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  • 1
    Language: English
    In: Journal of Thermal Analysis and Calorimetry, Nov, 2006, Vol.86(2), p.287
    Description: Byline: T. Hekmatara (1), G. Regdon (1), P. Sipos (1), I. ErAs (1), K. Pintye-Hodi (1) Keywords: chitosan; diltiazem hydrochloride; DSC; microspheres; TG Abstract: The main purpose of our study was to produce microspheres containing diltiazem hydrochloride and to perform the thermoanalytical examination of the components and microspheres. Thermal analysis is a very frequently used method in the preformulation tests of solid dosage forms. Diltiazem hydrochloride is a calcium-channel blocker with short biological half life, so it is a potential candidate for sustained or controlled release dosage forms. Various techniques are available for the microencapsulation of drugs. The technique of spray-drying was used during our investigations. It was found that the crystalline form of the active agents could not be observed in the drug-loaded chitosan microspheres, which indicates the molecular dispersion of the drug in the matrix. It was established that the preparation conditions influenced the morphology and size of the particles. Moreover, the sphericity of the microspheres was good. On the basis of our investigations, the 1:1 diltiazem hydrochloride--chitosan ratio is suggested as the best ratio. Author Affiliation: (1) Department of Pharmaceutical Technology, University of Szeged, Szeged, Hungary, 6720, Eotvos St. 6. Article History: Registration Date: 30/08/2005 Received Date: 24/01/2006 Accepted Date: 02/03/2006 Online Date: 29/05/2006
    Keywords: Diltiazem -- Analysis
    ISSN: 1388-6150
    E-ISSN: 15882926
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  • 2
    Language: English
    In: Journal of Controlled Release, 2007, Vol.117(1), pp.51-58
    Description: Poly(butyl cyanoacrylate) nanoparticles coated with poloxamer 188 (Pluronic® F68) and also, as shown previously, polysorbate 80 (Tween® 80) considerably enhance the anti-tumour effect of doxorubicin against an intracranial glioblastoma in rats. The investigation of plasma protein adsorption on the surface of the drug-loaded nanoparticles by two-dimensional electrophoresis (2-D PAGE) revealed that both surfactants, besides other plasma components, induced a considerable adsorption of apolipoprotein A-I (ApoA-I). It is hypothesized that delivery of doxorubicin to the brain by means of nanoparticles may be augmented by the interaction of apolipoprotein A-I that is anchored on the surface of the nanoparticles with the scavenger receptor class B type I (SR-BI) located at the blood–brain barrier. This is the first study that shows a correlation between the adsorption of apolipoprotein A-I on the nanoparticle surface and the delivery of the drug across the blood–brain barrier.
    Keywords: Apolipoprotein A-I ; Chemotherapy ; Glioblastoma ; Nanoparticles ; Poly(Butyl Cyanoacrylate) ; Poloxamer 188 ; Polysorbate 80 ; Rats ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0168-3659
    E-ISSN: 1873-4995
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  • 3
    Language: English
    In: Clinical neuropathology, 2009, Vol.28(3), pp.153-64
    Description: The objective of this study was to investigate the therapeutic effects of doxorubicin bound to polysorbate-coated nanoparticles that had previously been shown to significantly enhance survival in the orthotopic rat 101/8 glioblastoma model. Tumor-bearing...
    Keywords: Drug Delivery Systems ; Angiogenesis Inhibitors -- Administration & Dosage ; Brain Neoplasms -- Drug Therapy ; Doxorubicin -- Administration & Dosage ; Glioblastoma -- Drug Therapy
    ISSN: 0722-5091
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 4
    Language: English
    In: Clinical Neuropathology, 2009, Vol.28(05), pp.153-164
    ISSN: 0722-5091
    Source: CrossRef
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  • 5
    Language: English
    In: Journal of Thermal Analysis and Calorimetry, 2006, Vol.86(2), pp.287-290
    Description: The main purpose of our study was to produce microspheres containing diltiazem hydrochloride and to perform the thermoanalytical examination of the components and microspheres. Thermal analysis is a very frequently used method in the preformulation tests of solid dosage forms. Diltiazem hydrochloride is a calcium-channel blocker with short biological half life, so it is a potential candidate for sustained or controlled release dosage forms. Various techniques are available for the microencapsulation of drugs. The technique of spray-drying was used during our investigations. It was found that the crystalline form of the active agents could not be observed in the drug-loaded chitosan microspheres, which indicates the molecular dispersion of the drug in the matrix. It was established that the preparation conditions influenced the morphology and size of the particles. Moreover, the sphericity of the microspheres was good. On the basis of our investigations, the 1:1 diltiazem hydrochloride–chitosan ratio is suggested as the best ratio.
    Keywords: chitosan ; diltiazem hydrochloride ; DSC ; microspheres ; TG
    ISSN: 1388-6150
    E-ISSN: 1572-8943
    Source: Springer Science & Business Media B.V.
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