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  • 1
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 16 October 2012, Vol.109(42), pp.16758-9
    Description: Author contributions: A.P. and J.H. wrote the paper.
    Keywords: Gene Expression ; Escherichia Coli -- Genetics ; Gene Regulatory Networks -- Genetics ; Genetic Engineering -- Methods ; Microsatellite Repeats -- Genetics
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 2
    Language: English
    In: Science, 21 May 2010, Vol.328(5981), pp.987-988
    Keywords: 〈bold〉PERSPECTIVES〈/bold〉
    ISSN: 00368075
    E-ISSN: 10959203
    Source: Archival Journals (JSTOR)
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  • 3
    Language: English
    In: Science, 21 May 2010, Vol.328(5981), pp.987-988
    Keywords: Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Ontology ; Philosophy -- Metaphysics -- Microphysics ; Physical sciences -- Physics -- Microbiology ; Biological sciences -- Biology -- Mycology ; Biological sciences -- Biology -- Mycology
    ISSN: 00368075
    E-ISSN: 10959203
    Source: Archival Journals (JSTOR)
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  • 4
    Language: English
    In: Science, 05/21/2010, Vol.328(5981), pp.987-988
    Description: Oscillations are found at nearly every level of biology. From the dynamic instability of cytoskeletal elements in an individual cell to the circadian rhythms that regulate a multitude of operations at the organismal level, it is clear that periodicity is an essential characteristic of living systems. On page 1021 of this issue, Gregor et al. (1) describe how cell aggregation and development of the amoeba Dictyostelium discoideum is guided by emergent rhythmic behavior arising from the stochastic pulsing of individual cells with a chemical cue. By combining experimental and computational approaches, the authors present the exciting story of the dynamical onset of collective behavior in this organism. The findings raise the question of whether biology uses oscillations to solve problems typically assumed to have static or unidirectional solutions.
    Keywords: Cytoskeleton ; Oscillations ; Cell Aggregation ; Circadian Rhythms ; Periodicity ; Computer Applications ; Stochasticity ; Dictyostelium Discoideum ; Amoeba ; Miscellaneous ; Ontogeny;
    ISSN: 0036-8075
    E-ISSN: 1095-9203
    Source: American Association for the Advancement of Science (via CrossRef)
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  • 5
    Language: English
    In: Science (New York, N.Y.), 02 September 2011, Vol.333(6047), pp.1315-1319
    Description: Biological clocks are self-sustained oscillators that adjust their phase to the daily environmental cycles in a process known as entrainment. Molecular dissection and mathematical modeling of biological oscillators have progressed quite far, but quantitative insights on the entrainment of clocks are relatively sparse. We simultaneously tracked the phases of hundreds of synthetic genetic oscillators relative to a common external stimulus to map the entrainment regions predicted by a detailed model of the clock. Synthetic oscillators were frequency-locked in wide intervals of the external period and showed higher-order resonance. Computational simulations indicated that natural oscillators may contain a positive-feedback loop to robustly adapt to environmental cycles.
    Keywords: Biological Clocks -- Genetics
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 6
    Language: English
    In: Medicine and Science in Sports and Exercise, 2014, Vol.46(5)
    Description: The study aims to evaluate if there are differences in muscle activation when performing unilateral (UNI) and bilateral lifts with dumbbells (BIL) or a barbell (BB). The results indicate that in keeping with similar magnitude loads across the three conditions, muscle activation was the same.
    Keywords: Muscles – Research ; Exercise – Health Aspects ; Dumbbells – Usage
    ISSN: 0195-9131
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  • 7
    Article
    Article
    Language: English
    In: Science, 17 May 2002, Vol.296(5571), pp.1250-1251
    Keywords: Physical sciences -- Chemistry -- Chemical compounds ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Genetics ; Health sciences -- Medical conditions -- Physical trauma ; Biological sciences -- Biology -- Genetics ; Applied sciences -- Materials science -- Physical damage ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Zoology ; Biological sciences -- Biology -- Cytology
    ISSN: 00368075
    E-ISSN: 10959203
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  • 8
    Language: English
    In: Federal Communications Law Journal, April, 2015, Vol.67(2), p.293(31)
    Description: As desktop PCs give way to smartphones, and as engineers embed everyday objects-like cars, eyeglasses, and HVAC systems-with the ability to sense, remember, and communicate information to anyone or anything with an Internet connection, enterprising companies extract enormous amounts of consumer data in an effort to squeeze as much value out of consumers' attention as possible. In many ways, data has become the new oil. While this trend promises to improve efficiency, lower costs, and create products and services that enrich consumers' lives, it also raises complicated and evolving privacy dilemmas. To address these dilemmas, the United States relies heavily upon the Federal Trade Commission to safeguard consumers without stifling innovation. Concerned that technological advancement may be leaving privacy safeguards behind, the FTC recently unveiled a new framework for redressing privacy's dilemmas while also acknowledging that limits to its authority prevent the agency from achieving the framework's goals. To overcome these limits, the agency asked Congress to consider enhancing its privacy enforcement powers, but this request has drawn criticism from those who fear that an omnibus or top-down approach would suppress innovation. In order to ensure that privacy safeguards keep pace with rapidly evolving technology without suppressing innovation, this Note argues that consumers' digital interactions should be recognized as the commercial exchanges of value that they are. Recognizing the value exchange that occurs when consumers search the web or download apps would create a flexible mandate for entities that collect consumer data to disclose the bargain's material terms by requiring informed consent. This, in turn, might lead to "simplified choice" and "privacy by design" as companies competed over the "price" charged to consumers. While more critical thinking needs to be devoted to the topic, recognizing consumers' digital interactions as the commercial exchanges of value that they are could substantiate the FTC's new privacy framework without relying on congressional action, creating a flexible regulatory solution that scales to meet privacy's evolving dilemmas.
    Keywords: Right Of Privacy -- Laws, Regulations And Rules ; Digital Communications -- Laws, Regulations And Rules
    ISSN: 0163-7606
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  • 9
    In: Medicine & Science in Sports & Exercise, 2014, Vol.46(5S Suppl 1), pp.669-670
    ISSN: 0195-9131
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 10
    In: Nature, 2014, Vol.508(7496), p.387
    Description: One promise of synthetic biologyis the creation of genetic circuitry that enables the execution of logical programming in living cells. Such 'wet programming" is positioned to transform a wide and diverse swathe of biotechnology ranging from therapeutics and diagnostics to water treatment strategies. Although progress in the development of a library of genetic modules continues apace (1-4), a major challenge for their integration into larger circuits is the generation of sufficiently fast and precise communication between modules (5,6). An attractive approach is to integrate engineered circuits with host processes that facilitate robust cellular signalling (7). In this context, recent studies have demonstrated that bacterial protein degradation can trigger a precise response to stress by overloading a limited supply of intracellular proteases (8-10). Here we use protease competition to engineer rapid and tunable coupling of genetic circuits across multiple spatial and temporal scales. We characterize coupling delay times that are more than an order of magnitude faster than standard transcription-factor-based coupling methods (less than 1 min compared with ~20-40 min) and demonstrate tunability through manipulation of the linker between the protein and its degradation tag. We use this mechanism as a platform to couple genetic clocks at the intracellular and colony level, then synchronize the multi-colony dynamics to reduce variability in both clocks. We show how the coupled clock network can be used to encode independent environmental inputs into a single time series output, thus enabling frequency multiplexing (information transmitted on a common channel by distinct frequencies) in a genetic circuit context. Our results establish a general framework for the rapid and tunable coupling of genetic circuits through the use of native 'queueing" processes such as competitive protein degradation.
    Keywords: Cell Interactions -- Genetic Aspects ; Translation (Genetics) -- Research ; Synthetic Biology -- Genetic Aspects ; Genetic Research;
    ISSN: 0028-0836
    E-ISSN: 14764687
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