Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Language
Year
  • 1
    Language: German
    In: Operative Orthopädie und Traumatologie, 2012, Vol.24(1), pp.13-22
    Description: Byline: H. Haferkamp (1,8044) Keywords: Handgelenk; Distales radioulnares Gelenk; Radiusfraktur; Kapandji-Sauve-Operation; Arthrodese; Wrist joint; Distal radioulnar joint; Radius fracture; Kapandji-Sauve procedure; Arthrodesis Abstract (German): Operationsziel Verbesserung der Unterarmrotation sowie Reduktion oder vollige Beseitigung der durch die Zerstorung des distalen Radioulnargelenks bedingten Schmerzen, gegebenenfalls unter Beseitigung eines Ellenvorschubs. Indikationen Irreversible Zerstorung des distalen Radioulnargelenks durch Arthrose. Kontraindikationen Wiederherstellung der Funktion des distalen Radioulnargelenks durch Korrekturosteotomie des Radius oder Ellenverkurzung moglich. Instabilitat der distalen Ulna. Rheumatische Erkrankungen. Ausgepragte Osteoporose. Operationstechnik Das distale Radioulnargelenk wird verblockt. Durch Resektion eines distalen Ellenteilstucks wird ein neues Drehgelenk gebildet. Weiterbehandlung Postoperativ wird eine gepolsterte Unterarmgipsschiene fur 3--4 Wochen angelegt. Nach Abnahme des Gipses konnen auch vorsichtige Rotationsbewegungen des Unterarms durchgefuhrt werden. Starkere Belastungen sind nach knocherner Konsolidierung der radioulnaren Arthrodese nach 6--8 Wochen moglich. Ergebnisse Im Zeitraum von 1991 bis 2003 haben wir insgesamt 75 Operationen nach Kapandji-Sauve durchgefuhrt. An Komplikationen fanden sich eine knocherne Uberbruckung der Ellenlucke und 3 unvollstandige Konsolidierungen der radioulnaren Arthrodese, die nach Revisionsoperation mit Spongiosaanlagerung ausheilten. In 2 Fallen hatten wir ein Problem mit dem proximalen Ellenstumpf, wobei die Beschwerden in einem Fall durch Resektion eines Kugelkallus, in einem anderen Fall durch weitere Ellenverkurzung beseitigt werden konnten. Der postoperative Rotationsgewinn betrug bei 45 nachuntersuchten Patienten im Durchschnitt fur die Supination 34deg fur die Pronation 32deg, also insgesamt 66deg. Bei einer spateren Untersuchung der Langzeitergebnisse mit 25 Patienten wurde diese nach einem modifizierten Martini-Score bewertet. Dabei fanden sich unter Berucksichtigung der objektiven (Beweglichkeit, Kraft) und der subjektiven Parameter in 12% sehr gute, in 52% gute und in 8% befriedigende Ergebnisse. Ein schlechtes Ergebnis war in nur einem Fall (4%) zu verzeichnen. Abstract: Objective The Kapandji-Sauve procedure aims at improvement of rotation in the distal radioulnar joint and reduction of pain. Cases of ulnar impaction syndrome can also be corrected during the same procedure. Indications The most important indication is painful und restricted forearm rotation after fracture of the distal radius combined with obsolete dislocation or destruction of the distal radioulnar joint. Contraindications It is a salvage procedure and is contraindicated when reconstruction of the radioulnar joint or shortening of the ulna is possible. Further contraindications are rheumatic arthritis and osteoporosis. Surgical technique The Kapandji-Sauve procedure creates a new distal rotatory joint due to distal radioulnar fusion and segmental resection of the distal ulna. Postoperative management Forearm cast including the wrist for 3--4 weeks. Phyisiotherapy and intensive exercises of the fingers on postoperative day 1. After removing the cast, careful rotation exercises are possible. Results In 75 patients, the Kapandji-Sauve procedure was performed between 1990 and 2003. Failure was observed in one patient with a bony regeneration between the resected ulnar segment. In 3 cases, a nonunion of the radioulnar joint was found. After revision with bone grafting, bony consolidation of the joint was identified in all cases. In 2 cases, there were problems with the proximal ulnar stump, whereby this was corrected in one case by resection of a ball-type callus. In the other case, painful ulna-snapping was reduced by shortening of the ulna. In earlier follow-up with 45 patients and later long-turn follow-up, ranging from 3--12 years, not only were significant improvement of forearm rotation and reduction of pain observed, but also good patient satisfaction was found. Author Affiliation: (18044) Adolfstr. 28, 34121, Kassel, Deutschland Article History: Registration Date: 01/01/2010 Online Date: 10/05/2010
    Keywords: Wrist joint ; Distal radioulnar joint ; Radius fracture ; Kapandji-Sauvé procedure ; Arthrodesis
    ISSN: 0934-6694
    E-ISSN: 1439-0981
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Journal of Materials Science, 2018, Vol.53(19), pp.13713-13718
    Description: The mechanochemical Knoevenagel condensation of three fluorinated benzaldehyde derivates and malononitrile was investigated. The reactions were performed under solvent- and catalyst-free conditions and resulted in highly crystalline products after crystallization from a viscous phase in the milling jar. The quality of the obtained crystals was sufficient for single-crystal X-ray diffraction circumventing a recrystallization step. To gain more information on the reaction, progress was investigated in situ using time-resolved Raman spectroscopy. The results show a direct conversion of the reactants.
    Keywords: Knoevenagel-Condensation ; Benzaldehyde ; X-Ray-Diffraction ; Recrystallisation ; Solvents ; Reactant ; Time-Of-Use ; Raman-Spectroscopy ; Knoevenagel-Kondensation ; Benzaldehyd ; Röntgendiffraktion ; Rekristallisation ; Lösungsmittel ; Reaktant ; Nutzungszeit ; Raman-Spektroskopie ; Engineering;
    ISSN: 0022-2461
    E-ISSN: 1573-4803
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: The Journal of Bacteriology, 2011, Vol. 193(1), p.225
    Description: Intracellular bacteria live in an environment rich in most essential metabolites but need special mechanisms to access these substrates. Nucleotide transport proteins (NTTs) catalyze the import of ATP and other nucleotides from the eukaryotic host into the bacterial cell and render de novo synthesis of these compounds dispensable. The draft genome sequence of Simkania negevensis strain Z, a chlamydial organism considered a newly emerging pathogen, revealed four genes encoding putative nucleotide transport proteins (SnNTT1 to SnNTT4), all of which are transcribed during growth of S. negevensis in Acanthamoeba host cells, as confirmed by reverse transcription-PCR. Using heterologous expression in Escherichia coli, we could show that SnNTT1 functions as an ATP/ADP antiporter, SnNTT2 as a guanine nucleotide/ATP/H... symporter driven by the membrane potential, and SnNTT3 as a nucleotide triphosphate antiporter. In addition, SnNTT3 is able to transport dCTP, which has not been shown for a prokaryotic transport protein before. No substrate could be identified for SnNTT4. Taking these data together, S. negevensis employs a set of nucleotide transport proteins to efficiently tap its host's energy and nucleotide pools. Although similar to other chlamydiae, these transporters show distinct and unique adaptations with respect to substrate specificities and mode of transport. (ProQuest: ... denotes formulae/symbols omitted.)
    Keywords: Metabolites ; Bacteria ; Bacterial Proteins ; Adenosine Triphosphatase ; Eukaryotes ; Genomes ; Pathogens ; Gene Expression ; E Coli;
    ISSN: 0021-9193
    ISSN: 00219193
    E-ISSN: 10985530
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Cancer Research, 04/15/2013, Vol.73(8 Supplement), pp.1711-1711
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 01 May 2018, Vol.115(18), pp.4791-4796
    Description: The β-1,3-glucan chrysolaminarin is the main storage polysaccharide of diatoms. In contrast to plants and green algae, diatoms and most other algal groups do not accumulate storage polysaccharides in their plastids. The diatom possesses only a single gene encoding a putative β-1,3-glucan synthase (BGS). Here, we characterize this enzyme by expressing GFP fusion proteins in and by creating and investigating corresponding gene silencing mutants. We demonstrate that BGS is a vacuolar protein located in the tonoplast. Metabolite analyses of two mutant strains with reduced amounts of BGS reveal a reduction in their chrysolaminarin content and an increase of soluble sugars and lipids. This indicates that carbohydrates are shunted into alternative pathways when chrysolaminarin production is impaired. The mutant strains show reduced growth and lower photosynthetic capacities, while possessing higher photoprotective abilities than WT cells. Interestingly, a strong reduction in BGS expression also results in aberrations of the usually very regular thylakoid membrane patterns, including increased thylakoid thickness, reduced numbers of thylakoids per plastid, and increased numbers of lamellae per thylakoid stack. Our data demonstrate the complex intertwinement of carbohydrate storage in the vacuoles with carbohydrate metabolism, photosynthetic homeostasis, and plastid morphology.
    Keywords: Chrysolaminarin ; Photosynthesis ; Thylakoids ; Vacuole ; Β-1,3-Glucan Synthase ; Carbohydrate Metabolism -- Physiology ; Diatoms -- Metabolism ; Homeostasis -- Physiology ; Photosynthesis -- Physiology ; Thylakoids -- Metabolism ; Beta-Glucans -- Metabolism
    ISSN: 00278424
    E-ISSN: 1091-6490
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: The Journal of biological chemistry, 05 October 2012, Vol.287(41), pp.34722-9
    Description: The pro-death Bcl-2 family protein and tumor suppressor Bax is frequently mutated in tumors with microsatellite instability (MSI). The mutation often results in a "Bax negative" phenotype and therefore is generally thought to be beneficial to the development of the tumor. Here, we report the identification of a novel Bax isoform, BaxΔ2, which is unique to microsatellite unstable tumors. BaxΔ2 is generated by a unique combination of a microsatellite deletion in Bax exon 3 and alternative splicing of Bax exon 2. Consistently, BaxΔ2 is only detected in MSI cell lines and primary tumors. BaxΔ2 is a potent cell death inducer but does not directly target mitochondria. In addition, BaxΔ2 sensitizes certain MSI tumor cells to a subset of chemotherapeutic agents, such as adriamycin. Thus, our data provide evidence that mutation and alternative splicing of tumor suppressors such as Bax are not always beneficial to tumor development but can be detrimental instead.
    Keywords: Alternative Splicing ; Microsatellite Instability ; Neoplasms -- Metabolism ; Bcl-2-Associated X Protein -- Metabolism
    E-ISSN: 1083-351X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Journal of Bacteriology, July, 2013, Vol.195(13-14), p.3183(10)
    Description: All organisms require S-adenosylmethionine (SAM) as a methyl group donor and cofactor for various biologically important processes. However, certain obligate intracellular parasitic bacteria and also the amoeba symbiont Amoebophilus asiaticus have lost the capacity to synthesize this cofactor and hence rely on its uptake from host cells. Genome analyses revealed that A. asiaticus encodes a putative SAM transporter. The corresponding protein was functionally characterized in Escherichia coli: import studies demonstrated that it is specific for SAM and S-adenosylhomocysteine (SAH), the end product of methylation. SAM transport activity was shown to be highly dependent on the presence of a membrane potential, and by targeted analyses, we obtained direct evidence for a proton-driven SAM/SAH antiport mechanism. Sequence analyses suggest that SAM carriers from Rickettsiales might operate in a similar way, in contrast to chlamydial SAM transporters. SAM/SAH antiport is of high physiological importance, as it allows for compensation for the missing methylation cycle. The identification of a SAM transporter in A. asiaticus belonging to the Bacteroidetes phylum demonstrates that SAM transport is more widely spread than previously assumed and occurs in bacteria belonging to three different phyla (Proteobacteria, Chlamydiae, and Bacteroidetes).
    Keywords: Escherichia Coli -- Research ; Escherichia Coli -- Physiological Aspects ; Genomes -- Analysis ; Methylation -- Research
    ISSN: 0021-9193
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Journal of molecular biology, 02 November 2012, Vol.423(4), pp.590-9
    Description: Oxa1 serves as a protein insertase of the mitochondrial inner membrane that is evolutionary related to the bacterial YidC insertase. Its activity is critical for membrane integration of mitochondrial translation products and conservatively sorted inner membrane proteins after their passage through the matrix. All Oxa1 substrates identified thus far have bacterial homologs and are of endosymbiotic origin. Here, we show that Oxa1 is critical for the biogenesis of members of the mitochondrial carrier proteins. Deletion mutants lacking Oxa1 show reduced steady-state levels and activities of the mitochondrial ATP/ADP carrier protein Aac2. To reduce the risk of indirect effects, we generated a novel temperature-sensitive oxa1 mutant that allows rapid depletion of a mutated Oxa1 variant in situ by mitochondrial proteolysis. Oxa1-depleted mitochondria isolated from this mutant still contain normal levels of the membrane potential and of respiratory chain complexes. Nevertheless, in vitro import experiments showed severely reduced import rates of Aac2 and other members of the carrier family, whereas the import of matrix proteins was unaffected. From this, we conclude that Oxa1 is directly or indirectly required for efficient biogenesis of carrier proteins. This was unexpected, since carrier proteins are inserted into the inner membrane from the intermembrane space side and lack bacterial homologs. Our observations suggest that the function of Oxa1 is relevant not only for the biogenesis of conserved mitochondrial components such as respiratory chain complexes or ABC transporters but also for mitochondria-specific membrane proteins of eukaryotic origin.
    Keywords: Electron Transport Complex IV -- Metabolism ; Mitochondria -- Metabolism ; Mitochondrial Adp, ATP Translocases -- Metabolism ; Mitochondrial Proteins -- Metabolism ; Nuclear Proteins -- Metabolism ; Saccharomyces Cerevisiae -- Metabolism ; Saccharomyces Cerevisiae Proteins -- Metabolism
    ISSN: 00222836
    E-ISSN: 1089-8638
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    In: International Journal of Cancer, 01 March 2015, Vol.136(5), pp.E290-E300
    Description: Merkel cell polyomavirus (MCPyV)‐positive Merkel cell carcinoma (MCC) tumor cell growth is dependent on the expression of a viral Large T antigen (LT) with an intact retinoblastoma protein (RB)‐binding site. This RB‐binding domain in MCPyV‐LT is—in contrast to other polyomavirus LTs (., SV40)—embedded between two large MCPyV unique regions (MUR1 and MUR2). To identify elements of the MCPyV‐LT necessary for tumor cell growth, we analyzed the rescue activity of LT variants following knockdown of the endogenous LT in MCC cells. These experiments demonstrate that nuclear localization is essential for LT function, but that a motif previously described to be a nuclear localization sequence is neither required for nuclear accumulation of truncated MCPyV‐LT nor for promotion of MCC cell proliferation. Furthermore, large parts of the MURs distal to the RB binding domain as well as ALTO—a second protein encoded by an alternative reading frame in the MCPyV‐LT mRNA—are completely dispensable for MCPyV‐driven tumor cell proliferation. Notably, even MCPyV‐LTs in which the entire MURs have been removed are still able to promote MCC cellular growth although rescue activity is reduced which may be due to MUR1 being required for stable LT expression in MCC cells. Finally, we provide evidence implying that—while binding to Vam6p is not essential—HSC‐70 interaction is significantly involved in mediating MCPyV‐LT function in MCC cells including growth promotion and induction of E2F target genes. What's new? The Merkel cell polyomavirus (MCPyV) is the first virus of the polyomavirus family to be established as a causal factor of a human cancer. Merkel cell carcinoma is a rare but very aggressive skin cancer with high mortality rates. Here, the authors describe experiments defining certain domains and molecular functions of the Large T antigen encoded by MCPyV, which are either essential or dispensable for its growth‐promoting function in Merkel cell carcinoma cells.
    Keywords: Merkel Cell Carcinoma ; Polyomavirus ; Large T Antigen
    ISSN: 0020-7136
    E-ISSN: 1097-0215
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: German
    In: Der Urologe, 2018, Vol.57(3), pp.272-273
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00120-018-0594-6 Byline: A. Haferkamp (1) Author Affiliation: (1) grid.410607.4, Klinik und Poliklinik fur Urologie und Kinderurologie, Universitatsmedizin Mainz, Langenbeckstra[sz]e 1, 55131, Mainz, Deutschland Article History: Registration Date: 31/01/2018 Online Date: 15/03/2018
    Keywords: Nephrectomy ; Carcinoma, Renal Cell -- Diagnosis ; Kidney Neoplasms -- Diagnosis;
    ISSN: 0340-2592
    E-ISSN: 1433-0563
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages