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  • 1
    Article
    Article
    BMJ Publishing Group Ltd and British Society of Gastroenterology
    Language: English
    In: Gut July 2010, Vol.59(7), p.870
    Description: Ever since Ernest McCulloch and James E Till defined essential stem cell properties, the field of stem cell biology has attracted increasing interest.1 Manipulating embryonic stem cells has resulted in advanced genetic technologies such as knock-out and transgenic animals, providing valuable models to study genetic influence on a wide variety of diseases.2 The success in manipulating stem cells and the ability to differentiate them into diverse tissues brought with them countless concepts of utilising stem cells in medicine. The idea of perpetually dividing pluripotent cells, capable of differentiating into nearly every possible cell or tissue type, seems like an inexhaustible resource for regenerative medicine. At the same time it became increasingly clear that stem cells are not just beneficial since tumours of various origins also contain stem cells that help them to proliferate but also to escape conventional chemotherapy. Furthermore, even embryonic pluripotent stem cells have a tumourigenic potency, which is one of the major hurdles to their utilisation in therapeutic concepts. Thus, the existence of stem cells must be considered a double-edged sword.3
    Keywords: Liver ; Stem Cells
    ISSN: 0017-5749
    ISSN: 00175749
    E-ISSN: 1468-3288
    E-ISSN: 14683288
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  • 2
    Language: English
    In: The Lancet, 24 June 2017, Vol.389(10088), pp.2448-2449
    Description: Thus, the definition of a first and so far only standard of care for hepatocellular carcinoma, a milestone 10 years ago, was followed by gridlock; no standard treatment exists for patients with acquired resistance or intolerance to sorafenib.2 However, there is some hope. Another multikinase inhibitor, regorafenib, has been shown to significantly improve overall survival of patients after failure of sorafenib-pioneering for the first time systemic second-line therapy in these patients.3
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
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  • 3
    Language: English
    In: Gut August 2010, Vol.59(8), p.1046
    Description: Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo microscopy at subcellular resolution. The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC.
    Keywords: Basic Sciences ; Colorectal Carcinoma ; Endoscopy ; Gastrointestinal Cancer ; Imaging
    ISSN: 0017-5749
    ISSN: 00175749
    E-ISSN: 1468-3288
    E-ISSN: 14683288
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  • 4
    Language: German
    In: Zeitschrift für Gastroenterologie, 2016, Vol.54(12), pp.1418-1418
    ISSN: 0044-2771
    E-ISSN: 1439-7803
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  • 5
    In: Australian Universities Review, 2010, Vol.52(2), pp.66-71
    Description: This article is an exercise in applied ethics on the topic of determining workloads in academia. As such, it is an exercise in connecting positions on various moral problems to do with workload allocation to underlying moral principles. The article first outlines some moral principles which the author takes to underlie some discussions concerning workloads and then appeals to them in making some suggestions as to legitimate practice in allocating workloads. The two distinct groups of moral principles that bear upon workload allocation issues are the group that outlines features that should govern items in a workload formula, and the second group that outlines features that should govern procedures for the allocation of workloads. The first group includes: comprehensiveness; equity; skewing; feasibility; collegiality; manageability; challengeability; and transparency. The second group considers some vexatious workload issues such as; seniority; spread of types of work; shifts in workload profile; and research publication workload allocation.
    Keywords: Academic Staff University Relationship ; Academic Staff Workload ; Ethics ; Higher Education ; Research ; Teaching Conditions ; University Administration ; Working Hours ; Postsecondary Education
    ISSN: 0818-8068
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  • 6
    Language: English
    In: 2012, Vol.7(9), p.e44474
    Description: Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC). We have recently shown that HCV core protein mediates functional inactivation of the promyelocytic leukemia (PML) tumor suppressor pathway. However, the role of PML in HCC development yet remains unclear. To clarify the function of PML in liver carcinogenesis and HCV-associated pathogenesis we crossed PML-deficient mice with HCV transgene (HCV-Tg) expressing mice and treated the resulting animals with DEN/Phenobarbital, an established protocol for liver carcinogenesis. Seven months after treatment, livers were examined macroscopically and histologically. Genetic depletion of the tumor suppressor PML coincided with an increase in hepatocyte proliferation, resulting in development of multiple dysplastic nodules in 100% of the PML-deficient livers and of HCCs in 53%, establishing a tumor suppressive function of PML in the liver. In animals expressing the HCV-transgene in PML-deficient background, HCC development occurred even in 73%, while only 7% of their wildtype littermates developed HCC. The neoplastic nature of the tumors was confirmed by histology and expression of the HCC marker glutamine synthetase. Several pro- and antiapoptotic factors were tested for differential expression and liver carcinogenesis was associated with impaired expression of the proapoptotic molecule TRAIL in PML-deficient mice. In conclusion, this study provides first in vivo evidence that the tumor suppressor PML acts as an important barrier in liver carcinogenesis and HCV-dependent liver pathology.
    Keywords: Research Article ; Biology ; Medicine ; Cell Biology ; Oncology ; Gastroenterology And Hepatology
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: Journal of Hepatology, May 2016, Vol.64(5), pp.998-1000
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jhep.2015.12.015 Byline: Peter R. Galle Article History: Received 21 December 2015; Accepted 21 December 2015
    Keywords: Medicine
    ISSN: 0168-8278
    E-ISSN: 1600-0641
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  • 8
    Language: English
    In: Nucleic acids research, January 2013, Vol.41(Database issue), pp.D942-8
    Description: The CellLineNavigator database, freely available at http://www.medicalgenomics.org/celllinenavigator, is a web-based workbench for large scale comparisons of a large collection of diverse cell lines. It aims to support experimental design in the fields of genomics, systems biology and translational biomedical research. Currently, this compendium holds genome wide expression profiles of 317 different cancer cell lines, categorized into 57 different pathological states and 28 individual tissues. To enlarge the scope of CellLineNavigator, the database was furthermore closely linked to commonly used bioinformatics databases and knowledge repositories. To ensure easy data access and search ability, a simple data and an intuitive querying interface were implemented. It allows the user to explore and filter gene expression, focusing on pathological or physiological conditions. For a more complex search, the advanced query interface may be used to query for (i) differentially expressed genes; (ii) pathological or physiological conditions; or (iii) gene names or functional attributes, such as Kyoto Encyclopaedia of Genes and Genomes pathway maps. These queries may also be combined. Finally, CellLineNavigator allows additional advanced analysis of differentially regulated genes by a direct link to the Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resources.
    Keywords: Cell Line, Tumor ; Databases, Genetic ; Transcriptome ; Neoplasms -- Genetics
    ISSN: 03051048
    E-ISSN: 1362-4962
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  • 9
    Language: English
    In: Gastroenterology, 2011, Vol.140(5), pp.S-926-S-926
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 10
    Language: English
    In: Gastroenterology, May 2012, Vol.142(5), pp.S-783-S-783
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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