UID:
edoccha_9958066772202883
Format:
1 online resource (696 p.)
Edition:
1st ed. 2006.
ISBN:
1-280-83290-8
,
9786610832903
,
1-59259-994-X
Content:
Melanoma offers an excellent model for cancer biology and an opportunity to understand the progression of a normal skin cell-the melanocyte-to malignancy. In From Melanocytes to Melanoma: The Progression to Malignancy, leading researchers and clinicians join forces to explain how skin cancer develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, the malignant transformation of melanocytes, and the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The text is augmented by four color plates. Comprehensive and illuminating, From Melanocytes to Melanoma: The Progression to Malignancy, provides pathologists, dermatologists, surgeons, and medical oncologists with an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.
Note:
Description based upon print version of record.
,
The origin and development of neural crest-derived melanocytes / Debra L. Silver and William J. Pavan -- MITF : a matter of life and death for the developing melanocytes / Heinz Arnheiter ... [et al.] -- MITF : critical regulator of the melanocyte lineage / Erez Feige, Laura L. Poling, and David E. Fisher -- Melanocytes and the transcription factor Sox10 / Micheal Wegner -- Human cutaneous pigmentation : a collaborative act in the skin, directed by paracrine, autocrine, and endocrine factors and the environment / Zalfa A. Abdel-Malek and Ana Luisa Kadekaro -- Melanocyte distribution and function in human skin : effects of ultraviolet radiation / Yuji Yamaguchi and Vincent J. Hearing -- Altered signal transduction in melanoma / Pablo Lopez Bergami, Anindita Bhoumik, and Ze'ev Ronai -- BRN2 in melanocytic cell development, differentiation, and transformation / Anthony L. Cook ... [et al.] -- The dynamic roles of cell-surface receptors in melanoma development / Dong Fang and Meenhard Herlyn -- Familial melanoma genes, melanocyte immortalization, and melanoma initiation / Dorothy C. Bennett -- Genetic progression from melanocyte to malignant melanoma / Boris C. Bastian -- The multiple roles of the oncogenic protein SKI in human malignant melanoma / Dahu Chen ... [et al.] -- RB/E2F regulation and dual activity in the melanocytic system / Ruth Halaban -- Melanoma development and pigment cell transformation / Claudia Wellbrock --
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The biology and genetics of melanoma / Norman E. Sharpless and Lynda Chin -- The biology of xeroderma pigmentosum : insights into the role of ultraviolet light in the development of melanoma / James E. Cleaver -- Divergent pathways to cutaneous melanoma / David C. Whiteman and Adele C. Green -- Pigmentation, DNA repair, and candidate genes : the risk of cutaneous malignant melanoma in a mediterranean population / Maria Teresa Landi -- Low-penetrance genotypes, pigmentation phenotypes, and melanoma etiology / Peter A. Kanetsky and Timothy R. Rebbeck -- The biology of melanoma progression : from melanocyte to metastatic seeds / A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr. -- Optical imaging analysis of atypical nevi and melanoma / Amanda Pfaff Smith and Dorothea Becker -- Proteomics analysis of melanoma cell lines and cultured melanocytes / Katheryn A. Resing and Natalie G. Ahn -- Paradigm of metastasis for malignant melanoma / Stanley P.L. Leong -- Repair of UV-induced DNA damage and melanoma risk / Qingyi Wei -- High risk factors for melanoma metastasis / Neil A. Accortt and Seng-jaw Soong -- Role of melanoma inhibitory activity in early development of malignant melanoma / Anja-Katrin Bosserhoff -- Role and regulation of PAR-1 in melanoma progression / Carmen Tellez and Menashe Bar-Eli -- Molecular mechanisms of melanoma metastasis / Mohammed Kashani-Sabet --
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Overview of tumor progression in melanoma / David E. Elder -- The plasticity of melanoma cells and associated clinical implications / Mary J. C. Hendrix ... [et al.] -- The clinical use of molecular markers as predictors of disease outcome and response to therapy in malignant melanoma / Steve R. Martinez, Hiroya Takeuchi, Dave S.B. Hoon -- The role of DCT/TYRP2 in resistance of melanoma cells to drugs and radiation / Brian J. Pak and Yaacov Ben-David -- How melanoma cells evade chemotherapy : role of transporter-dependent and -independent resistance mechanisms / Kevin G. Chen and Michael M. Gottesman -- Apoptosis in melanoma: approaches to therapy / Heicke Rockmann and Dirk Schadendorf -- Role of melanoma-associated antigens / Rishab K. Gupta, Ana M. McElrath-Garza, and Donald L. Morton -- Host responses to melanoma : implications for immunotherapy / Julian A. Kim and Ernest Borden -- Future perspectives / Vincent J. Hearing and Stanley P.L. Leong.
,
English
Additional Edition:
ISBN 1-58829-459-5
Language:
English
DOI:
10.1007/978-1-59259-994-3
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