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  • 1
    Language: English
    In: Journal of Controlled Release, 28 September 2015, Vol.214, pp.76-84
    Description: Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6 months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, -Fe O ) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
    Keywords: Rhsa Nanoparticles ; Maghemite ; T-PA-Ligands to Galectins ; T-Papeptide1lac ; Single Photon Emission Computed Tomography–Computer Tomography (Spect–CT) ; Handheld Gamma Camera ; Magnetic Resonance Imaging (Mri) ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0168-3659
    E-ISSN: 1873-4995
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  • 2
    In: PLoS ONE, 2013, Vol.8(1)
    Description: Antisocial and criminal behaviors are multifactorial traits whose interpretation relies on multiple disciplines. Since these interpretations may have social, moral and legal implications, a constant review of the evidence is necessary before any scientific claim is considered as truth. A recent study proposed that men with wider faces relative to facial height (fWHR) are more likely to develop unethical behaviour mediated by a psychological sense of power. This research was based on reports suggesting that sexual dimorphism and selection would be responsible for a correlation between fWHR and aggression. Here we show that 4,960 individuals from 94 modern human populations belonging to a vast array of genetic and cultural contexts do not display significant amounts of fWHR sexual dimorphism. Further analyses using populations with associated ethnographical records as well as samples of male prisoners of the Mexico City Federal Penitentiary condemned by crimes of variable level of inter-personal aggression (homicide, robbery, and minor faults) did not show significant evidence, suggesting that populations/individuals with higher levels of bellicosity, aggressive behaviour, or power-mediated behaviour display greater fWHR. Finally, a regression analysis of fWHR on individual's fitness showed no significant correlation between this facial trait and reproductive success. Overall, our results suggest that facial attributes are poor predictors of aggressive behaviour, or at least, that sexual selection was weak enough to leave a signal on patterns of between- and within-sex and population facial variation.
    Keywords: Research Article ; Biology ; Social And Behavioral Sciences
    E-ISSN: 1932-6203
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  • 3
    In: Caleidoscopio - Revista Semestral de Ciencias Sociales y Humanidades, 07/01/1997, Vol.1(2), p.175
    ISSN: 1405-7107
    E-ISSN: 2395-9576
    Source: CrossRef
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  • 4
    In: Caleidoscopio - Revista Semestral de Ciencias Sociales y Humanidades, 01/01/1998, Vol.2(3), p.129
    ISSN: 1405-7107
    E-ISSN: 2395-9576
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  • 5
    In: Caleidoscopio - Revista Semestral de Ciencias Sociales y Humanidades, 01/01/1999, Vol.3(5), p.109
    ISSN: 1405-7107
    E-ISSN: 2395-9576
    Source: CrossRef
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  • 6
    In: Caleidoscopio - Revista Semestral de Ciencias Sociales y Humanidades, 01/01/1997, Vol.1(1), p.145
    ISSN: 1405-7107
    E-ISSN: 2395-9576
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  • 7
    In: Caleidoscopio - Revista Semestral de Ciencias Sociales y Humanidades, 01/01/1997, Vol.1(1), p.37
    ISSN: 1405-7107
    E-ISSN: 2395-9576
    Source: CrossRef
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  • 8
    Language: English
    In: Annales Geophysicae, 01 October 2018, Vol.36, pp.1347-1360
    Description: The Mexican Space Weather Service (SCiESMEX in Spanish) and National Space Weather Laboratory (LANCE in Spanish) were organized in 2014 and in 2016, respectively, to provide space weather monitoring and alerts, as well as scientific research in Mexico. In this work, we present the results of the first joint observations of two events (22 June and 29 September 2015) with our local network of instruments and their related products. This network includes the MEXART radio telescope (solar flare and radio burst), the Compact Astronomical Low-frequency, Low-cost Instrument for Spectroscopy in Transportable Observatories (CALLISTO) at the MEXART station (solar radio burst), the Mexico City Cosmic Ray Observatory (cosmic ray fluxes), GPS receiver networks (ionospheric disturbances), and the Teoloyucan Geomagnetic Observatory (geomagnetic field). The observations show that we detected significant space weather effects over the Mexican territory: geomagnetic and ionospheric disturbances (22 June 2015), variations in cosmic ray fluxes, and also radio communications' interferences (29 September 2015). The effects of these perturbations were registered, for the first time, using space weather products by SCiESMEX: total electron content (TEC) maps, regional geomagnetic index Kmex, radio spectrographs of low frequency, and cosmic ray fluxes. These results prove the importance of monitoring space weather phenomena in the region and the need to strengthening the instrumentation network.
    Keywords: Physics
    ISSN: 0992-7689
    E-ISSN: 1432-0576
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  • 9
    Language: English
    In: Archives of Oral Biology, 2005, Vol.50(10), pp.873-881
    Description: The quantitative importance of cell cycle arrest and apoptosis mechanisms in oral lichen planus (OLP) was analysed in order to assess the cell response to T lymphocyte aggression and establish a hypothesis on the influence of these phenomena in the malignant transformation process. The TUNEL assay and immunohistochemical methods were used to detect caspase-3, bax, and p21 in 32 tissue samples of oral mucosa with OLP and in 20 samples of normal oral mucosa. Positivity for TUNEL, caspase-3 and p21 was significantly more frequent in cases than in controls ( 〈 0.001). Both TUNEL and caspase-3 positivity was significantly greater in the basal versus suprabasal layer ( = 0.004 and 0.052, respectively). The basal and suprabasal expression of p21 was significantly higher in cases with a more intense liquefaction degeneration ( 〈 0.01). There was no significant difference in basal expression of bax between cases and controls. The quantitative importance of apoptosis was small in OLP. Epithelial cells attacked in OLP have a very low response to apoptosis and cell cycle arrest mechanisms, which may produce an epithelial substrate that favours malignant transformation.
    Keywords: Oral Lichen Planus ; Apoptosis ; Tunel Assay ; Caspase-3 ; P21 ; Zoology ; Dentistry
    ISSN: 0003-9969
    E-ISSN: 1879-1506
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  • 10
    In: FEMS Yeast Research, 2006, Vol. 6(1), pp.57-62
    Description: The protective role of trehalose against oxidative stress caused by hydrogen peroxide in Candida albicans has been investigated in the homozygous mutant ntc1 Δ /ntc1 Δ, disrupted in the NTC1 gene, which encodes the neutral (cytosolic) trehalase (Ntc1p). After a severe oxidative exposure (50 mM H 2 O 2 ), both parental (CAI-4) and ntc1 Δ /ntc1 Δ exponential-phase cells stored large amounts of intracellular trehalose. In turn, the degree of cell survival was roughly equivalent in both strains, although slightly higher in ntc1 Δ /ntc1 Δ cultures. The mechanism of ‘adaptive tolerance’ was functional in the two strains. Thus, a gently oxidative pretreatment (5 mM H 2 O 2 ) increased the recovery of cellular viability when it was followed by a severe challenge (50 mM H 2 O 2 ); this phenomenon was accompanied by a significant elevation of the endogenous trehalose content. Oxidative stress also induced specific activation of the antioxidant enzymes catalase and glutathione reductase upon gentle oxidative treatment (5 mM H 2 O 2 ), whereas superoxide dismutase activity was only activated upon prolonged exposure. Taken together, these results strongly suggest that in C. albicans neutral trehalase activity does not play an essential role in the protective response against oxidative stress. They also suggest that a diminished Ntc1p activity might favour the growth of C. albicans cells subjected to a strong oxidative exposure.
    Keywords: Oxidative Stress ; Ho ; Trehalose ; Neutral Trehalase ; Ntc1p ; 〈Kwd〉〈Italic〉Candida Albicans〈/Italic〉〈/Kwd〉
    ISSN: 15671356
    E-ISSN: 1567-1364
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