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  • 1
    Language: English
    In: Chemical reviews, 26 March 2014, Vol.114(6), pp.3072-86
    Description: A traditional view of protein-DNA interaction regards the protein as an active element and the DNA as a passive element. This view is often implied across molecular biology where DNA is assumed to function as a relatively stable and uniform polymer probed by proteins with its sequence elements serving to define location. However, DNA is highly dynamic, enwrapping layers of complexity. In particular, DNA actively contributes to processes that dictate how protein-DNA interactions form. Furthermore, its structural features are often crucial to the formation of both transient and stable protein-DNA complexes. Such structure-dependent interaction is distinguishable from proteins that use DNA solely as a sequence-defined scaffold. Here, we provide a general conceptual framework to explore the relationship between DNA and DNA-binding proteins. We consider how it is relevant in vivo and why it should be factored into experimental design and interpretation. We then review illustrative examples that have applied the single-molecule DNA curtain technique to study protein-DNA interactions and show how this framework enhances the understanding of singlemolecule results.
    Keywords: DNA -- Metabolism
    ISSN: 00092665
    E-ISSN: 1520-6890
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  • 2
    Language: English
    In: The American Journal of Human Genetics, 06 July 2017, Vol.101(1), pp.104-114
    Description: We present a rapid and powerful inference procedure for identifying loci associated with rare hereditary disorders using Bayesian model comparison. Under a baseline model, disease risk is fixed across all individuals in a study. Under an association model, disease risk depends on a latent bipartition of rare variants into pathogenic and non-pathogenic variants, the number of pathogenic alleles that each individual carries, and the mode of inheritance. A parameter indicating presence of an association and the parameters representing the pathogenicity of each variant and the mode of inheritance can be inferred in a Bayesian framework. Variant-specific prior information derived from allele frequency databases, consequence prediction algorithms, or genomic datasets can be integrated into the inference. Association models can be fitted to different subsets of variants in a locus and compared using a model selection procedure. This procedure can improve inference if only a particular class of variants confers disease risk and can suggest particular disease etiologies related to that class. We show that our method, called BeviMed, is more powerful and informative than existing rare variant association methods in the context of dominant and recessive disorders. The high computational efficiency of our algorithm makes it feasible to test for associations in the large non-coding fraction of the genome. We have applied BeviMed to whole-genome sequencing data from 6,586 individuals with diverse rare diseases. We show that it can identify multiple loci involved in rare diseases, while correctly inferring the modes of inheritance, the likely pathogenic variants, and the variant classes responsible.
    Keywords: Rare Diseases ; Mendelian Diseases ; Hereditary Disorders ; Rare Variants ; Rare Variant Association Test ; Bayesian Inference ; Whole-Genome Sequencing ; Biology
    ISSN: 0002-9297
    E-ISSN: 1537-6605
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  • 3
    In: Medicine & Science in Sports & Exercise, 2017, Vol.49(5S Suppl 1), pp.564-564
    ISSN: 0195-9131
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 4
    Language: English
    In: Medicine & Science in Sports & Exercise, 2018, Vol.50, p.250
    ISSN: 0195-9131
    Source: Wolters Kluwer - Ovid (via CrossRef)
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  • 5
    Language: English
    In: Medicine & Science in Sports & Exercise, 2014, Vol.46, p.859
    ISSN: 0195-9131
    Source: Wolters Kluwer - Ovid (via CrossRef)
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  • 6
    Language: English
    In: New Media & Society, April 2018, Vol.20(4), pp.1640-1657
    Description: Mobile application design can have a tremendous impact on consumer privacy. But how do mobile developers learn what constitutes privacy? We analyze discussions about privacy on two major developer forums: one for iOS and one for Android. We find that the different platforms produce markedly different definitions of privacy. For iOS developers, Apple is a gatekeeper, controlling market access. The meaning of “privacy” shifts as developers try to interpret Apple’s policy guidance. For Android developers, Google is one data-collecting adversary among many. Privacy becomes a set of defensive features through which developers respond to a data-driven economy’s unequal distribution of power. By focusing on the development cultures arising from each platform, we highlight the power differentials inherent in “privacy by design” approaches, illustrating the role of platforms not only as intermediaries for privacy-sensitive content but also as regulators who help define what privacy is and how it works.
    Keywords: Apple ; Collaboration ; Google ; Governance ; Mobile Media ; Platforms ; Privacy ; Values in Design ; Computer Science
    ISSN: 1461-4448
    E-ISSN: 1461-7315
    Source: SAGE HSS (Sage Publications)
    Source: Sage Journals (Sage Publications)
    Source: SAGE Communication and Media Studies (Sage Publications)
    Source: SAGE Journals (Sage Publications)
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  • 7
    Language: English
    In: Medicine and Science in Sports and Exercise, 2014, Vol.46(5)
    Description: The article reports on a study to evaluate the extent to which individual difference variables account for and predict overall muscular strength and enjoyment post resistance exercise. The results indicate that as with aerobic exercise research, these findings replicate the fact that individual difference variables (A, in this case) are useful in predicting affective responses (i.e., enjoyment).
    Keywords: College Students – Health Aspects ; Muscle Strength – Research ; Aerobic Exercises – Health Aspects
    ISSN: 0195-9131
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  • 8
    Language: English
    In: The Journal of Urology, April 2017, Vol.197(4), pp.e464-e464
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2017.02.1106 Byline: Daniel Greene, Bradley Gill, Yaw Nyame, Molly Elmer-Dewitt, Samuel Haywood, Edmund Sabanegh Author Affiliation: Cleveland, OH Article Note: (footnote) Source of Funding: None
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 9
    In: Middle East African Journal of Ophthalmology, 2012, Vol.19(2), p.247-250
    Description: This case describes a patient with chronic central retinal artery occlusion in one eye and end-stage traumatic glaucoma in the fellow eye. Optical coherence tomography (OCT) of the macula of the chronic phase of central retinal artery occlusion of the right eye indicated loss of the normal foveal depression, extensive inner retinal atrophy, and marked retinal thinning. In contrast, scans of the left eye with end-stage glaucoma demonstrated an intact foveal depression and limited retinal thinning. The pattern of macular OCT findings in this patient illustrates distinguishing features between chronic central retinal artery occlusion and chronic optic neuropathy due to end-stage glaucoma.
    Keywords: Central Retinal Artery Occlusion; Chronic Optic Neuropathy; Optical Coherence Tomography
    ISSN: 0974-9233
    E-ISSN: 09751599
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  • 10
    Language: English
    In: Journal of Corporate Finance, April 2016, Vol.37, pp.56-75
    Description: I compare the wealth of private firm owners that exit their firms through reverse mergers (RMs) to the wealth that could have been obtained in initial public offerings (IPOs), sellouts, or by remaining private. Private firm owners that use the RM exit mechanism have significantly less post-exit wealth than the wealth that could have been obtained in an IPO. This result is driven by differences in the pre-exit characteristics of firms that choose a RM compared to an IPO (a selection effect), not by use of the RM exit mechanism itself (a treatment effect). The gap between post-exit wealth and the wealth that could have been obtained in an IPO disappears for owners of RM firms whose pre-exit characteristics are sufficiently similar to propensity-score matched IPO firms. The post-exit wealth of RM firm owners is approximately the same as the wealth that could have been obtained in a sellout. The median change in private firm owner wealth as a result of the RM is positive when pre-exit private firm values are inferred from valuations in private–private takeovers. However, the median change in wealth is negative when pre-exit private firm values are obtained from valuations provided in fairness opinions. These conflicting findings appear to be driven by upwardly biased fairness opinion valuations.
    Keywords: Reverse Merger ; Initial Public Offering ; Acquisition ; Private Firm ; Fairness Opinion ; Wealth Gain ; Business
    ISSN: 0929-1199
    E-ISSN: 1872-6313
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