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  • 1
    In: Information - Wissenschaft & Praxis, 01/2012, Vol.63(5)
    Description: The educational quality of teaching in academia can be improved by using Audience Response Systems (ARS). Students have the chance to give feedback during classroom lessons and are much more involved in active communication concerning the content of the lectures. Using smart phones as a platform for ARS there are even more possibilities for involving the students. This article gives a brief overview over current ARS Systems used in academia and discusses possible future enhancements to these systems.
    Keywords: Unterrichten ; Unterrichtsprogramm ; Qualitätskontrolle ; Student ; Mobiles Gerät ; Bewertung ; Bewertungshilfsmittel ; Smartphone ; Engineering;
    ISSN: 1434-4653
    E-ISSN: 1619-4292
    Source: Walter de Gruyter (via CrossRef)
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  • 2
    Language: English
    In: Psychology of Sport & Exercise, March 2013, Vol.14(2), pp.266-274
    Description: To test the Cross-Stressor Adaptation hypothesis for females by examining whether physically exercising young women show reduced physiological and psychological stress responses to a psychosocial stressor. Forty-seven healthy young women with different levels of physical exercise (17 not or rarely exercising, 15 moderately exercising, 15 vigorously exercising) underwent the Trier Social Stress Test for Groups (TSST-G); physiological and psychological stress responses during and after stress induction were compared. ANOVAs with repeated measures were used to compare stress reactivity and recovery between the three exercise groups. Heart rate and salivary free cortisol were used as indicators of physiological stress response, state anxiety, mood, and calmness as indicators of psychological stress response. For physiological stress reactivity, the areas under the curve with respect to the ground ( ) were compared. In all three exercise groups, experimentally induced stress led to a significant rise in heart rate, cortisol, and state anxiety; mood and calmness significantly decreased. As hypothesized, the pattern of the physiological stress response differed for the three exercise groups, with lowered reactivity in the more active groups. However, the psychological stress response partly went in the opposite direction: Exercising participants reported a higher mood decrease, suggesting a dissociation of the physiological and psychological stress responses. The findings suggest that the Cross-Stressor Adaptation hypothesis is also valid for young women; however, only with regard to physiological stress response. The unexpected findings for psychological stress response need to be further explored in experimental studies. ► We found support for the Cross-Stressor Adaptation (CSA) hypothesis of exercise among women. ► Exercising women showed a reduced physiological reaction to psychosocial stress. ► In contrast exercising women's psychological stress response was partly elevated. ► The results indicate a dissociation of physiological and psychological stress responses. ► For the first time the CSA hypothesis is tested in a female sample applying a standardized stress protocol.
    Keywords: Cortisol ; Cross-Stressor Adaptation Hypothesis ; Exercise ; Heart Rate ; Stress Reactivity ; Trier Social Stress Test ; Recreation & Sports
    ISSN: 1469-0292
    E-ISSN: 1878-5476
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  • 3
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 28 June 2011, Vol.108(26), pp.10544-9
    Description: Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purify a CSC-like cell population from early skin tumors arising from treatment with 7,12-dimethylbenz[α]anthracene/12-o-tetradecanoylphorbol-13-acetate, which typically generates benign papillomas that occasionally progress to squamous cell carcinomas (SCCs). In the present study, we identify and characterize CSCs purified from malignant SCCs. We show that SCCs contain two highly tumorigenic CSC populations that differ in CD34 levels but are enriched for integrins and coexist at the SCC-stroma interface. Intriguingly, whether CD34(lo) or CD34(hi), α6(hi)β1(hi) populations can initiate secondary tumors by serial limit-dilution transplantation assays, but α6(lo)β1(lo) populations cannot. Moreover, secondary tumors generated from a single CSC of either subtype contain both CD34(lo) and CD34(hi) α6(hi)β1(hi)CSCs, indicating their nonhierarchical organization. Genomic profiling and hierarchical cluster analysis show that these two CSC subtypes share a molecular signature distinct from either the CD34(-) epidermal or the CD34(hi) hair follicle stem cell signature. Although closely related, α6(hi)β1(hi)CD34(lo) and α6(hi)β1(hi)CD34(hi) CSCs differ in cell-cycle gene expression and proliferation characteristics. Indeed, proliferation and expansion of α6(hi)β1(hi)CD34(hi) CSCs is sensitive to whether they can initiate a TGF-β receptor II-mediated response to counterbalance elevated focal adhesion kinase-mediated integrin signaling within the tumor. Overall, the coexistence and interconvertibility of CSCs with differing sensitivities to their microenvironment pose challenges and opportunities for SCC cancer therapies.
    Keywords: Signal Transduction ; Carcinoma, Squamous Cell -- Pathology ; Focal Adhesion Protein-Tyrosine Kinases -- Metabolism ; Integrins -- Metabolism ; Neoplastic Stem Cells -- Pathology ; Skin Neoplasms -- Pathology ; Transforming Growth Factor Beta -- Metabolism
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 4
    Language: English
    In: Earth and Planetary Science Letters, 2008, Vol.265(3), pp.546-558
    Description: Playa-like sediments from the Hajar Mountain range in northern Oman (22.83°N, 59.00°E; 1050 m asl) document variations of the paleoenvironmental and paleoclimate conditions over the last 20 ka. Based on high-resolution sediment sampling and their OSL dating, sedimentation rates were calculated and used as a proxy for paleorainfall. The results show that the Glacial to Lateglacial was characterized by arid conditions with a following transitional period of even less rainfall. At 10.5 ka, sedimentation rates increases abruptly, indicating the onset of the early Holocene humid period (EHHP). Rainfall reaches its maximum at 9–8 ka (EHHP-2) and a decreasing sedimentation rate after 8 ka characterizes the arid period of the middle to late Holocene. Variations of the hydrological regime are associated with the intensity of the boreal summer Indian monsoon and its related position of the ITCZ. For the onset of the EHHP, a northerly shift of the ITCZ is postulated, thus confirming earlier results from the southern Arabian Peninsula.
    Keywords: Indian Ocean Monsoon ; Climate Change ; Paleoprecipitation ; Sedimentation Rate ; Luminescence Dating ; Quaternary ; Arabia ; Oman ; Geology ; Physics
    ISSN: 0012-821X
    E-ISSN: 1385-013X
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  • 5
    Language: English
    In: Zeitschrift für Geomorphologie, Supplementary Issues, 01 February 2014, Vol.58(1), pp.5-26
    Description: Climatic signals are considered as well preserved in loess records. To assess their significance in a local and global context a reliable numerical chronology is needed. Luminescence dating provides an established dating method on natural mineral grains of quartz and feldspar by measuring the last time of the daylight exposure. For the field trip of the 37 super(th) meeting of the German working group on geomorphology to the Saxony-Anhalt loess belt, the upper part of the Quaternary profile Zeuchfeld has been reinvestigated. The profile is well known for its sandur (Zeuchfeld Sandur) situated at the base of the profile, assumed to be of Late Saalian age (MIS 6). Here, OSL quartz age estimates for the overlying loess deposits from the last glacial-interglacial cycle are reported. Furthermore, the underlying sandur has been sampled for conventional SAR dating on quartz and IR-RF dating on potassium rich feldspar. The OSL age estimates have been determined for three commonly used quartz grain size fractions (coarse, middle and fine grain). The results suggest at least two phases of loess deposition and preservation around 70 ka and 30 ka to 22 ka confirmed by previous assumptions based on field work and recent pedo- and lithostratigraphic correlation. In contrast, the quartz SAR and the IR-RF measurements from the underlying sandur yield a substantially older (pre-Saalian) age. The reasons for the assumed age overestimation and the details of the luminescence dating results are presented and discussed.
    Keywords: Sciences of the Universe ; Earth Sciences ; Geography
    ISSN: 1864-1687
    E-ISSN: 1864-1687
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  • 6
    Language: English
    In: Quaternary International, 16 November 2012, Vol.279-280, pp.152-153
    Keywords: Geology
    ISSN: 1040-6182
    E-ISSN: 1873-4553
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    Language: English
    In: Quaternary International, 16 November 2012, Vol.279-280, pp.153-153
    Keywords: Geology
    ISSN: 1040-6182
    E-ISSN: 1873-4553
    Source: ScienceDirect Journals (Elsevier)
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  • 8
    In: Zeitschrift für Geomorphologie, April 2017, Vol.61(1), pp.1-2
    ISSN: 1864-1687
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  • 9
    In: Nature, 2008, Vol.452(7184), p.225
    Description: In stratified epithelial tissues, homeostasis relies on the self-renewing capacity of stem cells located within the innermost basal layer. As basal cells become suprabasal, they lose proliferative potential and embark on a terminal differentiation programme. Here, we show that microRNA-203 is induced in the skin concomitantly with stratification and differentiation. By altering miR-203's spatiotemporal expression in vivo, we show that miR- 203 promotes epidermal differentiation by restricting proliferative potential and inducing cell-cycle exit. We identify p63 as one of the conserved targets of miR-203 across vertebrates. Notably, p63 is an essential regulator of stem-cell maintenance in stratified epithelial tissues. We show that miR- 203 directly represses the expression of p63: it fails to switch off suprabasally when either Dicer1 or miR-203 is absent and it becomes repressed basally when miR-203 is prematurely expressed. Our findings suggest that miR- 203 defines a molecular boundary between proliferative basal progenitors and terminally differentiating suprabasal cells, ensuring proper identity of neighbouring layers.
    Keywords: Differentiation ; Basal Cells ; Stem Cells ; Skin ; Mirna ; Homeostasis ; RNA;
    ISSN: 0028-0836
    E-ISSN: 14764687
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  • 10
    Language: English
    In: DEUQUA Special Publications, 2018, Vol.1, pp.1-2
    ISSN: DEUQUA Special Publications
    E-ISSN: 2625-8137
    Source: CrossRef
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