Nature, 3/2011, Vol.471(7340), pp.588-589
[...] the use of a core RNase rather than a Cas-specific protein provides a clear example of crosstalk between the CRISPR system and bacterial metabolism. [...] Deltcheva et al. find that all of these elements (tracrRNA, Csn1 and RNase III) are necessary for immunity - that is, for S. pyogenes to destroy an invading plasmid containing sequences complementary to the CRISPR spacer.
Bacterial Proteins–Chemistry ; Bacterial Proteins–Genetics ; Bacterial Proteins–Immunology ; Bacterial Proteins–Metabolism ; Biological Evolution–Genetics ; DNA, Viral–Metabolism ; DNA, Viral–Genetics ; Models, Biological–Genetics ; Plasmids–Metabolism ; RNA Interference–Biosynthesis ; RNA Precursors–Genetics ; RNA Precursors–Immunology ; RNA Processing, Post-Transcriptional–Metabolism ; RNA, Bacterial–Genetics ; RNA, Bacterial–Metabolism ; RNA, Bacterial–Genetics ; RNA, Bacterial–Immunology ; RNA, Guide–Metabolism ; Ribonuclease III–Virology ; Streptococcus Pyogenes–Virology ; Streptococcus Pyogenes–Virology ; Streptococcus Pyogenes–Virology ; Streptococcus Pyogenes–Virology ; E Coli ; Bacteria ; Ribonucleic Acid–RNA ; Proteins ; Genomes ; Plasmids ; Organisms ; Bacterial Proteins ; DNA, Viral ; RNA Precursors ; RNA, Bacterial ; RNA, Guide ; Ribonuclease III;
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