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  • 1
    Book
    Book
    Oxford [u.a.] : Oxford Univ. Press
    UID:
    b3kat_BV035958318
    Format: VIII, 284 S.
    Edition: 1. publ.
    ISBN: 9780195372649 , 0195372646 , 9780199838479
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Political Science
    RVK:
    Keywords: Repräsentative Demokratie ; Öffentlichkeit ; Politische Beteiligung ; Plebiszitäre Demokratie
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  • 2
    UID:
    gbv_1651285403
    Format: Online-Ressource (XX, 632 p. 75 illus., 47 illus. in color, online resource)
    ISBN: 9780387698052
    Series Statement: SpringerLink
    Content: Thomas Ried
    Content: Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials
    Note: Description based upon print version of record , Genetically Engineered Mice for Cancer Research; Foreword; Preface; Contents; Contributors; Chapter 1: Overview of Designing Genetically Engineered Mouse (GEM) Models; 1.1 Introduction; 1.2 Has the GEM Already Been Made?; 1.3 Considerations in Choosing ES Cell Genetic Background; 1.4 Considerations for Simple Gene Knockout Vector Design; 1.5 Knockin-SNPs; 1.6 Conditional Gene Modifications; 1.7 Reversible Gene Targeting; 1.8 Isogenic DNA; 1.9 Length of Homologous Arms; 1.10 Distance Between Homologous Arms; 1.11 Heterologous Elements Within Homologous Arms; 1.12 Positive Selection , 1.13 Negative Selection1.14 Pretesting Diagnostic Procedures; 1.15 Recombineering Systems; 1.16 BAC Transgenics Versus Subtle Mutations; 1.17 Summary; 1.18 Brief Historical Perspective; 1.18.1 Development of GEM Field; References; Chapter 2: The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer; 2.1 Introduction; 2.2 Cre-LoxP System; 2.3 Cre-LoxP-Mediated Gene Inactivation; 2.3.1 Generation of a Conditional Mutant Allele in Mice; 2.3.2 Deletion of the Neo Gene from a Conditional Mutant Allele; 2.3.3 Tissue-Specific Conditional Knockout Mice , 2.3.3.1 Cre-loxP-Mediated Knockout of SMAD4 in Multiple Tissues2.3.3.2 Cre-loxP-Mediated Knockout of BRCA1 in Breast Cancer Research; 2.4 Cre-loxP-Mediated Gene Activation; 2.4.1 Activation of Oncogenes Using the Cre-loxP Technology; 2.4.2 Activation of Tumor Suppressor Genes Using the Cre-LoxP Technology; 2.5 Conclusion and Future Directions; References; Chapter 3: Using Recombineering Technology to Create Genetically Engineered Mouse Models; 3.1 Introduction; 3.2 In Vivo Cloning in E. coli; 3.3 Recombineering Using Bacteriophage Recombination Genes , 3.4 Recombineering Using Defective l -Prophage3.5 Generating Knockout Mouse Models; 3.5.1 Subcloning or Retrieving Genomic DNA from BAC; 3.5.2 Inserting Selectable Markers; 3.6 Conditional Gene Modifications; 3.7 High-Throughput Recombineering; 3.8 Multiple Alterations; 3.9 Generating Transgenic Constructs; 3.10 Recombineering-Based Methods for Generating Subtle Alterations; 3.10.1 A Selection-Counter Selection Method to Generate Subtle Alterations in BACs; 3.10.2 Modifications Using Single-Stranded Oligonucleotides; 3.11 Humanized Mouse Models of Human Diseases , 3.12 Inserting Nonselectable Cassettes3.12.1 Generating Cre/Flp Lines for Conditional Knockout Mouse Models; 3.12.2 Generating Reporter Lines; 3.13 Concluding Remarks; References; Chapter 4: Insertional Mutagenesis for Generating Mouse Models of Cancer; 4.1 Introduction; 4.2 Viral Models of Cancer Induced by Insertional Mutagenesis; 4.3 Transposon-Based Models of Cancer Induced by Insertional Mutagenesis; 4.4 Important Considerations in Creating and Interpreting Results from Mouse Models of Cancer Based on Insertional Mutagenesis; 4.5 Conclusions and Future Progress; References , Chapter 5: The RCAS/TVA Somatic Gene Transfer Method in Modeling Human Cancer
    Additional Edition: ISBN 9780387698038
    Additional Edition: Druckausg. ISBN 978-038-769-803-8
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 3
    Book
    Book
    New York, NY : Oxford University Press
    UID:
    gbv_847355454
    Format: xi, 252 Seiten , 25 cm
    ISBN: 9780190944605 , 9780190215903
    Note: Literaturverzeichnis: Seite 223-239 , Hier auch später erschienene, unveränderte Nachdrucke
    Additional Edition: ISBN 9780190215910
    Additional Edition: ISBN 9780190611361
    Additional Edition: ISBN 9780190600679
    Language: English
    Subjects: Political Science
    RVK:
    RVK:
    RVK:
    RVK:
    Keywords: Demokratie ; Repräsentative Demokratie ; Sozialstatus
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  • 4
    Book
    Book
    New York, NY : Oxford University Press
    UID:
    b3kat_BV043703743
    Format: xi, 252 Seiten
    ISBN: 9780190215903
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Online-Ausgabe Green, Jeffrey E (Jeffrey Edward). Shadow of unfairness
    Language: English
    Subjects: Political Science
    RVK:
    RVK:
    RVK:
    RVK:
    Keywords: Demokratie ; Politische Beteiligung ; Ungleichheit
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  • 5
    Online Resource
    Online Resource
    Philadelphia : University of Pennsylvania Press
    UID:
    b3kat_BV048523278
    Format: 1 Online-Ressource (297 Seiten)
    Edition: 1st ed
    ISBN: 9780812298307
    Series Statement: Democracy, Citizenship, and Constitutionalism Ser
    Content: This volume offers theoretical, historical, and legal perspectives on religious freedom, as an experience, value, and right. Drawing on examples from around the world, its essays show how the terrain of religious freedom has never been smooth and how in recent years the landscape of religious freedom has shifted
    Note: Cover -- The Changing Terrain of Religious Freedom -- Title -- Copyright -- Dedication -- CONTENTS -- Introduction: The Landscape of Religious Freedom -- PART I. ETHICAL ARGUMENTS -- 1. A Right of Its Own: A Case for the Human Right of Religious Freedom -- 2. Can Freedom of Religion or Belief (FoRB) Be Universal? -- PART II. THE SOCIAL CONTINGENCY OF RELIGIOUS FREEDOM DISPUTES -- 3. Microclimates of Religious Freedom: Global Norms Meet Local Conditions in Territorial Hawai'i and Occupied Japan -- 4. The Protection of Religion as "Culture" and "History": Three Case Studies -- 5. "Baptism of Ire": Atheist Plaintiffs and Irreligious Freedom in Postwar America -- 6. The Heads or Tails of Cow Protection in India: Religious Freedom and Secular Agriculture -- 7. Bad Faith: Religious Fraud and Religious Freedom in the "Mighty I AM" Case -- PART III. THE (MIS)APPLICATION OF RELIGIOUS FREEDOM -- 8. The Historian's Pickaxe: Uncovering the Racist Origins of the Religious Right -- 9. Female Genital Cutting in Michigan: How Advocates of the Dawoodi Bohra Distorted Religious Freedom to Control Women's Sexual Conduct -- 10. The U.S. Supreme Court and the Future of Religious Freedom in the United States -- Notes -- List of Contributors -- Index -- Acknowledgments
    Additional Edition: Erscheint auch als Druck-Ausgabe Sharkey, Heather J. The Changing Terrain of Religious Freedom Philadelphia : University of Pennsylvania Press,c2021 ISBN 9780812253375
    Language: English
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  • 6
    Online Resource
    Online Resource
    New York : Oxford University Press
    UID:
    gbv_1003275222
    Format: 1 Online-Ressource (viii, 284 p)
    ISBN: 019987171X , 9780199871711
    Content: For centuries it has been assumed that democracy must refer to the empowerment of the People's voice. In this book, Green argues that it is both possible and desirable to understand democracy in terms of what the People gets to see instead of the traditional focus on what it gets to say
    Note: Includes bibliographical references and index
    Additional Edition: ISBN 9780195372649
    Additional Edition: Print version ISBN 9780195372649
    Language: English
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  • 7
    Online Resource
    Online Resource
    New York, NY : Oxford University Press
    UID:
    gbv_1003282873
    Format: 1 Online-Ressource (1 online resource)
    ISBN: 9780190600679
    Content: In this sequel to his prize-winning book, 'The Eyes of the People', Jeffrey Edward Green draws on philosophy, history, social science, and literature to ask what democracy can mean in a world where it is understood that socioeconomic status to some degree will always determine opportunities for civic engagement and career advancement
    Note: Includes bibliographical references and index , Previously issued in print: 2016 , Zielgruppe - Audience: Specialized
    Additional Edition: ISBN 9780190215903
    Additional Edition: Print version ISBN 9780190215903
    Language: English
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