Format:
Online-Ressource (IX, 188 p, online resource)
ISBN:
9783540312093
Series Statement:
Resent Results in Cancer Research 172
Content:
This book does nothing less than lay out the state of development of tomorrow's cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?
Content:
Sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs. DNA mutations of a limited set of genes are responsible for the multiple stages of tumorigenesis and metastasis. Matching of therapeutic intervention with insights into the underlying molecular disease mechanism has led to the development of drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to extrapolate this principle and derive more efficient drugs targeting cancer pathway components? Potential drug targets have been identified, but our ability to predict the consequences of inhibition of such components is still limited. The state of development of tomorrows cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities, is described in this book.
Note:
Includes bibliographical references
Additional Edition:
ISBN 9783540312086
Additional Edition:
Druckausg. Targeted interference with signal transduction events Berlin : Springer, 2007 ISBN 3540312080
Additional Edition:
ISBN 9783540312086
Language:
English
Subjects:
Medicine
Keywords:
Krebs
;
Targeted drug delivery
;
Signaltransduktion
;
Krebs
;
Targeted drug delivery
;
Signaltransduktion
;
Aufsatzsammlung
DOI:
10.1007/978-3-540-31209-3
URL:
Volltext
(lizenzpflichtig)
Author information:
Groner, Bernd
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