Format:
Online-Ressource (IX, 395 p. 56 illus., 37 illus. in color, online resource)
ISBN:
9783319056876
Series Statement:
SpringerLink
Content:
This book presents an overview of the RNA networks controlling gene expression in fungi highlighting the remaining questions and future challenges in this area.It covers several aspects of the RNA-mediated mechanisms that regulate gene expression in model yeasts and filamentous fungi, organisms of great importance for industry, medicine and agriculture. It is estimated that there are more than one million fungal species on the Earth. Despite their diversity (saprophytic, parasitic and mutualistic), fungi share common features distinctive from plants and animals and have been grouped taxonomically as an independent eukaryotic kingdom. In this book, 15 chapters written by experts in their fields cover the RNA-dependent processes that take place in a fungal cell ranging from formation of coding and non-coding RNAs to mRNA translation, ribosomal RNA biogenesis, gene silencing, RNA editing and epigenetic regulation.
Note:
Description based upon print version of record
,
Preface; Contents; About the Editors; 1 RNA Polymerase II-Dependent Transcription in Fungi and Its Interplay with mRNA Decay; Abstract; Transcription Initiation; PIC Assembly; Chromatin Remodelling Complexes; GTFs; RNA Pol II; Promoter DNA Melting; Promoter Escape; Transcription Elongation; The CTD Code Through Elongation; Pausing and Backtracking; Factors Counteracting and Regulating RNA Pol II Arrest; Chromatin Dynamics During Transcription Elongation; Transcription-Coupled Processes and Termination; 5vprime Capping; Splicing; 3vprime End Processing and Termination; mRNA Transport
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Interplay Between mRNA Synthesis and DecayReferences; 2 Pre-mRNA Splicing and the Spliceosome: Assembly, Catalysis, and Fidelity; Abstract; Gene Architecture; Pre-mRNA Splicing and the Spliceosome; Association of U1 snRNP with the pre-mRNA Transcript; Recognition of the Branchpoint; Assembly of the U4/U6bulletU5 Triple snRNP; Spliceosome Activation; Catalytic Steps; Spliceosome Remodeling Between Catalytic Steps I and II; Spliceosome Disassembly; Splicing Fidelity; Concluding Remarks; Acknowledgments; References; 3 Fungal Pre-mRNA 3vprime-End Processing; Abstract
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Pre-mRNA 3vprime-End Processing: An OverviewFungal Poly(A) Site Sequence Features; Fungal mRNA 3vprime Processing Factors; mRNA 3vprime Processing Factors in S. cerevisiae; CFIA; CFIB; CPF; Poly(A) Binding Proteins; S. pombe 3vprime Processing Factors; Regulators of mRNA 3vprime Processing; Factors Required for S. cerevisiae Histones mRNA 3vprime Processing; Release of mRNA 3vprime Processing Factors After Polyadenylation; Alternative Polyadenylation and its Regulation in Fungi; APA Regulation and Metabolism; APA Regulation and DNA Damage Response
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Nab4/Hrp1-Mediated APA Regulation and Copper StressAPA Regulation of Meiotic Gene Expression; Other Examples of Alternative Polyadenylation in Fungi; Gene Regulation at the 3vprime End; mRNA 3vprime Processing in the Regulation of S. pombe Meiotic Genes; mRNA 3vprime Processing Regulates the Expression of Neighboring Genes; Conclusion /Future Directions; References; 4 mRNA Export; Abstract; The Early Phase: From Pre-mRNA Transcription and Maturation to Formation of an Export Competent mRNP; The TREX Complex; The TREX-2 and the SAGA Complexes; mRNA Export Receptors; mRNA Export Adapters
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The Late Phase: The Nuclear Pore Complex and mRNA TranslocationmRNA Surveillance and Quality Control in the Nucleus; mRNA Export and its Regulation Via Post-Translational Protein Modifications; mRNA Export During Cellular Stress; References; 5 mRNA Translation: Fungal Variations on a Eukaryotic Theme; Abstract; Introduction; The Molecular Mechanism of Translation; Translation Initiation; Translation Elongation; Translation Termination and Ribosome Recycling; Round and Round: Translation on Circularised Messages; Global Regulation of Translational Activity
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mRNA Features that Determine the Efficiency of Protein Synthesis
Additional Edition:
ISBN 9783319056869
Additional Edition:
Druckausg. Fungal RNA biology Cham : Springer, 2014 ISBN 9783319056869
Language:
English
Subjects:
Biology
DOI:
10.1007/978-3-319-05687-6
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