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  • 1
    Language: English
    In: Journal of the American Chemical Society, 28 December 2011, Vol.133(51), pp.20672-5
    Description: Sintering of nanoparticles (NPs) of Ni supported on MgAl(2)O(4) was monitored in situ using transmission electron microscopy (TEM) during exposure to an equimolar mixture of H(2) and H(2)O at a pressure of 3.6 mbar at 750 °C, conditions relevant to methane steam reforming. The TEM images revealed an increase in the mean particle size due to disappearance of smaller, immobile NPs and the resultant growth of the larger NPs. A new approach for predicting the long-term sintering of NPs is presented wherein microscopic observations of the ripening of individual NPs (over a span of a few seconds) are used to extract energetic parameters that allow a description of the collective behavior of the entire population of NPs (over several tens of minutes).
    Keywords: Magnesium Compounds -- Chemical Properties ; Nickel (Metal) -- Chemical Properties ; Sintering -- Methods ; Transmission Electron Microscopes -- Usage;
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 2
    Language: English
    In: Journal of European Public Policy, 01 June 2011, Vol.18(4), pp.607-617
    Description: The Lisbon Treaty introduces a distinction between legislative, delegated and implementation acts and thus represents a new approach to delegated decision-making in the EU. This will lead to a reform of the comitology system. Against this background this contribution takes stock. What do we...
    Keywords: Comitology ; Delegated Decision-Making ; Lisbon Treaty ; Government ; Political Science
    ISSN: 1350-1763
    E-ISSN: 1466-4429
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  • 3
    Language: English
    In: Schizophrenia Research, March 2012, Vol.135(1-3), pp.105-111
    Description: Cognitive adaptation training (CAT) targets the adaptive behaviour of patients with schizophrenia and has shown promising results regarding the social aspects of psychosocial treatment. As yet, no reports have appeared on the use of CAT in combination with assertive community treatment (ACT). Our purpose was to evaluate the effect of CAT in comparison with ACT, focusing on social functions (primary outcome), symptoms, relapse, re-hospitalisation, and quality of life of outpatients with schizophrenia. The trial was a parallel, randomised, multicentre trial conducted in three centres treating patients with a first episode of schizophrenia disorder. A total of 62 outpatients diagnosed as having schizophrenia were randomly assigned to CAT + ACT or ACT alone. The CAT was conducted in the patient's home and included instruction in prompting for specific actions. The treatment lasted for 6 months, and the patients were assessed at baseline and at 6- and 9-month follow-ups. The results of mixed-effects regression models indicated no significant differences between intervention group and control group at 6 and 9 months in any outcome [Global Assessment of Functioning at 6 months (p = 0.32) and the Health of the Nation Outcome Scales social subscale at 6 months (p = 0.30)]. The results from this trial differ from previous CAT trials because use of CAT showed no significant effects. However, the low number of participants may have been responsible for these results. Thus, additional studies are needed to determine whether the use of some elements of CAT can help to make ACT more economically effective.
    Keywords: Assertive Community Treatment ; Psychological Adaptation ; Memory Disorders ; Rct
    ISSN: 0920-9964
    E-ISSN: 1573-2509
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  • 4
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 05 March 2013, Vol.110(10), pp.3782-7
    Description: The study of genetic disease mechanisms relies mostly on targeted mouse mutants that are derived from engineered embryonic stem (ES) cells. Nevertheless, the establishment of mutant ES cells is laborious and time-consuming, restricting the study of the increasing number of human disease mutations discovered by high-throughput genomic analysis. Here, we present an advanced approach for the production of mouse disease models by microinjection of transcription activator-like effector nucleases (TALENs) and synthetic oligodeoxynucleotides into one-cell embryos. Within 2 d of embryo injection, we created and corrected chocolate missense mutations in the small GTPase RAB38; a regulator of intracellular vesicle trafficking and phenotypic model of Hermansky-Pudlak syndrome. Because ES cell cultures and targeting vectors are not required, this technology enables instant germline modifications, making heterozygous mutants available within 18 wk. The key features of direct mutagenesis by TALENs and oligodeoxynucleotides, minimal effort and high speed, catalyze the generation of future in vivo models for the study of human disease mechanisms and interventions.
    Keywords: Disease Models, Animal ; Germ-Line Mutation ; Genetic Diseases, Inborn -- Genetics ; Oligodeoxyribonucleotides -- Administration & Dosage
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 5
    Language: English
    In: Community Mental Health Journal, 2013, Vol.49(6), pp.630-635
    Description: Cognitive adaptation training (CAT) has been tested as a psychosocial treatment, showing promising results. To date there are no reported tests of CAT treatment outside the United States. Thus, we decided to adjust CAT treatment and apply it to an Integrated Treatment setting in Denmark. In this article we describe and discuss the feasibility of using CAT treatment in a randomized clinical trial in Denmark. The treatment period was shorter and the patients were instructed in prompting for specific actions by using newer tools such as schedules in their mobile phones. Social functioning, symptoms and quality of life were assessed using instruments validated in a Danish context. It was judged that, after some adjustments to fit the Danish assertive community treatment, CAT treatment was feasible in a Danish setting.
    Keywords: Feasibility ; Assertive community treatment ; Psychological adaptation ; Memory disorders ; RCT
    ISSN: 0010-3853
    E-ISSN: 1573-2789
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  • 6
    In: JCMS: Journal of Common Market Studies, November 2012, Vol.50(6), pp.939-957
    Description: The Lisbon Treaty represented a rare opportunity to redesign parliamentary control of the European Commission's delegated powers. The new Treaty distinguishes between delegated and implementing acts and specifies that comitology rules must be decided by a co‐decision regulation. This necessitated a reform of the comitology system, which was decided in December 2010 after protracted inter‐institutional negotiations. This article asks why the new control system took its final form. The negotiations as a game of control positions are analyzed and the course of the negotiations is traced through documents and interviews. Support is found for the article's hypotheses, but it is also the case that events in some respects went further than expected.
    Keywords: Control Systems -- Analysis ; Decision Making -- Analysis;
    ISSN: 0021-9886
    E-ISSN: 1468-5965
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  • 7
    In: Annals of the New York Academy of Sciences, December 2011, Vol.12451(1), pp.E1-E5
    Description: Systems pharmacology approaches can be used to identify and predict drug‐induced adverse events. Disease‐centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
    Keywords: Systems Pharmacology ; Network Biology ; Personalized Medicine
    ISSN: 0077-8923
    E-ISSN: 1749-6632
    Source: John Wiley & Sons, Inc.
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  • 8
    Language: English
    In: Annals of the New York Academy of Sciences, December 2011, Vol.1245, pp.E1-5
    Description: Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
    Keywords: Drug-Related Side Effects and Adverse Reactions ; Gene Regulatory Networks -- Genetics ; Systems Biology -- Methods
    ISSN: 00778923
    E-ISSN: 1749-6632
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  • 9
    In: American Journal of Political Science, October 2014, Vol.58(4), pp.790-803
    Description: The search for the optimal size of political systems is one of the most enduring in political thought. Given the validity of arguments for and against small units, one might expect variation in rearrangements of unit sizes. However, the reform trend is uniform: units, often at the local level, are amalgamated to harvest scale effects. The purpose of this article is to evaluate the argument on economies of scale in the economic costs of running political systems. Our testing ground is a recent Danish reform. It allows us to avoid endogeneity problems often facing researchers of size reforms. The reform was directed by the central government and constitutes an exogenous shock to 239 municipalities, whereas 32 municipalities were left untouched. We thus have a quasi‐experiment with pre‐ and posttreatment observations for both an experiment and a control group. Our findings show that scale effects, measured as administrative costs per inhabitant, are considerable.
    Keywords: Democracy;
    ISSN: 0092-5853
    E-ISSN: 1540-5907
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  • 10
    In: Medicine & Science in Sports & Exercise, 2013, Vol.45(3), pp.553-561
    Description: INTRODUCTION: The present study investigated the fitness and health effects of medium-term soccer training for untrained hypertensive middle-age men. METHODS: Thirty-three untrained males (31–54 yr) with mild-to-moderate hypertension were randomized 2:1 to a soccer training group (STG, two 1-h sessions per week, n = 22, 68% on medication) and a doctor advice group receiving traditional physician-guided recommendations on cardiovascular risk factor modification (DAG, n = 11, 73% on medication). Two-way repeated-measures ANOVA time–group statistics was applied. RESULTS: During soccer training, average HR was 155 ± 9 bpm or 85% ± 7% HRmax. In STG, systolic and diastolic blood pressures decreased (P 〈 0.01) over 6 months from 151 ± 10 to 139 ± 10 mm Hg and from 92 ± 7 to 84 ± 6 mm Hg, respectively, with smaller (P 〈 0.05) decreases in DAG (from 153 ± 8 to 145 ± 8 mm Hg and from 96 ± 6 to 93 ± 6 mm Hg, respectively). In STG, V˙O2max increased (P 〈 0.01) from 32.6 ± 4.9 to 35.4 ± 6.6 mL·min·kg and relative V˙O2 during cycling at 100 W was lowered (P 〈 0.05) from 55% ± 7% to 50% ± 8% V˙O2max over 6 months, with no changes in DAG. In STG, resting HR was lowered by 8 ± 11 bpm (P 〈 0.05), and the augmentation index (a measure of arterial stiffness) was lowered (P 〈 0.05) by 7.3 ± 14.0 over 6 months, with no change in DAG. CONCLUSIONS: Six months of soccer training improved aerobic fitness, reduced blood pressure, and resulted in an array of other favorable effects on cardiovascular risk profile for untrained middle-age hypertensive men. Soccer training, therefore, may be a better nonpharmacological treatment for hypertensive men than traditional physician-guided advice.
    Keywords: Medicine ; Physical Therapy;
    ISSN: 0195-9131
    E-ISSN: 15300315
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