Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (501 p.)

Edition: 1st ed.

ISBN: 1-282-71188-1 , 9786612711886 , 0-08-095388-3

Content: The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream.

Note: Description based upon print version of record. , Front Cover; Bone Cancer: Progression and Therapeutic Approaches; Copyright Page; Contents; Foreword; Preface; List of Contributors; Section I: Epidemiology and Economical Aspects of Bone Cancer; Chapter 1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases; I. INCIDENCES OF PRIMARY BONE TUMORS; II. AGE; III. GENDER; IV. RACIAL DIFFERENCES IN INCIDENCES OF PRIMARY BONE TUMORS; V. SITE DISTRIBUTION; VI. INCIDENCES OF BONE TUMORS AS A SECONDARY EVENT; VII. INCIDENCES OF BONE METASTASES; VIII. PATHOLOGY OF BONE METASTASES; IX. COST OF ILLNESS , X. ECONOMICAL BURDEN OF BONE METASTASISXI. CONCLUSIONS; References; Section II: Bone Microenvironment and Bone Cancer; Chapter 2. Tumor-Bone Cell Interactions in Bone Metastases; I. INTRODUCTION; II. MECHANISMS OF OSTEOLYTIC METASTASES FROM SOLID TUMORS; III. SKELETAL COMPLICATIONS OF MULTIPLE MYELOMA; IV. OSTEOBLASTIC BONE METASTASES; References; Chapter 3. Early Bone Metastasis-Associated Molecular and Cellular Events; I. INTRODUCTION; II. BONE TROPISM OF CANCER CELLS; III. INTERACTION OF CANCER CELLS WITH THE BONE MARROW ENDOTHELIUM; IV. INVASION OF CANCER CELLS INTO THE BONE , V. OSTEOMIMETISMVI. IMPACT OF BONE MARROW STEM CELL NICHES; VII. CONCLUSION AND PERSPECTIVES; References; Chapter 4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and PTH Signaling Pathways; I. INTRODUCTION; II. CONTROL OF OSTEOBLAST DIFFERENTIATION BY PARATHYROID HORMONE AND WNT; III. WNT SIGNALING AND CANCER; IV. WNT SIGNALING AND OSTEOSARCOMA; V. DKK1 AND CANCER METASTASES TO BONE; VI. SFRP-2 AND MULTIPLE MYELOMA; VII. PTH AND OSTEOSARCOMA; VIII. CONCLUSIONS AND PERSPECTIVES; References; Chapter 5. Osteoclast Differentiation and Function , I. OSTEOCLASTS IN HEALTH AND DISEASEII. OSTEOCLAST RECRUITMENT; III. OSTEOCLAST FUNCTION; IV. CONTROLLING OSTEOCLAST FUNCTION IN THE CONTEXT OF OSTEOPOROSIS; V. OSTEOCLAST IN BONE MALIGNANCIES; VI. OSTEOCLASTS IN INFLAMMATORY DISEASES; VII. SUMMARY AND CONCLUSION; References; Chapter 6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Disease; I. INTRODUCTION; II. OSTEOCLASTOGENESIS IN MULTIPLE MYELOMA: ROLE OF CYTOKINES AND CELLS OF IMMUNE SYSTEM; III. NEW THERAPEUTIC APPROACHES FOR TREATMENT OF MULTIPLE MYELOMA BONE DISEASE PATIENTS; IV. CONCLUSIONS AND PERSPECTIVES , AcknowledgementsReferences; Chapter 7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation; I. INTRODUCTION; II. DEVELOPMENTAL STAGES OF MAXILLA AND TOOTH FORMATION; III. EPITHELIAL CELL FATE AND DIFFERENTIATION IN THE ODONTOGENIC AND NON-ODONTOGENIC PATHWAYS DURING NORMAL DEVELOPMENT AND IN ODONTOGENIC OSTEOLYTIC TUMORS AND CYSTS; IV. MOLECULAR STUDIES ON JAW TUMORS AND KOT; V. THERAPEUTIC STATEMENT IN ODONTOGENIC TUMORS AND CYSTS; VI. CONCLUSION; References , Chapter 8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer , English

Additional Edition: ISBN 0-12-374895-X

Language: English

UID:

Format: 243 Bl , Ill., graph. Darst

Edition: [Mikrofiche-Ausg.]

Note: Mikrofiche-Ausg.: 1 Mikrofiche , Grenoble, Univ., Diss., 1996

Language: Undetermined

Keywords: Hochschulschrift

UID:

Edition: 2010

ISBN: 9780123748959 , 012374895X

Language: English

URL: Volltext

UID:

Format: 1 online resource (730 pages) : , illustrations (some color)

Edition: Second edition.

ISBN: 0-12-416728-4

Series Statement: Elsevier science & technology books

Content: Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors

Content: and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Note: "Elsevier science & technology books." , Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone: bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer -- Deregulation of osteoblast differentiation in primary bone cancers -- Contribution of osteoclasts to the bone: tumor niche -- Involvement of osteocytes in cancer bone niche -- Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis -- Gap junction in bone remodeling and in primary bone tumors: osteosarcoma and Ewing sarcoma -- Macrophages and pathophysiology of bone cancers -- Cytokines and bone cancers -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Bone remodeling markers and bone cancer -- Cancer stem cells in representative bone tumors: osteosarcoma, Ewing sarcoma and metastases from breast and prostate carcinomas -- Homeobox genes from the Dlx family and bone cancers -- MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors -- Hypoxia and angiogenesis: from primary tumor to bone metastasis -- Modeling osteosarcoma: in vitro and in vivo approaches -- Stemness markers of osteosarcoma -- Molecular pathology of osteosarcoma -- Gene and proteomic profiling of osteosarcoma -- Ewing sarcoma family of tumors -- Biology of Ewing sarcoma -- Osteoclast-rich lesions of bone: a clinical and molecular overview -- Markers for bone sarcomas -- Margins and bone tumors: what are we talking about? -- Cytogenetics of bone tumors -- Genetic aspects of bone tumors -- Cytogenetic and molecular genetic alterations in bone tumors -- Genetics of giant cell tumors of bone -- Mammalian models of bone sarcomas -- Zebrafish models for studying bone cancers: mutants, transgenic fish and embryos -- Imaging of bone sarcomas -- New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials -- Therapeutic approaches for bone sarcomas -- Chondrosarcoma of bone: diagnosis and therapy -- Apoptosis and drug resistance in malignant bone tumors -- Giant cell tumors of bone -- EMT process in bone metastasis -- Histopathology of skeletal metastases -- Disseminated tumor cells in bone marrow of cancer patients -- MicroRNA-mediated regulation of bone metastasis formation: from primary tumors to skeleton -- Myeloma and osteoclast relationship -- In vivo models used in studies of bone metastases -- Interventional radiologic techniques in management of bone tumors -- Diagnosis of bone metastases in urological malignancies : an update -- Pre-clinical molecular imaging of "the seed and the soil" in bone metastasis -- Mechanisms and management of bone cancer pain -- Bone cancer: current opinion in palliative care -- Involvement of sympathetic nerves in bone metastasis -- Pain control with palliative radiotherapy in patients with bone metastases -- Cellular and molecular actions of bisphosphonates -- The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal of human peripheral blood [gamma delta] T cells for the treatment of bone cancer metastasis -- Systemic treatment of bone metastases in castration-resistant prostate cancer (CRPC): pre-clinical to clinical point of view -- A multi-targeted approach to treating bone metastases -- Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and future directions -- Bone-targeted agents and skeletal-related events in breast cancer patients with bone metastases -- Bone metastases : current status of bone-targeted treatments -- Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases.

Additional Edition: ISBN 1-322-10896-X

Additional Edition: ISBN 0-12-416721-7

Language: English

UID:

Format: 1 online resource (730 pages) : , illustrations (some color)

Edition: Second edition.

ISBN: 0-12-416728-4

Series Statement: Elsevier science & technology books

Content: Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors

Content: and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Note: "Elsevier science & technology books." , Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone: bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer -- Deregulation of osteoblast differentiation in primary bone cancers -- Contribution of osteoclasts to the bone: tumor niche -- Involvement of osteocytes in cancer bone niche -- Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis -- Gap junction in bone remodeling and in primary bone tumors: osteosarcoma and Ewing sarcoma -- Macrophages and pathophysiology of bone cancers -- Cytokines and bone cancers -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Bone remodeling markers and bone cancer -- Cancer stem cells in representative bone tumors: osteosarcoma, Ewing sarcoma and metastases from breast and prostate carcinomas -- Homeobox genes from the Dlx family and bone cancers -- MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors -- Hypoxia and angiogenesis: from primary tumor to bone metastasis -- Modeling osteosarcoma: in vitro and in vivo approaches -- Stemness markers of osteosarcoma -- Molecular pathology of osteosarcoma -- Gene and proteomic profiling of osteosarcoma -- Ewing sarcoma family of tumors -- Biology of Ewing sarcoma -- Osteoclast-rich lesions of bone: a clinical and molecular overview -- Markers for bone sarcomas -- Margins and bone tumors: what are we talking about? -- Cytogenetics of bone tumors -- Genetic aspects of bone tumors -- Cytogenetic and molecular genetic alterations in bone tumors -- Genetics of giant cell tumors of bone -- Mammalian models of bone sarcomas -- Zebrafish models for studying bone cancers: mutants, transgenic fish and embryos -- Imaging of bone sarcomas -- New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials -- Therapeutic approaches for bone sarcomas -- Chondrosarcoma of bone: diagnosis and therapy -- Apoptosis and drug resistance in malignant bone tumors -- Giant cell tumors of bone -- EMT process in bone metastasis -- Histopathology of skeletal metastases -- Disseminated tumor cells in bone marrow of cancer patients -- MicroRNA-mediated regulation of bone metastasis formation: from primary tumors to skeleton -- Myeloma and osteoclast relationship -- In vivo models used in studies of bone metastases -- Interventional radiologic techniques in management of bone tumors -- Diagnosis of bone metastases in urological malignancies : an update -- Pre-clinical molecular imaging of "the seed and the soil" in bone metastasis -- Mechanisms and management of bone cancer pain -- Bone cancer: current opinion in palliative care -- Involvement of sympathetic nerves in bone metastasis -- Pain control with palliative radiotherapy in patients with bone metastases -- Cellular and molecular actions of bisphosphonates -- The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal of human peripheral blood [gamma delta] T cells for the treatment of bone cancer metastasis -- Systemic treatment of bone metastases in castration-resistant prostate cancer (CRPC): pre-clinical to clinical point of view -- A multi-targeted approach to treating bone metastases -- Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and future directions -- Bone-targeted agents and skeletal-related events in breast cancer patients with bone metastases -- Bone metastases : current status of bone-targeted treatments -- Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases.

Additional Edition: ISBN 1-322-10896-X

Additional Edition: ISBN 0-12-416721-7

Language: English

UID:

Format: 1 online resource (1080 pages)

Edition: Third edition

ISBN: 0-323-89990-0 , 0-12-821666-2

Content: Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Note: Previous edition published as: Bone cancer : primary bone cancers and bone metastases / edited by Dominique Heymann. San Diego, California ; Waltham, Massachusetts : Elsevier/Academic Press, 2015. Second edition. , Basic aspects of bone cancers -- , Epidemiology of bone cancers -- , Animal models of bone cancers -- , Machine learning and artificial intelligence -- , Preparation of tissue samples -- , Bone microenvironment and bone cancer -- , Dialog between cancer cells and bone cells , Mediators of cell communications -- , Metabolism -- , Cell plasticity and tumor heterogeneity -- , Biomarkers , Primary bone tumors -- , Biological aspects -- , Imaging -- , Therapeutic approaches -- , Bone metastases -- , Biological aspects -- , Clinical aspects and imaging -- , Bone pain -- , Therapeutic approaches , Myeloma : a bone associated disease.

Additional Edition: Print version: Bone cancer. Amsterdam : Academic Press, 2021 ISBN 9780128216668

Language: English

UID:

Format: 1 online resource (1080 pages)

Edition: Third edition

ISBN: 0-323-89990-0 , 0-12-821666-2

Content: Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Note: Previous edition published as: Bone cancer : primary bone cancers and bone metastases / edited by Dominique Heymann. San Diego, California ; Waltham, Massachusetts : Elsevier/Academic Press, 2015. Second edition. , Basic aspects of bone cancers -- , Epidemiology of bone cancers -- , Animal models of bone cancers -- , Machine learning and artificial intelligence -- , Preparation of tissue samples -- , Bone microenvironment and bone cancer -- , Dialog between cancer cells and bone cells , Mediators of cell communications -- , Metabolism -- , Cell plasticity and tumor heterogeneity -- , Biomarkers , Primary bone tumors -- , Biological aspects -- , Imaging -- , Therapeutic approaches -- , Bone metastases -- , Biological aspects -- , Clinical aspects and imaging -- , Bone pain -- , Therapeutic approaches , Myeloma : a bone associated disease.

Additional Edition: Print version: Bone cancer. Amsterdam : Academic Press, 2021 ISBN 9780128216668

Language: English

UID:

Format: 1 online resource (1080 pages)

Edition: Third edition

ISBN: 0-323-89990-0 , 0-12-821666-2

Content: Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease.

Note: Previous edition published as: Bone cancer : primary bone cancers and bone metastases / edited by Dominique Heymann. San Diego, California ; Waltham, Massachusetts : Elsevier/Academic Press, 2015. Second edition. , Basic aspects of bone cancers -- , Epidemiology of bone cancers -- , Animal models of bone cancers -- , Machine learning and artificial intelligence -- , Preparation of tissue samples -- , Bone microenvironment and bone cancer -- , Dialog between cancer cells and bone cells , Mediators of cell communications -- , Metabolism -- , Cell plasticity and tumor heterogeneity -- , Biomarkers , Primary bone tumors -- , Biological aspects -- , Imaging -- , Therapeutic approaches -- , Bone metastases -- , Biological aspects -- , Clinical aspects and imaging -- , Bone pain -- , Therapeutic approaches , Myeloma : a bone associated disease.

Additional Edition: Print version: Bone cancer. Amsterdam : Academic Press, 2021 ISBN 9780128216668

Language: English

UID:

Format: 1 online resource (730 pages) : , illustrations (some color)

Edition: Second edition.

ISBN: 0-12-416728-4

Series Statement: Elsevier science & technology books

Content: Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors

Content: and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Note: "Elsevier science & technology books." , Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone: bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer -- Deregulation of osteoblast differentiation in primary bone cancers -- Contribution of osteoclasts to the bone: tumor niche -- Involvement of osteocytes in cancer bone niche -- Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis -- Gap junction in bone remodeling and in primary bone tumors: osteosarcoma and Ewing sarcoma -- Macrophages and pathophysiology of bone cancers -- Cytokines and bone cancers -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Bone remodeling markers and bone cancer -- Cancer stem cells in representative bone tumors: osteosarcoma, Ewing sarcoma and metastases from breast and prostate carcinomas -- Homeobox genes from the Dlx family and bone cancers -- MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors -- Hypoxia and angiogenesis: from primary tumor to bone metastasis -- Modeling osteosarcoma: in vitro and in vivo approaches -- Stemness markers of osteosarcoma -- Molecular pathology of osteosarcoma -- Gene and proteomic profiling of osteosarcoma -- Ewing sarcoma family of tumors -- Biology of Ewing sarcoma -- Osteoclast-rich lesions of bone: a clinical and molecular overview -- Markers for bone sarcomas -- Margins and bone tumors: what are we talking about? -- Cytogenetics of bone tumors -- Genetic aspects of bone tumors -- Cytogenetic and molecular genetic alterations in bone tumors -- Genetics of giant cell tumors of bone -- Mammalian models of bone sarcomas -- Zebrafish models for studying bone cancers: mutants, transgenic fish and embryos -- Imaging of bone sarcomas -- New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials -- Therapeutic approaches for bone sarcomas -- Chondrosarcoma of bone: diagnosis and therapy -- Apoptosis and drug resistance in malignant bone tumors -- Giant cell tumors of bone -- EMT process in bone metastasis -- Histopathology of skeletal metastases -- Disseminated tumor cells in bone marrow of cancer patients -- MicroRNA-mediated regulation of bone metastasis formation: from primary tumors to skeleton -- Myeloma and osteoclast relationship -- In vivo models used in studies of bone metastases -- Interventional radiologic techniques in management of bone tumors -- Diagnosis of bone metastases in urological malignancies : an update -- Pre-clinical molecular imaging of "the seed and the soil" in bone metastasis -- Mechanisms and management of bone cancer pain -- Bone cancer: current opinion in palliative care -- Involvement of sympathetic nerves in bone metastasis -- Pain control with palliative radiotherapy in patients with bone metastases -- Cellular and molecular actions of bisphosphonates -- The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal of human peripheral blood [gamma delta] T cells for the treatment of bone cancer metastasis -- Systemic treatment of bone metastases in castration-resistant prostate cancer (CRPC): pre-clinical to clinical point of view -- A multi-targeted approach to treating bone metastases -- Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and future directions -- Bone-targeted agents and skeletal-related events in breast cancer patients with bone metastases -- Bone metastases : current status of bone-targeted treatments -- Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases.

Additional Edition: ISBN 1-322-10896-X

Additional Edition: ISBN 0-12-416721-7

Language: English