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  • 1
    UID:
    almahu_9949419414502882
    Format: X, 302 p. , online resource.
    Edition: 1st ed. 2008.
    ISBN: 9780387691183
    Content: Tumor Induced Immune Suppression: Mechanisms and Therapeutic Reversal focuses on the critical question of tumor biology: "Why can tumors escape immune system control?" It also addresses one of the most important problems within the field of clinical oncology: the lack of efficient cancer vaccines. Edited by Dmitry Gabrilovich and Andy Hurwitz, the book is the first attempt at a systematic and comprehensive analysis of the various immunosuppressive mechanisms in cancer. This analysis includes information on: Different surface molecules that mediate T-cell suppression in cancer; The specific roles of dendritic cells, macrophages, and myeloid-derived suppressor cells in tumor non-responsiveness; The contribution of regulatory T cells in the inability of immune systems to mount antitumor response; The role of T-cell signaling and different metabolic pathways in tumor-associated immune suppression. This volume connects a multitude of different immunosuppressive mechanisms into one cohesive picture. Most of the chapters not only describe the biological phenomena, but also suggest specific approaches to their correction. This book should be of high interest for researchers in the fields of tumor immunology and general immunology, as well as for those who are involved in clinical oncology and cancer immunotherapy.
    Note: Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions -- Mechanisms of Tumor-Associated T-Cell Tolerance -- Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer -- Regulatory T Cells in Cancer -- Cancer-Induced Signaling Defects in Antitumor T Cells -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Myeloid-Derived Suppressor Cells in Cancer -- Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Arginine Availability Regulates T-Cell Function in Cancer -- Protein-Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3 -- Role of Reactive Oxygen Species in T-Cell Defects in Cancer -- Tumor Stroma and the Antitumor Immune Response.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9781441924001
    Additional Edition: Printed edition: ISBN 9780387517520
    Additional Edition: Printed edition: ISBN 9780387691176
    Language: English
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  • 2
    Online Resource
    Online Resource
    London :Imperial College Press ;
    UID:
    almahu_9948317319002882
    Format: xxiii, 422 p. : , ill.
    Edition: 3rd ed.
    Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.
    Language: English
    Keywords: Electronic books.
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  • 3
    Online Resource
    Online Resource
    Hackensack, N.J. :Imperial College Press,
    UID:
    almahu_9948309966102882
    Format: xxii, 355 p.
    Edition: 2nd ed.
    Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.
    Language: English
    Keywords: Electronic books.
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  • 4
    Online Resource
    Online Resource
    Hackensack, N.J. :Imperial College Press,
    UID:
    edocfu_9959245457902883
    Format: 1 online resource (378 p.)
    Edition: 2nd ed.
    ISBN: 1-281-86662-8 , 9786611866624 , 1-86094-605-4
    Content: This is a second edition of the book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been implicated in anti-tumor response.
    Note: Description based upon print version of record. , Contents; Preface; Contributors; 1 The Remarkable Neutrophil! Developing a Blueprint for Integrated Cellular Signaling; 2 The Neutrophil Respiratory Burst Oxidase; 3 Novel Neutrophil Receptors and Their Signal Transduction; 4 Mechanisms of Neutrophil Migration; 5 Neutrophils and Apoptosis; 6 Regulation of Neutrophil Functions by Long Chain Fatty Acids; 7 Cytokine Production by Neutrophils; 8 Neutrophils in Viral Infections; 9 Polymorphonuclear Neutrophils and Cancer: Ambivalent Role in Host Defense Against Tumor , 10 Use of Colony-Stimulating Factors for Treatment of Neutropenia and Infectious Diseases11 Neutrophil Transfusion Therapy in the G-CSF Era; Index , English
    Additional Edition: ISBN 1-86094-472-8
    Language: English
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  • 5
    Online Resource
    Online Resource
    London :Imperial College Press ;
    UID:
    edocfu_9959239853402883
    Format: 1 online resource (378 p.)
    ISBN: 1-84816-077-1
    Content: This invaluable volume, written by group of internationally established scientists, presents an overview of the most recent findings on the biology of neutrophils. These cells have become a focus of attention in recent years because of their fascinating biochemistry and molecular biology and their ability to affect the functions of other cells. The book describes, in detail, the molecular events leading to neutrophil activation, migration, microbial killing, production of oxidative radicals and cytokines, and eventually to the death of these cells. It presents new information that has never be
    Note: Description based upon print version of record. , PREFACE; LIST OF CONTRIBUTORS; CONTENTS; CHAPTER 1 MOLECULAR BASIS OF NEUTROPHIL ACTIVATION; 1. A Cell of Discovery; 2. Signal Transduction: Communication Across the Plasma Membrane; 2.1 General considerations; 2.2 Advantage: Neutrophil; 2.3 Molecular probes; 2.4 Metabolic agonists; 3. Molecular Pathways of Cellular Activation; 3.1 G protein-coupled receptors; 3.1.1 Neutrophil migration; 3.2 Tyrosine phosphorylation and neutrophil activation; 3.2.1 Tyrosine-kinase dependent chemotactic responses; 3.3 PIP 3 and the role of PI3 kinase; 3.4 Role of PLD in stimulated Neutrophils , 3.4.1 Phosphatidic acid and oxidative activation4. Activation of PLD; 5. Concluding Remarks: Joining Upstream and Downstream Processes; 6. References; CHAPTER 2 THE RESPIRATORY BURST OF NEUTROPHILS: OXIDATIVE PATHWAYS FOR THE INITIATION OF TISSUE DAMAGE AT SITES OF INFLAMMATION; 1. Introduction; 2. Respiratory Burst Oxidase; 3. Oxidative Killing Mechanisms; 3.1 Superoxide; 3.2 Hydrogen peroxide; 3.3 Myeloperoxidase-hydrogen peroxide-chloride system; 3.4 Hydroxyl radical; 3.5 Singlet oxygen; 3.6 Reactive nitrogen species; 4. Phagocytes, Myeloperoxidase and Oxidative Damage of Tissue , 4.1 Tyrosyl radical4.2 Human phagocytes use myeloperoxidase to generate a family of tyrosine oxidation products by a tyrosyl radical-dependent pathway; 4.3 Tyrosyl radical promotes the cross-linking of tyrosine residues in proteins; 4.4 Tyrosyl radical peroxidizes lipid moieties of LDL; 4.5 Myeloperoxidase converts tyrosine to a reactive aldehyde by an HOCl-dependent reaction; 4.6 Myeloperoxidase generates chlorine gas; 4.7 Myeloperoxidase chlorinates cholesterol; 5. Active Myeloperoxidase is Present in Human Atherosclerotic Lesions , 6. Oxidation Products Generated by Myeloperoxidase are Present in Human Atherosclerotic Lesions7. Conclusions; 8. References; CHAPTER 3 MECHANISM OF LEUKOCYTE ACCUMULATION IN POSTISCHEMIC TISSUES: ROLE OF OXYGEN FREE RADICALS; 1. Introduction; 2. Effects of Oxidants and Oxygen Free Radicals on PMN Adhesion Molecule Expression and Functional Adhesion; 3. Effects of Oxidants and Oxygen Free Radicals on CD18 Mediated PMN Adhesion in the Postischemic Heart; 4. Conclusion; 5. References; CHAPTER 4 REGULATION OF NEUTROPHIL FUNCTIONS BY FATTY ACIDS; 1. Introduction , 2. Sources of Arachidonic Acid and Other Fatty Acids2.1 De novo synthesis; 2.2 Diet; 2.3 Phospholipase A; 3. Transport and Uptake of Fatty Acids; 4. Metabolism of Arachidonic Acid and Other Fatty Acids; 4.1 General; 4.2 Metabolism in neutrophils; 4.2.1 5-lipoxygenase; 4.2.2 12-lipoxygenase; 4.2.3 15-lipoxygenase; 4.2.4 Cyclooxygenase; 4.2.5. ω-oxidation; 5. Transcellular Metabolism; 6. Biological Properties of Arachidonic Acid; 6.1 Effects on neutrophil adhesion, cell migration and chemotaxis; 6.2 Activation of the NADPH oxidase; 6.3 Stimulation of degranulation , 7. Effects of n-3 Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acid on Neutrophils , English
    Additional Edition: ISBN 1-86094-082-X
    Language: English
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  • 6
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    gbv_1647111544
    Format: Online-Ressource (digital)
    ISBN: 9780387691183
    Series Statement: SpringerLink
    Additional Edition: ISBN 9780387691176
    Additional Edition: Buchausg. u.d.T. ISBN 978-0-387-69117-6
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 7
    UID:
    gbv_1653639210
    Format: Online-Ressource (XIV, 464 p. 38 illus., 34 illus. in color, online resource)
    Edition: 2nd ed. 2014
    ISBN: 9781489980564
    Series Statement: SpringerLink
    Content: Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights
    Note: Description based upon print version of record , Preface.- Regulatory T Cells and CancerTh17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 - Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer -- Index.
    Additional Edition: ISBN 9781489980557
    Additional Edition: Erscheint auch als Druck-Ausgabe Tumor-induced immune suppression New York, NY [u.a.] : Springer, 2014 ISBN 9781489980557
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    RVK:
    Keywords: Immunsuppression ; Tumor
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 8
    Online Resource
    Online Resource
    London :Imperial College Press ; | London :Imperial College Press,
    UID:
    edocfu_9959239610802883
    Format: 1 online resource (xxiii, 422 pages) : , illustrations (some color)
    Edition: 3rd ed.
    ISBN: 1-299-46292-8 , 1-84816-837-3
    Series Statement: Gale eBooks
    Uniform Title: Neutrophils (2013)
    Content: This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of
    Note: Description based upon print version of record. , List of Contributors; Preface; Contents; Chapter 1: Molecular Regulation of Granulopoiesis Sachin Kumar and Marie-Dominique Filippi; 1.1 Introduction; 1.2 Sequential Steps of PMN Development; 1.2.1 From HSC to granulocytic precursors; 1.2.2 Final stages of granulocytic maturation - Acquisition of granulocyte characteristics; 1.3 Regulation of Steady State Granulopoiesis; 1.3.1 Growth factors; 1.3.1.1 G-CSF: Sources and functions; 1.3.1.2 G-CSFR and downstream signaling pathways; 1.3.1.3 G-CSFR signaling: Instructive or permissive?; 1.3.2 Transcription factors (TF) , 1.3.2.1 PU.1 - Generation of CMP from HSC1.3.2.2 C/EBPα - Generation of GMP from CMP; 1.3.2.3 C/EBPε - Terminal stages of differentiation; 1.3.2.4 Gfi-1 - Terminal stages of differentiation; 1.3.2.5 Other transcription factors important for granulopoiesis; 1.3.2.5.1 Retinoic acid receptors; 1.3.2.5.2 HoxA10; 1.3.2.5.3 LEF-1; 1.3.3 MicroRNA; 1.3.4 Cell cycle regulation; 1.4 Emergency Granulopoiesis; 1.5 Conclusion; References; Chapter 2: The Neutrophil Respiratory Burst Oxidase Mark T. Quinn; 2.1 Introduction; 2.2 NADPH Oxidase Components; 2.2.1 Flavocytochrome b; 2.2.2 p47phox; 2.2.3 p67phox , 2.2.4 p40phox2.2.5 Rac; 2.2.6 Rap1A; 2.3 Oxidase Protein Binding Interactions; 2.3.1 Flavocytochrome b-p47phox interactions; 2.3.2 p40phox-p47phox-p67phox interactions; 2.3.3 Rac interactions; 2.4 Model of NADPH Oxidase Assembly; 2.5 Oxidant Production; 2.5.1 Superoxide anion (O2 -); 2.5.2 Hydrogen peroxide (H2O2); 2.5.3 Hypochlorous acid (HOCl); 2.5.4 Hydroxyl radical (HO); 2.5.5 Singlet oxygen ( 1O2 *); 2.5.6 Nitric oxide (NO) and peroxynitrite (ONOO-); 2.7 Summary; Acknowledgments; References , Chapter 3: Novel Neutrophil Receptors and Their Signal Transduction Nicole R. Fortenbery, Xianhong Chen and Sheng Wei3.1 Introduction; 3.2 Siglecs; 3.2.1 Identification of siglecs; 3.2.2 Characterization of siglecs; 3.2.3 Siglec-5; 3.2.4 Siglec-9; 3.2.5 Siglec-14; 3.2.6 Siglec signaling; 3.2.7 Clinical applications; 3.3 Triggering Receptor Expressed by Myeloid Cells (TREM); 3.3.1 Identification of TREM; 3.3.2 Characterization of TREM-1; 3.3.3 TREM-1-DAP12 and signal transduction; 3.3.4 TREM-1 ligand(s); References , Chapter 4 Mechanisms of Neutrophil Migration Fong W. Lam, Rolando E. Rumbaut and Alan R. Burns4.1 Introduction; 4.2 Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955); 4.2.1 The first observations; 4.2.2 Mechanistic insight; 4.3 Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration; 4.4 Integrin Regulation of Neutrophil Transendothelial Migration; 4.5 Paracellular Neutrophil Transendothelial Migration; 4.5.1 Endothelial cleft organization; 4.5.2 Tight junctions and preferred transmigration sites; 4.5.3 Adherens junctions; 4.5.4 Gap junctions , 4.5.5 PECAM-1 , English
    Additional Edition: ISBN 1-84816-836-5
    Language: English
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  • 9
    Online Resource
    Online Resource
    London :Henry Stewart Talks,
    UID:
    edoccha_9961427317202883
    Format: 1 videorecording (48 min., 53 sec.) , 004853
    Series Statement: Immunotherapy of cancer,
    Note: Animated audio-visual presentation with synchronized narration. , Title from title frames. , Contents: Myeloid derived suppressor cells (MDSC) and their potent immune suppressive activity -- MDSC in cancer -- MDSC in chronic infections -- MDSC during stress -- MDSC in surgical trauma -- The two main populations of MDSC: monocytic MDSC (M-MDSC) and polymorphonuclear MDSC (PMN-MDSC) -- Biological differences between MDSC and their normal counterparts -- Multiple mechanisms of expansion regulation and immune suppressive function of MDSC -- MDSC role in antigen-specific T cell tolerance in tumor-bearing mice -- Therapeutic regulation of MDSC in mice and humans.
    Language: English
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  • 10
    Online Resource
    Online Resource
    London :Henry Stewart Talks,
    UID:
    edoccha_9961433428302883
    Format: 1 videorecording (40 min., 58 sec.) : , sound, color , 004058
    Series Statement: The immune system - key concepts and questions,
    Note: Animated audio-visual presentation with synchronized narration. , Title from title frames. , Contents: Myeloid cells in cancer -- Tumor associated macrophages and MDSC regulate tumor progression -- Immunosuppressive activity of MDSC -- Effect of S100A9 on suppressive activity -- IFNAR1 is downregulated in MDSCs -- Ferroptosis -- Approaches to target myeloid cells in cancer.
    Language: English
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