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  • 1
    UID:
    b3kat_BV046791867
    Format: 1 Online-Ressource (xiii, 212 Seiten)
    Edition: Second edition
    ISBN: 9783030430320
    Series Statement: Advances in experimental medicine and biology 1257
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-43031-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-43033-7
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-43034-4
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    UID:
    b3kat_BV046878681
    Format: 1 Online-Ressource (xii, 233 Seiten) , Illustrationen
    Edition: Second edition
    ISBN: 9783030430856
    Series Statement: Advances in experimental medicine and biology Volume 1258
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-43084-9
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-43086-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-43087-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 3
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Imprint: Springer
    UID:
    gbv_1724272853
    Format: 1 Online-Ressource(XIII, 212 p. 24 illus., 17 illus. in color.)
    Edition: 2nd ed. 2020.
    ISBN: 9783030430320
    Series Statement: Advances in Experimental Medicine and Biology 1257
    Content: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.
    Content: This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.
    Additional Edition: ISBN 9783030430313
    Additional Edition: ISBN 9783030430337
    Additional Edition: ISBN 9783030430344
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030430313
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030430337
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030430344
    Language: English
    URL: Cover
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  • 4
    UID:
    gbv_1728462347
    Format: 1 Online-Ressource(XIII, 233 p. 34 illus., 23 illus. in color.)
    Edition: 2nd ed. 2020.
    ISBN: 9783030430856
    Series Statement: Advances in Experimental Medicine and Biology 1258
    Content: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.
    Content: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
    Additional Edition: ISBN 9783030430849
    Additional Edition: ISBN 9783030430863
    Additional Edition: ISBN 9783030430870
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030430849
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030430863
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783030430870
    Language: English
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