Format:
Online-Ressource (XVII, 354p. 61 illus., 45 illus. in color, digital)
Edition:
1
ISBN:
9781461401063
,
1283351838
,
9781283351836
Series Statement:
Advances in Experimental Medicine and Biology 946
Content:
Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists
Note:
Includes bibliographical references and index
,
Preface; Contents; List of Contributors; Pentraxins in Humoral Innate Immunity; 1 Introduction; 2 The Pentraxin Superfamily; 3 The Short Pentraxins in Innate Immunity; 4 The Long Pentraxin PTX3; 4.1 Gene Organization and Expression; 4.2 Protein Structure; 4.3 Interaction with Complement and Fc? Receptors; 4.4 PTX3 in Pathogen Recognition and Inflammation; 4.5 Self versus Modified Self-Discrimination; 4.6 PTX3 Role in Tissue Remodelling; 4.7 Diagnostic and Prognostic Potential of PTX3 in Infectious Disorders; 5 Concluding Remarks; References
,
Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution1 Introduction; 2 Structure and Biochemical Properties of Galectins; 3 Biological Roles of Galectins in Development and Regulation of Immune Homeostasis; 4 Galectins as Pattern Recognition Receptors; 5 Some Microbial Pathogens and Parasites Subvert the Role of Galectins as PRRs; 6 Conclusions; References; The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells-An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids; 1 Introduction
,
2 Stem Cell Mobilization2.1 Stem Cell Mobilization as Part of Stress Response; 2.2 Activation of Complement Cascade (CC); 2.3 Involvement of Granulocytes in Mobilization; 2.4 Role of Sphingosine 1-Phosphate (S1P); 3 Stem Cell Homing; 3.1 Conditioning for Transplantation Induces Proteolytic Microenvironment in BM; 3.2 Conditioning for Transplantation Activates Complement Cascade (CC) in BM; 4 Implications of "Priming Phenomenon" that Enhances Responsiveness of CXCR4 Receptor to SDF-1 Gradient; 5 Conclusions; References
,
Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds1 Introduction; 2 The Burden of Chronic Wounds; 3 Surveying the Microbial Diversity of Chronic Wounds; 4 The Skin is the First Line of Defense; 5 The Innate Immune Response During Normal Wound Healing; 6 An Aberrant Innate Immune Response in Chronic Wounds; 7 Conclusions and Perspectives; References; Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity; 1 Introduction; 2 Keystone Pathogens in the Periodontal Biofilm
,
3 Porphyromonas gingivalis: Interfering with Host Immunity for the Microbial "Common Good"?3.1 The LPS as a Tool to Antagonize TLR4; 3.2 The Gingipains as a Means to Manipulate Complement and Leukocytes; 3.3 Fimbriae: Multitasking Beyond Colonization; 4 Is the Presence of P. gingivalis Benefiting Other Periodontal Bacteria?; 5 Perspectives and Conclusions; References; A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects; 1 Immunoglobulins; 2 A Conserved Binding Site at the Junction of Two Constant Domains
,
3 Functional Consequences of Host Proteins Binding to the Conserved Site on Immunoglobulins
Additional Edition:
ISBN 9781461401056
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-40105-6
Language:
English
Subjects:
Medicine
Keywords:
Angeborene Immunität
DOI:
10.1007/978-1-4614-0106-3
URL:
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