8), Rolf D. Kortmann (2), Andre O. Bueren (1,9), Stefan Rutkowski (1) Keywords: Brain tumor; Primitive neuroectodermal tumor (PNET); Pineoblastoma; Adults; Radiotherapy; Chemotherapy Abstract: Central nervous system primitive neuroectodermal tumors (CNS-PNET) and pineoblastomas (PBL) are rare in adulthood. Knowledge on clinical outcome and the efficacy and toxicities of chemotherapy in addition to radiotherapy is limited. Patients older than 21 years at diagnosis were followed in the observational arm of the prospective pediatric multicenter trial HIT 2000. After surgery, craniospinal irradiation and maintenance or sandwich chemotherapy were recommended. Radiotherapy was normo- (35.2 Gy tumor region, 55.0 Gy metastasis, 49.6 Gy) or hyperfractionated (40.0 Gy tumor bed, 68.0 Gy metastasis, 50--60 Gy). Maintenance chemotherapy consisted of eight courses (vincristine, lomustine, cisplatin). Sandwich chemotherapy included two cycles of postoperative chemotherapy followed by radiotherapy, and four courses of maintenance chemotherapy. Seventeen patients (CNS-PNET, n = 7 PBL, n = 10), median age 30 years, were included. Eight patients had a postoperative residual tumor and four patients metastatic disease. The median follow-up of ten surviving patients was 41 months. The estimated rates for 3-year progression-free survival (PFS) and overall survival were 68 +- 12 and 66 +- 13 %, respectively. PBL compared to CNS-PNET tended towards a better PFS, although the difference was not clear (p = 0.101). Both chemotherapeutic (maintenance, n = 6 sandwich, n = 8) protocols did not differ in their PFS and were feasible with acceptable toxicities. Intensified regimens of combined chemo- and radiotherapy are generally feasible in adults with CNS-PNET/PBL. The impact of intensified chemotherapy on survival should be further assessed. Author Affiliation: (1) Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany (2) Department of Radiation Oncology, University of Leipzig, Leipzig, Germany (3) Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany (4) Department of Neuropathology, University of Bonn, Bonn, Germany (5) Department of Neuroradiology, University of Wuerzburg, Wuerzburg, Germany (6) Department of Oncology, University Children's Hospital, Zurich, Switzerland (7) Department of Neurology and Wilhelm Sander-NeuroOncology Unit, University Hospital Regensburg, Regensburg, Germany (8) Department of Pediatrics, University of Wuerzburg, Wuerzburg, Germany (9) Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Goettingen, Goettingen, Germany Article History: Registration Date: 24/12/2013 Received Date: 18/08/2013 Accepted Date: 23/12/2013 Online Date: 10/01/2014 Article note: Andre O.von Bueren and Stefan Rukowski are contributed equally. Joachim Kuehl--Deceased.
    Keywords: Adults ; Nuclear Radiation ; Pediatrics
    ISSN: 0167-594X
    Source: Cengage Learning, Inc.
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