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  • 1
    Language: English
    In: Oral and Maxillofacial Surgery, 2010, Vol.14(4), pp.223-226
    Description: Byline: Torsten Hansen (1), C. James Kirkpatrick (1) Keywords: Warthin tumour; Lymphatic vessels; Podoplanin; D2-40; Immunohistochemistry Abstract: Purpose Warthin tumour is the second most common benign tumour of the parotid gland. This study was designed to investigate the lymphatic vessels in Warthin tumours in an effort to understand better its pathogenesis. Materials and methods Tissue specimens of 31 patients (19 men and 11 women mean age 57 years, median size of the tumours 2.86 cm) were analysed by means of immunohistochemistry applying the monoclonal antibody D2-40. Results We found numerous D2-40-positive sinus-like vessels particularly at the inner layer of the capsule. Conclusions Since subcapsular sinuses are a major morphological feature of lymph nodes in general, the finding of podoplanin expression in the large majority of subcapsular vessels in Warthin tumours confirms the view that this tumour has its origin in regional lymph nodes. Author Affiliation: (1) Institute of Pathology, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55101, Mainz, Germany Article History: Registration Date: 06/04/2010 Online Date: 22/04/2010
    Keywords: Warthin tumour ; Lymphatic vessels ; Podoplanin ; D2-40 ; Immunohistochemistry
    ISSN: 1865-1550
    E-ISSN: 1865-1569
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  • 2
    Language: English
    In: Accident Analysis and Prevention, March, 2012, Vol.45, p.529(10)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.aap.2011.09.007 Byline: Trine Staff (a)(b), Torsten Eken (c), Trond Boye Hansen (d), Petter Andreas Steen (e), Signe SA[cedilla]vik (f) Keywords: Motor vehicle accident; Seatbelt; Cargo; Anatomical injury severity; Accident prevention Abbreviations: AIS, Abbreviated Injury Scale; ANEC, The European Association for the Co-ordination of Consumer Representation in Standardisation; EMS, emergency medical service; ELR, emergency locking seatbelt retractor; IQR, interquartile range; MVA, motor vehicle accident; MV, motor vehicle; NISS, New Injury Severity Score Abstract: a* Unrestrained objects weighing 〉2kg were prevalent in compartments of crashed cars. a* Heavy objects in the boot often moved into the compartment on impact. a* Seatbacks were significantly offset or wrecked by moving unrestrained objects. a* Seatback offset was associated with severe head, thoracic, and abdominal injuries. a* Improved rear seat weight resistance and use of cargo barriers, nets, and straps is needed. Author Affiliation: (a) Norwegian Air Ambulance Foundation, Department of Research, Holterveien 24, PO Box 94, 1441 DrA[cedilla]bak, Norway (b) Norwegian National Centre for Prehospital Emergency Medicine (NAKOS), Oslo University Hospital, PO Box 4956 Nydalen, 0424 Oslo, Norway (c) Oslo University Hospital, UllevA[yen]l, Department of Anaesthesiology, PO Box 4956 Nydalen, 0424 Oslo, Norway (d) Oslo University Hospital, Prehospital Centre, PO Box 4956 Nydalen, 0424 Oslo, Norway (e) University of Oslo, Institute of Clinical Medicine and Oslo University Hospital, Prehospital Centre, PO Box 4956, Nydalen, 0424 Oslo, Norway (f) Akershus University Hospital, Department of Anaesthesiology, 1478 LA[cedilla]renskog, Norway Article History: Received 17 May 2011; Revised 13 August 2011; Accepted 6 September 2011
    Keywords: Traffic Accidents -- Accidents ; Emergency Medical Services -- Accidents ; Emergency Medicine
    ISSN: 0001-4575
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Southern Med Review, April, 2011, Vol.4(1), p.40(8)
    Description: Objective: To assess whether linking the Global Alliance for Vaccine and Immunization (GAVI) service support with performance-based interventions has influenced the quality of reporting and of immunization systems. GAVI Service Support (ISS) combines performance assessment, recommendations and implementation support with financial reward. Methods: A retrospective study based on data from Data Quality Audit (DQA), a validated standardized indicator-based performance assessment tool which evaluates reporting consistency, accuracy and the quality of the immunization system. Participants are nine developing countries, sampling 421 health units, 72 districts, which have had two consecutive DQAs in the period 2002 to 2005. Results: Both the quality of reporting and the immunization system improved following GAVI ISS intervention. Reporting quality was associated with the enhanced overall quality of the immunization system and with immunization coverage. Immunisation coverage improved in eight of the nine countries. Conclusions: The study indicates that the combined GAVI ISS intervention strategy is effective, resulting in increased immunization coverage, enhanced reporting quality and improved quality of the immunization system set-up at all levels of healthcare. High quality reporting is instrumental in focusing immunization management on setting targets for increased coverage, demonstrated by the correlation between increased reporting quality and immunization coverage. Repeated assessments are recommended to ensure sustainable immunization system improvements. Keywords: Immunization system; immunization reporting; quality improvements; performance-based financial reward strategy; Global Alliance for Vaccines and Immunization
    Keywords: Information Management -- Analysis ; Vaccination -- Health Aspects ; Vaccination -- Quality Management ; Developing Countries -- Health Policy
    ISSN: 1174-2704
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  • 4
    Language: English
    In: Expert Review of Anticancer Therapy, 01 April 2011, Vol.11(4), pp.601-612
    Description: Lymph node status is the most important single prognostic factor in esophageal cancer. The detection of involved lymph nodes is therefore the key to cure. This article will provide a meta-analysis and metaregression analysis on the diagnostic performances of current lymph node-detection devices; discuss the recent status of the sentinel lymph node concept in esophageal cancer by the two sentinel node-mapping procedures (the radio-guided and the blue dye techniques) and the developing computed tomography (CT) lymphography; discuss the detection of micrometastases; and the potential clinical application of molecular-based patients' profiles. Combined use of endoscopic ultrasonography fine-needle aspiration and CT significantly improves the diagnostic performance for regional lymph node metastases. Endoscopic ultrasonography is highly sensitive and specific for celiac lymph node metastases, while CT should mostly be performed in order to exclude other abdominal lymph node metastases. Sentinel lymph node navigation may be feasible for cT1N0 or cT2N0 esophageal cancer, and immunohistochemical staining of micrometastatic disease might be feasible in combination with this modality.
    Keywords: Esophageal Cancer ; Imaging Devices ; Lymph Node Metastasis ; Meta-Analysis ; Micrometastasis ; Molecular Markers ; Sentinel Lymph Node Navigation ; Systematic Review ; Medicine
    ISSN: 1473-7140
    E-ISSN: 1744-8328
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  • 5
    Language: English
    In: Expert Review of Anticancer Therapy, 01 April 2011, Vol.11(4), pp.571-578
    Description: There has been much recent debate regarding the best surgical procedure to treat esophageal cancer, in particular with regard to the optimum extent of lymphadenectomy to improve survival while minimizing morbidity. No results obtained by prospective, randomized studies on the comparison of radical esophagectomy and extended lymphadenectomy with limited or less invasive resections following neoadjuvant therapy with regard to perioperative morbidity and prognosis are available to date. Until now, there has been no evidence suggesting the usefulness of sentinel lymph node navigation in esophageal cancers, regardless of the cell type. Furthermore, the question as to the benefits and risks of two-field and three-field lymphadenectomy in esophageal cancer has not yet been conclusively answered. This article will discuss the recent status of lymph node-dissection procedures stage-dependently according to the two different tumor entities and with regard to minimally invasive esophagectomy, including the novel 2010 Tumor, Node, Metastasis-staging system.
    Keywords: Esophageal Cancer ; Individualized Lymph Node Dissection Strategies ; Limited Resection and Limited Lymphadenectomy ; Lymph Node Metastasis ; Minimally Invasive Esophagectomy ; Neoadjuvant Therapy ; Three-Field/Two-Field Lymphadenectomy ; Medicine
    ISSN: 1473-7140
    E-ISSN: 1744-8328
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  • 6
    In: Dalton Transactions, Dalton Transactions, 2011, Vol.40(30), pp.7689-7692
    Description: Dehydrogenation of Me 2 NH·BH 3 ( 1 ) by group 4 metallocene alkyne complexes of the type Cp 2 M(L)(η 2 -Me 3 SiC 2 SiMe 3 ) [Cp = η 5 -cyclopentadienyl; M = Ti, no L ( 2Ti ); M = Zr, L = pyridine ( 2Zr )] and group 4 metal amido complexes of the type M(NMe 2 ) 4 [M = Ti ( 8Ti ), Zr ( 8Zr )] is presented.
    Keywords: Titanium ; Boranes ; Alkynes ; Dehydrogenation ; Pyridines ; Prints ; Metallocenes ; Catalysis ; Miscellaneous Sciences (So) ; Analysis (MD) ; Chemical Analysis (Ep) ; Chemical Analysis (Ed) ; Chemical Analysis (EC) ; Theoretical (General) (Ea);
    ISSN: 1477-9226
    E-ISSN: 1477-9234
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  • 7
    Language: English
    In: Gastroenterology, May 2012, Vol.142(5), pp.S-1094-S-1094
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 8
    Language: English
    In: International journal of cancer, 15 March 2011, Vol.128(6), pp.1259-68
    Description: A genetic basis of hepatocellular carcinoma (HCC) has been well-established and major signaling pathways, such as p53, Wnt-signaling, transforming growth factor-β (TGF-β) and Ras pathways, have been identified to be essential to HCC development. Lately, the family of platelet-derived growth factors (PDGFs) has shifted to the center of interest. We have reported on spontaneously developing liver fibrosis in PDGF-B transgenic mice. Since HCC rarely occurs in healthy liver, but dramatically increases at the cirrhosis stage of which liver fibrosis is a preliminary stage, we investigated liver cancer development in chemically induced liver carcinogenesis in these mice. HCC induction was performed by treatment of the mice with diethylnitrosamine and phenobarbital. At an age of 6 months, the tumor development of these animals was analyzed. Not only the development of dysplastic lesions in PDGF-B transgenic mice was significantly increased but also their malignant transformation to HCC. Furthermore, we were able to establish a key role of PDGF-B signaling at diverse stages of liver cancer development. Here, we show that development of liver fibrosis is likely through upregulation of TGF-β receptors by PDGF-B. Additionally, overexpression of PDGF-B also leads to an increased expression of β-catenin as well as vascular endothelial growth factor and platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), all factors with established roles in carcinogenesis. We were able to extend the understanding of key genetic regulators in HCC development by PDGF-B and decode essential downstream signals.
    Keywords: Carcinoma, Hepatocellular -- Metabolism ; Liver Neoplasms, Experimental -- Metabolism ; Proto-Oncogene Proteins C-Sis -- Metabolism
    E-ISSN: 1097-0215
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  • 9
    Language: English
    In: BJU international, March 2011, Vol.107(5), pp.755-759
    Description: • To determine the value of systematic intraoperative peripheral frozen sections (FS) with or without extended resection during nerve-sparing radical prostatectomy for prediction of biochemical recurrence (BCR) compared with inked surgical margins. • Between 1999 and 2003, in a prospective study, multiple peripheral FS (median 14; range 5-20) were taken from the urethral stump, circumferentially from the bladder neck, and from the lateral pedicles in 200 consecutive bilateral nerve-sparing radical prostatectomies for clinically localized prostate cancer by a single surgeon. • Patients with stage pT3b or more and/or positive lymph nodes were excluded. • Of the 188 patients, 178 (94.7%) were followed over a median of 82 months (62-124). • BCR, defined as prostate-specific antigen (PSA) ≥ 0.2 ng/mL, was related to status of both, inked specimen margins and FS. • Of all 188 prostatectomy specimens, 49 (26.1%) had positive surgical margins (PSM); these were found posterolaterally in 15 (30.6%), apically in 13 (26.5%), basally in 10 (20.4%) and at multiple sites in 11 (22.4%) specimens. • Intraoperative peripheral FS were positive in 19 (10.7%) patients, including 6.2% at urethral stump, 3.3% at lateral pedicles and 1.1% at bladder neck. • In organ-confined disease, BCR-free survival was 93.3% (111/119) for patients with negative surgical margins (NSM) and 72% (18/25) for patients with PSM (inked specimen), but negative peripheral FS (P 〈 0.001). • Five- and 10-year BCR-free survival for NSM was 94.9% and 92.8%, for PSM with negative peripheral FS it was 75.3% and 70.6%, and for PSM with positive peripheral FS it was 62.5% and 62.5%, respectively. • Frozen section biopsies of peripheral resection margins during nerve-sparing radical prostatectomy are not reliable in predicting PSM. • Intraoperative achievement of a locally disease-free status, as monitored by negative circumferential intraoperative FS of peripheral margins, is not associated with a statistically significant BCR-free survival benefit compared with patients with negative surgical margins on the prostatectomy specimen. • Based on these findings, we do not recommend a routine of systematically taking intraoperative FS biopsies during nerve-sparing radical prostatectomy.
    Keywords: Frozen Sections ; Neoplasm Recurrence, Local -- Pathology ; Prostate -- Pathology ; Prostatectomy -- Methods ; Prostatic Neoplasms -- Pathology
    ISSN: 14644096
    E-ISSN: 1464-410X
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  • 10
    In: Digestive Endoscopy, May 2015, Vol.27(4), pp.531-531
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/den.12439/abstract Byline: Andreas Holstein, Torsten Hansen, Johannes J. Tebbe ***** No abstract is available for this article. *****
    Keywords: Stents;
    ISSN: 0915-5635
    E-ISSN: 1443-1661
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