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  • 1
    Language: English
    In: Journal of the American Geriatrics Society, January 2011, Vol.59(1), pp.171-2
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1532-5415.2010.03212.x Byline: Kerstin Amadori (*), Eva Herrmann ([dagger]), Rupert K. Pullen ([double dagger]) Author Affiliation: (*)Medizinisch-Geriatrische Klinik, Agaplesion Diakonissen-Krankenhaus, Frankfurt am Main, Germany ([dagger])Institute of Biostatistics and Mathematical Modeling, Johann Wolfgang Goethe University of Frankfurt, Frankfurt am Main, Germany ([double dagger])Medizinisch-Geriatrische Klinik, Agaplesion Diakonissen-Krankenhaus, Frankfurt am Main, Germany
    Keywords: Psychological Tests ; Depressive Disorder -- Diagnosis ; Geriatric Assessment -- Methods
    ISSN: 00028614
    E-ISSN: 1532-5415
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  • 2
    Language: English
    In: Biochemistry, 12 February 2013, Vol.52(6), pp.1045-54
    Description: Tumor suppressor Nore1, its acronym coming from novel Ras effector, is one of the 10 members of the Rassf (Ras association domain family) protein family that have been identified. It is expressed as two mRNA splice variants, Nore1A and a shorter isoform, Nore1B. It forms homo- and heterocomplexes through its C-terminal SARAH (Sav/Rassf/Hpo) domain. The oligomeric state of Nore1 and other SARAH domain-containing proteins is important for their cellular activities. However, there are few experimental data addressing the structural and biophysical characterization of these domains. In this study, we show that the recombinant SARAH domain of Nore1 crystallizes as an antiparallel homodimer with representative characteristics of coiled coils. As is typical for coiled coils, the SARAH domain shows a heptad register, yet the heptad register is interrupted by two stutters. The comparisons of the heptad register of Nore1-SARAH with the primary structure of Rassf1-4, Rassf6, MST1, MST2, and WW45 indicate that these proteins have a heptad register interrupted by two stutters, too. Moreover, on the basis of the structure of Nore1-SARAH, we also generate structural models for Rassf1 and Rassf3. These models indicate that Rassf1- and Rassf3-SARAH form structures very similar to that of Nore1-SARAH. In addition, we show that, as we have previously found for MST1, the SARAH domain of Nore1 undergoes association-dependent folding. Nevertheless, the Nore1 homodimer has a lower affinity and thermodynamic stability than the MST1 homodimer, while the monomer is slightly more stable. Our experimental results along with our theoretical considerations indicate that the SARAH domain is merely a dimerization domain and that the differences between the individual sequences lead to different stabilities and affinities that might have an important functional role.
    Keywords: Adaptor Proteins, Signal Transducing -- Chemistry ; Cell Cycle Proteins -- Chemistry ; Hepatocyte Growth Factor -- Chemistry ; Protein-Serine-Threonine Kinases -- Chemistry ; Proto-Oncogene Proteins -- Chemistry ; Tumor Suppressor Proteins -- Chemistry
    ISSN: 00062960
    E-ISSN: 1520-4995
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  • 3
    In: PLoS ONE, 2013, Vol.8(3)
    Description: Background To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery. Methods and Findings We performed a meta-analysis of randomised controlled trials and observational with the following data sources: Medline, Cochrane Library, and reference lists of identified articles. The primary outcome measure was early (in-hospital/30-day) mortality. The secondary outcome measures were any transfusion of packed red blood cells within 24 hours after surgery, any re-operation for bleeding or massive bleeding, and acute renal dysfunction or failure within the selected cited publications, respectively. Out of 328 search results, 31 studies (15 trials and 16 observational studies) included 33,501 patients. Early mortality was significantly increased after aprotinin vs. lysine analogues with a pooled risk ratio (95% CI) of 1.58 (1.13–2.21), p〈0.001 in the low (n = 14,297) and in the intermediate risk subgroup (1.42 (1.09–1.84), p〈0.001; n = 14,427), respectively. Contrarily, in the subgroup of high risk patients (n = 4,777), the risk for mortality did not differ significantly between aprotinin and lysine analogues (1.03 (0.67–1.58), p = 0.90). Conclusion Aprotinin may be associated with an increased risk of mortality in low and intermediate risk cardiac surgery, but presumably may has no effect on early mortality in a subgroup of high risk cardiac surgery compared to lysine analogues. Thus, decisions to re-license aprotinin in lower risk patients should critically be debated. In contrast, aprotinin might probably be beneficial in high risk cardiac surgery as it reduces risk of transfusion and bleeding complications.
    Keywords: Research Article ; Medicine
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: PLoS ONE, June 25, 2015, Vol.10(6)
    Description: Paired associative stimulation (PAS.sub.LTP) of the human primary motor cortex (M1) can induce LTP-like plasticity by increasing corticospinal excitability beyond the stimulation period. Previous studies showed that two consecutive PAS.sub.LTP protocols interact by homeostatic metaplasticity, but animal experiments provided evidence that LTP can be augmented by repeated stimulation protocols spaced by ~30min. Here we tested in twelve healthy selected PAS.sub.LTP responders the possibility that LTP-like plasticity can be augmented in the human M1 by systematically varying the interval between two consecutive PAS.sub.LTP protocols. The first PAS.sub.LTP protocol (PAS1) induced strong LTP-like plasticity lasting for 30-60min. The effect of a second identical PAS.sub.LTP protocol (PAS.sub.2) critically depended on the time between PAS.sub.1 and PAS.sub.2 . At 10min, PAS.sub.2 prolonged the PAS.sub.1 -induced LTP-like plasticity. At 30min, PAS.sub.2 augmented the LTP-like plasticity induced by PAS.sub.1, by increasing both magnitude and duration. At 60min and 180min, PAS.sub.2 had no effect on corticospinal excitability. The cumulative LTP-like plasticity after PAS.sub.1 and PAS.sub.2 at 30min exceeded significantly the effect of PAS.sub.1 alone, and the cumulative PAS.sub.1 and PAS.sub.2 effects at 60min and 180min. In summary, consecutive PAS.sub.LTP protocols interact in human M1 in a time-dependent manner. If spaced by 30min, two consecutive PAS.sub.LTP sessions can augment LTP-like plasticity in human M1. Findings may inspire further research on optimized therapeutic applications of non-invasive brain stimulation in neurological and psychiatric diseases.
    Keywords: Neurophysiology
    ISSN: 1932-6203
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  • 5
    Language: English
    In: Journal of Clinical Epidemiology, 2010, Vol.63(3), pp.343-343
    Keywords: Medicine
    ISSN: 0895-4356
    E-ISSN: 1878-5921
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  • 6
    Language: English
    In: PLoS ONE, 01 January 2015, Vol.10(9), p.e0138130
    Description: Sphingolipids constitute bioactive molecules with functional implications in liver homeostasis. Particularly, ablation of very long chain ceramides in a knockout mouse model has been shown to cause a severe hepatopathy.We aimed to evaluate the serum sphingolipid profile of 244 patients with...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: Clinical Infectious Diseases, 1 January 2011, Vol.52(1), pp.122-127
    Description: Background. To determine the rate of seroconversion after 2 doses of a novel split virion, inactivated, adjuvanted pandemic H1N1 influenza vaccine (A/California/7/2009) in human immunodeficiency virus type 1 (HIV-1)—infected patients (ClinicalTrials.gov NCT01017172). Methods. Diagnostic study of adult HIV-1—infected patients scheduled for H1N1 influenza A vaccination. Blood samples where taken before and 21 days after the first dose and 21 days after the second dose of the vaccine. Antibody (AB) titers were determined by hemagglutination inhibition assay. Seroconversion was defined by either an AB titer ≤1:10 before and ≥1:40 after or ≥1:10 before and a ≥4-fold increase in AB titer 21 days after vaccination. Results. One hundred thirty-five patients received 2 doses of the H1N1 vaccine and were analyzed. The rate of seroconversion was 68.2% (95% confidence interval, 59.6—75.9) after the first dose and 91.9% (95% confidence interval, 85.9—95.9) after the second dose. Patients who did not seroconvert had a lower mean nadir CD4 cell count (±standard deviation; 81 ± 99 vs 190 ± 148 cells/μL; P = .006), had a longer duration of HIV infection (±standard deviation; 13.1 ± 5.9 vs 8.8 ± 6.8 years; P = .04), and were more likely to have an AB titer ≥1:40 before vaccination (4% vs 55%; P 〈 .001) when compared with patients with seroconversion. No other differences were found between the 2 groups, including AIDS status, highly active antiretroviral therapy status, HIV RNA - polymerase chain reaction load 〈50 copies/mL, CD4 cell count, sex, body mass index, and chronic hepatitis. Conclusion. Among HIV-infected patients, the rate of seroconversion after the first dose of an adjuvanted H1N1 influenza A vaccine was 68% and increased to 92% after a second doses.
    Keywords: Health sciences -- Medical treatment -- Biological therapy ; Health sciences -- Medical sciences -- Pharmacology ; Biological sciences -- Biology -- Microbiology ; Biological sciences -- Biology -- Microbiology ; Health sciences -- Medical treatment -- Biological therapy ; Health sciences -- Medical sciences -- Immunology ; Health sciences -- Medical sciences -- Immunology ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Health and wellness -- Public health ; Health sciences -- Medical treatment -- Drug therapy
    ISSN: 10584838
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  • 8
    Language: English
    In: PLoS ONE, 2012, Vol.7(2), p.e30796
    Description: Cellular CD81 is a well characterized hepatitis C virus (HCV) entry factor, while the relevance of soluble exosomal CD81 in HCV pathogenesis is poorly defined. We performed a case-control study to investigate whether soluble CD81 in the exosomal serum fraction is associated with HCV replication and inflammatory activity. ; Four cohorts were investigated, patients with chronic hepatitis C (n = 37), patients with chronic HCV infection and persistently normal ALT levels (n = 24), patients with long term sustained virologic response (SVR, n = 7), and healthy volunteers (n = 23). Concentration of soluble CD81 was assessed semi-quantitatively after differential centrifugation ranging from 200 g to 100,000 g in the fifth centrifugation fraction by immunoblotting and densitometry. ; Soluble CD81 was increased in patients with chronic hepatitis C compared to healthy subjects (p = 0.03) and cured patients (p = 0.017). Patients with chronic HCV infection and persistently normal ALT levels and patients with long term SVR had similar soluble CD81 levels as healthy controls (p〉0.2). Overall, soluble CD81 levels were associated with ALT levels (r = 0.334, p = 0.016) and severe liver fibrosis (p = 0.027). ; CD81 is increased in the exosomal serum fraction in patients with chronic hepatitis C and appears to be associated with inflammatory activity and severity of fibrosis.
    Keywords: Research Article ; Medicine ; Immunology ; Pathology ; Gastroenterology And Hepatology
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: 2012, Vol.7(8), p.e42735
    Description: Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of the present study was to evaluate sensitivity and specificity of ARFI-imaging for differentiation of thyroid nodules and to compare it to the well evaluated qualitative real-time elastography (RTE). ; ARFI-imaging involves the mechanical excitation of tissue using acoustic pulses to generate localized displacements resulting in shear-wave propagation which is tracked using correlation-based methods and recorded in m/s. Inclusion criteria were: nodules ≥5 mm, and cytological/histological assessment. All patients received conventional ultrasound, real-time elastography (RTE) and ARFI-imaging. ; One-hundred-fifty-eight nodules in 138 patients were available for analysis. One-hundred-thirty-seven nodules were benign on cytology/histology, and twenty-one nodules were malignant. The median velocity of ARFI-imaging in the healthy thyroid tissue, as well as in benign and malignant thyroid nodules was 1.76 m/s, 1.90 m/s, and 2.69 m/s, respectively. While no significant difference in median velocity was found between healthy thyroid tissue and benign thyroid nodules, a significant difference was found between malignant thyroid nodules on the one hand and healthy thyroid tissue (p = 0.0019) or benign thyroid nodules (p = 0.0039) on the other hand. No significant difference of diagnostic accuracy for the diagnosis of malignant thyroid nodules was found between RTE and ARFI-imaging (0.74 vs. 0.69, p = 0.54). The combination of RTE with ARFI did not improve diagnostic accuracy. ; ARFI can be used as an additional tool in the diagnostic work up of thyroid nodules with high negative predictive value and comparable results to RTE.
    Keywords: Research Article ; Biology ; Medicine ; Diabetes And Endocrinology ; Physiology ; Oncology ; Radiology And Medical Imaging
    E-ISSN: 1932-6203
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  • 10
    Language: English
    In: PLoS ONE, 01 January 2017, Vol.12(10), p.e0186720
    Description: Liver steatosis has shown to be associated with coronary artery disease (CAD). The aim of our study was to evaluate the association between the presence and severity of CAD and Non-alcoholic fatty liver disease (NAFLD) assessed by transient elastography (TE) and controlled attenuation parameter...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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