Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Year
  • 1
    In: Oncogene, 2010, Vol.29(15), p.2272
    Description: Human chromosomal fragile sites are regions of the genome that are prone to DNA breakage, and are classified as common or rare, depending on their frequency in the population. Common fragile sites frequently coincide with the location of genes involved in carcinogenic chromosomal translocations, suggesting their role in cancer formation. However, there has been no direct evidence linking breakage at fragile sites to the formation of a cancer-specific translocation. Here, we studied the involvement of fragile sites in the formation of RET/PTC rearrangements, which are frequently found in papillary thyroid carcinoma (PTC). These rearrangements are commonly associated with radiation exposure; however, most of the tumors found in adults are not linked to radiation. In this study, we provide structural and biochemical evidence that the RET, CCDC6 and NCOA4 genes participating in two major types of RET/PTC rearrangements, are located in common fragile sites FRA10C and FRA10G, and undergo DNA breakage after exposure to fragile site-inducing chemicals. Moreover, exposure of human thyroid cells to these chemicals results in the formation of cancer-specific RET/PTC rearrangements. These results provide the direct evidence for the involvement of chromosomal fragile sites in the generation of cancer-specific rearrangements in human cells. Oncogene (2010) 29, 2272-2280; doi:10.1038/onc.2009.502; published online 25 January 2010 Keywords: fragile site; RET/PTC rearrangement; FRA10C/FRA10G; papillary thyroid carcinomas
    Keywords: Dna Damage -- Physiological Aspects ; Dna Damage -- Research ; Proto-oncogenes -- Physiological Aspects ; Proto-oncogenes -- Research ; Thyroid Cancer -- Risk Factors ; Thyroid Cancer -- Genetic Aspects ; Thyroid Cancer -- Research;
    ISSN: 0950-9232
    E-ISSN: 14765594
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Article
    Article
    Language: English
    In: Clinical Chemistry, 02/01/2014, Vol.60(2), pp.424-424
    Description: We appreciate the interest in our recently published CALIPER (Canadian Laboratory Initiative for Pediatric Reference Intervals)1 manuscripts and are delighted to see that the publications are stimulating further discussion in the field. Overall, the authors of these letters have raised several important questions, but they appear to have overlooked some important points when reviewing the published studies. They also fail to acknowledge the numerous limitations inherent in interpretation of cortisol as addressed in our published articles: namely, that circadian rhythms in infants differ from those of adults, that the stress of phlebotomy can alter cortisol concentrations, and that we examined a single time point in each individual within a large population of children rather than multiple time points in a small number of individuals. That being said, in our population, the reference intervals did not differ significantly between morning and afternoon. We did not seek to answer in our studies whether the influence of circadian rhythms could be observed within individuals, but rather, whether such a change could be observed across the population. Of course, our population is ethnically diverse and is representative of a healthy population in Ontario, Canada. Therefore, we believe that our conclusions are not altered by points raised in these letters. We agree that performing sequential sampling for cortisol measurement at multiple time points over 3–5 days would be ideal to assess the diurnal variation for cortisol. However, such a determination was well beyond the scope of the recently published CALIPER studies, which established reference value distributions in a large, healthy population of children. We would like to respond first to the question raised by Rovnaghi et al. (1) regarding the differences in age partitions between the CALIPER immunoassay study published in Clinical Chemistry (2) and the HPLC-MS/MS study published in Clinical Biochemistry (3 …
    Keywords: Medicine;
    ISSN: 0009-9147
    E-ISSN: 1530-8561
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Chemosphere, April 2013, Vol.91(5), pp.685-691
    Description: ► Effectiveness of packing materials was in order of α-Al O 〉 SiO 〉 ZrO 〉 glass wool. ► The decomposition efficiency and the BET surface area were deteriorated over time. ► FTIR spectra evidenced the accumulation of polymer-like deposits in the reactor. ► Plasma-mediated regeneration restored the used packing materials to the former states. This work investigated the decomposition of ethylene in a continuous flow dielectric-packed bed plasma reactor filled with various packing materials at atmospheric pressure and room temperature. When compared to the case without any packing material, the reactor filled with packing materials remarkably facilitated the plasma-induced decomposition of ethylene in the order of α-alumina 〉 silica 〉 zirconia 〉 glass wool (GW). Under identical condition, the increase in the decomposition efficiency (DE) with increasing the specific energy input was more rapid in the plasma reactor filled with the packing materials than in the blank plasma reactor. In the early stage, almost complete decomposition of ethylene was observed with the α-alumina, but after a certain period of time, the DE decreased with time. Unlike the α-alumina, the other packing materials examined did not show any significant deterioration in the decomposition over time during 10-h operation. After the regeneration of the used packing materials by using the plasma in the presence of oxygen, the original decomposition performance was nearly recovered. The decrease in the BET surface area due to the formation of polymer deposits was observed in the used α-alumina and silica; however the surface area was almost regained by the regeneration. While no other byproducts except carbon oxides and N O were detected with the α-alumina and silica, methane, acetylene, formaldehyde and N O were identified in the effluent gas with the zirconia and GW packing materials.
    Keywords: Plasma ; Dielectric-Packed Bed ; Ethylene ; Decomposition ; Byproducts ; Regeneration ; Chemistry ; Ecology
    ISSN: 0045-6535
    E-ISSN: 1879-1298
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    In: Diabetic Medicine, February 2012, Vol.29(2), pp.232-235
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1464-5491.2011.03385.x Byline: D. Warriner, M. Debono, R. A. Gandhi, E. Chong, F. Creagh Keywords: glucose metabolism; glycaemic control; insulin; pharmacokinetics; therapeutics Abstract: Diabet. Med. 29, 232-235 (2012) Abstract Background A 26-year-old man with Type 1 diabetes presented with an overdose of 4800 units of the long-acting insulin analogue, glargine (Lantus). Glucose supplementation of approximately 800 g/day was associated with acute hepatic injury. Methods On day 4, a depot of insulin was excised from the patient's abdominal wall; this was followed by a reduction in his glucose requirements and improvement in liver function. Conclusions This report highlights the risk of acute hepatic injury during the treatment of insulin overdose and the importance of careful glucose supplementation. It also demonstrates how earlier excision of an insulin depot could potentially prevent this problem and hasten recovery. Article History: Accepted 15 July 2011 Article note: Dr Fionuala Creagh, Department of Diabetes and Endocrinology, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK. E-mail: fionuala.creagh@sth.nhs.uk
    Keywords: Glucose Metabolism ; Glycaemic Control ; Insulin ; Pharmacokinetics ; Therapeutics
    ISSN: 0742-3071
    E-ISSN: 1464-5491
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Chemosphere, December 2014, Vol.117, pp.440-446
    Description: In order to explore the effects of the shape of ZnO nanomaterials on the plasma-catalytic decomposition of butane and the distribution of byproducts, three types of ZnO nanomaterials (nanoparticles (NPs), nanorods (NRs) and nanowires (NWs)) were prepared and coated on multi-channel porous alumina ceramic membrane. The structures and morphologies of the nanomaterials were confirmed by X-ray diffraction method and scanning electron microscopy. The observed catalytic activity of ZnO in the oxidative decomposition of butane was strongly shape-dependent. It was found that the ZnO NWs exhibited higher catalytic activity than the other nanomaterials and could completely oxidize butane into carbon oxides (CO ). When using the bare or ZnO NPs-coated ceramic membrane, several unwanted partial oxidation and decomposition products like acetaldehyde, acetylene, methane and propane were identified during the decomposition of butane. When the ZnO NWs- or ZnO NRs-coated membrane was used, however, the formation of such unwanted byproducts except methane was completely avoided, and full conversion into CO was achieved. Better carbon balance and CO selectivity were obtained with the ZnO NWs and NRs than with the NPs.
    Keywords: Non-Thermal Plasma ; Zno Nanomaterials ; Shape Effect ; Butane ; Decomposition ; Chemistry ; Ecology
    ISSN: 0045-6535
    E-ISSN: 1879-1298
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Anesthesia & Analgesia, 2016, Vol.123, pp.83-84
    ISSN: 0003-2999
    E-ISSN: 15267598
    Source: Wolters Kluwer - Ovid (via CrossRef)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Journal of Epidemiology and Community Health January 2015, Vol.69(1), p.A1
    Description: Restless legs syndrome (RLS) is common amongst patients receiving dialysis. It is unclear how to optimally treat RLS in dialysis patients. We conducted a systematic review to identify therapies to reduce the severity of RLS.
    Keywords: Access To Hlth CARE ; Accidents ; Addictive Behaviour/Addiction
    ISSN: 0143-005X
    ISSN: 0143005X
    E-ISSN: 1470-2738
    E-ISSN: 14702738
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Chemosphere, Dec, 2014, Vol.117, p.440(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.chemosphere.2014.08.026 Byline: M. Sanjeeva Gandhi, Young Sun Mok Abstract: * Different shapes of ZnO crystals resulted in different plasma-catalytic activities. * Harmful byproducts were completely avoided with ZnO nanowires and rods. * ZnO nanowires achieved the best carbon balance and CO.sub.x selectivity. Article History: Received 7 May 2014; Revised 5 August 2014; Accepted 7 August 2014 Article Note: (miscellaneous) Handling Editor: O. Hao
    Keywords: Butane -- Chemical Properties ; Ceramics -- Chemical Properties ; Zinc Oxide -- Chemical Properties
    ISSN: 0045-6535
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Journal of Speech, Language, and Hearing Research, Oct, 2010, Vol.53(5), p.1111(11)
    Description: Purpose: To establish normative data for children on the Words-in-Noise Test (WIN; R. H. Wilson, 2003; R. H. Wilson & R. McArdle, 2007). Method: Forty-two children in each of 7 age groups, ranging in age from 6 to 12 years (n = 294), and 24 young adults (age range: 18-27 years) with normal hearing for pure tones participated. All listeners were screened at 15 dB HL (American National Standards Institute, 2004) with the octave interval between 500 and 4000 Hz. Randomizations of WIN Lists 1, 2, and 1 or WIN Lists 2, 1, and 2 were presented with the noise fixed at 70 dB SPL, followed by presentation at 90 dB SPL of the 70 Northwestern University Auditory Test No. 6 (T. W. Tillman & R. Carhart, 1966) words used in the WIN. Finally, the Peabody Picture Vocabulary Test--Revised (L. M. Dunn & L. M. Dunn, 1981) was administered. Testing was conducted in a quiet room. Results: There were 3 main findings: (a) The biggest change in recognition performance occurred between the ages of 6 and 7 years; (b) from 9 to 12 years, recognition performance was stable; and (c) performance by young adults (18-27 years) was slightly better (1-2 dB) than performance by the older children. Conclusion: The WIN can be used with children as young as 6 years of age; however, age-specific ranges of normal recognition performance must be used. KEY WORDS: auditory perception, children, hearing loss, speech perception, speech recognition in multitalker babble
    Keywords: Noise (Sound) -- Psychological Aspects ; Recognition (Memory) -- Research ; Childhood Auditory Perception -- Physiological Aspects ; Childhood Auditory Perception -- Demographic Aspects ; Hearing Loss -- Development And Progression ; Hearing Loss -- Demographic Aspects
    ISSN: 1092-4388
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: BMJ, 10, 10 March March 2010, Vol.340
    Description: Flecainide can “organise” atrial fibrillation into atrial flutter with 1:1 conduction, leading to cardiovascular compromise.
    Keywords: Drugs: Cardiovascular System ; Arrhythmias
    ISSN: 0959-8138
    ISSN: 09598138
    ISSN: 0959535X
    E-ISSN: 1468-5833
    E-ISSN: 14685833
    E-ISSN: 17561833
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages