Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 1
    Language: English
    In: Facial Plastic Surgery, 2015, Vol.31(04), pp.345-350
    Description: Injuries to the eye and its adnexa are common in head and neck trauma centers. An ophthalmologist experienced in ocular traumatology is not always available. Therefore, every emergency physician should be familiar with the basic evaluation, triage, and management of ocular trauma. Above all, the identification of a need for immediate treatment should be implemented in the algorithm of an emergency room, especially in a head and neck trauma center, to reduce the risk of a devastating loss of vision. This article formulates the different types of ocular trauma and their required first-line therapy.
    Keywords: Orbital compartment ; Retrobulbar hematoma ; Cantholysis ; Open-globe injury ; Eyelid injury
    ISSN: 0736-6825
    E-ISSN: 1098-8793
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Medical Microbiology and Immunology, 2013, Vol.202(1), pp.37-47
    Description: Although several host factors have been identified to influence the course of HCMV infection, it still remains unclear why in AIDS patients without highly active antiretroviral therapy human cytomegalovirus (HCMV) retinitis is one of the most common opportunistic infections, whereas in other immunosuppressed individuals it has a low incidence. It was suggested that HCMV glycoprotein B strains may be suitable as marker for virulence and HCMV retinitis. Moreover, UL144 ORF, a member of the TNF-α receptor superfamily, may play a crucial role in innate defences and adaptive immune response of HCMV infection. Furthermore, sequence analyses of HCMV genes UL128, UL130, and UL131A as major determinants of virus entry and replication in epithelial and other cell types were performed. To evaluate the association of sequence variability of depicted viral genes with HCMV retinitis and in vitro growth properties in retinal pigment epithelial cells (RPE) and human foreskin fibroblasts (HFF), we compared 14 HCMV isolates obtained from vitreous fluid and urine of AIDS patients with clinically proven HCMV retinitis. Isolates were analyzed by PCR cycle sequencing and phylogenetic analysis. In addition, sequences of HCMV strains AF1, U8, U11, VR1814, and its cell culture adapted derivates were included. Sequence analysis of gB yielded three genetic subtypes (gB type 1 (5 isolates), gB type 2 (12 isolates), and gB type 3 (5 Isolates)), whereas sequence analysis of UL144 showed a greater diversity (7 isolates type 1A, 2 isolates type 1C, 7 isolates type 2, and 3 isolates type 3). In contrast, the UL128, UL130, and UL131A genes of all low-passage isolates were highly conserved and showed no preferential clustering. Moreover, in HFF and RPE cells, all of our HCMV isolates replicated efficiently independently of their genetic subtype. In conclusion, beside a possible link between the gB subtype 2 and HCMV retinitis, our study found no direct evidence for a connection between UL144/UL128/UL130/UL131A genotypes and the incidence of HCMV retinitis in AIDS patients.
    Keywords: Cytomegalovirus ; Viral tropism and virulence ; Retinitis ; AIDS
    ISSN: 0300-8584
    E-ISSN: 1432-1831
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Antimicrobial Agents and Chemotherapy, 12/01/1998, Vol.42(12), pp.3332-3332
    Description: Defensins are a family of small cationic, antibiotic peptides that contain six cysteines in disulfide linkage. The mechanism of action of these peptides is based on their ability to form pores in the cytoplasmatic membrane in microorganisms. The first peptide antibiotic that has been identified in humans, hBD-1, is produced constitutively in the epithelium of the urinary tract, trachea, and lungs. In a recent study, a second human beta-defensin, hBD-2, has been isolated from skin. It has been demonstrated that hBD-2 is highly effective in killing gram-negative bacteria and Candida albicans. These findings prompted us to investigate whether beta-defensins are present in the conjunctiva of the human eye.
    Keywords: Antibiotics ; Conjunctiva ; Gram-Negative Bacteria ; Peptide and Protein Antibiotics ; Defensins ; Hbd-1 ; Man ; Defensins ; Hbd-1 ; Man;
    ISSN: 0066-4804
    E-ISSN: 1098-6596
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: German
    In: Klinische Monatsblatter fur Augenheilkunde, October 2003, Vol.220(10), pp.699-703
    Description: Side by side with the progress in computers and imaging, telemedicine has already been used successfully in a large number of specialties of medicine. But high-quality images are not always suitable for transfer via modem because of their file size. The present experimental study was conducted to determine the effects of image compression by the JPEG algorithm on image quality and on the reliability of diagnosis after compression. Digital photographs of the retina were taken and the JPEG compressed images assessed by an experienced ophthalmologist. The present study showed a high reliability of diagnosis and a good agreement between the observations taken at the patient and at the computer. For this reason, JPEG image compression algorithm is suitable for reducing image size for producing high-quality images manageable for transmitting via modem in a store-and-forward teleophthalmological system.
    Keywords: Data Compression -- Trends ; Fluorescein Angiography -- Trends ; Ophthalmology -- Trends ; Radiographic Image Enhancement -- Trends ; Remote Consultation -- Trends ; Retinal Diseases -- Diagnosis ; Telemedicine -- Trends
    ISSN: 0023-2165
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Ophthalmologica, 1997, Vol.211(Suppl 1), pp.53-61
    Description: All opportunistic infections of the eye have their origin in the suppression of the immune system of the host. The immunosuppression can be acquired through the human immune deficiency virus or as a result of immunosuppressive therapy in solid-organ transplant recipients with a maintenance therapy of cyclosporin and prednisone or during chemotherapy in patients with myelo-proliferative disorders. Generally, in less than 2% could severe opportunistic infections of the eye, like cytomegalovirus (CMV) or herpes virus infection, be found in transplant and cancer patients with chemotherapy. About 35–70% of patients with AIDS exhibit ocular manifestations of disease, so the most notable opportunistic infection with an incidence of 35% would be CMV retinitis. Less frequent are progressive outer retinal necrosis syndrome, Kaposi's sarcoma and optic neuropathies. This paper reviews recent advances in the diagnosis and special local therapies of the worst opportunistic infections in immunocompromised hosts.
    Keywords: Paper ; AIDS ; Cytomegalovirus ; Opportunistic Infection ; Immunosuppression ; Chemotherapy ; Medicine
    ISSN: 0030-3755
    E-ISSN: 1423-0267
    Source: Karger Journals (S. Karger AG)
    Source: Karger (S. Karger AG)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: Acta Ophthalmologica Scandinavica, April 2005, Vol.83(2), pp.264-265
    Keywords: Anterior Chamber -- Drug Effects ; Fluorocarbons -- Adverse Effects ; Retinal Detachment -- Surgery;
    ISSN: 1395-3907
    E-ISSN: 1600-0420
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: German
    In: Klinische Monatsblätter für Augenheilkunde, 2003, Vol.220(10), pp.699-703
    Description: Zusammenfassung Die Telemedizin nimmt dank der raschen Entwicklung im Bereich der elektronischen Datenverarbeitung inzwischen einen festen Platz in der konsiliarischen Mitbeurteilung in fast allen Bereichen der Medizin ein. Nicht immer sind aber hochauflösende Bilder aufgrund ihrer Dateigröße für den Versand via Datenfernübertragung geeignet. In der vorliegenden Studie wurde der Einfluss des Komprimierungsverfahrens JPEG auf die Bildqualität und die Beurteilbarkeit der Befunde geprüft. Hierzu wurden von Patienten Fundusfotos mittels einer Digitalkamera erfasst und nach Komprimierung nochmals befundet. Es hat sich gezeigt, dass auch nach Komprimierung der digitalen Fundusfotos bei guter Bildqualität mit hoher Diagnosesicherheit eine gute Übereinstimmung mit Befunden, die direkt am Patienten erhoben wurden, gefunden werden konnten. Daher ist auch die telemedizinische Beurteilung digital erfasster Augenhintergrundveränderungen nach Kompression der Bilddaten mittels JPEG grundsätzlich möglich und kann somit eine Hilfestellung in der Beurteilung andernorts erhobener Befunde sein.
    Description: Side by side with the progress in computers and imaging, telemedicine has already been used successfully in a large number of specialities of medicine. But high-quality images are not always suitable for transfer via modem because of their file size. The present experimental study was conducted to determine the effects of image compression by the JPEG algorithm on image quality and on the reliability of diagnosis after compression. Digital photographs of the retina were taken and the JPEG compressed images assessed by an experienced ophthalmologist. The present study showed a high reliability of diagnosis and a good agreement between the observations taken at the patient and at the computer. For this reason, JPEG image compression algorithm is suitable for reducing image size for producing high-quality images manageable for transmitting via modem in a store-and-forward teleophthalmological system.
    Keywords: Fundusveränderungen ; Telemedizin ; Fundusfotografie ; Komprimierungsverfahren ; Jpeg ; Diagnosesicherheit ; Bildqualität ; Retinal Photographs ; Telemedicine ; Retinal Disease ; Image Compression ; Jpeg ; Reliability Of Diagnosis ; Image Quality
    ISSN: 0023-2165
    E-ISSN: 1439-3999
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: German
    In: Klinische Monatsblätter für Augenheilkunde, 2002, Vol.219(7), pp.512-518
    Description: Zusammenfassung Hintergrund: Subfoveale Blutungen stellen eine häufige Komplikation choroidaler Neovaskularisationen bei der altersbezogenen Makuladegeneration (AMD) dar. Es konnte gezeigt werden, dass sich durch die intravitreale Injektion von rekombinantem Gewebsplasminogenaktivator (rt-PA) und Gas eine Dislokation solcher Hämorrhagien und damit eine Visusverbesserung erreichen lässt. Bisher wurde diese Methode jedoch vor allem zur Behandlung großflächiger Blutungen eingesetzt. Wir untersuchten die Wirksamkeit der kombinierten intravitrealen Injektion von rt-PA und Gas zur Therapie kleinflächiger subfovealer Blutungen. Patienten und Methode: In einer prospektiven Studie wurden 25 Augen von 25 Patienten mit akuter (≤ 28 Tage) subfovealer Blutung bei AMD und deutlichem Visusverlust mittels intravitrealer Injektion von rt-PA (50 µg) und Schwefelhexafluorid (0,5 ml) behandelt. Die Größe der Blutungen reichte von ? - 2 Papillendurchmesser. Die Nachuntersuchungszeit lag bei 4 - 18 Monaten (Mittel: 7,1 Monate). Ergebnisse: Bei 11 von 25 Augen (44 %) konnte eine maximale Verbesserung der zentralen Sehschärfe von zwei oder mehr Visusstufen erzielt werden. Am Ende der Nachbeobachtungszeit lag dieser Anteil noch bei 28 %. In der Gruppe der 9 Augen mit einer Latenzzeit ≤ 14 Tage wurde in sieben Fällen (78 %) eine maximale Visusverbesserung von mindestens zwei Stufen erreicht, wohingegen nur bei 4 von 16 Augen mit einer Latenzzeit 〉 14 Tage ein vergleichbares Ergebnis beobachtet wurde (p = 0,017). Nebenwirkungen oder Komplikationen wurden nicht beobachtet. Schlussfolgerungen: Unsere Ergebnisse weisen darauf hin, dass sich durch die intravitreale Injektion von rt-PA und Gas eine rasche Verbesserung der zentralen Sehschärfe sowie eine Erweiterung der diagnostischen und therapeutischen Möglichkeiten bei AMD-bedingten kleinflächigen subfovealen Blutungen erreichen lässt. Die Latenzzeit (≤ 14 Tage) ist dabei von entscheidender prognostischer Bedeutung. Eine langfristige Verbesserung der Visusprognose ist allerdings durch die Progression der zugrunde liegenden AMD begrenzt. Das Komplikationsrisiko dieser minimalinvasiven Methode scheint gering.
    Description: Background: Subfoveal haemorrhage is a serious complication of choroidal neovascularization in age-related macular degeneration (ARMD). Recent studies have demonstrated that intravitreal injections of the fibrinolytic agent recombinant tissue plasminogen activator (rt-PA) and expansile gas may be effective in displacing submacular blood and facilitating visual improvement. However, in most of these studies, this technique has been used for the management of major haemorrhages. The purpose of our study was to investigate the efficacy of treating minor subfoveal haemorrhages with intravitreal rt-PA and pneumatic displacement. Patients and methods: In a prospective study, 25 consecutive eyes of 25 patients with recent (≤ 28 days) subfoveal haemorrhage secondary to ARMD and severe visual loss were treated with intravitreous injections of rt-PA (50 µg) and sulfur hexafluoride (0,5 ml). The extent of the haemorrhage ranged from ? to 2 disc areas. Patient follow-up ranged between 4 and 18 months. Results: Best postoperative visual acuity compared with preoperative visual acuity was improved by two or more Snellen lines in 11 of 25 eyes (44 %). Seven eyes (28 %) maintained this level at the final visit. Duration of haemorrhage was associated with a better gain of lines of vision. In a subgroup of 9 eyes with duration of haemorrhage ≤ 14 days, 7 (78 %) improved by two or more Snellen visual acuity lines, whereas only 4 of 16 eyes (25 %) with duration of haemorrhage 〉 14 days showed a comparable outcome (p = 0.017). There were no side effects or complications. Conclusions: Our findings suggest that intravitreous injections of rt-PA and sulfur hexafluoride are of value for an improved and accelerated visual recovery in ARMD patients with minor subfoveal haemorrhages. Duration of haemorrhage ≤ 14 is associated with a better gain of lines of vision. Final visual outcome, however, is limited by the underlying ARMD. In addition, a rapid displacement of subfoveal haemorrhages may reveal discrete choroidal neovascular membranes amenable to further treatment. The complication rate of this therapeutic approach appears to be low.
    Keywords: Altersbezogene Makuladegeneration ; Choroidale Neovaskularisation ; Rekombinanter Gewebsplasminogenaktivator ; Age-Related Macular Degeneration ; Choroidal Neovascularization ; Recombinant Tissue Plasminogen Activator
    ISSN: 0023-2165
    E-ISSN: 1439-3999
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis, August 2002, Vol.6(4), pp.271-81
    Description: Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the elderly. Successful therapy is not yet available for the majority of patients, especially not for patients with dry AMD. AMD at cellular and molecular levels is at least in part a microcirculatory disorder...
    Keywords: Blood Viscosity ; Blood Component Removal -- Methods ; Macular Degeneration -- Therapy
    ISSN: 1091-6660
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Ophthalmology, 2001, Vol.108(8), pp.1485-1492
    Description: To investigate the efficacy and safety of treating submacular hemorrhages secondary to age-related macular degeneration (ARMD) with intravitreous recombinant tissue plasminogen activator (rt-PA) and gas under various conditions. Prospective, noncomparative case series. Forty-three consecutive eyes of 42 patients with recent (range, 2-28 days) subfoveal hemorrhage secondary to ARMD were included in this study. The size of subretinal hemorrhage ranged from 0.25 to 30 disc areas. All patients were treated with intravitreous injections of rt-PA (50 microg) and sulfur hexafluoride (0.5 ml). Postoperative prone positioning was maintained for 24 to 72 hours. Patient follow-up ranged from 4 to 18 months (mean, 6 months). Best and final postoperative visual acuity in relation to size and onset of hemorrhage, displacement of subretinal blood, and surgical complications. Best postoperative visual acuity compared with preoperative visual acuity was improved two or more Snellen lines in 19 eyes (44%) and stable in 24 eyes (56%). Final visual acuity was improved two or more lines in 13 eyes (30%), stable in 26 (61%), and two or more lines worse in 4 eyes (9%). Duration of hemorrhage 〈or=14 days was associated with a better gain of lines of vision (P = 0.0058). Best postoperative acuity was maintained for an average of 4.2 months (range, 0.5-12 months). Overall, complete displacement of blood from under the fovea was achieved in 35 eyes (81%). Nine eyes (21%) developed recurrent hemorrhage, which required repeat treatment. In three patients (7%), a mild breakthrough vitreous hemorrhage was observed. Our findings suggest that intravitreous injections of rt-PA and gas are of value for an improved and accelerated visual recovery in ARMD patients with submacular hemorrhage, although final visual outcome is often limited by the progression of the underlying ARMD. Patients with retinal hemorrhages of recent onset (〈or=14 days) seem to have the most favorable results. A rapid displacement of submacular blood may reveal discrete choroidal neovascular membranes amenable to further treatment. The complication rate of this minimally invasive technique seems to be low.
    Keywords: Medicine
    ISSN: 0161-6420
    E-ISSN: 1549-4713
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages