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  • 1
    Language: English
    In: Endocrinology, January 2014, Vol.155(1), pp.12-4
    Keywords: Gene Expression Regulation ; Adipose Tissue -- Metabolism ; Bone Marrow -- Metabolism ; Leptin -- Metabolism ; Receptors, Leptin -- Genetics
    ISSN: 00137227
    E-ISSN: 1945-7170
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  • 2
    Language: English
    In: PLoS ONE, 2012, Vol.7(2), p.e31508
    Description: Macrophage inflammatory protein-1α (CCL3) plays a well-known role in infectious and viral diseases; however, its contribution to atherosclerotic lesion formation and lipid metabolism has not been determined. Low density lipoprotein receptor deficient (LDLR −/− ) mice were transplanted with bone marrow from CCL3 −/− or C57BL/6 wild type donors. After 6 and 12 weeks on western diet (WD), recipients of CCL3 −/− marrow demonstrated lower plasma cholesterol and triglyceride concentrations compared to recipients of C57BL/6 marrow. Atherosclerotic lesion area was significantly lower in female CCL3 −/− recipients after 6 weeks and in male CCL3 −/− recipients after 12 weeks of WD feeding ( P 〈0.05). Surprisingly, male CCL3 −/− recipients had a 50% decrease in adipose tissue mass after WD-feeding, and plasma insulin, and leptin levels were also significantly lower. These results were specific to CCL3, as LDLR −/− recipients of monocyte chemoattractant protein −/− (CCL2) marrow were not protected from the metabolic consequences of high fat feeding. Despite these improvements in LDLR −/− recipients of CCL3 −/− marrow in the bone marrow transplantation (BMT) model, double knockout mice, globally deficient in both proteins, did not have decreased body weight, plasma lipids, or atherosclerosis compared with LDLR −/− controls. Finally, there were no differences in myeloid progenitors or leukocyte populations, indicating that changes in body weight and plasma lipids in CCL3 −/− recipients was not due to differences in hematopoiesis. Taken together, these data implicate a role for CCL3 in lipid metabolism in hyperlipidemic mice following hematopoietic reconstitution.
    Keywords: Research Article ; Biology ; Medicine ; Immunology ; Diabetes And Endocrinology
    E-ISSN: 1932-6203
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  • 3
    Language: English
    In: Diabetes, September 2013, Vol.62(9), pp.3180-8
    Description: Obesity is one of the leading causes of morbidity in the U.S. Accumulation of proinflammatory immune cells in adipose tissue (AT) contributes to the development of obesity-associated disorders. Weight loss is the ideal method to counteract the negative consequences of obesity; however, losses are rarely maintained, leading to bouts of weight cycling. Fluctuations in weight have been associated with worsened metabolic and cardiovascular outcomes; yet, the mechanisms explaining this potential correlation are not known. For determination of whether weight cycling modulates AT immune cell populations, inflammation, and insulin resistance, mice were subjected to a diet-switch protocol designed to induce weight cycling. Weight-cycled mice displayed decreased systemic glucose tolerance and impaired AT insulin sensitivity when compared with mice that gained weight but did not cycle. AT macrophage number and polarization were not modulated by weight cycling. However, weight cycling did increase the number of CD4(+) and CD8(+) T cells in AT. Expression of multiple T helper 1-associated cytokines was also elevated subsequent to weight cycling. Additionally, CD8(+) effector memory T cells were present in AT of both obese and weight-cycled mice. These studies indicate that an exaggerated adaptive immune response in AT may contribute to metabolic dysfunction during weight cycling.
    Keywords: Adipose Tissue -- Immunology ; Body Weight -- Physiology
    ISSN: 00121797
    E-ISSN: 1939-327X
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  • 4
    Language: English
    In: Immunity, 14 November 2013, Vol.39(5), pp.803-805
    Description: Allergies are widely considered misguided Th2 cell responses. In this issue, and show that mice mount anti-venom Th2 cell responses that share components of the “allergic” response but confer protection.
    Keywords: Medicine ; Biology
    ISSN: 1074-7613
    E-ISSN: 1097-4180
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  • 5
    Language: English
    In: Diabetes, Nov, 2014, Vol.63(11), p.3827(8)
    Keywords: Type 1 Diabetes -- Risk Factors ; Type 1 Diabetes -- Care And Treatment ; Mast Cells -- Research ; Immune Response -- Analysis
    ISSN: 0012-1797
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  • 6
    Language: Spanish
    In: Revista de Derecho Penal y Criminologia, Jan-June, 2012, Vol.33(94), p.127(27)
    Description: Desde mediados del siglo XIX, epoca en que nacieron las ciencias sociales, al decidir los precursores que la sociedad podia ser objeto de investigacion cientifica, al igual que los objetos materiales de las ciencias naturales, adquirieron la obligacion de estructurarse propiamente como ciencias, para lo cual parece que el tiempo transcurrido aun no ha sido suficiente. En el caso de la Criminologia (cuando se concibe como ciencia factica causal-explicativa), luego de tener perfecta claridad sobre su objeto: los factores codeterminantes o "causas" de las conductas desviadas, la tarea debe ser la definicion e incorporacion del moderno concepto de explicacion cientifica, intentando superar las complejidades epistemologicas surgidas alrededor de expresiones como las de autonomia, interdisciplinariedad, metodo, plurifactorialidad, y el propio problematico concepto de causa, entre otros. La teoria, como concrecion de la explicacion cientifica, no solo sera la fase final del objeto, sino el mas util aporte que hara la Criminologia a la Ciencia Penal y a la Politica Criminal, para la prediccion, prevencion y control de la criminalidad. Palabras clave: Criminologia, explicacion cientifica, factores codeterminantes, causalidad, metodo, plurifactorialidad, interdisciplinariedad, teoria. since middle 19th Century, age in which the Social Sciences were born, when the precursors decided that the Society could be a matter of scientific investigation, as well as the material objects of Natural Science, acquired the obligation of being structured as they are, however, it seems that the time that has passed has not been good enough. In the case of Criminology (when this one is conceived as a factual causal-explicative science) after having perfectly understood its object: determinant factors or "causes" of misbehavior; the task must be the definition and incorporation of the modern concept of the scientific explanation, trying to exceed the epistemologist complexity that has arisen around the expressions such as autonomy, interdisciplinary, method, multifactorial elements, and the problematic concept of cause itself, among others. The theory as the concretion of the scientific explanation, not only will be the final phase of the object, but the most useful contribution that the Criminology will give to the Criminal Science and to the Criminal Policy, to predict, prevent and control criminality. Keywords: Criminology, scientific explanation, determinant factors, causalities, methods, multi-factorial elements, interdisciplinary, theory (1) **.
    Keywords: Social Security
    ISSN: 0121-0483
    E-ISSN: 23462108
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  • 7
    Language: Spanish
    In: Derecho Penal y Criminología, 2016, Vol.37(102), pp.13-29
    Description: Faced with the dilemma posed between science and science explanation as causal or teleological explanation, the article proposes, under the challenge materialized in the complexity of the causal processes of actual crime, a comprehensive explanation of the phenomenon. Because of the function of essential auxiliary science of criminology etiological, for criminal science is crucial, so the paper presente the incorporation of the principle of final cause or motivating factor. Knowledge of the true origins of a phenomenon, enables is prediction and thus its prevention or control, only then will a possible task for criminal policy.
    Description: Ante la disyuntiva planteada entre la ciencia como explicación causal y la ciencia como explicación teleológica, propongo, en virtud del gran reto materializado en la complejidad de los procesos causales de la criminalidad actual, una explicación integral del fenómeno. Por la función de ciencia auxiliar indispensable de la criminología etiológica para la ciencia penal, resulta crucial su labor explicativa, por lo cual planteo la incorporación del principio de la causa final o factor motivacional. El conocimiento de los verdaderos orígenes de un fenómeno posibilita la predicción y, con ello, la prevención o el control, que solo así serán una tarea posible para la política criminal.
    Keywords: Criminology ; Teleological ; Explanation ; Causal Explanation ; Comprehensive Explanation ; Criminal Policy ; Criminología ; Explicación Teleológica ; Explicación Causal ; Explicación Integral ; Política Criminal
    ISSN: 2346-2108
    ISSN: 01210483
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  • 8
    Language: Spanish
    In: Cambios y Permanencias, 01 December 2013, Issue 4, pp.1-18
    ISSN: 2027-5528
    E-ISSN: 2027-5528
    Source: Directory of Open Access Journals (DOAJ)
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  • 9
    In: Escritura e Imagen, 12/17/2018, Vol.14(0)
    Description: La música como expresión artística esconde significados que trascienden a la estética, que pueden analizarse desde otras disciplinas y campos de estudio. La retórica como arte del discurso y herramienta del lenguaje, puede encontrarse en la composición musical como elemento persuasivo, que utiliza el pathos como medio para producir emociones en el oyente. El presente texto analiza el Estudio Patético Op. 8 No. 12 de Aleksandr Scriabin desde la perspectiva del discurso, a fin de encontrar las figuras retóricas asociadas al concepto del pathos griego, utilizando como referencias análisis previos a obras musicales con el adjetivo patético. El texto también busca aportar claridad respecto al concepto de lo patético, cuyo significado ha sufrido transformaciones a lo largo de los siglos, alterando su concepción griega original. El presente análisis propone abordar las obras musicales desde la perspectiva de la retórica, a fin de lograr una mayor comprensión de la composición y una mejor interpretación por parte del ejecutante.
    Keywords: Discourse Analysis ; Music ; Rhetoric ; Aesthetics ; Música ; Estética ; Discurso ; Retórica ; Pathos;
    ISSN: 1885-5687
    E-ISSN: 1988-2416
    Source: CrossRef
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  • 10
    Language: Portuguese
    In: Argumentos (México, D.F.), 01 December 2011, Vol.24(67), pp.115-132
    Description: Las vanguardias artísticas del siglo XX anticiparon y representaron la descomunal violencia de la guerra mundial. Para comunicarse transformaron, de manera radical, las prácticas creativas de la época e incorporaron en ellas al espectador. Sin embargo, sólo los entendidos tuvieron capacidad para tomar parte en los procesos de comunicación, y así se disparó la secular separación entre el sistema del arte y el sistema social. Con base en la teoría de sistemas de Niklas Luhmann, este artículo sostiene lo anterior, y estudia las características y el desarrollo de los procesos creativos a lo largo de la historia. Para ello, se remonta a orígenes mismos de la civilización, y concluye que actualmente el sistema del arte está escindido del resto de la sociedad: gira en torno a sí mismo.
    Keywords: Humanities, Multidisciplinary ; Social Sciences, Interdisciplinary ; Sociology ; Sistema Del Arte ; Prácticas Creativas ; Procesos de Comunicación ; Operación de Observación ; Forma ; Art System ; Creative Practices ; Communication Processes ; Observational Operation ; Form ; History & Archaeology
    ISSN: 0187-5795
    Source: SciELO
    Source: SciELO Mexico
    Source: SciELO Complete
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