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Berlin Brandenburg

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  • 1
    In: Journal Of Experimental Botany, 2017, Vol. 68(11), pp.2633-2636
    Keywords: Assimilation ; Carbon Isotope ; Environmental Drivers ; Respiration ; Transpiration.
    ISSN: 0022-0957
    E-ISSN: 1460-2431
    Source: Oxford University Press
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  • 2
    Language: English
    In: Neuroscience Letters, 15 June 2011, Vol.497(1), pp.49-54
    Description: ► TFPI-2 expression is absent in the majority of high grade glioma cell lines. ► Knockdown of TFPI-2 enhances glioma cell proliferation, migration and invasion. ► The anti-invasive properties of TFPI-2 are associated with MMP-1 and MMP-2 inhibition. ► TFPI-2 is an important tumor suppressor and frequently lost during gliomagenesis. Glioblastoma is the most malignant primary brain tumor. Due to its highly promigratory and proinvasive properties, standard therapy including surgery, chemotherapy and radiation fails in eradicating this highly aggressive type of cancer. Here, we evaluated the role of TFPI-2, a Kunitz-type serine protease inhibitor, which has been previously described as a tumor suppressor gene in several types of cancer, including glioma. TFPI-2 expression was absent in five of nine investigated high-grade glioma cell lines. Lentiviral knockdown of TFPI-2 in two of the TFPI-2-expressing cell lines (MZ-18 and Hs 638) was associated with pronounced changes in the cellular behavior: glioma cell proliferation, migration and invasion were significantly increased in TFPI-2 knockdown cells in comparison to empty vector-transfected control cells. Since TFPI-2 might exert its tumor suppressor function by inhibiting MMPs, we subsequently analyzed the effects of specific MMP inhibitors on cell invasion of TFPI-2 KD cells vs. control cells. The data obtained from these experiments suggest that the anti-invasive properties of TFPI-2 are associated with inhibition of MMP-1 and MMP-2, while inhibition of MMP-9 seems to play a minor role in this context. Our findings underscore the important role of TFPI-2 as a tumor suppressor gene and indicate that TFPI-2 may be a useful diagnostic marker for the aggressive phenotype of glial tumors.
    Keywords: Brain Tumor ; Tumor Suppressor ; Tumor Microenvironment ; Ecm Degradation ; Cell Proliferation ; Mmps ; Medicine ; Anatomy & Physiology
    ISSN: 0304-3940
    E-ISSN: 1872-7972
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  • 3
    In: New Phytologist, March 2016, Vol.209(4), pp.1338-1340
    Description: Byline: Arthur Gessler, Kerstin Treydte Keywords: .sub.13C and .sub.14C; bomb-radiocarbon approach; carbon storage and remobilization; drought; metabolic activity; nonstructural carbon pool; old-grown trees ***** No abstract is available for this article. *****
    Keywords: 13 C And 14 C ; Bomb‐Radiocarbon Approach ; Carbon Storage And Remobilization ; Drought ; Metabolic Activity ; Nonstructural Carbon Pool ; Old‐Grown Trees
    ISSN: 0028-646X
    E-ISSN: 1469-8137
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  • 4
    Language: English
    In: Patient Education and Counseling, June 2012, Vol.87(3), pp.343-350
    Description: To test the effect of patient counseling using educational tools, on rates of return for follow-up in newly diagnosed hypertensive and/or diabetic patients in a rural African context. Free screening for hypertension and elevated blood glucose was offered in primary health care centers in central Cameroon during 9 campaigns of 3 days each. Individuals with untreated hypertension and/or diabetes were divided into 2 groups: a control group receiving counseling according to routine procedures, and an intervention group receiving counseling with different educational tools to explain the diagnosis and its implications to the patient. Prevalence of hypertension and/or diabetes in the screened population was 41%. At 3 months from screening, rates of return visits were higher in the intervention group than in the control group: 55/169 (32%) vs. 15/92 (16%), OR 2.4; 95%CI 1.3–4.7; 〈 0.001. Screening may identify untreated individuals efficiently. Rates of return visits after screening, although low in both groups, could be doubled by a short communication intervention. This study suggests that modest communication interventions, e.g., the application of educational tools, may bring important benefits and increase the effectiveness of public health measures to combat chronic diseases in settings of limited resources.
    Keywords: Hypertension ; Diabetes ; Low-and-Middle Income Countries ; Patient Counseling ; Adherence ; Medicine ; Public Health
    ISSN: 0738-3991
    E-ISSN: 1873-5134
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  • 5
    Language: English
    In: 2015, Vol.10(6), p.e0130288
    Description: The Hey protein family, comprising Hey1, Hey2 and HeyL in mammals, conveys Notch signals in many cell types. The helix-loop-helix (HLH) domain as well as the Orange domain, mediate homo- and heterodimerization of these transcription factors. Although distinct interaction partners have been identified so far, their physiological relevance for Hey functions is still largely unclear. Using a tandem affinity purification approach and mass spectrometry analysis we identified members of an ubiquitin E3-ligase complex consisting of FBXO45, PAM and SKP1 as novel Hey1 associated proteins. There is a direct interaction between Hey1 and FBXO45, whereas FBXO45 is needed to mediate indirect Hey1 binding to SKP1. Expression of Hey1 induces translocation of FBXO45 and PAM into the nucleus. Hey1 is a short-lived protein that is degraded by the proteasome, but there is no evidence for FBXO45-dependent ubiquitination of Hey1. On the contrary, Hey1 mediated nuclear translocation of FBXO45 and its associated ubiquitin ligase complex may extend its spectrum to additional nuclear targets triggering their ubiquitination. This suggests a novel mechanism of action for Hey bHLH factors.
    Keywords: Research Article
    E-ISSN: 1932-6203
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  • 6
    In: Psycho‐Oncology, October 2012, Vol.21(10), pp.1082-1090
    Description: Byline: Nancy Pistrang, Zara Jay, Sue Gessler, Chris Barker Abstract Objective Peer support is much valued by cancer patients. Previous research has focused on support groups, typically for women with breast cancer; little has addressed one-to-one support. This qualitative study examined a telephone-delivered one-to-one peer support intervention for women with gynaecological cancer, focusing on recipients' experiences of process and outcome. Methods Semi-structured interviews were conducted with 24 women recently treated for gynaecological cancer who had received peer support for up to a 3-month period. Transcripts were analysed thematically using the 'Framework' approach. Results Six key components of the peer support process were identified: an emotional bond, empathy, talking openly, reciprocity, information and guidance, and humour. Their importance was highlighted by cases in which they were absent or problematic. Participants described several benefits, for example hope and confidence, making sense of the illness experience and rebuilding one's life. However, one-third reported limited or no benefits, although there was no evidence of adverse outcomes. Conclusions One-to-one telephone peer support shares common features with support groups but is uniquely dependent on an effective working relationship between the support provider and recipient. Peer support can address the disease- and treatment-specific concerns of women with gynaecological cancer, as well as the adaptive tasks of recovery faced by cancer survivors. Further research needs to examine who is more or less likely to benefit from one-to-one peer support and which parameters of the intervention, such as duration and matching, influence its effectiveness. Patient-relevant outcomes should be included in future controlled trials. Copyright A[c] 2011 John Wiley & Sons, Ltd. Correspondence: Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London WC1E 6BT, England. E-mail: n.pistrang@ucl.ac.uk
    Keywords: Cancer ; Oncology ; Gynaecological Cancer ; Peer Support ; Psychosocial Interventions ; Social Support
    ISSN: 1057-9249
    E-ISSN: 1099-1611
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  • 7
    Language: English
    In: Forest Ecology and Management, June 15, 2013, Vol.298, p.82(11)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.foreco.2013.03.001 Byline: Charlotte Grossiord, Andre Granier, Arthur Gessler, Martina Pollastrini, Damien Bonal Abstract: acents The influence of species mixture on carbon accumulation and water use was studied in a boreal plantation. acents A large variability in functional parameters was observed among species and mixtures. acents The presence of birch in mixtures was the key driver for ecosystem functioning. acents Species mixture did not enhance productivity and water use efficiency at a young stage. Article History: Received 8 January 2013; Revised 25 February 2013; Accepted 2 March 2013
    Keywords: Water -- Environmental Aspects ; Water Use -- Environmental Aspects ; Plantations -- Environmental Aspects ; Ecosystems -- Environmental Aspects
    ISSN: 0378-1127
    Source: Cengage Learning, Inc.
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  • 8
    In: New Phytologist, October 2013, Vol.200(1), pp.144-157
    Description: The oxygen stable isotope composition of plant organic matter (OM) (particularly of wood and cellulose in the tree ring archive) is valuable in studies of plant–climate interaction, but there is a lack of information on the transfer of the isotope signal from the leaf to heterotrophic tissues. We studied the oxygen isotopic composition and its enrichment above source water of leaf water over diel courses in five tree species covering a broad range of life forms. We tracked the transfer of the isotopic signal to leaf water‐soluble OM and further to phloem‐transported OM. Observed leaf water evaporative enrichment was consistent with values predicted from mechanistic models taking into account nonsteady‐state conditions. While leaf water‐soluble OM showed the expected 18O enrichment in all species, phloem sugars were less enriched than expected from leaf water enrichment in Scots pine (Pinus sylvestris), European larch (Larix decidua) and Alpine ash (Eucalyptus delegatensis). Oxygen atom exchange with nonenriched water during phloem loading and transport, as well as a significant contribution of assimilates from bark photosynthesis, can explain these phloem 18O enrichment patterns. Our results indicate species‐specific uncoupling between the leaf water and the OM oxygen isotope signal, which is important for the interpretation of tree ring data.
    Keywords: Broadleaf ; Conifer ; Diel Course ; Oxygen Atom Exchange ; Phloem Transport
    ISSN: 0028-646X
    E-ISSN: 1469-8137
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  • 9
    Language: English
    In: European Journal of Pediatrics, 2010, Vol.169(2), pp.197-199
    Description: Byline: Peter Gessler (1), Peter Buchal (2), Hans U. Schwenk (1), Bendicht Wermuth (3) Keywords: Hyperammonemia; N-Acetylglutamate synthase; Carbamylglutamate; Neurodevelopment Abstract: Introduction N-Acetylglutamate synthase (NAGS) deficiency is a rare urea cycle disorder, which may present in the neonatal period with severe hyperammonemia and marked neurological impairment. Case report We report on a Turkish family with a patient who died due to hyperammonemia in the neonatal period. Reduced activity of NAGS and carbamyl phosphate synthetase were found at autopsy. A second child who developed hyperammonemia on the second day of life was immediately treated with arginine hydrochloride, sodium benzoate and protein restriction. After NAGS deficiency was suspected by enzyme analysis, sodium benzoate was replaced by N-carbamylglutamate (NCG). A third child who developed slight hyperammonemia on the third day of life was treated with NCG before enzyme analysis confirmed reduced NAGS activity. Neither of the patients developed hyperammonemia in the following years. After the human NAGS gene was identified, mutation analysis revealed that the older sibling on NCG therapy was homozygous for a 971G〉A (W324X) mutation. The parents and the younger sibling were heterozygous. Therapy was continued in the older sibling until now without any adverse effects and favourable neurodevelopment outcome. In the younger sibling, therapy was stopped without any deterioration of urea cycle function. Conclusion NAGS deficiency can be successfully treated with NCG and arginine hydrochloride with favourable outcome. Molecular diagnostic rather than enzyme analysis should be used in patients with suspected NAGS deficiency. Author Affiliation: (1) Klinikum, Klinik fur Kinder und Jugendliche, 78461, Konstanz, Germany (2) Klinikum, Apotheke, 78461, Konstanz, Germany (3) Inselspital, Universitatsinstitut fur Klinische Chemie, 3010, Bern, Switzerland Article History: Registration Date: 19/05/2009 Received Date: 23/02/2009 Accepted Date: 19/05/2009 Online Date: 17/06/2009
    Keywords: Hyperammonemia ; -Acetylglutamate synthase ; Carbamylglutamate ; Neurodevelopment
    ISSN: 0340-6199
    E-ISSN: 1432-1076
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  • 10
    In: Journal of Applied Microbiology, April 2013, Vol.114(4), pp.1193-1200
    Description: Byline: M. Storari, R. Rohr, I. Pertot, C. Gessler, G.A.L. Broggini Keywords: climate change; hydroxynaphthol blue; mycotoxins; polyketide synthase Abstract Aims To develop two assays based on the loop-mediated isothermal amplification (LAMP) of DNA for the quick and specific identification of Aspergillus carbonarius and ochratoxigenic strains of the Aspergillus niger clade isolated from grapes. Methods and Results Two sets of primers were designed based on the polyketide synthase genes involved or putatively involved in ochratoxin A (OTA) biosynthesis in A. carbonarius and A. niger clade. Hydroxynaphthol blue was used as indirect method to indicate DNA amplification. The limit of detection of both assays was comparable to that of a PCR reaction. Specificities of the reactions were tested using DNA from different black aspergilli isolated from grapes. The two LAMP assays were then used to identify A. carbonarius and ochratoxigenic A. niger and A. awamori grown in pure cultures without a prior DNA extraction. Conclusions The two LAMP assays permitted to quickly and specifically identify DNA from OTA-producing black aspergilli, as well as isolates grown in pure culture. Significance and Impact of the Study Monitoring vineyards for the presence of OTA-producing strains is part of the measures to minimize the occurrence of OTA in grape products. The two LAMP assays developed here could be potentially used to speed the screening process of vineyards for the presence of OTA-producing black aspergilli. Author Affiliation:
    Keywords: Climate Change ; Hydroxynaphthol Blue ; Mycotoxins ; Polyketide Synthase
    ISSN: 1364-5072
    E-ISSN: 1365-2672
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