KOBV Portal

Hits per page

hits 1 - 10 | 18 hits

Sorting

Book

Selbstorganisation in der Zeit : mit 1 Tabelle (1990)

Ebeling, Werner ; Engel, Harald ; Herzel, Hanspeter

Berlin :Akad.-Verl.,

add to watchlist on the watchlist

Details

UID:

almahu_BV004352393

Format: 205 S. : graph. Darst.

ISBN: 3-05-500709-3

Series Statement: Wissenschaftliche Taschenbücher 309 : Reihe Mathematik und Physik

Note: Literaturverz. S. 185 - 200

Language: German

Subjects: Physics , Mathematics , Philosophy

RVK:

CC 6350

RVK:

SK 950

RVK:

UG 3900

Keywords: Selbstorganisation ; Synergetik ; Zeit ; Selbstorganisation ; Nichtlineares System

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Book

Inter-library loan

Stabi Berlin

HU Berlin

UB Potsdam

BTU Cottbus

TU Berlin

Akademie d. Wiss.

Online Resource

Selbstorganisation in der Zeit / (2022)

Ebeling, Werner, ; Engel, Harald, ; Herzel, Hanspeter,

Berlin ; : De Gruyter,

add to watchlist on the watchlist

Details

UID:

almafu_9960141745202883

Format: 1 online resource (212 p.) : , Mit 57 Abbildungen und 1 Tabelle

Edition: Reprint 2021

ISBN: 9783112566503

Series Statement: Wissenschaftliche Taschenbücher ; 309

Note: Frontmatter -- , Inhaltsverzeichnis -- , 1. Einleitung -- , 2. Phänomenologie zeitlicher Strukturen -- , 3. Physikalische Grundgesetze des Zeitverhaltens -- , 4. Mechanische und chemische Oszillationen -- , 5. Entropie als Ordnungsmaß -- , 6. Methoden der Zeitreihenanalyse -- , 7. Beispiele komplexen Zeitverhaltens -- , 8. Die Zeitstruktur der Evolution -- , Literatur -- , Sachverzeichnis -- , Backmatter , In German.

Additional Edition: ISBN 9783112566497

Language: German

DOI: 10.1515/9783112566503

URL: https://doi.org/10.1515/9783112566503

URL: https://www.degruyter.com/isbn/9783112566503

URL: https://doi.org/10.1515/9783112566503

URL: https://www.degruyter.com/isbn/9783112566503

URL: lizenzpflichtig

URL: Cover

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Open Access Request

FU Berlin

UB Potsdam

Image

Herzel, Hans-Peter.

Herzel, Hanspeter

add to watchlist on the watchlist

Details

UID:

almahu_BV048474136

Format: Foto (schwarz/weiß) ; , 8° / 10 x 15.

Additional Edition: Elektronische Reproduktion Berlin

Language: Undetermined

URL: Vollständiger Inhalt (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Image

Inter-library loan

HU Berlin

Book

Selbstorganisation in der Zeit : mit 1 Tabelle (1990)

Ebeling, Werner ; Engel, Harald ; Herzel, Hanspeter

Berlin : Akademie-Verlag (Berlin, Ost)

add to watchlist on the watchlist

Details

UID:

kobvindex_ZLB12313563

Format: 205 Seiten , graph. Darst. , 20 cm

Edition: 1

ISBN: 3055007093

Series Statement: Wissenschaftliche Taschenbücher Bd. 309

Note: Literaturverz. S. 185 - 200

Language: German

Keywords: Selbstorganisation

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Book

Inter-library loan

Berlin VÖBB/ZLB

Online Resource

Inter-layer and inter-subject variability of diurnal gene expression in human skin (2022)

del Olmo, Marta ; Spörl, Florian ; Korge, Sandra ; [et al.]

Berlin : Humboldt-Universität zu Berlin

add to watchlist on the watchlist

Details

UID:

edochu_18452_28810

Format: 1 Online-Ressource (11 Seiten)

Content: The skin is the largest human organ with a circadian clock that regulates its function. Although circadian rhythms in specific functions are known, rhythms in the proximal clock output, gene expression, in human skin have not been thoroughly explored. This work reports 24 h gene expression rhythms in two skin layers, epidermis and dermis, in a cohort of young, healthy adults, who maintained natural, regular sleep-wake schedules. 10% of the expressed genes showed such diurnal rhythms at the population level, of which only a third differed between the two layers. Amplitude and phases of diurnal gene expression varied more across subjects than layers, with amplitude being more variable than phases. Expression amplitudes in the epidermis were larger and more subject-variable, while they were smaller and more consistent in the dermis. Core clock gene expression was similar across layers at the population-level, but were heterogeneous in their variability across subjects. We also identified small sets of biomarkers for internal clock phase in each layer, which consisted of layer-specific non-core clock genes. This work provides a valuable resource to advance our understanding of human skin and presents a novel methodology to quantify sources of variability in human circadian rhythms.

Content: Peer Reviewed

In: Oxford : Oxford University Press, 4,4

Language: English

DOI: 10.18452/28159

DOI: 10.1093/nargab/lqac097

URN: urn:nbn:de:kobv:11-110-18452/28810-5

URL: Volltext (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Fulltext

HU Berlin

Online Resource

Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator (2016)

Pett, Jan Patrick ; Korenčič, Anja ; Wesener, Felix ; [et al.]

Berlin : Humboldt-Universität zu Berlin

add to watchlist on the watchlist

Details

UID:

edochu_18452_30047

Format: 1 Online-Ressource (15 Seiten)

Content: Mammals evolved an endogenous timing system to coordinate their physiology and behaviour to the 24h period of the solar day. While it is well accepted that circadian rhythms are generated by intracellular transcriptional feedback loops, it is still debated which network motifs are necessary and sufficient for generating self-sustained oscillations. Here, we systematically explore a data-based circadian oscillator model with multiple negative and positive feedback loops and identify a series of three subsequent inhibitions known as “repressilator” as a core element of the mammalian circadian oscillator. The central role of the repressilator motif is consistent with time-resolved ChIP-seq experiments of circadian clock transcription factors and loss of rhythmicity in core clock gene knockouts.

Content: Peer Reviewed

In: San Francisco, Calif. : Public Library of Science, 12,12

Language: English

DOI: 10.18452/29438

DOI: 10.1371/journal.pcbi.1005266

URN: urn:nbn:de:kobv:11-110-18452/30047-9

URL: Volltext (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Fulltext

HU Berlin

Online Resource

Conceptual Models of Entrainment, Jet Lag, and Seasonality (2020)

Tokuda, Isao ; Schmal, Christoph ; Ananthasubramaniam, Bharath ; [et al.]

Berlin : Humboldt-Universität zu Berlin

add to watchlist on the watchlist

Details

UID:

edochu_18452_23138

Format: 1 Online-Ressource (10 Seiten)

Content: Understanding entrainment of circadian rhythms is a central goal of chronobiology. Many factors, such as period, amplitude, Zeitgeber strength, and daylength, govern entrainment ranges and phases of entrainment. We have tested whether simple amplitude-phase models can provide insight into the control of entrainment phases. Using global optimization, we derived conceptual models with just three free parameters (period, amplitude, and relaxation rate) that reproduce known phenotypic features of vertebrate clocks: phase response curves (PRCs) with relatively small phase shifts, fast re-entrainment after jet lag, and seasonal variability to track light onset or offset. Since optimization found multiple sets of model parameters, we could study this model ensemble to gain insight into the underlying design principles. We found complex associations between model parameters and entrainment features. Arnold onions of representative models visualize strong dependencies of entrainment on periods, relative Zeitgeber strength, and photoperiods. Our results support the use of oscillator theory as a framework for understanding the entrainment of circadian clocks.

Content: Peer Reviewed

In: Lausanne : Frontiers Research Foundation, 11

Language: English

DOI: 10.18452/22520

DOI: 10.3389/fphys.2020.00334

URN: urn:nbn:de:kobv:11-110-18452/23138-6

URL: Volltext (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Fulltext

HU Berlin

Online Resource

Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping (2024)

Ector, Carolin ; Schmal, Christoph ; Didier, Jeff ; [et al.]

Berlin : Humboldt-Universität zu Berlin

add to watchlist on the watchlist

Details

UID:

edochu_18452_32591

Format: 1 Online-Ressource (16 Seiten)

Content: The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the circadian rhythm can enhance treatment efficacy and minimize side effects. Yet, uncovering the optimal treatment timings remains challenging, limiting their widespread adoption. In this work, we introduce a high-throughput approach integrating live-imaging and data analysis techniques to deep-phenotype cancer cell models, evaluating their circadian rhythms, growth, and drug responses. We devise a streamlined process for profiling drug sensitivities across different times of the day, identifying optimal treatment windows and responsive cell types and drug combinations. Finally, we implement multiple computational tools to uncover cellular and genetic factors shaping time-of-day drug sensitivity. Our versatile approach is adaptable to various biological models, facilitating its broad application and relevance. Ultimately, this research leverages circadian rhythms to optimize anti-cancer drug treatments, promising improved outcomes and transformative treatment strategies.

Content: Peer Reviewed

In: : Nature Springer, 2024, 15

Language: English

DOI: 10.18452/31972

DOI: 10.1038/s41467-024-51611-3

URN: urn:nbn:de:kobv:11-110-18452/32591-5

URL: Volltext (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Fulltext

HU Berlin

Online Resource

IL-2 Expression in Activated Human Memory FOXP3+ Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation (2012)

Bendfeldt, Hanna ; Benary, Manuela ; Scheel, Tobias ; [et al.]

Berlin : Humboldt-Universität zu Berlin

add to watchlist on the watchlist

Details

UID:

edochu_18452_21440

Format: 1 Online-Ressource (10 Seiten)

Content: The human CD4+FOXP3+ T cell population is heterogeneous and consists of various subpopulations which remain poorly defined. Anergy and suppression are two main functional characteristics of FOXP3+Treg cells. We used the anergic behavior of FOXP3+Treg cells for a better discrimination and characterization of such subpopulations. We compared IL-2-expressing with IL-2-non-expressing cells within the memory FOXP3+ T cell population. In contrast to IL-2-non-expressing FOXP3+ cells, IL-2-expressing FOXP3+ cells exhibit intermediate characteristics of Treg and Th cells concerning the Treg cell markers CD25, GITR, and Helios. Besides lower levels of FOXP3, they also have higher levels of the transcription factors NFATc2, c-Fos, NF-κBp65, and c-Jun. An approach combining flow cytometric measurements with statistical interpretation for quantitative transcription factor analysis suggests that the physiological expression levels not only of FOXP3 but also of NFATc2, c-Jun, c-Fos, and NF-κBp65 are limiting for the decision whether IL-2 is expressed or not in activated peripheral human memory FOXP3+ cells. These findings demonstrate that concomitant high levels of NFATc2, c-Jun, c-Fos, and NF-κBp65 lead in addition to potential IL-2 expression in those FOXP3+ cells with low levels of FOXP3. We hypothesize that not only the level of FOXP3 expression but also the amounts of the four transcription factors studied represent determining factors for the anergic phenotype of FOXP3+ Treg cells.

Content: Peer Reviewed

In: Lausanne : Frontiers Research Foundation, 3

Language: English

DOI: 10.18452/20715

DOI: 10.3389/fimmu.2012.00264

URN: urn:nbn:de:kobv:11-110-18452/21440-1

URL: Volltext (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Fulltext

HU Berlin

Online Resource

p53 and p21 dynamics encode single-cell DNA damage levels, fine-tuning proliferation and shaping population heterogeneity (2023)

Gutu, Nica ; Binish, Neha ; Keilholz, Ulrich ; [et al.]

Berlin : Humboldt-Universität zu Berlin

add to watchlist on the watchlist

Details

UID:

edochu_18452_31248

Format: 1 Online-Ressource (11 Seiten)

Content: Cells must accurately and quickly detect DNA damage through a set of checkpoint mechanisms that enable repair and control proliferation. Heterogeneous levels of cellular stress and noisy signaling processes can lead to phenotypic variability but little is known about their role in underlying proliferation heterogeneity. Here we study two previously published single cell datasets and find that cells encode heterogeneous levels of endogenous and exogenous DNA damage to shape proliferation heterogeneity at the population level. Using a comprehensive time series analysis of short- and long-term signaling dynamics of p53 and p21, we show that DNA damage levels are quantitatively translated into p53 and p21 signal parameters in a gradual manner. Analyzing instantaneous proliferation and signaling differences among equally-radiated cells, we identify time-localized changes in the period of p53 pulses that drive cells out of a low proliferative state. Our findings suggest a novel role of the p53-p21 network in quantitatively encoding DNA damage strength and fine-tuning proliferation trajectories.

Content: Peer Reviewed

In: London : Springer Nature, 6,1

Language: English

DOI: 10.18452/30662

DOI: 10.1038/s42003-023-05585-5

URN: urn:nbn:de:kobv:11-110-18452/31248-2

URL: Volltext (kostenfrei)

Bookmarklink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Online Resource

Fulltext

HU Berlin

hits 1 - 10 | 18 hits

Nothing or not found what you are looking for? Please check your search query or use the Interlibrary Loan Search.

Kooperativer Bibliotheksverbund

Berlin Brandenburg