Format:
Online-Ressource (VIII, 364 p. 71 illus., 10 illus. in color, online resource)
ISBN:
9783642399688
Series Statement:
SpringerLink
Content:
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the ""arms race"" with resistant pathogens.This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various re
Note:
Description based upon print version of record
,
Preface; Contents; Part ICurrent Trends in Antibiotics, Pathogens and Medical Needs; 1 The Origin and Evolution of Antibiotics; Abstract; 1.1…Introduction; 1.2…What's in a Name?; 1.3…Many Sources, Uses, and Functions; 1.4…How Old Are ''Antibiotics''?; 1.5…Antibiotic Myths; 1.6…Mode of Action and Evolution of Targets; 1.7…Parallel Chemical and Protein Evolution; 1.8…Conclusions; References; 2 Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections; Abstract; 2.1…Introduction
,
2.2…Methicillin-Resistant S. aureus as a Cause of HospitalHospital- and Community-Acquired InfectionsCommunity-Acquired Infections2.3…Infections Caused by Glycopeptide-Resistant EnterococciEnterococci; 2.4…Issues with Clostridium difficileClostridium difficile Infections; 2.5…Conclusions; 3 Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs; Abstract; 3.1…Introduction; 3.2…MDR, XDR and PDR Pathogens, and Resistance Mechanisms; 3.2.1 Resistance to beta -Lactam Antibiotics; 3.2.2 Resistance to Aminoglycosides; 3.2.3 Resistance to Tigecycline
,
3.2.4 Resistance to Fluoroquinolones3.2.5 Resistance to Colistin; 3.2.6 Resistance to Phosphonic Acid Derivatives; 3.3…Emerging Gram-Negative Resistant Pathogens; 3.3.1 Pseudomonas aeruginosa; 3.3.1.1 Antibiotic Resistance Mechanisms; 3.3.1.2 Risk Factors for Infections and Resistance Development; 3.3.2 Acinetobacter baumannii; 3.3.2.1 Antibiotic Resistance Mechanisms; 3.3.2.2 Risk Factors for Infections and Resistance Development; 3.3.3 Enterobacteriaceae and Klebsiella pneumoniae; 3.3.3.1 Antibiotic Resistance Mechanisms; 3.3.3.2 Risk Factors for Infections and Resistance Development
,
3.3.3.3 Klebsiella pneumoniae3.4…The Complexity of the Resistance Problem; 3.4.1 Novel Antimicrobials; 3.4.2 Novel beta -Lactam and beta -Lactamase Inhibitors; 3.4.2.1 Novel Cephalosporins; 3.4.2.2 Novel Carbapenems; 3.4.2.3 Novel Monobactams; 3.4.2.4 Novel beta -Lactamase Inhibitors; 3.4.3 Novel Non beta -Lactam Antibiotic Compounds; 3.4.3.1 Compounds Belonging to Known Class of Antimicrobial Agents; 3.4.3.2 Compounds Which Represent New Classes of Antimicrobials; 3.5…Conclusions; References; Part IIFamilies of Novel Candidates and Conventional Antibiotics
,
4 The beta -Lactam Antibiotics: Their Future in the Face of ResistanceAbstract; 4.1…Introduction; 4.2…Recent Advances in the Chemistry of the beta -Lactams; 4.2.1 New Cephalosporins; 4.2.1.1 Latest Generation Cephalosporins; 4.2.1.2 beta -Lactam Hybrid Structures; 4.2.1.3 TD-1792, A Covalent Cephalosporin-Vancomycin Hybrid; 4.2.1.4 beta -Lactamase-Catalyzed Antibiotic Release from Cephalosporins; 4.2.2 New Generation Carbapenems; 4.2.2.1 Anti-Gram-Positive Carbapenems; 4.2.2.2 Anti-Gram-Negative Carbapenems; 4.2.2.3 The Future of the Carbapenems; 4.2.3 New Generation Monocyclic beta -Lactams
,
4.2.3.1 The Monosulfactams
Additional Edition:
ISBN 9783642399671
Additional Edition:
Druckausg. Antimicrobials Berlin : Springer, 2014 ISBN 3642399673
Additional Edition:
ISBN 9783642399671
Language:
English
Subjects:
Medicine
Keywords:
Antibiotikum
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-39968-8
Bookmarklink
