Format:
Online-Ressource
ISSN:
1521-4141
Content:
Abstract: CD22 (Siglec‐2) is a B‐cell membrane‐bound lectin that recognizes glycan ligands containing α2,6‐linked sialic acid (α2,6Sia) and negatively regulates signaling through the B‐cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B‐cell activation similar to the Fc receptor for IgG (FcγRIIB).
In:
volume:42
In:
number:1
In:
year:2011
In:
pages:241-247
In:
extent:7
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 42, Heft 1 (2011), 241-247 (gesamt 7), 1521-4141
Language:
English
DOI:
10.1002/eji.201141899
URN:
urn:nbn:de:101:1-2023030108194911605774
URL:
https://doi.org/10.1002/eji.201141899
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023030108194911605774
URL:
https://d-nb.info/1282161709/34
URL:
https://doi.org/10.1002/eji.201141899
Bookmarklink