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Complement-Targeted Therapies in Lupus (2015)

Gilkeson, Gary S. [Verfasser] ; SpringerLink (Online service)

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UID:

(DE-101)1167081498

Format: Online-Ressource , online resource.

ISSN: 2198-6002 , 2198-6002

In: volume:1

In: number:1

In: day:22

In: month:1

In: year:2015

In: pages:10-18

In: date:3.2015

In: Current treatment options in rheumatology, Berlin [u.a.] : Springer, 2015-, 1, Heft 1 (22.1.2015), 10-18, 3.2015, 2198-6002

Language: English

DOI: 10.1007/s40674-014-0009-9

URN: urn:nbn:de:101:1-2018091515433394033805

URL: https://doi.org/10.1007/s40674-014-0009-9

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2018091515433394033805

URL: https://d-nb.info/1167081498/34

URL: http://dx.doi.org/10.1007/s40674-014-0009-9

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Cellular requirements for anti‐DNA production induced in mice by immunization with bacterial DNA (2005)

Gilkeson, Gary S. [Verfasser] ; Pritchard, Anita J. [Verfasser] ; Pisetsky, David S. [Verfasser]

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UID:

(DE-101)1317022173

Format: Online-Ressource

ISSN: 1521-4141

Content: Abstract: To further define DNA immunization as a model for anti‐DNA production, we investigated the cellular requirements for this response in mice immunized with single‐stranded DNA from E. coli. The anti‐DNA responses of genetically immune‐deficient mice and congenic controls were measured by ELISA after immunization with E. coli DNA as complexes with methylated bovine serum albumin in complete Freund's adjuvant. T cell‐deficient BALB/c‐nulnu mice failed to produce IgG anti‐DNA by this protocol despite high backgrounds of IgM anti‐DNA. In contrast, CBA/N mice expressing the xid defect displayed IgG anti‐DNA responses comparable to those of CBA/J mice despite a reduced IgM response; the specificity of CBA/N and CBA/J anti‐DNA antibodies was similar as determined by binding to synthetic DNA and RNA antigens. These results suggest that the anti‐DNA response stimulated by DNA immunization is dependent on T cells but not the B cell population affected by xid. The intact IgG response of immunized xid mice differs from that of lupus mice bearing xid where this gene defect leads to significant reduction of spontaneous anti‐DNA production.

In: volume:20

In: number:8

In: year:2005

In: pages:1789-1794

In: extent:6

In: European journal of immunology, Weinheim : Wiley-VCH, 1971-, 20, Heft 8 (2005), 1789-1794 (gesamt 6), 1521-4141

Language: English

DOI: 10.1002/eji.1830200825

URN: urn:nbn:de:101:1-2024012407103063128468

URL: https://doi.org/10.1002/eji.1830200825

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2024012407103063128468

URL: https://d-nb.info/1317022173/34

URL: https://doi.org/10.1002/eji.1830200825

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Mechanisms of tissue injury in lupus nephritis (2011)

Nowling, Tamara K. [Verfasser] ; Gilkeson, Gary S. [Mitwirkender] ; SpringerLink (Online service)

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UID:

(DE-101)1099338530

Format: Online-Ressource , online resource.

ISSN: 1478-6354 , 1465-9913

In: volume:13

In: number:6

In: day:21

In: month:12

In: year:2011

In: pages:1-9

In: date:12.2011

In: Arthritis Research & Therapy, London : BioMed Central, 1999-, 13, Heft 6 (21.12.2011), 1-9, 12.2011, 1465-9913

Language: English

DOI: 10.1186/ar3528

URN: urn:nbn:de:1111-2016050320814

URL: https://doi.org/10.1186/ar3528

URL: https://nbn-resolving.org/urn:nbn:de:1111-2016050320814

URL: https://d-nb.info/1099338530/34

URL: http://dx.doi.org/10.1186/ar3528

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Peroxynitrite Formation and Decreased Catalase Activity in Autoimmune MRL-lpr/lpr Mice (2000)

Keng, Teresa [Verfasser] ; Privalle, Christopher T. [Sonstige] ; Gilkeson, Gary S. [Sonstige] ; [et al.]

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UID:

(DE-101)1170337457

Format: Online-Ressource , online resource.

ISSN: 1528-3658 , 1528-3658

In: volume:6

In: number:9

In: day:1

In: month:9

In: year:2000

In: pages:779-792

In: date:9.2000

In: Molecular medicine, [London] : BioMed Central, 1994-, 6, Heft 9 (1.9.2000), 779-792, 9.2000, 1528-3658

Language: English

DOI: 10.1007/BF03402193

URN: urn:nbn:de:101:1-2018110108082554560322

URL: https://doi.org/10.1007/BF03402193

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2018110108082554560322

URL: https://d-nb.info/1170337457/34

URL: http://dx.doi.org/10.1007/BF03402193

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Absence of functional alternative complement pathway alleviates lupus cerebritis (2007)

Alexander, Jessy J. [Verfasser] ; Jacob, Alexander [Verfasser] ; Vezina, Paul [Verfasser] ; [et al.]

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UID:

(DE-101)1298116678

Format: Online-Ressource

ISSN: 1521-4141

In: volume:37

In: number:6

In: year:2007

In: pages:1691-1701

In: extent:11

In: European journal of immunology, Weinheim : Wiley-VCH, 1971-, 37, Heft 6 (2007), 1691-1701 (gesamt 11), 1521-4141

Language: English

DOI: 10.1002/eji.200636638

URN: urn:nbn:de:101:1-2023080305402443725507

URL: https://doi.org/10.1002/eji.200636638

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023080305402443725507

URL: https://d-nb.info/1298116678/34

URL: https://doi.org/10.1002/eji.200636638

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Differences in Vϰ gene utilization and VH CDR3 sequence among anti‐DNA from C3H‐lpr mice and lupus mice with nephritis (2005)

Wloch, Mary Kopke [Verfasser] ; Alexander, Audrey L. [Verfasser] ; Pippen, Anne M. M. [Verfasser] ; [et al.]

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UID:

(DE-101)1310828261

Format: Online-Ressource

ISSN: 1521-4141

Content: Abstract: To investigate the molecular properties of anti‐DNA from lpr mice that express high levels of anti‐DNA without immune‐mediated nephritis, the sequences of VH and Vϰ genes encoding 11 monoclonal anti‐DNA antibodies derived from C3H‐lpr/lpr (C3H‐lpr) mice were studied. All of the C3H‐lpr monoclonal anti‐DNA bound single‐stranded DNA while five also bound double‐stranded DNA. Two of the hybridomas were clonally related as determined by Southern analysis and sequencing. Sequence analysis of C3H‐lpr anti‐DNA revealed the use of VH genes that encode anti‐DNA from the MRL‐lpr/lpr and (NZB X NZW) F1 mouse models of lupus, although differences occurred in the VH CDR3 amino acid content. In contrast, the Vϰ genes from C3H‐lpr mice lacked significant identity with previously reported Vϰ genes for anti‐DNA from lupus models. These results indicate that anti‐DNA from C3H‐lpr mice differ from anti‐DNA from lupus mice with nephritis in patterns of V gene expression and suggest a molecular basis for the lack of pathogenicity of anti‐DNA in these mice.

In: volume:26

In: number:9

In: year:2005

In: pages:2225-2233

In: extent:9

In: European journal of immunology, Weinheim : Wiley-VCH, 1971-, 26, Heft 9 (2005), 2225-2233 (gesamt 9), 1521-4141

Language: English

DOI: 10.1002/eji.1830260939

URN: urn:nbn:de:101:1-2023112305151935466767

URL: https://doi.org/10.1002/eji.1830260939

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023112305151935466767

URL: https://d-nb.info/1310828261/34

URL: https://doi.org/10.1002/eji.1830260939

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Interferon regulatory factor‐1 gene deletion decreases glomerulonephritis in MRL/lpr mice (2006)

Reilly, Christopher M. [Verfasser] ; Olgun, Selen [Verfasser] ; Goodwin, David [Verfasser] ; [et al.]

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UID:

(DE-101)130197529X

Format: Online-Ressource

ISSN: 1521-4141

In: volume:36

In: number:5

In: year:2006

In: pages:1296-1308

In: extent:13

In: European journal of immunology, Weinheim : Wiley-VCH, 1971-, 36, Heft 5 (2006), 1296-1308 (gesamt 13), 1521-4141

Language: English

DOI: 10.1002/eji.200535245

URN: urn:nbn:de:101:1-2023090905495821683308

URL: https://doi.org/10.1002/eji.200535245

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023090905495821683308

URL: https://d-nb.info/130197529X/34

URL: https://doi.org/10.1002/eji.200535245

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Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus (2014)

Cunningham, Melissa A. [Verfasser] ; Wirth, Jena R. [Mitwirkender] ; Freeman, Linnea R. [Mitwirkender] ; [et al.]

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UID:

(DE-101)1093612193

Format: Online-Ressource , online resource.

ISSN: 1742-2094 , 1742-2094

In: volume:11

In: number:1

In: day:16

In: month:12

In: year:2014

In: pages:1-15

In: date:12.2014

In: Journal of neuroinflammation, London : BioMed Central, 2004-, 11, Heft 1 (16.12.2014), 1-15, 12.2014, 1742-2094

Language: English

DOI: 10.1186/s12974-014-0171-x

URN: urn:nbn:de:1111-2016032337628

URL: https://doi.org/10.1186/s12974-014-0171-x

URL: https://nbn-resolving.org/urn:nbn:de:1111-2016032337628

URL: https://d-nb.info/1093612193/34

URL: http://dx.doi.org/10.1186/s12974-014-0171-x

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A GA microsatellite in the Fli1promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis (2010)

Morris, Erin E. [Verfasser] ; Amria, May Y. [Mitwirkender] ; Kistner-Griffin, Emily [Mitwirkender] ; [et al.]

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UID:

(DE-101)1099308097

Format: Online-Ressource , online resource.

ISSN: 1478-6354 , 1465-9913

In: volume:12

In: number:6

In: day:18

In: month:11

In: year:2010

In: pages:1-9

In: date:12.2010

In: Arthritis Research & Therapy, London : BioMed Central, 1999-, 12, Heft 6 (18.11.2010), 1-9, 12.2010, 1465-9913

Language: English

DOI: 10.1186/ar3189

URN: urn:nbn:de:1111-2016050317510

URL: https://doi.org/10.1186/ar3189

URL: https://nbn-resolving.org/urn:nbn:de:1111-2016050317510

URL: https://d-nb.info/1099308097/34

URL: http://dx.doi.org/10.1186/ar3189

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Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis (2023)

Allen, Peter C. [Verfasser] ; Smith, Sarah [Verfasser] ; Wilson, Robert C. [Verfasser] ; [et al.]

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UID:

(DE-101)1286891272

Format: Online-Ressource , online resource.

ISSN: 1868-7083 , 1868-7083

In: volume:15

In: number:1

In: day:17

In: month:2

In: year:2023

In: pages:1-15

In: date:12.2023

In: Clinical epigenetics, [Erscheinungsort nicht ermittelbar] : BioMed Central, 2010-, 15, Heft 1 (17.2.2023), 1-15, 12.2023, 1868-7083

Language: English

DOI: 10.1186/s13148-023-01445-5

URN: urn:nbn:de:101:1-2023042421133190402368

URL: https://doi.org/10.1186/s13148-023-01445-5

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023042421133190402368

URL: https://d-nb.info/1286891272/34

URL: https://doi.org/10.1186/s13148-023-01445-5

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